Browsing Harvard Medical School by Title

Now showing items 2939-2958 of 18428

    • COGNITIVE FUNCTION IN ELDERLY PATIENTS AFTER CARDIAC SURGERY: A SECONDARY ANALYSIS OF THE MINDDS TRIAL 

      Namirembe, Grace Erinah (2023-05-03)
      Postoperative cognitive dysfunction (POCD) is a common complication in elderly patients characterized by attention deficit, impaired memory and concentration that can last several months. POCD has been formally recognized ...

    • Cognitive Function Is Disrupted by Both Hypo- and Hyperglycemia in School-Aged Children With Type 1 Diabetes: A Field Study 

      Gonder-Frederick, Linda A.; Zrebiec, John Frank; Bauchowitz, Andrea U.; Ritterband, Lee M.; Magee, Joshua C.; Cox, Daniel J.; Clarke, William L. (American Diabetes Association, 2009)
      Objective: We developed a field procedure using personal digital assistant (PDA) technology to test the hypothesis that naturally occurring episodes of hypo- and hyperglycemia are associated with deterioration in cognitive ...

    • Cognitive Functioning and Academic Performance in Elementary School Children with Anxious/Depressed and Withdrawn Symptoms 

      Lundy, SM; Sliva, GE; Kaemingk, K.L.; Goodwin, Joy; Quan, Stuart Fun (Bentham Science Publishers Ltd., 2010)
      Rationale: Few studies have evaluated the relationship between depressive symptomatology and neuropsychological performance in children without symptomatic depression.Objectives: This study determined the relationship ...

    • Cognitive Performance in a High-Functioning Community-Dwelling Elderly Population 

      Inouye, Sharon; Albert, Marilyn S.; Mohs, Richard; Sun, Kolie; Berkman, Lisa F. (Oxford University Press (OUP), 1993-07-01)
      Background: The purpose of this study was to examine the role of demographic factors as predictors of cognitive performance in a high-functioning, community-dwelling elderly population. Methods: The study cohort consisted ...

    • Cognitive profile and brain morphological changes in obstructive sleep apnea 

      Torelli, Federico; Moscufo, Nicola; Garreffa, Girolamo; Placidi, Fabio; Romigi, Andrea; Zannino, Silvana; Bozzali, Marco; Fasano, Fabrizio; Giulietti, Giovanni; Djonlagic, Ina; Malhotra, Atul; Marciani, Maria Grazia; Guttmann, Charles (Elsevier BV, 2011-01)

    • Cognitive Rehabilitation Interventions for Neglect and Related Disorders: Moving from Bench to Bedside in Stroke Patients 

      Barrett, Anna M.; Buxbaum, Laurel J.; Coslett, H. Branch; Edwards, Emmeline; Heilman, Kenneth M.; Hillis, Argye E.; Milberg, William P.; Robertson, Ian H. (Massachusetts Institute of Technology Press (MIT Press), 2006)

    • Cognitive Remediation in Schizophrenia 

      Kaneko, Yoshio Arturo; Keshavan, Matcheri S (Korean College of Neuropsychopharmacology, 2012)
      Cognitive deficits in schizophrenia are pervasive, severe, and largely independent of the positive and negative symptoms of the illness. These deficits are increasingly considered to be core features of schizophrenia with ...

    • Cognitive remediation versus active computer control in bipolar disorder with psychosis: study protocol for a randomized controlled trial 

      Lewandowski, Kathryn Eve; Sperry, Sarah H.; Ongur, Dost; Cohen, Bruce M.; Norris, Lesley A.; Keshavan, Matcheri S. (BioMed Central, 2016)
      Background: Cognitive dysfunction is a major feature of bipolar disorder with psychosis and is strongly associated with functional outcomes. Computer-based cognitive remediation has shown promise in improving cognition in ...

    • Cognitive status impacts age-related changes in attention to novel and target events in normal adults. 

      Daffner, Kirk R.; Chong, Hyemi; Riis, Jenna; Rentz, Dorene May; Wolk, David A.; Budson, Andrew E.; Holcomb, Phillip J. (American Psychological Association (APA), 2007)
      In this study, the authors investigated the relationship between the cognitive status of normal adults and age-related changes in attention to novel and target events. Old, middle-age, and young subjects, divided into ...

    • Cognitive Trajectories after Postoperative Delirium 

      Saczynski, Jane S.; Marcantonio, Edward Ralph; Quach, Lien; Fong, Tamara G; Gross, Alden; Inouye, Sharon; Jones, Richard Norman (New England Journal of Medicine (NEJM/MMS), 2012)
      Background Delirium is common after cardiac surgery and may be associated with long-term changes in cognitive function. We examined postoperative delirium and the cognitive trajectory during the first year after cardiac ...

    • Cognitive Vulnerability to Major Depression: View from the Intrinsic Network and Cross-network Interactions 

      Wang, Xiang; Öngür, Dost; Auerbach, Randy P.; Yao, Shuqiao (Lippincott Williams & Wilkins, 2016)
      Abstract Although it is generally accepted that cognitive factors contribute to the pathogenesis of major depressive disorder (MDD), there are missing links between behavioral and biological models of depression. Nevertheless, ...

    • Cognitively Stimulating Activities: Effects on Cognition across Four Studies with up to 21 Years of Longitudinal Data 

      Mitchell, Meghan B.; Cimino, Cynthia R.; Benitez, Andreana; Brown, Cassandra L.; Gibbons, Laura E.; Kennison, Robert F.; Shirk, Steven D.; Atri, Alireza; Robitaille, Annie; MacDonald, Stuart W. S.; Lindwall, Magnus; Zelinski, Elizabeth M.; Willis, Sherry L.; Schaie, K. Warner; Johansson, Boo; Dixon, Roger A.; Mungas, Dan M.; Hofer, Scott M.; Piccinin, Andrea M. (Hindawi Publishing Corporation, 2012)
      Engagement in cognitively stimulating activities has been considered to maintain or strengthen cognitive skills, thereby minimizing age-related cognitive decline. While the idea that there may be a modifiable behavior that ...

    • The cohesin-associated protein Wapal is required for proper Polycomb-mediated gene silencing 

      Stelloh, Cary; Reimer, Michael H.; Pulakanti, Kirthi; Blinka, Steven; Peterson, Jonathan; Pinello, Luca; Jia, Shuang; Roumiantsev, Sergei; Hessner, Martin J.; Milanovich, Samuel; Yuan, Guo-Cheng; Rao, Sridhar (BioMed Central, 2016)
      Background: The cohesin complex consists of multiple core subunits that play critical roles in mitosis and transcriptional regulation. The cohesin-associated protein Wapal plays a central role in off-loading cohesin to ...

    • Cohort Profile: The AGES 2003 Cohort Study in Aichi, Japan 

      Nishi, Akihiro; Kondo, Katsunori; Hirai, Hiroshi; Kawachi, Ichiro (Japan Epidemiological Association, 2011)
      Background: The longevity of Japanese is thought to be associated with psychosocial factors such as sense of coherence, social support, and social capital. However, the actual factors responsible and the extent of their ...

    • A Cohort Study of Possible Risk Factors for Over-Reporting of Antihypertensive Adherence 

      Choo, Peter W; Rand, Cynthia S; Inui, Thomas S; Lee, Mei-Ling Ting; Canning, Claire; Platt, Richard (BioMed Central, 2001)
      Background: The identification of poor medicinal adherence is difficult because direct observation of medication use is usually impractical. Up to 50% of individuals on chronic therapies may not be taking their medication ...

    • Cold Blockade of Axonal Transport Activates Premitotic Activity of Schwann Cells and Wallerian Degeneration 

      Oaklander, Anne Louise; Spencer, Peter S. (Wiley, 1988)
      Between 3 and 4 days after transection of cat sciatic nerve, Schwann cell-associated premitotic activity spreads anterogradely along degenerating distal nerve stumps at a rate of approximately 200 mm/day. We inves- tigated ...

    • The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue 

      Lynes, Matthew David; Leiria, Luiz; Lundh, Morten; Bartelt, Alexander; Shamsi, Farnaz; Huang, Tianwen; Takahashi, Hirokazu; Hirshman, Michael F; Schlein, Christian; Lee, Alexandra; Baer, Lisa A; May, Francis J; Gao, Fei; Narain, Niven R; Chen, Emily Y; Kiebish, Michael A; Cypess, Aaron; Blüher, Matthias; Goodyear, Laurie Joy; Hotamisligil, Gokhan S.; Stanford, Kristin I; Tseng, Yu-Hua (Springer Nature, 2017)
      Brown adipose tissue (BAT) and beige adipose tissue combust fuels for heat production in adult humans, and so constitute an appealing target for the treatment of metabolic disorders such as obesity, diabetes and ...

    • COLD-PCR Amplification of Bisulfite-Converted DNA Allows the Enrichment and Sequencing of Rare Un-Methylated Genomic Regions 

      Castellanos-Rizaldos, Elena; Milbury, Coren A.; Karatza, Elli; Chen, Clark C.; Makrigiorgos, G. Mike; Merewood, Anne (Public Library of Science, 2014)
      Aberrant hypo-methylation of DNA is evident in a range of human diseases including cancer and diabetes. Development of sensitive assays capable of detecting traces of un-methylated DNA within methylated samples can be ...

    • Collaborating to Move Research Forward: Proceedings of the 10th Annual Bladder Cancer Think Tank 

      Kamat, Ashish M.; Agarwal, Piyush; Bivalacqua, Trinity; Chisolm, Stephanie; Daneshmand, Sia; Doroshow, James H.; Efstathiou, Jason A.; Galsky, Matthew; Iyer, Gopa; Kassouf, Wassim; Shah, Jay; Taylor, John; Williams, Stephen B.; Quale, Diane Zipursky; Rosenberg, Jonathan E. (IOS Press, 2016)
      The 10th Annual Bladder Cancer Think Tank was hosted by the Bladder Cancer Advocacy Network and brought together a multidisciplinary group of clinicians, researchers, representatives and Industry to advance bladder cancer ...

    • Collaboration gets the most out of software 

      Morin, Andrew; Eisenbraun, Ben; Key, Jason; Sanschagrin, Paul C; Timony, Michael A; Ottaviano, Michelle; Sliz, Piotr (eLife Sciences Publications, Ltd, 2013)
      By centralizing many of the tasks associated with the upkeep of scientific software, SBGrid allows researchers to spend more of their time on research.