Browsing Harvard Medical School by Title
Now showing items 2410-2429 of 18428
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Cesarean Section Surgical Site Infections in Sub-Saharan Africa: A Multi-Country Study from Medecins Sans Frontieres
(Springer US, 2014)Background: Surgical site infections (SSI) are a significant cause of post-surgical morbidity and mortality and can be an indicator of surgical quality. The objectives of this study were to measure post-operative SSI after ... -
Cesium-associated hypokalemia successfully treated with amiloride
(Oxford University Press, 2015)Self-treatment of cancer with cesium chloride, despite proven lack of efficacy, continues to produce serious adverse effects. Among these is hypokalemia predisposing to life-threatening arrhythmia. The mechanism of ... -
CETP genotype and changes in lipid levels in response to weight-loss diet intervention in the POUNDS LOST and DIRECT randomized trials
(American Society for Biochemistry & Molecular Biology (ASBMB), 2014)Little is known about whether cholesteryl ester transfer protein (CETP) genetic variation may modify the effect of weight-loss diets varying in fat content on changes in lipid levels. We analyzed the interaction between ... -
CFEOM1, the Classic Familial Form of Congenital Fibrosis of the Extraocular Muscles, is Genetically Heterogeneous but Does Not Result from Mutations in ARIX
(BioMed Central, 2002)Background: To learn about the molecular etiology of strabismus, we are studying the genetic basis of 'congenital fibrosis of the extraocular muscles' (CFEOM). These syndromes are characterized by congenital restrictive ... -
cGAS-Like Receptors Sense RNA and Control 3′2′-cGAMP Signalling in Drosophila
(Springer Science and Business Media LLC, 2021-07-14)<jats:title>Abstract</jats:title><jats:p>Cyclic GMP–AMP synthase (cGAS) is a cytosolic DNA sensor that produces the second messenger cG[2′–5′]pA[3′–5′]p (2′3′-cGAMP) and controls activation of innate immunity in mammalian ... -
CGBayesNets: Conditional Gaussian Bayesian Network Learning and Inference with Mixed Discrete and Continuous Data
(Public Library of Science, 2014)Bayesian Networks (BN) have been a popular predictive modeling formalism in bioinformatics, but their application in modern genomics has been slowed by an inability to cleanly handle domains with mixed discrete and continuous ... -
Challenge of Drosophila melanogaster with Cryptococcus neoformans and Role of the Innate Immune Response
(American Society for Microbiology, 2004)We found that the ingestion of Cryptococcus neoformans by Drosophila melanogaster resulted in the death of the fly but that the ingestion of Saccharomyces cerevisiae or the nonpathogenic Cryptococcus kuetzingii or Cryptococcus ... -
Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology
(American Association for Cancer Research (AACR), 2013-02-19)Enhanced permeability of the tumor vasculature allows macromolecules to enter the tumor interstitial space, while the suppressed lymphatic filtration allows them to stay there. This phenomenon - EPR has been the basis of ... -
Challenges and Pitfalls Associated with Diagnostic and Prognostic Applications of Functional Neuroimaging in Disorders of Consciousness
(Bentham Open, 2015)The diagnostic assessment of patients with disorder of consciousness is currently based on clinical testing at the bedside and prone to a high error rate in the assessment of the degree of conscious awareness. Investigation ... -
The Challenges and Promises of New Therapies for Cystic Fibrosis
(The Rockefeller University Press, 2012)Therapeutic intervention in cystic fibrosis (CF) remains a challenge, partly because of the number of organs and tissues affected by the lack of a functional cystic fibrosis transmembrane conductance regulator (CFTR) ... -
Challenges for Routine Health System Data Management in a Large Public Programme to Prevent Mother-to-Child HIV Transmission in South Africa
(Public Library of Science, 2009)Background: Recent changes to South Africa's prevention of mother-to-child transmission of HIV (PMTCT) guidelines have raised hope that the national goal of reducing perinatal HIV transmission rates to less than 5% can be ... -
Challenges in Celiac Disease: Improving Diagnosis and Identifying Accurate Surrogate Endpoints to Assess Mucosal Recovery
(2016-05-18)Great strides have been made improving serological screening tests to diagnose Celiac Disease (CD) and in recognizing the heterogenous presentation of CD. However, it is still vastly under-diagnosed. One in five children ... -
Challenges in clinical genomics
(BioMed Central, 2012)A report on the Genomic Disorders 2012: Genomics of Rare Diseases meeting, Hinxton, UK, 21-23 March 2012. -
Challenges in conducting genome-wide association studies in highly admixed multi-ethnic populations: the Generation R Study
(Springer Netherlands, 2015)Genome-wide association studies (GWAS) have been successful in identifying loci associated with a wide range of complex human traits and diseases. Up to now, the majority of GWAS have focused on European populations. ... -
Challenges in EGFRvIII Detection in Head and Neck Squamous Cell Carcinoma
(Public Library of Science, 2015)Objective: Head and neck squamous cell carcinoma (HNSCC) accounts for more than 5% of all cancers worldwide. The mortality rate of HNSCC has remained unchanged (approximately 50%) over the last few decades. Ubiquitous ... -
Challenges in Prevention and Care Delivery for Women with Cervical Cancer in Sub-Saharan Africa
(Frontiers Media S.A., 2016)Virtually all cases of invasive cervical cancer are associated with infection by high-risk strains of human papilloma virus. Effective primary and secondary prevention programs, as well as effective treatment for early-stage ... -
Challenges in Using Cultured Primary Rodent Hepatocytes or Cell Lines to Study Hepatic HDL Receptor SR-BI Regulation by Its Cytoplasmic Adaptor PDZK1
(Public Library of Science, 2013)Background: PDZK1 is a four PDZ-domain containing cytoplasmic protein that binds to a variety of membrane proteins via their C-termini and can influence the abundance, localization and/or function of its target proteins. ... -
Challenges of the 21st Century: Part 1 - Diagnostic, prognostic and interventional anatomy
(Spanish Society of Anatomy; Mexican Society of Anatomy, 2021-04)Gross anatomy is a fundamental component of the medical school curriculum, anatomy research and cardiology. There remain new and continued applications of anatomical research that are critical to maintain (and improve) the ... -
Challenges of the 21ST Century: Part 2 - Dynamic angiography in the investigation of cavitation in coronary arteries: Standard description of coronary lesions and blood flow
(2021-04)There is no confirmed mechanism in the formation and growth of atherosclerotic plaques, or coronary artery disease (CAD). In all patients, the entire arterial tree is exposed to the atherogenic effects of systemic risk ... -
Challenges of the 21st Century: Part 3 - The anatomical risk factors which predict future disaster
(Spanish Society of Anatomy; Mexican Society of Anatomy, 2021-04)A novel approach using dynamic angiography to study cavitation in coronary arteries as related to anatomical structure and fluid dynamics was applied to patient cases. Cases were evaluated to determine if vessel ...