Browsing Harvard Medical School by Title
Now showing items 3397-3416 of 18428
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Confocal Laser Endomicroscopy for the Morphometric Evaluation of Microvessels in Human Colorectal Cancer Using Targeted Anti-CD31 Antibodies
(Public Library of Science, 2012)Introduction: Numerous anti-angiogenic agents are currently developed to limit tumor growth and metastasis. While these drugs offer hope for cancer patients, their transient effect on tumor vasculature is difficult to ... -
Conformational dynamics of bacteriophage T7 DNA polymerase and its processivity factor, Escherichia coli thioredoxin
(National Academy of Sciences, 2010)Gene 5 of bacteriophage T7 encodes a DNA polymerase (gp5) responsible for the replication of the phage DNA. Gp5 polymerizes nucleotides with low processivity, dissociating after the incorporation of 1 to 50 nucleotides. ... -
Conformational States of a Soluble, Uncleaved HIV-1 Envelope Trimer
(American Society for Microbiology, 2017)The HIV-1 envelope spike [Env; trimeric (gp160)(3) cleaved to (gp120/gp41) 3] induces membrane fusion, leading to viral entry. It is also the viral component targeted by neutralizing antibodies. Vaccine development requires ... -
Conformational States of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein Ectodomain
(American Society for Microbiology, 2006)The severe acute respiratory syndrome coronavirus enters cells through the activities of a spike protein (S) which has receptor-binding (S1) and membrane fusion (S2) regions. We have characterized four sequential states. ... -
Confounding by indication affects antimicrobial risk factors for methicillin-resistant Staphylococcus aureus but not vancomycin-resistant enterococci acquisition
(BioMed Central, 2014)Background: Observational studies rarely account for confounding by indication, whereby empiric antibiotics initiated for signs and symptoms of infection prior to the diagnosis of infection are then viewed as risk factors ... -
The Confusion Assessment Method: A Systematic Review of Current Usage
(Wiley-Blackwell, 2008) -
Congenital chloride-losing diarrhea in a Mexican child with the novel homozygous SLC26A3 mutation G393W
(Frontiers Media S.A., 2015)Congenital chloride diarrhea is an autosomal recessive disease caused by mutations in the intestinal lumenal membrane Cl−/HCO−3 exchanger, SLC26A3. We report here the novel SLC26A3 mutation G393W in a Mexican child, the ... -
Congenital Heart Disease–Causing Gata4 Mutation Displays Functional Deficits In Vivo
(Public Library of Science, 2012)Defects of atrial and ventricular septation are the most frequent form of congenital heart disease, accounting for almost 50% of all cases. We previously reported that a heterozygous G296S missense mutation of GATA4 caused ... -
Congenital hypogonadotropic hypogonadism with split hand/foot malformation: a clinical entity with a high frequency of FGFR1 mutations
(2014)Purpose Congenital hypogonadotropic hypogonadism (CHH) and split hand/foot malformation (SHFM) are two rare genetic conditions. Here we report a clinical entity comprising CHH and SHFM. Methods: We identified patients with ... -
Conic Sampling: An Efficient Method for Solving Linear and Quadratic Programming by Randomly Linking Constraints within the Interior
(Public Library of Science, 2012)Linear programming (LP) problems are commonly used in analysis and resource allocation, frequently surfacing as approximations to more difficult problems. Existing approaches to LP have been dominated by a small group of ... -
Connecting the Lines between Hypogonadism and Atherosclerosis
(Hindawi Publishing Corporation, 2012)Epidemiological studies show that atherosclerotic cardiovascular disease is a leading cause of morbidity and mortality worldwide and point to gender differences with ageing males being at highest risk. Atherosclerosis is ... -
Connective tissue growth factor as a novel therapeutic target in high grade serous ovarian cancer
(Impact Journals LLC, 2015)Ovarian cancer is the most common cause of death among women with gynecologic cancer. We examined molecular profiles of fibroblasts from normal ovary and high-grade serous ovarian tumors to identify novel therapeutic targets ... -
The Connectome Visualization Utility: Software for Visualization of Human Brain Networks
(Public Library of Science, 2014)In analysis of the human connectome, the connectivity of the human brain is collected from multiple imaging modalities and analyzed using graph theoretical techniques. The dimensionality of human connectivity data is high, ... -
Connexin43 Inhibition Prevents Human Vein Grafts Intimal Hyperplasia
(Public Library of Science, 2015)Venous bypass grafts often fail following arterial implantation due to excessive smooth muscle cells (VSMC) proliferation and consequent intimal hyperplasia (IH). Intercellular communication mediated by Connexins (Cx) ... -
Conscientiousness is modified by genetic variation in catechol-O-methyltransferase to reduce symptom complaints in IBS patients
(BlackWell Publishing Ltd, 2014)Background: Attention to and perception of physical sensations and somatic states can significantly influence reporting of complaints and symptoms in the context of clinical care and randomized trials. Although anxiety and ... -
Conscious Brain-to-Brain Communication in Humans Using Non-Invasive Technologies
(Public Library of Science, 2014)Human sensory and motor systems provide the natural means for the exchange of information between individuals, and, hence, the basis for human civilization. The recent development of brain-computer interfaces (BCI) has ... -
Consciousness and Neurosurgery
(Ovid Technologies (Wolters Kluwer Health), 2004)THE NEURONAL BASIS of consciousness is the greatest challenge to the scientific worldview. Much relevant empirical work is carried out on the minimal neuronal mechanisms underlying any one specific conscious percept. Two ... -
Consensus guideline for the diagnosis and treatment of aromatic l-amino acid decarboxylase (AADC) deficiency
(BioMed Central, 2017)Aromatic L-amino acid decarboxylase deficiency (AADCD) is a rare, autosomal recessive neurometabolic disorder that leads to a severe combined deficiency of serotonin, dopamine, norepinephrine and epinephrine. Onset is early ... -
Consensus on guidelines for stereotactic neurosurgery for psychiatric disorders
(BMJ Publishing Group, 2014)Background: For patients with psychiatric illnesses remaining refractory to ‘standard’ therapies, neurosurgical procedures may be considered. Guidelines for safe and ethical conduct of such procedures have previously and ...