Now showing items 2219-2238 of 18424

    • Caspase-11 Controls Interleukin-1β Release through Degradation of TRPC1 

      Py, Bénédicte F.; Jin, Mingzhi; Desai, Bimal N.; Penumaka, Anirudh; Zhu, Hong; Kober, Maike; Dietrich, Alexander; Lipinski, Marta M.; Henry, Thomas; Clapham, David E.; Yuan, Junying (2014)
      SUMMARY Caspase-11 is a highly inducible caspase that controls both inflammatory responses and cell death. Caspase-11 controls interleukin 1β (IL-1β) secretion by potentiating caspase-1 activation and induces caspase-1-independent ...
    • Caspase-8 Inactivation in T Cells Increases Necroptosis and Suppresses Autoimmunity in \(Bim^{−/−}\) Mice 

      Bohgaki, Toshiyuki; Mozo, Julien; Matysiak-Zablocki, Elzbieta; Bohgaki, Miyuki; Sanchez, Otto; Strasser, Andreas; Hakem, Anne; Hakem, Razqallah; Salmena, Leonardo (The Rockefeller University Press, 2011)
      Dysregulation of either the extrinsic or intrinsic apoptotic pathway can lead to various diseases including immune disorders and cancer. In addition to its role in the extrinsic apoptotic pathway, caspase-8 plays nonapoptotic ...
    • Casting Light from the Shadows: Coping and Defenses Amidst a Pandemic 

      McDowell, Michal J.; Salvi, Joshua D. (Physicians Postgraduate Press, Inc, 2020-06-09)
    • Catalase Prevents Maternal Diabetes–Induced Perinatal Programming via the Nrf2–HO-1 Defense System 

      Chang, Shiao-Ying; Chen, Yun-Wen; Zhao, Xin-Ping; Chenier, Isabelle; Tran, Stella; Sauvé, Alexandre; Ingelfinger, Julie R.; Zhang, Shao-Ling (American Diabetes Association, 2012)
      We investigated whether overexpression of catalase (CAT) in renal proximal tubular cells (RPTCs) could prevent the programming of hypertension and kidney disease in the offspring of dams with maternal diabetes. Male offspring ...
    • Catalyzing a Reproductive Health and Social Justice Movement 

      Verbiest, Sarah; Malin, Christina Kiko; Drummonds, Mario; Kotelchuck, Milton (Springer US, 2016)
      Objectives: The maternal and child health (MCH) community, partnering with women and their families, has the potential to play a critical role in advancing a new multi-sector social movement focused on creating a women’s ...
    • Catastrophic NAD+ Depletion in Activated T Lymphocytes Through Nampt Inhibition Reduces Demyelination and Disability in EAE 

      Bruzzone, Santina; Fruscione, Floriana; Morando, Sara; Ferrando, Tiziana; Poggi, Alessandro; Garuti, Anna; D'Urso, Agustina; Selmo, Martina; Benvenuto, Federica; Cea, Michele; Zoppoli, Gabriele; Moran, Eva; Soncini, Debora; Ballestrero, Alberto; Sordat, Bernard; Patrone, Franco; Uccelli, Antonio; Nencioni, Alessio; Mostoslavsky, Raul (Public Library of Science, 2009)
      Nicotinamide phosphoribosyltransferase (Nampt) inhibitors such as FK866 are potent inhibitors of NAD+ synthesis that show promise for the treatment of different forms of cancer. Based on Nampt upregulation in activated T ...
    • Catch me if you can: Leukemia Escape after CD19-Directed T Cell Immunotherapies 

      Ruella, Marco; Maus, Marcela V. (Research Network of Computational and Structural Biotechnology, 2016)
      Immunotherapy is the revolution in cancer treatment of this last decade. Among multiple approaches able to harness the power of the immune system against cancer, T cell based immunotherapies represent one of the most ...
    • Catching a Virus in the Act of RNA Release: a Novel Poliovirus Uncoating Intermediate Characterized by Cryo-Electron Microscopy 

      Levy, Hazel C.; Bostina, Mihnea; Filman, David J.; Hogle, James M. (American Society for Microbiology, 2010)
      Poliovirus infection requires that the particle undergo a series of conformational transitions that lead to cell entry and genome release. In an effort to understand the conformational changes associated with the release ...
    • CATCHR and HOPS-CORVET tethering complexes share a similar architecture 

      Chou, Hui-Ting; Dukovski, Danijela; Chambers, Melissa G.; Reinisch, Karin M.; Walz, Thomas (2016)
      We show that the Saccharomyces cerevisiae GARP complex and the Cog1-4 subcomplex of the COG complex, both members of the complexes associated with tethering containing helical rods (CATCHR) family of multisubunit tethering ...
    • Catechol-O-Methyltransferase val158met Polymorphism Predicts Placebo Effect in Irritable Bowel Syndrome 

      Hall, Kathryn Tayo; Lembo, Anthony J.; Kirsch, Irving; Ziogas, Dimitrios C.; Douaiher, Jeffrey; Jensen, Karin; Conboy, Lisa Ann; Kelley, John Michael; Kokkotou, Efi G.; Kaptchuk, Ted Jack (Public Library of Science, 2012)
      Identifying patients who are potential placebo responders has major implications for clinical practice and trial design. Catechol-O-methyltransferase (COMT), an important enzyme in dopamine catabolism plays a key role in ...
    • Catecholate Siderophores Protect Bacteria from Pyochelin Toxicity 

      Adler, Conrado; Corbalán, Natalia S.; Seyedsayamdost, Mohammad; Pomares, María Fernanda; de Cristóbal, Ricardo E.; Clardy, Jon C.; Kolter, Roberto Guillermo; Vincent, Paula A. (Public Library of Science, 2012)
      Background: Bacteria produce small molecule iron chelators, known as siderophores, to facilitate the acquisition of iron from the environment. The synthesis of more than one siderophore and the production of multiple ...
    • The Categorical Representation of Facial Expressions by 7-Month-Old Infants 

      Ludemann, Pamela M.; Nelson, Charles A. (American Psychological Association (APA), 1988)
      We investigated the ability of 7-month-olds to categorize the facial expressions happy, fear, and surprise when these expressions varied both by the model depicting the expression and by how intensely the expression was ...
    • Categorizing the dispersion of open chromatin usage patterns of Treg related genes using an variational autoencoder based algorithm 

      Zeng, Danting (2023-05-10)
      Cellular programs are controlled by the coordinated interactions between transcription factors (TF) and cis-regulatory genomic sequences, including enhancer elements which can be far from the TF they regulate. This enables ...
    • Category-specific visual responses of single neurons in the human medial temporal lobe 

      Fried, Itzhak; Kreiman, Gabriel; Koch, Christof (Nature Publishing Group, 2000)
    • categoryCompare, an analytical tool based on feature annotations 

      Flight, Robert M.; Harrison, Benjamin J.; Mohammad, Fahim; Bunge, Mary B.; Moon, Lawrence D. F.; Petruska, Jeffrey C.; Rouchka, Eric C. (Frontiers Media S.A., 2014)
      Assessment of high-throughput—omics data initially focuses on relative or raw levels of a particular feature, such as an expression value for a transcript, protein, or metabolite. At a second level, analyses of annotations ...
    • Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo 

      Cullen, Valerie; Lindfors, Maria; Ng, Juliana; Paetau, Anders; Swinton, Erika; Kolodziej, Piotr; Boston, Heather; Saftig, Paul; Woulfe, John; Myllykangas, Liisa; Schlossmacher, Michael G; Tyynelä, Jaana; Feany, Mel B. (BioMed Central, 2009)
      Background: Elevated SNCA gene expression and intracellular accumulation of the encoded α-synuclein (aSyn) protein are associated with the development of Parkinson disease (PD). To date, few enzymes have been examined for ...
    • Cathepsin K Deficiency Reduces Elastase Perfusion-Induced Abdominal Aortic Aneurysms in Mice 

      Sun, Jiusong; Sukhova, Galina K.; Zhang, Jie; Chen, Han; Sjoberg, Sara; Libby, Peter; Xia, Mingcan; Xiong, Na; Gelb, Bruce D.; Shi, Guo-Ping (Ovid Technologies (Wolters Kluwer Health), 2011)
      Objective: Cathepsin K (CatK) is one of the most potent mammalian elastases. We have previously shown increased expression of CatK in human abdominal aortic aneurysm (AAA) lesions. Whether this protease participates directly ...
    • Cathepsin K knockout alleviates aging-induced cardiac dysfunction 

      Hua, Yinan; Robinson, Timothy J; Cao, Yongtao; Shi, Guo-Ping; Ren, Jun; Nair, Sreejayan (BlackWell Publishing Ltd, 2014)
      Aging is a major risk factor for cardiovascular disease. It has previously been shown that protein levels of cathepsin K, a lysosomal cysteine protease, are elevated in the failing heart and that genetic ablation of cathepsin ...
    • Cathepsin K Knockout Mitigates High-Fat Diet–Induced Cardiac Hypertrophy and Contractile Dysfunction 

      Hua, Yinan; Zhang, Yingmei; Dolence, Julia; Shi, Guo-Ping; Ren, Jun; Nair, Sreejayan (American Diabetes Association, 2013)
      The cysteine protease cathepsin K has been implicated in pathogenesis of cardiovascular disease. We hypothesized that ablation of cathepsin K protects against obesity-associated cardiac dysfunction. Wild-type mice fed a ...
    • Cathepsin K-mediated notch1 activation contributes to neovascularization in response to hypoxia 

      Jiang, Haiying; Wu Cheng, Xian; Shi, Guo-Ping; Hu, Lina; Inoue, Aiko; Yamamura, Yumiko; Wu, Hongxian; Takeshita, Kyosuke; Li, Xiang; Huang, Zhe; Song, Haizhen; Asai, Masashi; Hao, Chang-Ning; Unno, Kazumasa; Koike, Teruhiro; Oshida, Yoshiharu; Okumura, Kenji; Murohara, Toyoaki; Kuzuya, Masafumi (Nature Research (part of Springer Nature), 2014)
      Cysteine proteases play important roles in pathobiology. Here we reveal that cathepsin K (CatK) has a role in ischaemia-induced neovascularization. Femoral artery ligation-induced ischaemia in mice increases CatK expression ...