Now showing items 3512-3531 of 18424

    • Contributions of Mamu-A*01 Status and TRIM5 Allele Expression, But Not CCL3L Copy Number Variation, to the Control of SIVmac251 Replication in Indian-Origin Rhesus Monkeys 

      Chan, Tiffany; O'Brien, Kara L.; Goldstein, David B.; Haynes, Barton F.; Malik, Harmit S.; Lim, So-Yon; Gelman, Rebecca Sue; Whitney, James B.; Barouch, Dan Hung; Letvin, Norman Lee (Public Library of Science, 2010)
      CCL3 is a ligand for the HIV-1 co-receptor CCR5. There have recently been conflicting reports in the literature concerning whether CCL3-like gene (CCL3L) copy number variation (CNV) is associated with resistance to HIV-1 ...
    • Contributions of the mother–infant relationship to dissociative, borderline, and conduct symptoms in young adulthood 

      Lyons-Ruth, Karlen (Wiley, 2008)
      Recent high-risk longitudinal studies have documented a unique contribution of the quality of the early mother–child relationship to diverse forms of psychopathology in young adulthood, even with family economic status, ...
    • Contributions of the RhoGEF activity of p210 BCR/ABL to disease progression 

      Tala, Ilona; Chen, Ru; Hu, Tinghui; Fitzpatrick, Ethan R; Williams, David A; Whitehead, Ian P (2014)
      We have previously identified a tyrosine kinase-independent, guanine nucleotide exchange factor (GEF) activity that is contained within the region of p210 BCR/ABL that distinguishes it from p190 BCR/ABL. In the current ...
    • Contributors to Contrast Between Glioma and Brain Tissue in Chemical Exchange Saturation Transfer Sensitive Imaging at 3Tesla 

      Scheidegger, Rachel; Wong, Eric; Alsop, David (Elsevier BV, 2014-10-01)
      Off-resonance saturation transfer images have shown intriguing differences in intensity in glioma compared to normal brain tissues. Interpretation of these differences is complicated, however, by the presence of multiple ...
    • Control and Manipulation of Pathogens with an Optical Trap for Live Cell Imaging of Intercellular Interactions 

      Tam, Jenny M.; Castro, Carlos E.; Heath, Robert John William; Cardenas, Michael L.; Xavier, Ramnik; Lang, Matthew J.; Vyas, Jatin Mahesh (Public Library of Science, 2010)
      The application of live cell imaging allows direct visualization of the dynamic interactions between cells of the immune system. Some preliminary observations challenge long-held beliefs about immune responses to microorganisms; ...
    • Control Capacity and A Random Sampling Method in Exploring Controllability of Complex Networks 

      Jia, Tao; Barabási, Albert-László (Nature Publishing Group, 2013)
      Controlling complex systems is a fundamental challenge of network science. Recent advances indicate that control over the system can be achieved through a minimum driver node set (MDS). The existence of multiple MDS's ...
    • Control Centrality and Hierarchical Structure in Complex Networks 

      Liu, Yang-Yu; Slotine, Jean-Jacques; Barabasi, Albert-Laszio (Public Library of Science, 2012)
      We introduce the concept of control centrality to quantify the ability of a single node to control a directed weighted network. We calculate the distribution of control centrality for several real networks and find that ...
    • Control of androgen receptor action by a novel nuclear receptor binding motif in Bag-1L 

      Cato, Laura; Jehle, Katja; Neeb, Antje; Cato, Andrew CB; Brown, Myles (BioMed Central, 2013)
    • Control of Bone Mass and Remodeling by PTH Receptor Signaling in Osteocytes 

      Plotkin, Lilian I.; Galli, Carlo; Goellner, Joseph J.; Gortazar, Arancha R.; Allen, Matthew R.; Robling, Alexander G.; Turner, Charles H.; Jilka, Robert L.; Weinstein, Robert S.; Manolagas, Stavros C.; Bellido, Teresita; O'Brien, Charles A.; Bouxsein, Mary Larsen; Schipani, Ernestina (Public Library of Science, 2008)
      Osteocytes, former osteoblasts buried within bone, are thought to orchestrate skeletal adaptation to mechanical stimuli. However, it remains unknown whether hormones control skeletal homeostasis through actions on osteocytes. ...
    • Control of Breathing in Children With Mild Sleep Apnoea: A 6-Year Follow-Up Study 

      Rice, Amber; Costy-Bennett, Seres; Goodwin, James; Quan, Stuart; Fregosi, Ralph F (European Respiratory Society (ERS), 2010-01)
      We have previously shown that children (average age 9 yrs) with mildly elevated obstructive apnoea/hypopnoea indices (OAHI) retained CO(2) at rest. Here, we report the results of a 6-yr follow-up study on 14 children from ...
    • Control of Cell Fate Determination by p21ras/Ras1, an Essential Component of Torso Signaling in Drosophila 

      Lu, Xiangyi; Chou, Tze-Bin; Williams, Nidhi Gupta; Roberts, Thomas; Perrimon, Norbert (Cold Spring Harbor Laboratory, 1993-04-01)
      Determination of cell fate at the posterior termini of the Drosophila embryo is specified by the activation of the torso (tor) receptor tyrosine kinase. This signaling pathway is mediated by the serine/threonine kinase ...
    • Control of IBMIR in Neonatal Porcine Islet Xenotransplantation in Baboons 

      Hawthorne, W J; Salvaris, E J; Phillips, P; Hawkes, J; Liuwantara, D; Burns, H; Barlow, H; Stewart, A B; Peirce, S B; Hu, M; Lew, A M; Robson, S C; Nottle, M B; D'Apice, A J F; O'Connell, P J; Cowan, P J (Blackwell Publishing Ltd, 2014)
      The instant blood-mediated inflammatory reaction (IBMIR) is a major obstacle to the engraftment of intraportal pig islet xenografts in primates. Higher expression of the galactose-α1,3-galactose (αGal) xenoantigen on ...
    • Control of Lipid Metabolism by Tachykinin in Drosophila 

      Song, Wei; Veenstra, Jan A.; Perrimon, Norbert (Elsevier BV, 2014-10-09)
      The intestine is a key organ for lipid uptake and distribution, and abnormal intestinal lipid metabolism is associated with obesity and hyperlipidemia. Although multiple regulatory gut hormones secreted from enteroendocrine ...
    • Control of peripheral tolerance by regulatory T cell-intrinsic Notch signaling 

      Charbonnier, Louis-Marie; Wang, Sen; Georgiev, Peter; Sefik, Esen; Chatila, Talal A (2015)
      Notch receptors direct the differentiation of T helper (TH) cell subsets, but their influence on regulatory T (Treg) cell responses is obscure. We here report that lineage-specific deletion of components of the Notch pathway ...
    • Control of Proinflammatory Gene Programs by Regulated Trimethylation and Demethylation of Histone H4K20 

      Stender, Joshua D.; Pascual, Gabriel; Liu, Wen; Kaikkonen, Minna U.; Do, Kevin; Spann, Nathanael J.; Boutros, Michael; Perrimon, Norbert; Rosenfeld, Michael G.; Glass, Christopher K. (Elsevier BV, 2012-10-12)
      Regulation of genes that initiate and amplify inflammatory programs of gene expression is achieved by signal-dependent exchange of co-regulator complexes that function to read, write and erase specific histone modifications ...
    • Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53 

      Yoon, K. W.; Byun, S.; Kwon, Eunjeong; Hwang, So-Young; Chu, Kiki; Hiraki, Masatsugu; Jo, Seung-Hee; Weins, Astrid; Hakroush, Samy; Cebulla, Angelika; Sykes, David Brian; Greka, Anna; Mundel, Peter; Fisher, David E.; Mandinova, Anna; Lee, Sam Whan (American Association for the Advancement of Science (AAAS), 2015)
      The inefficient clearance of dying cells can lead to abnormal immune responses, such as unresolved inflammation and autoimmune conditions. We show that tumor suppressor p53 controls signaling-mediated phagocytosis of ...
    • Control of steroid receptor dynamics and function by genomic actions of the cochaperones p23 and Bag-1L 

      Cato, Laura; Neeb, Antje; Brown, Myles; Cato, Andrew C. B. (Nuclear Receptor Signaling Atlas, 2014)
      Molecular chaperones encompass a group of unrelated proteins that facilitate the correct assembly and disassembly of other macromolecular structures, which they themselves do not remain a part of. They associate with a ...
    • Control of Stomach Smooth Muscle Development and Intestinal Rotation by Transcription Factor BARX1 

      Jayewickreme, Chenura D.; Shivdasani, Ramesh Arjun (Elsevier BV, 2015-09-01)
      Diverse functions of the homeodomain transcription factor BARX1 include Wnt-dependent, non-cell autonomous specification of the stomach epithelium, tracheo-bronchial septation, and Wnt-independent expansion of the spleen ...
    • Control of T Helper Cell Differentiation through Cytokine Receptor Inclusion in the Immunological Synapse 

      Maldonado, Roberto A.; Soriano, Michelle A.; Perdomo, L. Carolina; Sigrist, Kirsten; Irvine, Darrell J.; Decker, Thomas; Glimcher, Laurie Hollis (The Rockefeller University Press, 2009)
      The antigen recognition interface formed by T helper precursors (Thps) and antigen-presenting cells (APCs), called the immunological synapse (IS), includes receptors and signaling molecules necessary for Thp activation and ...
    • Control of the innate immune response by the mevalonate pathway 

      Akula, Murali K.; Shi, Man; Jiang, Zhaozhao; Foster, Celia E.; Miao, David; Li, Annie S.; Zhang, Xiaoman; Gavin, Ruth M.; Forde, Sorcha D.; Germain, Gail; Carpenter, Susan; Rosadini, Charles V.; Gritsman, Kira; Chae, Jae Jin; Hampton, Randolph; Silverman, Neal; Gravallese, Ellen M.; Kagan, Jonathan C.; Fitzgerald, Katherine A.; Kastner, Daniel L.; Golenbock, Douglas T.; Bergo, Martin O.; Wang, Donghai (2016)
      Deficiency of mevalonate kinase (MVK) causes systemic inflammation. However, the molecular mechanisms linking the mevalonate pathway to inflammation remain obscure. Geranylgeranyl pyrophosphate (GGPP), a non-sterol ...