Browsing Harvard Medical School by Title
Now showing items 2628-2647 of 18424
-
Chinese Pediatrician Attitudes and Practices Regarding Child Exposure to Secondhand Smoke (SHS) and Clinical Efforts against SHS Exposure
(MDPI, 2015)Background: Secondhand Smoke (SHS) exposure is a leading cause of childhood illness and premature death. Pediatricians play an important role in helping parents to quit smoking and reducing children’s SHS exposure. This ... -
Chinese pediatrician beliefs about counseling and medications for parents who smoke: a survey in southern China
(BioMed Central, 2015)Background: Pediatricians play an important role in promoting smoking cessation among the parents of young children as more behavioral counseling and cessation treatment are made available in the Chinese healthcare system. ... -
Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma
(Nature Pub. Group, 2015)Real-time monitoring of drug efficacy in glioblastoma multiforme (GBM) is a major clinical problem as serial re-biopsy of primary tumours is often not a clinical option. MGMT (O6-methylguanine DNA methyltransferase) and ... -
Chip-Based Comparison of the Osteogenesis of Human Bone Marrow- and Adipose Tissue-Derived Mesenchymal Stem Cells under Mechanical Stimulation
(Public Library of Science, 2012)Adipose tissue-derived stem cells (ASCs) are considered as an attractive stem cell source for tissue engineering and regenerative medicine. We compared human bone marrow-derived mesenchymal stem cells (hMSCs) and hASCs ... -
ChIP-chip versus ChIP-seq: Lessons for Experimental Design and Data Analysis
(BioMed Central, 2011)Background: Chromatin immunoprecipitation (ChIP) followed by microarray hybridization (ChIP-chip) or high-throughput sequencing (ChIP-seq) allows genome-wide discovery of protein-DNA interactions such as transcription ... -
Chip–NMR biosensor for detection and molecular analysis of cells
(Nature Research, 2008)Rapid and accurate measurement of biomarkers in tissue and fluid samples is a major challenge in medicine. Here we report the development of a new, miniaturized diagnostic magnetic resonance (DMR) system for multiplexed, ... -
Chitinase 3-like 1 induces survival and proliferation of intestinal epithelial cells during chronic inflammation and colitis-associated cancer by regulating S100A9
(Impact Journals LLC, 2015)Many host-factors are inducibly expressed during the development of inflammatory bowel disease (IBD), each having their unique properties, such as immune activation, bacterial clearance, and tissue repair/remodeling. ... -
Chitinase 3-Like 1 Promotes Macrophage Recruitment and Angiogenesis in Colorectal Cancer
(Nature Publishing Group, 2012)Chitinase 3-like 1 (CHI3L1), one of mammalian members of the chitinase family, is expressed in several types of human cancer, and elevated serum level of CHI3L1 is suggested to be a biomarker of poor prognosis in advanced ... -
Chitosan Acetate Bandage as a Topical Antimicrobial Dressing for Infected Burns
(American Society for Microbiology, 2009)An engineered chitosan acetate bandage preparation (HemCon) is used as a hemostatic dressing, and its chemical structure suggests that it should also be antimicrobial. We previously showed that when a chitosan acetate ... -
CHK1 Inhibition as a Strategy for Targeting Fanconi Anemia (FA) DNA Repair Pathway Deficient Tumors
(BioMed Central, 2009)Background: DNA repair deficient tumor cells have been shown to accumulate high levels of DNA damage. Consequently, these cells become hyper-dependent on DNA damage response pathways, including the CHK1-kinase-mediated ... -
Chlamydial and human heat shock protein 60s activate human vascular endothelium, smooth muscle cells, and macrophages
(American Society for Clinical Investigation, 1999)Both chlamydial and human heat shock protein 60s (HSP 60), which colocalize in human atheroma, may contribute to inflammation during atherogenesis. We tested the hypothesis that chlamydial or human HSP 60 activates human ... -
CHMP5 controls bone turnover rates by dampening NF-κB activity in osteoclasts
(The Rockefeller University Press, 2015)Physiological bone remodeling requires that bone formation by osteoblasts be tightly coupled to bone resorption by osteoclasts. However, relatively little is understood about how this coupling is regulated. Here, we ... -
Chocolate and prevention of cardiovascular disease: a systematic review
(BioMed Central, 2006)Background: Consumption of chocolate has been often hypothesized to reduce the risk of cardiovascular disease (CVD) due to chocolate's high levels of stearic acid and antioxidant flavonoids. However, debate still lingers ... -
Chocolate-candy consumption and three-year weight gain among postmenopausal U.S. women
(2014)OBJECTIVE To test the hypothesis that greater chocolate-candy intake is associated with more weight gain in postmenopausal women. DESIGN AND METHODS Prospective cohort study involving 107,243 post-menopausal American women ... -
Choice of anticoagulant affects measurement of plasma fibrinogen.
(American Association for Clinical Chemistry, 1993) -
A Cholera Conjugate Vaccine Containing O-specific Polysaccharide (OSP) of V. cholerae O1 Inaba and Recombinant Fragment of Tetanus Toxin Heavy Chain (OSP:rTTHc) Induces Serum, Memory and Lamina Proprial Responses against OSP and Is Protective in Mice
(Public Library of Science, 2015)Background: Vibrio cholerae is the cause of cholera, a severe watery diarrhea. Protection against cholera is serogroup specific. Serogroup specificity is defined by the O-specific polysaccharide (OSP) component of ... -
The Cholera Epidemic in Zimbabwe, 2008–2009: A Review and Critique of the Evidence
(2017-06)The 2008–2009 Zimbabwe cholera epidemic resulted in 98,585 reported cases and caused more than 4,000 deaths. In this study, we used a mixed-methods approach that combined primary qualitative data from a 2008 Physicians for ... -
Cholera in Haiti: The Equity Agenda and the Future of Tropical Medicine
(The American Society of Tropical Medicine and Hygiene, 2012) -
Cholera Toxin Promotes Pathogen Acquisition of Host-Derived Nutrients
(Springer Science and Business Media LLC, 2019-07-31)Vibrio cholerae is the causative agent of cholera, a potentially lethal enteric bacterial infection1. Cholera toxin (CT) is required for V. cholerae to cause severe disease and is also thought to promote transmission of ...