Browsing Harvard Medical School by Title

Now showing items 1904-1923 of 18428

    • BRAF inhibition is associated with increased clonality in tumor-infiltrating lymphocytes 

      Cooper, Zachary A; Frederick, Dennie T; Juneja, Vikram R; Sullivan, Ryan J; Lawrence, Donald P; Piris, Adriano; Sharpe, Arlene H; Fisher, David E; Flaherty, Keith T; Wargo, Jennifer A (Landes Bioscience, 2013)
      There have been significant advances with regard to BRAF-targeted therapies against metastatic melanoma. However, the majority of patients receiving BRAF inhibitors (BRAFi) manifest disease progression within a year. We ...

    • BRAF V600E Mutations are Common in Pleomorphic Xanthoastrocytoma: Diagnostic and Therapeutic Implications 

      Lam, Quynh; Vernovsky, Kathy; Vena, Natalie; Lennerz, Jochen K.; Dias-Santagata, Dora; Borger, Darrell R.; Batchelor, Tracy Todd; Ligon, Keith Lloyd; Iafrate, Anthony John; Ligon, Azra Hadi; Louis, David Neil; Santagata, Sandro; Dias-Santagata, Dora (Public Library of Science, 2011)
      Pleomorphic xanthoastrocytoma (PXA) is low-grade glial neoplasm principally affecting children and young adults. Approximately 40% of PXA are reported to recur within 10 years of primary resection. Upon recurrence, patients ...

    • BRAF V600E-Positive Multisite Langerhans Cell Histiocytosis in a Preterm Neonate 

      Bates, Sara V.; Lakshmanan, Ashwini; Green, Adam L.; Terry, Jefferson; Badalian-Very, Gayane; Rollins, Barrett J.; Fleck, Patricia; Aslam, Muhammad; Degar, Barbara A. (Thieme Medical Publishers, 2013)
      Hemorrhagic pustules with a “blueberry muffin” appearance accompanied by respiratory failure in a neonate present a challenging differential diagnosis that includes infections and neoplasms. We present a case of multiorgan, ...

    • Brain Activation During Working Memory Is Altered in Patients With Type 1 Diabetes During Hypoglycemia 

      Bolo, Nicolas R.; Musen, Gail; Jacobson, Alan Marc; Weinger, Katie; McCartney, Richard L.; Flores, Veronica; Renshaw, Perry Franklin; Simonson, Donald Craig (American Diabetes Association, 2011)
      OBJECTIVE To investigate the effects of acute hypoglycemia on working memory and brain function in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS Using blood oxygen level–dependent (BOLD) functional magnetic ...

    • Brain activity and connectivity during poetry composition: Toward a multidimensional model of the creative process 

      Liu, Siyuan; Erkkinen, Michael G.; Healey, Meghan L.; Xu, Yisheng; Swett, Katherine E.; Chow, Ho Ming; Braun, Allen R. (John Wiley and Sons Inc., 2015)
      Abstract Creativity, a multifaceted construct, can be studied in various ways, for example, investigating phases of the creative process, quality of the creative product, or the impact of expertise. Previous neuroimaging ...

    • The Brain Activity Map Project and the Challenge of Functional Connectomics 

      Alivisatos, A. Paul; Chun, Miyoung; Church, George; Greenspan, Ralph J.; Roukes, Michael L.; Yuste, Rafael (Elsevier BV, 2012-06-21)
      The function of neural circuits is an emergent property that arises from the coordinated activity of large numbers of neurons. To capture this, we propose launching a large-scale, international public effort, the Brain ...

    • Brain basis of self: self-organization and lessons from dreaming 

      Kahn, David (Frontiers Media S.A., 2013)
      Through dreaming, a different facet of the self is created as a result of a self-organizing process in the brain. Self-organization in biological systems often happens as an answer to an environmental change for which the ...

    • Brain Changes in Responders vs. Non-Responders in Chronic Migraine: Markers of Disease Reversal 

      Hubbard, Catherine S.; Becerra, Lino; Smith, Jonathan H.; DeLange, Justin M.; Smith, Ryan M.; Black, David F.; Welker, Kirk M.; Burstein, Rami; Cutrer, Fred M.; Borsook, David (Frontiers Media S.A., 2016)
      The aim of this study was to identify structural and functional brain changes that accompanied the transition from chronic (CM; ≥15 headache days/month) to episodic (EM; <15 headache days/month) migraine following prophylactic ...

    • Brain correlates of autonomic modulation: Combining heart rate variability with fMRI 

      Napadow, Vitaly J.; Dhond, Rupali; Conti, Giulia; Makris, Nikos; Brown, Emery Neal; Barbieri, Riccardo (Elsevier BV, 2008)
      The central autonomic network (CAN) has been described in animal models but has been difficult to elucidate in humans. Potential confounds include physiological noise artifacts affecting brainstem neuroimaging data, and ...

    • Brain correlates of phasic autonomic response to acupuncture stimulation: An event-related fMRI study 

      Napadow, Vitaly J.; Lee, Jeungchan; Kim, Jieun; Cina, Stephen; Maeda, Yumi; Barbieri, Riccardo; Harris, Richard E.; Kettner, Norman; Park, Kyungmo (Wiley-Blackwell, 2012)
      Autonomic nervous system (ANS) response to acupuncture has been investigated by multiple studies; however, the brain circuitry underlying this response is not well understood. We applied event-related fMRI (er-fMRI) in ...

    • BRAIN DIFFERENCES IN AUTISM SPECTRUM DISORDER 

      Li, Shijun (2021-05-21)
      Identifying brain abnormalities in autism spectrum disorder (ASD) is critical for early diagnosis and intervention. A novel method Inception 3D-ResNet (iResNet) has been applied to identify brain structural brain differences ...

    • Brain encoding of acupuncture sensation — Coupling on-line rating with fMRI 

      Napadow, Vitaly J.; Dhond, Rupali P.; Kim, Jieun; LaCount, Lauren; Vangel, Mark G.; Harris, Richard E; Kettner, Norman; Park, Kyungmo (Elsevier BV, 2009)
      Acupuncture-induced sensations have historically been associated with clinical efficacy. These sensations are atypical, arising from sub-dermal receptors, and their neural encoding is not well known. In this fMRI study, ...

    • Brain endothelial cell‐targeted gene therapy of neurovascular disorders 

      Marchiò, Serena; Sidman, Richard L; Arap, Wadih; Pasqualini, Renata (John Wiley and Sons Inc., 2016)
      Neurovascular disorders are difficult to treat due to the blood–brain barrier (BBB), which prevents delivery of most drugs from the blood into the brain. Gene therapy can potentially overcome this barrier, but classical ...

    • Brain functional networks in syndromic and non-syndromic autism: a graph theoretical study of EEG connectivity 

      Peters, Jurriaan M.; Taquet, Maxime; Vega, Clemente; Jeste, Shafali S; Fernández, Iván; Tan, Jacqueline E; Nelson, Charles A.; Sahin, Mustafa; Warfield, Simon Keith (Springer Science + Business Media, 2013)
      Background Graph theory has been recently introduced to characterize complex brain networks, making it highly suitable to investigate altered connectivity in neurologic disorders. A current model proposes autism spectrum ...

    • Brain Genomics Superstruct Project initial data release with structural, functional, and behavioral measures 

      Holmes, Avram J.; Hollinshead, Marisa O.; O’Keefe, Timothy M.; Petrov, Victor I.; Fariello, Gabriele R.; Wald, Lawrence L.; Fischl, Bruce; Rosen, Bruce R.; Mair, Ross W.; Roffman, Joshua L.; Smoller, Jordan W.; Buckner, Randy L. (Nature Publishing Group, 2015)
      The goal of the Brain Genomics Superstruct Project (GSP) is to enable large-scale exploration of the links between brain function, behavior, and ultimately genetic variation. To provide the broader scientific community ...

    • The brain imaging data structure, a format for organizing and describing outputs of neuroimaging experiments 

      Gorgolewski, Krzysztof J.; Auer, Tibor; Calhoun, Vince D.; Craddock, R. Cameron; Das, Samir; Duff, Eugene P.; Flandin, Guillaume; Ghosh, Satrajit S.; Glatard, Tristan; Halchenko, Yaroslav O.; Handwerker, Daniel A.; Hanke, Michael; Keator, David; Li, Xiangrui; Michael, Zachary; Maumet, Camille; Nichols, B. Nolan; Nichols, Thomas E.; Pellman, John; Poline, Jean-Baptiste; Rokem, Ariel; Schaefer, Gunnar; Sochat, Vanessa; Triplett, William; Turner, Jessica A.; Varoquaux, Gaël; Poldrack, Russell A. (Nature Publishing Group, 2016)
      The development of magnetic resonance imaging (MRI) techniques has defined modern neuroimaging. Since its inception, tens of thousands of studies using techniques such as functional MRI and diffusion weighted imaging have ...

    • The Brain in Schizotypal Personality Disorder: A Review of Structural MRI and CT Findings 

      Dickey, Chandlee C.; McCarley, Robert William; Shenton, Martha Elizabeth (Ovid Technologies (Wolters Kluwer Health), 2002)
      Studies of schizotypal personality disorder (SPD) are important because the condition is genetically related to schizophrenia and because data accumulating to confirm its biological underpinnings are challenging some ...

    • The BRAIN Initiative: developing technology to catalyse neuroscience discovery 

      Jorgenson, Lyric A.; Newsome, William T.; Anderson, David J.; Bargmann, Cornelia I.; Brown, Emery N.; Deisseroth, Karl; Donoghue, John P.; Hudson, Kathy L.; Ling, Geoffrey S. F.; MacLeish, Peter R.; Marder, Eve; Normann, Richard A.; Sanes, Joshua R.; Schnitzer, Mark J.; Sejnowski, Terrence J.; Tank, David W.; Tsien, Roger Y.; Ugurbil, Kamil; Wingfield, John C. (The Royal Society, 2015)
      The evolution of the field of neuroscience has been propelled by the advent of novel technological capabilities, and the pace at which these capabilities are being developed has accelerated dramatically in the past decade. ...

    • Brain lesion and lesion network analyses of anterograde and retrograde amnesia 

      Ding, Mengyuan (2023-05-11)
      This thesis investigates lesion location and lesion network analyses in anterograde and retrograde amnesia using a systematic review of amnesia case reports and case series in the published peer-reviewed medical literature. ...

    • The Brain Metabolome of Male Rats across the Lifespan 

      Zheng, Xiaojiao; Chen, Tianlu; Zhao, Aihua; Wang, Xiaoyan; Xie, Guoxiang; Huang, Fengjie; Liu, Jiajian; Zhao, Qing; Wang, Shouli; Wang, Chongchong; Zhou, Mingmei; Panee, Jun; He, Zhigang; Jia, Wei (Nature Publishing Group, 2016)
      Comprehensive and accurate characterization of brain metabolome is fundamental to brain science, but has been hindered by technical limitations. We profiled the brain metabolome in male Wistar rats at different ages (day ...