Browsing Harvard Medical School by Title

Now showing items 2510-2529 of 18428

    • Characterization of Defects in Ion Transport and Tissue Development in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)-Knockout Rats 

      Tuggle, Katherine L.; Birket, Susan E.; Cui, Xiaoxia; Hong, Jeong; Warren, Joe; Reid, Lara; Chambers, Andre; Ji, Diana; Gamber, Kevin; Chu, Kengyeh K.; Tearney, Guillermo; Tang, Li Ping; Fortenberry, James A.; Du, Ming; Cadillac, Joan M.; Bedwell, David M.; Rowe, Steven M.; Sorscher, Eric J.; Fanucchi, Michelle V. (Public Library of Science, 2014)
      Animal models for cystic fibrosis (CF) have contributed significantly to our understanding of disease pathogenesis. Here we describe development and characterization of the first cystic fibrosis rat, in which the cystic ...

    • Characterization of Early Steps in the Poliovirus Infection Process: Receptor-Decorated Liposomes Induce Conversion of the Virus to Membrane-Anchored Entry-Intermediate Particles 

      Tuthill, Tobias J.; Bubeck, Doryen; Rowlands, David J.; Hogle, James M. (American Society for Microbiology, 2006)
      The mechanism by which poliovirus infects the cell has been characterized by a combination of biochemical and structural studies, leading to a working model for cell entry. Upon receptor binding at physiological temperature, ...

    • Characterization of Effector T Cells in Dry Eye Disease 

      Annan, Jaafar; Chauhan, Sunil; Ecoiffier, Tatiana; Zhang, Qiang; Saban, Daniel; Dana, Reza (Association for Research in Vision and Ophthalmology (ARVO), 2009)
      purpose. Dry eye disease (DED) is associated with ocular surface inflammation that is thought to be mediated primarily by CD4 T cells. The purpose of this study was to investigate whether this T cell–mediated immune response ...

    • Characterization of Factors Associated With Systemic Corticosteroid Use in Severe Asthma: Data From the Severe Asthma Research Program 

      Wysocki, Kenneth; Park, Seo Young; Bleecker, Eugene R.; Busse, William; Castro, Mario; Chung, Kian Fan; Gaston, Benjamin M.; Erzurum, Serpil C.; Israel, Elliot; Teague, W. Gerald; Moore, Charity G.; Wenzel, Sally E. (Elsevier BV, 2014-03)
      Background Exhaled nitric oxide (FeNO) associates with asthma and eosinophilic inflammation. However, relationships between nitric oxide synthases, arginase, FeNO, asthma severity and inflammation remain poorly ...

    • Characterization of G protein coupling mediated by the conserved D1343.49 of DRY motif, M2416.34, and F2516.44 residues on human CXCR1 

      Han, Xinbing; Feng, Yan; Chen, Xinhua; Gerard, Craig; Boisvert, William A. (Elsevier, 2015)
      CXCR1, a receptor for interleukin-8 (IL-8), plays an important role in defending against pathogen invasion during neutrophil-mediated innate immune response. Human CXCR1 is a G protein-coupled receptor (GPCR) with its ...

    • Characterization of HIV-1 Subtype C Envelope Glycoproteins From Perinatally Infected Children With Different Courses of Disease 

      Hoffmann, Federico; He, Jun; He, Xiang; Kankasa, Chipepo; West, John T; Mitchell, Charles D; Orti, Guillermo; Wood, Charles; Zhang, Hong; Ruprecht, Ruth Margrit (BioMed Central, 2006)
      Background: The causal mechanisms of differential disease progression in HIV-1 infected children remain poorly defined, and much of the accumulated knowledge comes from studies of subtype B infected individuals. The ...

    • Characterization of HPV and host genome interactions in primary head and neck cancers 

      Parfenov, Michael; Pedamallu, Chandra Sekhar; Gehlenborg, Nils; Freeman, Samuel; Danilova, Ludmila; Bristow, Christopher; Lee, Semin; Hadjipanayis, Angela; Ivanova, Elena; Wilkerson, Matthew; Protopopov, Alexei; Yang, Lixing; Seth, Sahil; Song, Xingzhi; Tang, Jiabin; Ren, Xiaojia; Zhang, Jianhua; Pantazi, Angeliki; Santoso, Netty; Xu, Andrew; Mahadeshwar, Harshad; Wheeler, David; Haddad, Robert; Jung, Joonil; Ojesina, Akinyemi; Issaeva, Natalia; Yarbrough, Wendell; Hayes, D. Neil; Grandis, Jennifer; El-Naggar, Adel; Meyerson, Matthew; Park, Peter; Chin, Lynda; Seidman, J. G.; Hammerman, Peter; Kucherlapati, Raju; Cancer Genome Atlas Network; Ally, Adrian; Balasundaram, Miruna; Birol, Inanc; Bowlby, Reanne; Butterfield, Yaron S. N.; Carlsen, Rebecca; Cheng, Dean; Chu, Andy; Dhalla, Noreen; Guin, Ranabir; Holt, Robert; Jones, Steven J. M.; Lee, Darlene; Li, Haiyan; Marra, Marco; Mayo, Michael; Moore, Richard; Mungall, Andrew; Robertson, A. Gordon; Schein, Jacqueline; Sipahimalani, Payal; Tam, Angela; Thiessen, Nina; Wong, Tina; Mahadeshwar, Harshad; Haseley, Psalm; Zeng, Dong; Bristow, Christopher; Hadjipanayis, Angela; Seidman, Jonathan; Akbani, Rehan; Casasent, Tod; Liu, Wenbin; Lu, Yiling; Mills, Gordon; Motter, Thomas; Weinstein, John; Diao, Lixia; Wang, Jing; Fan, You Hong; Liu, Jinze; Wang, Kai; Auman, J. Todd; Balu, Saianand; Bodenheimer, Tom; Buda, Elizabeth; Hoadley, Katherine; Hoyle, Alan; Jefferys, Stuart; Jones, Corbin; Kimes, Patrick; Marron, J. S.; Meng, Shaowu; Mieczkowski, Piotr; Mose, Lisle; Parker, Joel; Perou, Charles; Prins, Jan; Roach, Jeffrey; Shi, Yan; Simons, Janae; Singh, Darshan; Soloway, Mathew; Cancer Genome Atlas Network (National Academy of Sciences, 2014)

    • Characterization of Human CD39+ Th17 Cells with Suppressor Activity and Modulation in Inflammatory Bowel Disease 

      Longhi, Maria Serena; Moss, Alan; Bai, Aiping; Wu, Yan; Huang, Huang; Cheifetz, Adam; Quintana, Francisco J.; Robson, Simon C. (Public Library of Science, 2014)
      Induced regulatory T-cells (iT-reg) and T helper type 17 (Th17) in the mouse share common CD4 progenitor cells and exhibit overlapping phenotypic and functional features. Here, we show that human Th17 cells endowed with ...

    • Characterization of Human Liver Stromal Cells 

      Guinn, Samantha (2017-06-07)
      The liver is a highly immunologic, metabolic organ in the body with many functions including but not limited to amino acid and carbohydrate metabolism, synthesis of plasma proteins, metabolism of pharmaceuticals, defense ...

    • Characterization of Human Thrombospondin-4 

      Lawler, Jack; McHenry, Katherine; Duquette, Mark; Derick, Laura (American Society for Biochemistry and Molecular Biology, 1995)

    • Characterization of Immortalized MARCO and SR-AI/II-deficient Murine Alveolar Macrophage Cell Lines 

      Zhou, Hongwei; Imrich, Amy; Kobzik, Lester (BioMed Central, 2008)
      Background: Alveolar macrophages (AM) avidly bind and ingest unopsonized inhaled particles and bacteria through class A scavenger receptors (SRAs) MARCO and SR-AI/II. Studies to characterize the function of these SRAs have ...

    • Characterization of Immune Evasion Mechanisms of Breast Cancer Disseminated Cells in the Lung 

      ZHAO, XI (2021-07-19)
      Despite recent advances in cancer immunotherapies, many patients still die from metastasis. Metastases arise from cells that escape the primary tumor and disseminate to distant organs. A more comprehensive understanding ...

    • Characterization of Langerin-Expressing Dendritic Cell Subsets in the Normal Cornea 

      Hattori, Takaaki; Chauhan, Sunil Kumar; Lee, Hyunsoo; Ueno, Hiroki; Dana, Reza; Kaplan, Daniel H.; Saban, Daniel R. (Association for Research in Vision and Ophthalmology (ARVO), 2011)
      Purpose. In addition to Langerhans cells (LCs), other dendritic cells (CD11c+) have recently been shown to express Langerin (c-type lectin). In skin, (non-LC) Langerin+ dendritic cells initiate adaptive immunity. However, ...

    • Characterization of Mammalian Selenoprotein O: A Redox-Active Mitochondrial Protein 

      Han, Seong-Jeong; Lee, Byung Cheon; Yim, Sun Hee; Gladyshev, Vadim N.; Lee, Seung-Rock (Public Library of Science, 2014)
      Selenoproteins exhibit diverse biological functions, most of which are associated with redox control. However, the functions of approximately half of mammalian selenoproteins are not known. One such protein is Selenoprotein ...

    • Characterization of methionine oxidation and methionine sulfoxide reduction using methionine-rich cysteine-free proteins 

      Liang, Xinwen; Kaya, Alaattin; Zhang, Yan; Le, Dung T; Hua, Deame; Gladyshev, Vadim N (BioMed Central, 2012)
      Background: Methionine (Met) residues in proteins can be readily oxidized by reactive oxygen species to Met sulfoxide (MetO). MetO is a promising physiological marker of oxidative stress and its inefficient repair by MetO ...

    • Characterization of Multi-Drug Resistant Enterococcus faecalis Isolated from Cephalic Recording Chambers in Research Macaques (Macaca spp.) 

      Woods, Stephanie E.; Lieberman, Mia T.; Lebreton, Francois; Trowel, Elise; de la Fuente-Núñez, César; Dzink-Fox, Joanne; Fox, James G.; Gilmore, Michael S. (Public Library of Science, 2017)
      Nonhuman primates are commonly used for cognitive neuroscience research and often surgically implanted with cephalic recording chambers for electrophysiological recording. Aerobic bacterial cultures from 25 macaques ...

    • Characterization of novel human Tfh cell subsets 

      Hui, Anson (2023-05-10)
      T follicular helper cells (Tfh) are critical for class switched affinity matured antibody production. Their developmental trajectory involves serial reciprocal interactions with antigen presenting cells, initially being ...

    • Characterization of Novel Src Family Kinase Inhibitors to Attenuate Microgliosis 

      Manocha, Gunjan D.; Puig, Kendra L.; Austin, Susan A.; Seyb, Kathleen; Glicksman, Marcie A.; Combs, Colin K. (Public Library of Science, 2015)
      Microgliosis is a major hallmark of Alzheimer’s disease (AD) brain pathology. Aβ peptide is hypothesized to act as a stimulus for microglia leading to activation of non-receptor tyrosine kinases and subsequent secretion ...

    • Characterization of Phthalate Exposure among Pregnant Women Assessed by Repeat Air and Urine Samples 

      Adibi, Jennifer J.; Whyatt, Robin M.; Calafat, Antonia M.; Camann, David; Nelson, Heather; Bhat, Hari K.; Perera, Frederica P.; Silva, Manori J.; Williams, Paige L.; Herrick, Robert F.; Hauser, Russ B. (National Institute of Environmental Health Sciences, 2008)
      Background: Although urinary concentrations of phthalate metabolites are frequently used as biomarkers in epidemiologic studies, variability during pregnancy has not been characterized. Methods: We measured phthalate ...

    • Characterization of Planctomyces limnophilus and Development of Genetic Tools for Its Manipulation Establish It as a Model Species for the Phylum Planctomycetes 

      Jogler, Christian; Glöckner, Frank Oliver; Kolter, Roberto (American Society for Microbiology, 2011)
      Planctomycetes represent a remarkable clade in the domain Bacteria because they play crucial roles in global carbon and nitrogen cycles and display cellular structures that closely parallel those of eukaryotic cells. Studies ...