Browsing Harvard Medical School by Title

Now showing items 2708-2727 of 18428

    • Cigarette smoking and risk of ovarian cancer: a pooled analysis of 21 case–control studies 

      Faber, Mette T.; Kjær, Susanne K.; Dehlendorff, Christian; Chang-Claude, Jenny; Andersen, Klaus K.; Høgdall, Estrid; Webb, Penelope M.; Jordan, Susan J.; Rossing, Mary Anne; Doherty, Jennifer A.; Lurie, Galina; Thompson, Pamela J.; Carney, Michael E.; Goodman, Marc T.; Ness, Roberta B.; Modugno, Francesmary; Edwards, Robert P.; Bunker, Clareann H.; Goode, Ellen L.; Fridley, Brooke L.; Vierkant, Robert A.; Larson, Melissa C.; Schildkraut, Joellen; Cramer, Daniel William; Terry, Kathryn Lynne; Vitonis, Allison F.; Bandera, Elisa V.; Olson, Sara H.; King, Melony; Chandran, Urmila; Kiemeney, Lambertus A.; Massuger, Leon F. A. G.; van Altena, Anne M.; Vermeulen, Sita H.; Brinton, Louise; Wentzensen, Nicolas; Lissowska, Jolanta; Yang, Hannah P.; Moysich, Kirsten B.; Odunsi, Kunle; Kasza, Karin; Odunsi-Akanji, Oluwatosin; Song, Honglin; Pharaoh, Paul; Shah, Mitul; Whittemore, Alice S.; McGuire, Valerie; Sieh, Weiva; Sutphen, Rebecca; Menon, Usha; Gayther, Simon A.; Ramus, Susan J.; Gentry-Maharaj, Aleksandra; Pearce, Celeste Leigh; Wu, Anna H.; Pike, Malcolm C.; Risch, Harvey A.; Jensen, Allan (Springer Science + Business Media, 2013)
      Purpose The majority of previous studies have observed an increased risk of mucinous ovarian tumors associated with cigarette smoking, but the association with other histological types is unclear. In a large pooled ...

    • The ciliopathy-associated CPLANE proteins direct basal body recruitment of intraflagellar transport machinery 

      Toriyama, Michinori; Lee, Chanjae; Taylor, S. Paige; Duran, Ivan; Cohn, Daniel H.; Bruel, Ange-Line; Tabler, Jacqueline M.; Drew, Kevin; Kelley, Marcus R.; Kim, Sukyoung; Park, Tae Joo; Braun, Daniella; Pierquin, Ghislaine; Biver, Armand; Wagner, Kerstin; Malfroot, Anne; Panigrahi, Inusha; Franco, Brunella; Al-lami, Hadeel Adel; Yeung, Yvonne; Choi, Yeon Ja; Duffourd, Yannis; Faivre, Laurence; Rivière, Jean-Baptiste; Chen, Jiang; Liu, Karen J.; Marcotte, Edward M.; Hildebrandt, Friedhelm; Thauvin-Robinet, Christel; Krakow, Deborah; Jackson, Peter K.; Wallingford, John B. (2016)
      Summary Cilia use microtubule-based intraflagellar transport (IFT) to organize intercellular signaling. The ciliopathies are a spectrum of human disease resulting from defects in cilia structure or function. Mechanisms ...

    • The CIN4 Chromosomal Instability qPCR Classifier Defines Tumor Aneuploidy and Stratifies Outcome in Grade 2 Breast Cancer 

      Szász, Attila Marcell; Eklund, Aron C.; Sztupinszki, Zsófia; Rowan, Andrew; Tőkés, Anna-Mária; Székely, Borbála; Kiss, András; Szendrői, Miklós; Győrffy, Balázs; Swanton, Charles; Kulka, Janina; Li, Qiyuan; Szallasi, Zoltan (Public Library of Science, 2013)
      Purpose Quantifying chromosomal instability (CIN) has both prognostic and predictive clinical utility in breast cancer. In order to establish a robust and clinically applicable gene expression-based measure of CIN, we ...

    • CIN85 drives B cell responses by linking BCR signals to the canonical NF-κB pathway 

      Kometani, Kohei; Yamada, Takayuki; Sasaki, Yoshiteru; Yokosuka, Tadashi; Saito, Takashi; Rajewsky, Klaus; Ishiai, Masamichi; Hikida, Masaki; Kurosaki, Tomohiro (The Rockefeller University Press, 2011)
      CIN85 transduces B cell receptor signals to IKK-β, and its expression in B cells is essential for T cell–independent type II antibody responses in mice.

    • Cingulate fasciculus integrity disruption in schizophrenia: a magnetic resonance diffusion tensor imaging study 

      Kubicki, Marek R.; Westin, Carl-Fredrik; Nestor, Paul Gerard; Wible, Cynthia Gayle; Frumin, Melissa; Maier, Stephan Ernst; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier BV, 2003)
      Background: Evidence suggests that a disruption in limbic system network integrity and, in particular, the cingulate gyrus (CG), may play a role in the pathophysiology of schizophrenia; however, the cingulum bundle (CB), ...

    • Cingulum bundle integrity associated with delusions of control in schizophrenia: Preliminary evidence from diffusion-tensor tractography 

      Whitford, Thomas; Kubicki, Marek R.; Pelavin, Paula E.; Lucia, Diandra; Schneiderman, Jason S.; Pantelis, Christos; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier BV, 2015)
      Background—Delusions of control are among the most distinctive and characteristic symptoms of schizophrenia. Several theories have been proposed that implicate aberrant communication between spatially disparate brain regions ...

    • CIP2A Promotes Proliferation of Spermatogonial Progenitor Cells and Spermatogenesis in Mice 

      Ventelä, Sami; Côme, Christophe; Mäkelä, Juho-Antti; Hobbs, Robin M.; Mannermaa, Leni; Kallajoki, Markku; Chan, Edward K.; Pandolfi, Pier Paolo; Toppari, Jorma; Westermarck, Jukka (Public Library of Science, 2012)
      Protein phosphatase 2A (PP2A) is a critical regulator of protein serine/threonine phosphorylation. However, the physiological and developmental roles of different PP2A complexes are very poorly understood. Here, we show ...

    • The Circadian Clock Gates the Intestinal Stem Cell Regenerative State 

      Karpowicz, Phillip; Zhang, Yong; Hogenesch, John B.; Emery, Patrick; Perrimon, Norbert (Elsevier BV, 2013-04-25)
      The intestine has evolved under constant environmental stresses, because an animal may ingest harmful pathogens or chemicals at any time during its lifespan. Following damage, intestinal stem cells (ISCs) regenerate the ...

    • A Circadian Clock Gene, Cry, Affects Heart Morphogenesis and Function in Drosophila as Revealed by Optical Coherence Microscopy 

      Alex, Aneesh; Li, Airong; Zeng, Xianxu; Tate, Rebecca E.; McKee, Mary L.; Capen, Diane E.; Zhang, Zhan; Tanzi, Rudolph E.; Zhou, Chao (Public Library of Science, 2015)
      Circadian rhythms are endogenous, entrainable oscillations of physical, mental and behavioural processes in response to local environmental cues such as daylight, which are present in the living beings, including humans. ...

    • Circadian Phase-Shifting Effects of Bright Light, Exercise, and Bright Light + Exercise 

      Youngstedt, Shawn D.; Kline, Christopher E.; Elliott, Jeffrey A.; Zielinski, Mark R.; Devlin, Tina M.; Moore, Teresa A. (Ubiquity Press, 2016)
      Limited research has compared the circadian phase-shifting effects of bright light and exercise and additive effects of these stimuli. The aim of this study was to compare the phase-delaying effects of late night bright ...

    • A Circuit Mechanism for Differentiating Positive and Negative Associations 

      Namburi, Praneeth; Beyeler, Anna; Yorozu, Suzuko; Calhoon, Gwendolyn G.; Halbert, Sarah A.; Wichmann, Romy; Holden, Stephanie S.; Mertens, Kim L.; Anahtar, Melodi; Felix-Ortiz, Ada C.; Wickersham, Ian R.; Gray, Jesse M.; Tye, Kay M. (2015)
      The ability to differentiate stimuli predicting positive or negative outcomes is critical for survival, and perturbations of emotional processing underlie many psychiatric disease states. Synaptic plasticity in the basolateral ...

    • A Circuit Supporting Concentration-Invariant Odor Perception in Drosophila 

      Asahina, Kenta; Louis, Matthieu; Piccinotti, Silvia; Vosshall, Leslie B (BioMed Central, 2009)
      Background: Most odors are perceived to have the same quality over a large concentration range, but the neural mechanisms that permit concentration-invariant olfactory perception are unknown. In larvae of the vinegar fly ...

    • Circulating adiponectin and cardiovascular mortality in patients with type 2 diabetes mellitus: evidence of sexual dimorphism 

      Menzaghi, Claudia; Xu, Min; Salvemini, Lucia; De Bonis, Concetta; Palladino, Giuseppe; Huang, Tao; Copetti, Massimiliano; Zheng, Yan; Li, Yanping; Fini, Grazia; Hu, Frank B; Bacci, Simonetta; Qi, Lu; Trischitta, Vincenzo (BioMed Central, 2014)
      Background: The pathogenesis of cardiovascular (CV) mortality, whose rate is increased in type 2 diabetes, is poorly understood. While high serum adiponectin is associated with increased CV mortality in the general population, ...

    • Circulating and Dietary Omega‐3 and Omega‐6 Polyunsaturated Fatty Acids and Incidence of CVD in the Multi‐Ethnic Study of Atherosclerosis 

      de Oliveira Otto, Marcia C.; Wu, Jason H. Y.; Baylin, Ana; Vaidya, Dhananjay; Rich, Stephen S.; Tsai, Michael Y.; Jacobs, David R.; Mozaffarian, Dariush (Blackwell Publishing Ltd, 2013)
      Background: Dietary guidelines support intake of polyunsaturated fatty acids (PUFAs) in fish and vegetable oils. However, some controversy remains about benefits of PUFAs, and most prior studies have relied on self‐reported ...

    • Circulating and disseminated tumor cells from breast cancer patient-derived xenograft-bearing mice as a novel model to study metastasis 

      Giuliano, Mario; Herrera, Sabrina; Christiny, Pavel; Shaw, Chad; Creighton, Chad J; Mitchell, Tamika; Bhat, Raksha; Zhang, Xiaomei; Mao, Sufeng; Dobrolecki, Lacey E; Al-rawi, Ahmed; Chen, Fengju; Veneziani, Bianca M; Zhang, Xiang H-F; Hilsenbeck, Susan G; Contreras, Alejandro; Gutierrez, Carolina; Jeselsohn, Rinath M; Rimawi, Mothaffar F; Osborne, C Kent; Lewis, Michael T; Schiff, Rachel; Trivedi, Meghana V (BioMed Central, 2015)
      Introduction: Real-time monitoring of biologic changes in tumors may be possible by investigating the transitional cells such as circulating tumor cells (CTCs) and disseminated tumor cells in bone marrow (BM-DTCs). However, ...

    • Circulating Angiogenic Factors and the Risk of Adverse Outcomes among Haitian Women with Preeclampsia 

      March, Melissa I.; Geahchan, Carl; Wenger, Julia; Raghuraman, Nandini; Berg, Anders; Haddow, Hamish; Mckeon, Bri Ann; Narcisse, Rulx; David, Jean Louis; Scott, Jennifer; Thadhani, Ravi; Karumanchi, S. Ananth; Rana, Sarosh (Public Library of Science, 2015)
      Objective: Angiogenic factors are strongly associated with adverse maternal and fetal outcomes among women with preterm preeclampsia (PE) in developed countries. We evaluated the role of angiogenic factors and their ...

    • Circulating anti-angiogenic factors during hypertensive pregnancy and increased risk of respiratory distress syndrome in preterm neonates 

      Wang, Alice; Holston, Alexander M.; Yu, Kai F.; Zhang, Jun; Toporsian, Mourad; Karumanchi, Subbian Ananth; Levine, Richard J. (Informa healthcare, 2012)
      Objective: To test the hypothesis that high circulating concen-trations of maternal anti-angiogenic factors are associated with increased risk of respiratory distress syndrome (RDS). Study Design: This is a nested case-control ...

    • Circulating Endothelial Progenitor Cells Are Up-Regulated in a Mouse Model of Endometriosis 

      Becker, Christian M.; Beaudry, Paul; Funakoshi, Tae; Benny, Ofra; Zaslavsky, Alexander; Zurakowski, David; Folkman, Judah; D\'Amato, Robert J.; Ryeom, Sandra (American Society for Investigative Pathology, 2011)
      Endometriosis is a debilitating disease characterized by the growth of ectopic endometrial tissue. It is widely accepted that angiogenesis plays an integral part in the establishment and growth of endometriotic lesions. ...

    • Circulating Fatty Acids and Prostate Cancer Risk: Individual Participant Meta-Analysis of Prospective Studies 

      Crowe, Francesca L.; Appleby, Paul N.; Travis, Ruth C.; Barnett, Matt; Brasky, Theodore M.; Bueno-de-Mesquita, H. Bas; Chajes, Veronique; Chavarro, Jorge E.; Chirlaque, Maria-Dolores; English, Dallas R.; Gibson, Robert A.; Giles, Graham G.; Goodman, Gary E.; Henning, Susanne M.; Kaaks, Rudolf; King, Irena B.; Kolonel, Lawrence N.; Kristal, Alan R.; Neuhouser, Marian L.; Park, Song-Yi; Severi, Gianluca; Siddiq, Afshan; Stampfer, Meir J.; Stattin, Pär; Tangen, Catherine M.; Tjønneland, Anne; Trichopoulos, Dimitrios; Tumino, Rosario; Wilkens, Lynne R.; Key, Timothy J.; Allen, Naomi E. (Oxford University Press, 2014)
      Background: Individual studies have suggested that some circulating fatty acids are associated with prostate cancer risk, but have not been large enough to provide precise estimates of associations, particularly by stage ...

    • Circulating Human Neonatal Naïve B Cells are Deficient in CD73 Impairing Purine Salvage 

      Pettengill, Matthew Aaron; Levy, Ofer (Frontiers Media S.A., 2016)
      Background: Extracellular purines, in particular adenosine (Ado) and adenosine-triphosphate, are critical immunoregulatory molecules. Expression and activity of purine ecto-enzymes on B cells in neonatal and adult blood ...