Browsing Harvard Medical School by Title
Now showing items 2182-2201 of 18428
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Career on the Move: Geography, Stratification, and Scientific Impact
(Nature Publishing Group, 2014)Changing institutions is an integral part of an academic life. Yet little is known about the mobility patterns of scientists at an institutional level and how these career choices affect scientific outcomes. Here, we examine ... -
Caregiver Burden in Epilepsy: Determinants and Impact
(Hindawi Publishing Corporation, 2014)Aim. Caregiver burden (CB) in epilepsy constitutes an understudied area. Here we attempt to identify the magnitude of this burden, the factors associated with it, and its impact to caregiver quality of life (QOL). Methods:. ... -
Caregiver Evaluation of the Quality of End-Of-Life Care (CEQUEL) Scale: The Caregiver's Perception of Patient Care Near Death
(Public Library of Science, 2013)Purpose End-of-life (EOL) measures are limited in capturing caregiver assessment of the quality of EOL care. Because none include caregiver perception of patient suffering or prolongation of death, we sought to develop and ... -
Caregiver Perceptions and Motivation for Disclosing or Concealing the Diagnosis of HIV Infection to Children Receiving HIV Care in Mbarara, Uganda: A Qualitative Study
(Public Library of Science, 2014)Background: Disclosure of the diagnosis of HIV to HIV-infected children is challenging for caregivers. Despite current recommendations, data suggest that levels of disclosure of HIV status to HIV-infected children receiving ... -
Caries prevalence and impact on oral health-related quality of life in children with sickle cell disease: cross-sectional study
(BioMed Central, 2015)Background: Children with sickle cell disease (SCD) may present oral conditions that can compromise children's health even more. However, there is still no consensus on the association between SCD and dental caries. The ... -
Carotid Artery Intima-media Thickness, Carotid Plaque and Coronary Heart Disease and Stroke in Chinese
(Public Library of Science, 2008)Background: Our aim was to prospectively investigate the association between carotid artery intima-media thickness (IMT) as well as carotid plaque and incidence of coronary heart disease (CHD) and stroke in Chinese, among ... -
Carotid Atherosclerosis, Cerebrospinal Fluid Pressure, and Retinal Vessel Diameters: The Asymptomatic Polyvascular Abnormalities in Community Study
(Public Library of Science, 2016)Purpose To assess relationships between carotid artery atherosclerosis and retinal arteriolar and venular diameters. Methods: The community-based longitudinal Asymptomatic Polyvascular Abnormalities Community Study (APAC) ... -
Cartilage issues in football—today's problems and tomorrow's solutions
(BMJ Publishing Group, 2015)Articular cartilage injury is prevalent in football players and results from chronic joint stress or acute traumatic injuries. Articular cartilage injury can often result in progressive painful impairment of joint function ... -
Cartilage Oligomeric Matrix Protein Is a Calcium-binding Protein, and a Mutation in Its Type 3 Repeats Causes Conformational Changes
(American Society for Biochemistry and Molecular Biology, 2000)Mutations in residues in the type 3 calcium-binding repeats and COOH-terminal globular region of cartilage oligomeric matrix protein (COMP) lead to two skeletal dysplasias, pseudoachondroplasia and multiple epiphyseal ... -
Cartilage Oligomeric Matrix Protein/Thrombospondin 5 Supports Chondrocyte Attachment through Interaction with Integrins
(American Society for Biochemistry and Molecular Biology, 2005)Cartilage oligomeric matrix protein/ thrombospondin 5 ( COMP/ TSP5) is a major component of the extracellular matrix of the musculoskeletal system. Although COMP/ TSP5 abnormalities are associated with several pathological ... -
Cas9 as a Versatile Tool for Engineering Biology
(Springer Science and Business Media LLC, 2013-10)RNA-guided Cas9 nucleases derived from clustered regularly interspaced short palindromic repeats (CRISPR)-Cas systems have dramatically transformed our ability to edit the genomes of diverse organisms. We believe tools and ... -
Cas9 Functionally Opens Chromatin
(Public Library of Science, 2016)Using a nuclease-dead Cas9 mutant, we show that Cas9 reproducibly induces chromatin accessibility at previously inaccessible genomic loci. Cas9 chromatin opening is sufficient to enable adjacent binding and transcriptional ... -
Cas9 gRNA Engineering for Genome Editing, Activation and Repression
(Springer Science and Business Media LLC, 2015-11)We demonstrate that by altering the length of Cas9-associated guide RNA(gRNA) we were able to control Cas9 nuclease activity and simultaneously perform genome editing and transcriptional regulation with a single Cas9 ... -
CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering
(2013)Prokaryotic type II CRISPR-Cas systems can be adapted to enable targeted genome modifications across a range of eukaryotes.1–7. Here we engineer this system to enable RNA-guided genome regulation in human cells by tethering ... -
Cascade of neural processing orchestrates cognitive control in human frontal cortex
(eLife Sciences Publications, Ltd, 2016)Rapid and flexible interpretation of conflicting sensory inputs in the context of current goals is a critical component of cognitive control that is orchestrated by frontal cortex. The relative roles of distinct subregions ... -
Case 10-2009: A 23-Year-Old Woman With an Abnormal Papanicolaou Smear
(Massachusetts Medical Society, 2009-03-26) -
Case 14-2013 — A 70-Year-Old Woman With Vaginal Bleeding
(Massachusetts Medical Society, 2013-05-09) -
Case 16-2004
(New England Journal of Medicine (NEJM/MMS), 2004) -
Case 32-2003 — a 37-Year-Old Woman With Atypical Squamous Cells on a Papanicolaou Smear
(Massachusetts Medical Society, 2003-10-16)Presentation of Case: A 37-year-old woman was referred to the colposcopy clinic because of two Papanicolaou smears showing atypical squamous cells of undetermined significance (ASC-US). One and two years previously, the ... -
Case 40-2010 — A 68-Year-Old Woman with Chest Pain during an Airplane Flight
(New England Journal of Medicine (NEJM/MMS), 2010)A 68-year-old woman was transferred to this hospital because of substernal chest pain. An ECG showed evidence of MI. Coronary angiography was performed, with stenting of an occluded coronary artery. On the fourth hospital ...