Browsing Harvard Medical School by Title

Now showing items 2883-2902 of 18428

    • Closing the data gaps for surgical care delivery in LMICs 

      Riviello, Robert; Scott, John W (Elsevier BV, 2016)
      In their study in The Lancet Global Health, Tarsicio Uribe-Leitz and colleagues1 find great discrepancies in surgical outcomes across the regions of the world.1 The authors examined three procedures that are fairly ...

    • Closing the delivery gaps in pediatric HIV care in Togo, West Africa: using the care delivery value chain framework to direct quality improvement 

      Fiori, Kevin; Schechter, Jennifer; Dey, Monica; Braganza, Sandra; Rhatigan, Joseph; Houndenou, Spero; Gbeleou, Christophe; Palerbo, Emmanuel; Tchangani, Elfamozo; Lopez, Andrew; Bensen, Emily; Hirschhorn, Lisa R. (Taylor & Francis, 2016)
      ABSTRACT Providing quality care for all children living with HIV/AIDS remains a global challenge and requires the development of new healthcare delivery strategies. The care delivery value chain (CDVC) is a framework that ...

    • Closing the Research-To-Practice Gap in Digital Psychiatry 

      Lipschitz, Jessica; Hogan, Timothy P.; Mohr, David C.; Bauer, Mark (Physicians Postgraduate Press, Inc, 2019-05-14)

    • Clostridium difficile outbreaks: Prevention and treatment strategies 

      Martinez, Fernando J; Leffler, Daniel Alexander; Kelly, Ciaran Patrick (Dove Medical Press, 2012)
      The incidence and severity of Clostridium difficile infection (CDI) have increased dramatically over the past decade. Its treatment, however, has largely remained the same with the exception of oral vancomycin use as a ...

    • Cloud Computing for Comparative Genomics 

      Wall, Dennis Paul; Kudtarkar, Parul; Fusaro, Vincent Alfred; Pivovarov, Rimma; Patil, Prasad; Tonellato, Peter J (BioMed Central, 2010)
      Background: Large comparative genomics studies and tools are becoming increasingly more compute-expensive as the number of available genome sequences continues to rise. The capacity and cost of local computing infrastructures ...

    • Cloud Computing for Comparative Genomics with Windows Azure Platform 

      Kim, Insik; Jung, Jae-Yoon; DeLuca, Todd; Nelson, Tristan; Wall, Dennis Paul Paul (Libertas Academica, 2012)
      Cloud computing services have emerged as a cost-effective alternative for cluster systems as the number of genomes and required computation power to analyze them increased in recent years. Here we introduce the Microsoft ...

    • Cloud-Enabled Microscopy and Droplet Microfluidic Platform for Specific Detection of Escherichia coli in Water 

      Golberg, Alexander; Linshiz, Gregory; Kravets, Ilia; Stawski, Nina; Hillson, Nathan J.; Yarmush, Martin L.; Marks, Robert S.; Konry, Tania (Public Library of Science, 2014)
      We report an all-in-one platform – ScanDrop – for the rapid and specific capture, detection, and identification of bacteria in drinking water. The ScanDrop platform integrates droplet microfluidics, a portable imaging ...

    • Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles 

      Goldstein, Jacqueline I; Jarskog, L Fredrik; Hilliard, Chris; Alfirevic, Ana; Duncan, Laramie; Fourches, Denis; Huang, Hailiang; Lek, Monkol; Neale, Benjamin M; Ripke, Stephan; Shianna, Kevin; Szatkiewicz, Jin P; Tropsha, Alexander; van den Oord, Edwin JCG; Cascorbi, Ingolf; Dettling, Michael; Gazit, Ephraim; Goff, Donald C; Holden, Arthur L; Kelly, Deanna L; Malhotra, Anil K; Nielsen, Jimmi; Pirmohamed, Munir; Rujescu, Dan; Werge, Thomas; Levy, Deborah L; Josiassen, Richard C; Kennedy, James L; Lieberman, Jeffrey A; Daly, Mark J; Sullivan, Patrick F (2014)
      Clozapine is a particularly effective antipsychotic medication but its use is curtailed by the risk of clozapine-induced agranulocytosis/granulocytopenia (CIAG), a severe adverse drug reaction occurring in up to 1% of ...

    • The Clustered, Regularly Interspaced, Short Palindromic Repeats-associated Endonuclease 9 (CRISPR/Cas9)-created MDM2T309G Mutation Enhances Vitreous-induced Expression of MDM2 and Proliferation and Survival of Cells 

      Duan, Yajian; Ma, Gaoen; Huang, Xionggao; D'Amore, Patricia Ann; Zhang, Feng; Lei, Hetian (American Society for Biochemistry & Molecular Biology (ASBMB), 2016)
      The 309G allele of single nucleotide polymorphisms (SNPs) in the mouse double minute (MDM2) promoter locus is associated with a higher risk of cancer and proliferative vitreoretinopathy (PVR), but as to whether this SNP ...

    • Clusterin Seals the Ocular Surface Barrier in Mouse Dry Eye 

      Bauskar, Aditi; Mack, Wendy J.; Mauris, Jerome; Argüeso, Pablo; Heur, Martin; Nagel, Barbara A.; Kolar, Grant R.; Gleave, Martin E.; Nakamura, Takahiro; Kinoshita, Shigeru; Moradian-Oldak, Janet; Panjwani, Noorjahan; Pflugfelder, Stephen C.; Wilson, Mark R.; Fini, M. Elizabeth; Jeong, Shinwu (Public Library of Science, 2015)
      Dry eye is a common disorder caused by inadequate hydration of the ocular surface that results in disruption of barrier function. The homeostatic protein clusterin (CLU) is prominent at fluid-tissue interfaces throughout ...

    • Clustering Heart Rate Dynamics Is Associated with β-Adrenergic Receptor Polymorphisms: Analysis by Information-Based Similarity Index 

      Yang, Albert C.; Tsai, Shih-Jen; Hong, Chen-Jee; Wang, Cynthia; Chen, Tai-Jui; Liou, Ying-Jay; Gaetano, Carlo; Peng, Chung-Kang (Public Library of Science, 2011)
      Background: Genetic polymorphisms in the gene encoding the β-adrenergic receptors (β -AR) have a pivotal role in the functions of the autonomic nervous system. Using heart rate variability (HRV) as an indicator of autonomic ...

    • Clustering of plaques contributes to plaque growth in a mouse model of Alzheimer’s disease 

      McCarter, Joanna F.; Liebscher, Sabine; Bachhuber, Teresa; Abou-Ajram, Claudia; Hübener, Mark; Hyman, Bradley T.; Haass, Christian; Meyer-Luehmann, Melanie (Springer Berlin Heidelberg, 2013)
      Amyloid-β (Aβ) plaque deposition plays a central role in the pathogenesis of Alzheimer’s disease (AD). Post-mortem analysis of plaque development in mouse models of AD revealed that plaques are initially small, but then ...

    • CMTR1 is associated with increased asthma exacerbations in patients taking inhaled corticosteroids 

      Dahlin, Amber; Denny, Joshua; Roden, Dan M.; Brilliant, Murray H.; Ingram, Christie; Kitchner, Terrie E.; Linneman, James G.; Shaffer, Christian M.; Weeke, Peter; Xu, Hua; Kubo, Michiaki; Tamari, Mayumi; Clemmer, George L.; Ziniti, John; McGeachie, Michael J.; Tantisira, Kelan G.; Weiss, Scott T.; Wu, Ann Chen (John Wiley and Sons Inc., 2015)
      Abstract Inhaled corticosteroids (ICS) are the most effective controller medications for asthma, and variability in ICS response is associated with genetic variation. Despite ICS treatment, some patients with poor asthma ...

    • CNS Activity of Alectinib in Advanced ALK-Rearranged NSCLC: A Retrospective Review 

      Jiang, Ginger (2018-05-15)
      Purpose: Central nervous system (CNS) metastases are a significant contributor to morbidity and mortality in ALK-rearranged non-small cell lung cancer (NSCLC). While the ability ofalectinib is known to have excellent CNS ...

    • CNS Metastasis Patterns in BRCA1/2 Mutation Associated and Non-BRCA Associated Breast Cancers 

      Song, Yun (2015-06-08)
      BRCA1 and BRCA2 germline mutations give rise to phenotypically distinct breast cancers (BC): triple negative (TNBC) and hormone positive, respectively. Different BC subtypes are associated with different patterns of ...

    • CNS Penetration of Intrathecal-Lumbar Idursulfase in the Monkey, Dog and Mouse: Implications for Neurological Outcomes of Lysosomal Storage Disorder 

      Calias, Pericles; Pan, Jing; Savioli, Nancy; Huang, Yan; Lotterhand, Jason; Alessandrini, Mary; Liu, Nan; Fischman, Alan J.; Powell, Jan L.; Heartlein, Michael W.; Papisov, Mikhail Ivanovich; Belov, Vasily (Public Library of Science, 2012)
      A major challenge for the treatment of many central nervous system (CNS) disorders is the lack of convenient and effective methods for delivering biological agents to the brain. Mucopolysaccharidosis II (Hunter syndrome) ...

    • CNTNAP2 polymorphisms and structural brain connectivity: A diffusion-tensor imaging study 

      Clemm von Hohenberg, Christian; Wigand, Marlene C.; Kubicki, Marek R.; Leicht, Gregor; Giegling, Ina; Karch, Susanne; Hartmann, Annette M.; Konte, Bettina; Friedl, Marion; Ballinger, Thomas; Eckbo, Ryan; Bouix, Sylvain; Jäger, Lorenz; Shenton, Martha Elizabeth; Rujescu, Dan; Mulert, Christoph (Elsevier BV, 2013)
      CNTNAP2 is a gene on chromosome 7 that has shown associations with autism andschizophrenia, and there is evidence that it plays an important role for neuronal synchronization and brain connectivity. In this study, we ...

    • CNV analysis in a large schizophrenia sample implicates deletions at 16p12.1 and SLC1A1 and duplications at 1p36.33 and CGNL1 

      Rees, Elliott; Walters, James T.R.; Chambert, Kimberly D.; O'Dushlaine, Colm; Szatkiewicz, Jin; Richards, Alexander L.; Georgieva, Lyudmila; Mahoney-Davies, Gerwyn; Legge, Sophie E.; Moran, Jennifer L.; Genovese, Giulio; Levinson, Douglas; Morris, Derek W.; Cormican, Paul; Kendler, Kenneth S.; O'Neill, Francis A.; Riley, Brien; Gill, Michael; Corvin, Aiden; Sklar, Pamela; Hultman, Christina; Pato, Carlos; Pato, Michele; Sullivan, Patrick F.; Gejman, Pablo V.; McCarroll, Steven A.; O'Donovan, Michael C.; Owen, Michael J.; Kirov, George (Oxford University Press, 2013)
      Large and rare copy number variants (CNVs) at several loci have been shown to increase risk for schizophrenia. Aiming to discover novel susceptibility CNV loci, we analyzed 6882 cases and 11 255 controls genotyped on ...

    • A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer 

      Lunardi, Andrea; Ala, Ugo; Epping, Mirjam T.; Salmena, Leonardo; Clohessy, John G.; Webster, Kaitlyn A.; Wang, Guocan; Mazzucchelli, Roberta; Bianconi, Maristella; Stack, Edward C.; Lis, Rosina; Patnaik, Akash; Cantley, Lewis C.; Bubley, Glenn; Cordon-Cardo, Carlos; Gerald, William L.; Montironi, Rodolfo; Signoretti, Sabina; Loda, Massimo; Nardella, Caterina; Pandolfi, Pier Paolo (2013)
      Here we report an integrated analysis that leverages data from treatment of genetic mouse models of prostate cancer along with clinical data from patients to elucidate new mechanisms of castration resistance. We show that ...

    • Co-existence of IL7R high and SH2B3 low expression distinguishes a novel high-risk acute lymphoblastic leukemia with Ikaros dysfunction 

      Ge, Zheng; Gu, Yan; Xiao, Lichan; Han, Qi; Li, Jianyong; Chen, Baoan; Yu, James; Kawasawa, Yuka Imamura; Payne, Kimberly J.; Dovat, Sinisa; Song, Chunhua (Impact Journals LLC, 2016)
      Acute lymphoblastic leukemia (ALL) remains the leading cause of cancer-related death in children and young adults. Compared to ALL in children, adult ALL has a much lower cure rate. Therefore, it is important to understand ...