Now showing items 2351-2370 of 18424

    • Cell-of-origin chromatin organization shapes the mutational landscape of cancer 

      Polak, Paz; Karlić, Rosa; Koren, Amnon; Thurman, Robert; Sandstrom, Richard; Lawrence, Michael; Reynolds, Alex; Rynes, Eric; Vlahoviček, Kristian; Stamatoyannopoulos, John A.; Sunyaev, Shamil R. (2015)
      Cancer is a disease potentiated by mutations in somatic cells. Cancer mutations are not distributed uniformly along the genome. Instead, different genomic regions vary by up to 5-fold in the local density of somatic ...
    • Cell-penetrating peptide TAT-mediated delivery of acidic FGF to retina and protection against ischemia–reperfusion injury in rats 

      Wang, Yi; Lin, Haihuan; Lin, Shaoqiang; Qu, Jia; Xiao, Jian; Huang, Yadong; Xiao, Yechen; Fu, Xiaobing; Yang, Yongguang; Li, Xiaokun (Blackwell Publishing Ltd, 2009)
      Abstract The development of non-invasive ocular drug delivery systems is of practical importance in the treatment of retinal disease. In this study, we evaluated the efficacy of transactivator of transcription protein ...
    • Cell-Size-Dependent Transcription of FLC and Its Antisense Long Non-Coding RNA COOLAIR Explain Cell-to-Cell Expression Variation 

      Ietswaart, Robert; Rosa, Stefanie; Wu, Zhe; Dean, Caroline; Howard, Martin (Elsevier BV, 2017-06-28)
      Single-cell quantification of transcription kinetics and variability promotes a mechanistic understanding of gene regulation. Here, using single-molecule RNA fluorescence in situ hybridization and mathematical modeling, ...
    • Cell-type selective chromatin remodeling defines the active subset of FOXA1-bound enhancers 

      Eeckhoute, J.; Lupien, M.; Meyer, Clifford; Verzi, M. P.; Shivdasani, Ramesh Arjun; Liu, Xiaole (Shirley) Shirley; Brown, Myles A. (Cold Spring Harbor Laboratory Press, 2008)
      Selective activity of a specific set of enhancers defines tissue-specific gene transcription. The pioneer factor FOXA1 has been shown to induce functional enhancer competency through chromatin openings. We have previously ...
    • CELLCOUNTER: Novel Open-Source Software for Counting Cell Migration and Invasion In Vitro 

      Li, Xiaoni; Yang, Hongshun; Huang, Hailiang; Zhu, Tao (Hindawi Publishing Corporation, 2014)
      Transwell Boyden chamber based migration/invasion assay is a simple and extensively used approach for the characterization of cell motility in vitro. Cell motility is quantified by counting the number of cells that pass ...
    • CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types 

      Nelms, Bradlee D.; Waldron, Levi; Barrera, Luis A.; Weflen, Andrew W.; Goettel, Jeremy A.; Guo, Guoji; Montgomery, Robert K.; Neutra, Marian R.; Breault, David T.; Snapper, Scott B.; Orkin, Stuart H.; Bulyk, Martha L.; Huttenhower, Curtis; Lencer, Wayne I. (BioMed Central, 2016)
      We present a sensitive approach to predict genes expressed selectively in specific cell types, by searching publicly available expression data for genes with a similar expression profile to known cell-specific markers. Our ...
    • Cells in Tight Spaces: The Role of Cell Shape in Cell Function 

      Shah, Jagesh V. (The Rockefeller University Press, 2010)
      In this issue, Pitaval et al. (2010. J. Cell Biol. doi:10.1083/jcb.201004003) demonstrate that cell geometry can regulate the elaboration of a primary cilium. Their findings and approaches are part of a historical line of ...
    • Cellular and Cytokine Responses to Salmonella enterica Serotype Typhi Proteins in Patients with Typhoid Fever in Bangladesh 

      Bhuiyan, Saruar; Sayeed, Abu; Khanam, Farhana; Leung, Daniel T.; Rahman Bhuiyan, Taufiqur; Sheikh, Alaullah; Salma, Umme; LaRocque, Regina C.; Harris, Jason B.; Pacek, Marcin; Calderwood, Stephen B.; LaBaer, Joshua; Ryan, Edward T.; Qadri, Firdausi; Charles, Richelle C. (The American Society of Tropical Medicine and Hygiene, 2014)
      We assessed interferon-gamma (IFN-γ) responses via enzyme-linked immunosorbent spot (ELISPOT) to a number of S. Typhi antigens in samples from humans with S. Typhi bacteremia and typhoid fever in Bangladesh. Compared with ...
    • Cellular and Humoral Mechanisms Involved in the Control of Tuberculosis 

      Zuñiga, Joaquin; Torres-García, Diana; Santos-Mendoza, Teresa; Rodriguez-Reyna, Tatiana S.; Granados, Julio; Yunis, Edmond J. (Hindawi Publishing Corporation, 2012)
      Mycobacterium tuberculosis (Mtb) infection is a major international public health problem. One-third of the world's population is thought to have latent tuberculosis, a condition where individuals are infected by the ...
    • Cellular and Molecular Architecture of the Intestinal Stem Cell Niche 

      McCarthy, Neil; Kraiczy, Judith; Shivdasani, Ramesh (Springer Nature, 2020-09-03)
      Intestinal stem and progenitor cells replicate and differentiate in distinct compartments, influenced by Wnt, BMP, and other sub-epithelial cues. The cellular sources of these signals were long obscure because intestinal ...
    • Cellular and molecular immune profiles in renal transplant recipients after conversion from Tacrolimus to Sirolimus 

      Gallon, Lorenzo; Traitanon, Opas; Sustento-Reodica, Nedjema; Leventhal, Joseph; Ansari, M. Javeed; Gehrau, Ricardo C.; Ariyamuthu, Venkatesh; De Serres, Sacha A; Alvarado, Antonio; Chhabra, Darshika; Mathew, James M; Najafian, Nader; Mas, Valeria (2014)
      Tacrolimus and Sirolimus are commonly used maintenance immunesuppressants in kidney transplantation. Since their effects on immune cells and allograft molecular profiles have not been elucidated, we characterized the effects ...
    • Cellular and molecular mechanisms underlying muscular dystrophy 

      Rahimov, Fedik; Kunkel, Louis M. (The Rockefeller University Press, 2013)
      The muscular dystrophies are a group of heterogeneous genetic diseases characterized by progressive degeneration and weakness of skeletal muscle. Since the discovery of the first muscular dystrophy gene encoding dystrophin, ...
    • Cellular and neurochemical basis of sleep stages in the thalamocortical network 

      Krishnan, Giri P; Chauvette, Sylvain; Shamie, Isaac; Soltani, Sara; Timofeev, Igor; Cash, Sydney S; Halgren, Eric; Bazhenov, Maxim (eLife Sciences Publications, Ltd, 2016)
      The link between the combined action of neuromodulators in the brain and global brain states remains a mystery. In this study, using biophysically realistic models of the thalamocortical network, we identified the critical ...
    • Cellular Changes of the Corneal Epithelium and Stroma in Herpes Simplex Keratitis 

      Hamrah, Pedram; Sahin, Afsun; Dastjerdi, Mohammad H.; Shahatit, Bashar M.; Bayhan, Hasan A.; Dana, Reza; Pavan-Langston, Deborah (Elsevier BV, 2012)
      Purpose To analyze the morphology of corneal epithelial cells and keratocytes by in vivo confocal microscopy (IVCM) in patients with herpes simplex keratitis (HSK) as associated with corneal innervation. Design ...
    • Cellular Expression Profile for Interstitial Cells of Cajal in Bladder - A Cell Often Misidentified as Myocyte or Myofibroblast 

      Yu, Weiqun; Zeidel, Mark Lawrence; Hill, Warren Gary (Public Library of Science, 2012)
      Background: Interstitial cells of Cajal (ICC) have been identified in urinary bladder of several species, but their presence in mice remains uncertain. Meanwhile, dozens of reports indicate that dysregulation of connexin ...
    • Cellular forces and matrix assembly coordinate fibrous tissue repair 

      Sakar, Mahmut Selman; Eyckmans, Jeroen; Pieters, Roel; Eberli, Daniel; Nelson, Bradley J.; Chen, Christopher S. (Nature Publishing Group, 2016)
      Planar in vitro models have been invaluable tools to identify the mechanical basis of wound closure. Although these models may recapitulate closure dynamics of epithelial cell sheets, they fail to capture how a wounded ...
    • Cellular Immunotherapy for Refractory Hematological Malignancies 

      Reagan, John L; Fast, Loren D; Safran, Howard; Nevola, Martha; Winer, Eric S; Castillo, Jorge; Butera, James N; Quesenberry, Matthew I; Young, Carolyn T; Quesenberry, Peter J. (Springer Science and Business Media LLC, 2013-06-19)
      Acute myeloid leukemia (AML) and other aggressive refractory hematological malignancies unresponsive to upfront therapy remain difficult conditions to treat. Often, the focus of therapy is centered on achieving complete ...
    • Cellular interaction of folic acid conjugated superparamagnetic iron oxide nanoparticles and its use as contrast agent for targeted magnetic imaging of tumor cells 

      Singh, Gurpal; Arora, Vikas; Mewar, Sujeet; Sharma, Uma; Jagannathan, NR; Sapra, Sameer; Dinda, Amit K; Kharbanda, Surender; Singh, Harpal; Kumar, Manoj (Dove Medical Press, 2012)
      The purpose of the study was to develop tumor specific, water dispersible superparamagnetic iron oxide nanoparticles (SPIONs) and evaluate their efficacy as a contrast agent in magnetic resonance imaging (MRI). We have ...
    • Cellular Interference in Craniofrontonasal Syndrome: Males Mosaic for Mutations in the X-Linked EFNB1 Gene Are More Severely Affected than True Hemizygotes 

      Twigg, Stephen R.F.; Babbs, Christian; van den Elzen, Marijke E.P.; Goriely, Anne; McGowan, Simon J.; Giannoulatou, Eleni; Lonie, Lorne; Ragoussis, Jiannis; Akha, Elham Sadighi; Knight, Samantha J.L.; Zechi-Ceide, Roseli M.; Hoogeboom, Jeannette A.M.; Toriello, Helga V.; Wall, Steven A.; Rita Passos-Bueno, M.; Brunner, Han G.; Mathijssen, Irene M.J.; Wilkie, Andrew O.M.; Pober, Barbara R.; Taylor, Stephen (Oxford University Press, 2013)
      Craniofrontonasal syndrome (CFNS), an X-linked disorder caused by loss-of-function mutations of EFNB1, exhibits a paradoxical sex reversal in phenotypic severity: females characteristically have frontonasal dysplasia, ...
    • Cellular Interrogation: Exploiting Cell-to-Cell Variability to Discriminate Regulatory Mechanisms in Oscillatory Signalling 

      Estrada, Javier; Andrew, Natalie; Gibson, Daniel; Chang, Frederick; Gnad, Florian; Gunawardena, Jeremy (Public Library of Science, 2016)
      The molecular complexity within a cell may be seen as an evolutionary response to the external complexity of the cell’s environment. This suggests that the external environment may be harnessed to interrogate the cell’s ...