Browsing Harvard Medical School by Title
Now showing items 3314-3333 of 18428
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A comprehensive survey of the mutagenic impact of common cancer cytotoxics
(BioMed Central, 2016)Background: Genomic mutations caused by cytotoxic agents used in cancer chemotherapy may cause secondary malignancies as well as contribute to the evolution of treatment-resistant tumour cells. The stable diploid genome ... -
Comprehensive Three-Dimensional Analysis of the Neuroretinal Rim in Glaucoma Using High-Density Spectral-Domain Optical Coherence Tomography Volume Scans
(The Association for Research in Vision and Ophthalmology, 2016)Purpose To describe spectral-domain optical coherence tomography (OCT) methods for quantifying neuroretinal rim tissue in glaucoma and to compare these methods to the traditional retinal nerve fiber layer thickness diagnostic ... -
Comprehensive Transgender Healthcare: The Gender Affirming Clinical and Public Health Model of Fenway Health
(Springer US, 2015)This report describes the evolution of a Boston community health center’s multidisciplinary model of transgender healthcare, research, education, and dissemination of best practices. This process began with the development ... -
Comprehensive treatment of dementia with Lewy bodies
(BioMed Central, 2015)Dementia with Lewy bodies is an under-recognized disease; it is responsible for up to 20 % of all dementia cases. Accurate diagnosis is essential because the management of dementia with Lewy bodies is more complex than ... -
Comprehensive variation discovery in single human genomes
(2014)Complete knowledge of the genetic variation in individual human genomes is a crucial foundation for understanding the etiology of disease. Genetic variation is typically characterized by sequencing individual genomes and ... -
Comprehensive Volumetric Confocal Microscopy with Adaptive Focusing
(Optical Society of America, 2011)Comprehensive microscopy of distal esophagus could greatly improve the screening and surveillance of esophageal diseases such as Barrett’s esophagus by providing histomorphologic information over the entire region at risk. ... -
Compressed sensing for highly efficient imaging transcriptomics
(Springer Science and Business Media LLC, 2021-04-15)Tissue and organ function rely on the organization of cells and molecules in specific spatial structures. In order to understand these structures and how they relate to tissue function in health and disease, we would ideally ... -
A Compressed Sensing Framework for Efficient Dissection of Neural Circuits
(Springer Nature, 2018-12-20)A fundamental question in neuroscience is how neural networks generate behavior. The lack of genetic tools and unique promoters to functionally manipulate specific neuronal subtypes makes it challenging to determine the ... -
Compressive genomics for protein databases
(Oxford University Press, 2013)Motivation: The exponential growth of protein sequence databases has increasingly made the fundamental question of searching for homologs a computational bottleneck. The amount of unique data, however, is not growing nearly ... -
Computation-Based Discovery of Related Transcriptional Regulatory Modules and Motifs Using an Experimentally Validated Combinatorial Model
(Cold Spring Harbor Laboratory, 2002-07)Gene expression is regulated by transcription factors that interact with cis-regulatory elements. Predicting these elements from sequence data has proven difficult. We describe here a successful computational search for ... -
Computational Analysis of Mouse piRNA Sequence and Biogenesis
(Public Library of Science, 2007)The recent discovery of a new class of 30-nucleotide long RNAs in mammalian testes, called PIWI-interacting RNA (piRNA), with similarities to microRNAs and repeat-associated small interfering RNAs (rasiRNAs), has raised ... -
Computational and Serologic Analysis of Novel and Known Viruses in Species Human Adenovirus D in Which Serology and Genomics Do Not Correlate
(Public Library of Science, 2012)In November of 2007 a human adenovirus (HAdV) was isolated from a bronchoalveolar lavage (BAL) sample recovered from a biopsy of an AIDS patient who presented with fever, cough, tachycardia, and expiratory wheezes. To ... -
Computational and Statistical Approaches to Analyzing Variants Identified by Exome Sequencing
(BioMed Central, 2011)New sequencing technology has enabled the identification of thousands of single nucleotide polymorphisms in the exome, and many computational and statistical approaches to identify disease-association signals have emerged. -
Computational discovery of sense-antisense transcription in the human and mouse genomes
(BioMed Central, 2002)Background: Overlapping but oppositely oriented transcripts have the potential to form senseantisense perfect double-stranded (ds) RNA duplexes. Over recent years, the number and variety of examples of mammalian ... -
A computational framework for boosting confidence in high-throughput protein-protein interaction datasets
(BioMed Central, 2012)Improving the quality and coverage of the protein interactome is of tantamount importance for biomedical research, particularly given the various sources of uncertainty in high-throughput techniques. We introduce a ... -
Computational imaging reveals mitochondrial morphology as a biomarker of cancer phenotype and drug response
(Nature Publishing Group, 2016)Mitochondria, which are essential organelles in resting and replicating cells, can vary in number, mass and shape. Past research has primarily focused on short-term molecular mechanisms underlying fission/fusion. Less is ... -
Computational Knowledge Integration in Biopharmaceutical Research
(2003)An initiative to increase biopharmaceutical research productivity by capturing, sharing and computationally integrating proprietary scientific discoveries with public knowledge is described. This initiative involves both ... -
Computational meta'omics for microbial community studies
(European Molecular Biology Organization, 2013)Complex microbial communities are an integral part of the Earth's ecosystem and of our bodies in health and disease. In the last two decades, culture-independent approaches have provided new insights into their structure ... -
A computational method for identification of vaccine targets from protein regions of conserved human leukocyte antigen binding
(BioMed Central, 2015)Background: Computational methods for T cell-based vaccine target discovery focus on selection of highly conserved peptides identified across pathogen variants, followed by prediction of their binding of human leukocyte ... -
A Computational Model of Aging and Calcification in the Aortic Heart Valve
(Public Library of Science, 2009)The aortic heart valve undergoes geometric and mechanical changes over time. The cusps of a normal, healthy valve thicken and become less extensible over time. In the disease calcific aortic stenosis (CAS), calcified nodules ...