Browsing Harvard Medical School by Title

Now showing items 2895-2914 of 18428

    • CMTR1 is associated with increased asthma exacerbations in patients taking inhaled corticosteroids 

      Dahlin, Amber; Denny, Joshua; Roden, Dan M.; Brilliant, Murray H.; Ingram, Christie; Kitchner, Terrie E.; Linneman, James G.; Shaffer, Christian M.; Weeke, Peter; Xu, Hua; Kubo, Michiaki; Tamari, Mayumi; Clemmer, George L.; Ziniti, John; McGeachie, Michael J.; Tantisira, Kelan G.; Weiss, Scott T.; Wu, Ann Chen (John Wiley and Sons Inc., 2015)
      Abstract Inhaled corticosteroids (ICS) are the most effective controller medications for asthma, and variability in ICS response is associated with genetic variation. Despite ICS treatment, some patients with poor asthma ...

    • CNS Activity of Alectinib in Advanced ALK-Rearranged NSCLC: A Retrospective Review 

      Jiang, Ginger (2018-05-15)
      Purpose: Central nervous system (CNS) metastases are a significant contributor to morbidity and mortality in ALK-rearranged non-small cell lung cancer (NSCLC). While the ability ofalectinib is known to have excellent CNS ...

    • CNS Metastasis Patterns in BRCA1/2 Mutation Associated and Non-BRCA Associated Breast Cancers 

      Song, Yun (2015-06-08)
      BRCA1 and BRCA2 germline mutations give rise to phenotypically distinct breast cancers (BC): triple negative (TNBC) and hormone positive, respectively. Different BC subtypes are associated with different patterns of ...

    • CNS Penetration of Intrathecal-Lumbar Idursulfase in the Monkey, Dog and Mouse: Implications for Neurological Outcomes of Lysosomal Storage Disorder 

      Calias, Pericles; Pan, Jing; Savioli, Nancy; Huang, Yan; Lotterhand, Jason; Alessandrini, Mary; Liu, Nan; Fischman, Alan J.; Powell, Jan L.; Heartlein, Michael W.; Papisov, Mikhail Ivanovich; Belov, Vasily (Public Library of Science, 2012)
      A major challenge for the treatment of many central nervous system (CNS) disorders is the lack of convenient and effective methods for delivering biological agents to the brain. Mucopolysaccharidosis II (Hunter syndrome) ...

    • CNTNAP2 polymorphisms and structural brain connectivity: A diffusion-tensor imaging study 

      Clemm von Hohenberg, Christian; Wigand, Marlene C.; Kubicki, Marek R.; Leicht, Gregor; Giegling, Ina; Karch, Susanne; Hartmann, Annette M.; Konte, Bettina; Friedl, Marion; Ballinger, Thomas; Eckbo, Ryan; Bouix, Sylvain; Jäger, Lorenz; Shenton, Martha Elizabeth; Rujescu, Dan; Mulert, Christoph (Elsevier BV, 2013)
      CNTNAP2 is a gene on chromosome 7 that has shown associations with autism andschizophrenia, and there is evidence that it plays an important role for neuronal synchronization and brain connectivity. In this study, we ...

    • CNV analysis in a large schizophrenia sample implicates deletions at 16p12.1 and SLC1A1 and duplications at 1p36.33 and CGNL1 

      Rees, Elliott; Walters, James T.R.; Chambert, Kimberly D.; O'Dushlaine, Colm; Szatkiewicz, Jin; Richards, Alexander L.; Georgieva, Lyudmila; Mahoney-Davies, Gerwyn; Legge, Sophie E.; Moran, Jennifer L.; Genovese, Giulio; Levinson, Douglas; Morris, Derek W.; Cormican, Paul; Kendler, Kenneth S.; O'Neill, Francis A.; Riley, Brien; Gill, Michael; Corvin, Aiden; Sklar, Pamela; Hultman, Christina; Pato, Carlos; Pato, Michele; Sullivan, Patrick F.; Gejman, Pablo V.; McCarroll, Steven A.; O'Donovan, Michael C.; Owen, Michael J.; Kirov, George (Oxford University Press, 2013)
      Large and rare copy number variants (CNVs) at several loci have been shown to increase risk for schizophrenia. Aiming to discover novel susceptibility CNV loci, we analyzed 6882 cases and 11 255 controls genotyped on ...

    • A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer 

      Lunardi, Andrea; Ala, Ugo; Epping, Mirjam T.; Salmena, Leonardo; Clohessy, John G.; Webster, Kaitlyn A.; Wang, Guocan; Mazzucchelli, Roberta; Bianconi, Maristella; Stack, Edward C.; Lis, Rosina; Patnaik, Akash; Cantley, Lewis C.; Bubley, Glenn; Cordon-Cardo, Carlos; Gerald, William L.; Montironi, Rodolfo; Signoretti, Sabina; Loda, Massimo; Nardella, Caterina; Pandolfi, Pier Paolo (2013)
      Here we report an integrated analysis that leverages data from treatment of genetic mouse models of prostate cancer along with clinical data from patients to elucidate new mechanisms of castration resistance. We show that ...

    • Co-existence of IL7R high and SH2B3 low expression distinguishes a novel high-risk acute lymphoblastic leukemia with Ikaros dysfunction 

      Ge, Zheng; Gu, Yan; Xiao, Lichan; Han, Qi; Li, Jianyong; Chen, Baoan; Yu, James; Kawasawa, Yuka Imamura; Payne, Kimberly J.; Dovat, Sinisa; Song, Chunhua (Impact Journals LLC, 2016)
      Acute lymphoblastic leukemia (ALL) remains the leading cause of cancer-related death in children and young adults. Compared to ALL in children, adult ALL has a much lower cure rate. Therefore, it is important to understand ...

    • Co-Infection with Mycobacterium tuberculosis Impairs HIV-Specific CD8+ and CD4+ T Cell Functionality 

      Chetty, Shivan; Govender, Pamla; Zupkosky, Jennifer; Pillay, Mona; Ghebremichael, Musie; Moosa, Mahomed-Yunus S.; Ndung’u, Thumbi; Porichis, Filippos; Kasprowicz, Victoria O.; Paxton, William A. (Public Library of Science, 2015)
      The ability of antigen-specific T cells to simultaneously produce multiple cytokines is thought to correlate with the functional capacity and efficacy of T cells. These 'polyfunctional' T cells have been associated with ...

    • The Co-Morbidity Burden of Children and Young Adults with Autism Spectrum Disorders 

      Wattanasin, Nich; Churchill, Susanne; Kohane, Isaac Samuel; McMurry, Andrew; MacFadden, Douglas; Rappaport, Leonard Allan; Kunkel, Louis Martens; Bickel, Jonathan; Spence, Sarah J.; Murphy, Shawn Norman; Weber, Griffin M. (Public Library of Science, 2012)
      Objectives: Use electronic health records Autism Spectrum Disorder (ASD) to assess the comorbidity burden of ASD in children and young adults. Study Design: A retrospective prevalence study was performed using a distributed ...

    • Co-occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart 

      He, Aibin; Kong, Sek Won; Ma, Qing; Pu, William T. (National Academy of Sciences, 2011)
      Identification of genomic regions that control tissue-specific gene expression is currently problematic. ChIP and high-throughput sequencing (ChIP-seq) of enhancer-associated proteins such as p300 identifies some but not ...

    • Co-Operative Additive Effects between HLA Alleles in Control of HIV-1 

      Matthews, Philippa C.; Listgarten, Jennifer; Carlson, Jonathan M.; Payne, Rebecca; Huang, Kuan-Hsiang Gary; Frater, John; Goedhals, Dominique; Steyn, Dewald; van Vuuren, Cloete; Paioni, Paolo; Jooste, Pieter; Ogwu, Anthony; Shapiro, Roger L.; Mncube, Zenele; Ndung'u, Thumbi; Walker, Bruce David; Heckerman, David; Goulder, Philip J. R. (Public Library of Science, 2012)
      Background: HLA class I genotype is a major determinant of the outcome of HIV infection, and the impact of certain alleles on HIV disease outcome is well studied. Recent studies have demonstrated that certain HLA class I ...

    • Co-opting STING signaling for NK-cell based immunotherapies in thoracic malignancies 

      Chen, Minyue (2023-05-10)
      Thoracic cancers, including small cell lung cancer (SCLC) and malignant pleural mesothelioma (MPM), are aggressive forms of lung cancer. In contrast to non-small cell lung cancer, their treatment is mainly based on ...

    • Co-receptor Binding Site Antibodies Enable CD4-Mimetics to Expose Conserved Anti-cluster A ADCC Epitopes on HIV-1 Envelope Glycoproteins 

      Richard, Jonathan; Pacheco, Beatriz; Gohain, Neelakshi; Veillette, Maxime; Ding, Shilei; Alsahafi, Nirmin; Tolbert, William D.; Prévost, Jérémie; Chapleau, Jean-Philippe; Coutu, Mathieu; Jia, Manxue; Brassard, Nathalie; Park, Jongwoo; Courter, Joel R.; Melillo, Bruno; Martin, Loïc; Tremblay, Cécile; Hahn, Beatrice H.; Kaufmann, Daniel E.; Wu, Xueling; Smith, Amos B.; Sodroski, Joseph; Pazgier, Marzena; Finzi, Andrés (Elsevier, 2016)
      Human immunodeficiency virus type 1 (HIV-1) has evolved a sophisticated strategy to conceal conserved epitopes of its envelope glycoproteins (Env) recognized by antibody-dependent cellular cytotoxicity (ADCC)-mediating ...

    • Co-Registered Spectrally Encoded Confocal Microscopy and Optical Frequency Domain Imaging System 

      Kang, D.K.; Suter, Melissa; Boudoux, Caroline; Yachimski, P.S.; Puricelli, W.P.; Nishioka, Norman Shizuaki; Mino-Kenudson, Mari; Lauwers, Gregory Y.; Bouma, Brett; Tearney, Guillermo James (Wiley-Blackwell, 2010)
      Spectrally encoded confocal microscopy and optical frequency domain imaging are two non-contact optical imaging technologies that provide images of tissue cellular and architectural morphology, which are both used for ...

    • Co-transcriptional histone methylations 

      Buratowski, Stephen (BioMed Central, 2013)

    • Coactivators p300 and PCAF Physically and Functionally Interact with the Foamy Viral Trans-activator 

      Bannert, Helmut; Muranyi, Walter; Ogryzko, Vasily V; Nakatani, Yoshihiro Pat; Flügel, Rolf M (BioMed Central, 2004)
      Background: Foamy virus Bel1/Tas trans-activators act as key regulators of gene expression and directly bind to Bel1 response elements (BRE) in both the internal and the 5'LTR promoters leading to strong transcriptional ...

    • Coadministration of Lopinavir/Ritonavir and Rifampicin in HIV and Tuberculosis Co-Infected Adults in South Africa 

      Murphy, Richard A.; Marconi, Vincent C.; Gandhi, Rajesh Tim; Kuritzkes, Daniel Robert; Sunpath, Henry (Public Library of Science, 2012)
      Background: In HIV-infected patients receiving rifampicin-based treatment for tuberculosis (TB), the dosage of lopinavir/ritonavir (LPV/r) is adjusted to prevent sub-therapeutic lopinavir concentrations. In this setting, ...

    • Coagulation induced by C3aR-dependent NETosis drives protumorigenic neutrophils during small intestinal tumorigenesis 

      Guglietta, Silvia; Chiavelli, Andrea; Zagato, Elena; Krieg, Carsten; Gandini, Sara; Ravenda, Paola Simona; Bazolli, Barbara; Lu, Bao; Penna, Giuseppe; Rescigno, Maria (Nature Publishing Group, 2016)
      Excessive activation of blood coagulation and neutrophil accumulation have been described in several human cancers. However, whether hypercoagulation and neutrophilia are linked and involved in cancer development is currently ...

    • Coat Protein Activation of Alfalfa Mosaic Virus Replication Is Concentration Dependent 

      Guogas, Laura; Laforest, Siana; Gehrke, Lee (American Society for Microbiology, 2005)
      Alfalfa mosaic virus (AMV) and ilarvirus RNAs are infectious only in the presence of the viral coat protein; therefore, an understanding of coat protein's function is important for defining viral replication mechanisms. ...