Browsing Harvard Medical School by Title
Now showing items 3736-3755 of 18428
-
A Critical Role for NMDA Receptors in Parvalbumin Interneurons for Gamma Rhythm Induction and Behavior
(Nature Publishing Group, 2012)Synchronous recruitment of fast-spiking (FS) parvalbumin (PV) interneurons generates gamma oscillations, rhythms that emerge during performance of cognitive tasks. Administration of N-methyl-D-aspartate (NMDA) receptor ... -
A critical role for suppressors of cytokine signaling 3 in regulating LPS-induced transcriptional activation of matrix metalloproteinase-13 in osteoblasts
(PeerJ Inc., 2013)Suppressor of cytokine signaling 3 (SOCS3) is a key regulator of cytokine signaling in macrophages and T cells. Although SOCS3 seems to contribute to the balance between the pro-inflammatory actions of IL-6 family of ... -
The Critical Role of Lymph Nodes in Corneal Alloimmunization and Graft Rejection
(Association for Research in Vision and Ophthalmology, 2001)purpose. To elucidate the role of draining cervical lymph nodes (CLNs) in corneal alloimmunity. methods. Fully mismatched orthotopic corneal transplantation was performed in BALB/c hosts that had their CLNs excised ... -
Critical Role of Sphingosine-1-Phosphate Receptor-2 in the Disruption of Cerebrovascular Integrity in Experimental Stroke
(2015)The use and effectiveness of current stroke reperfusion therapies are limited by the complications of reperfusion injury, which include increased cerebrovascular permeability and hemorrhagic transformation. Sphingosine-1-phosphate ... -
Critically Re-Evaluating a Common Technique: Accuracy, Reliability, and Confirmation Bias of EMG
(Ovid Technologies (Wolters Kluwer Health), 2015)Objectives: (1) To assess the diagnostic accuracy of EMG in radiculopathy. (2) To evaluate the intrarater reliability and interrater reliability of EMG in radiculopathy. (3) To assess the presence of confirmation bias in ... -
Crocetin protects against cardiac hypertrophy by blocking MEK-ERK1/2 signalling pathway
(Blackwell Publishing Ltd, 2009)Abstract Oxidative stress plays a critical role in the progression of pathological cardiac hypertrophy and heart failure. Because crocetin represses oxidative stress in vitro and in vivo, we have suggested that crocetin ... -
The Crooked Neck Gene of Drosophila Contains a Motif Found in a Family of Yeast Cell Cycle Genes
(Cold Spring Harbor Laboratory, 1991-06-01)The crooked neck (crn) gene of Drosophila encodes a protein of 702 amino acids and contains 16 tandemly arranged copies of a 34-amino-acid repeat that is similar to the tetratrico peptide repeat (TPR). Multiple copies of ... -
A cross sectional study of anemia and iron deficiency as risk factors for arsenic-induced skin lesions in Bangladeshi women
(BioMed Central, 2016)Background: In the Ganges Delta, chronic arsenic poisoning is a health concern affecting millions of people who rely on groundwater as their potable water source. The prevalence of anemia is also high in this region, ... -
Cross Species Genomic Analysis Identifies a Mouse Model as Undifferentiated Pleomorphic Sarcoma/Malignant Fibrous Histiocytoma
(Public Library of Science, 2009)Undifferentiated pleomorphic sarcoma/Malignant Fibrous Histiocytoma (MFH) is one of the most common subtypes of human soft tissue sarcoma. Using cross species genomic analysis, we define a geneset from the \(LSL\)-\(Kras^{G12D}\); ... -
A cross-case comparative analysis of international security forces’ impacts on health systems in conflict-affected and fragile states
(BioMed Central, 2015)Background: Destruction of health systems in fragile and conflict-affected states increases civilian mortality. Despite the size, scope, scale and political influence of international security forces intervening in fragile ... -
Cross-Cultural Adaptation and Validation of Behçet's Disease Quality of Life Questionnaire
(BioMed Central, 2011)Background: Currently, there is one Behçet’s disease (BD) specific self reporting questionnaire developed and published in the literature, The Leeds BD-quality of life (QoL). We conducted a cross-cultural adaptation and ... -
Cross-cultural adaptation of instruments assessing breastfeeding determinants: a multi-step approach
(BioMed Central, 2014)Background: Cross-cultural adaptation is a necessary process to effectively use existing instruments in other cultural and language settings. The process of cross-culturally adapting, including translation, of existing ... -
Cross-Cultural Adaptation, Validation, and Reliability Testing of the Modified Oswestry Disability Questionnaire in Persian Population with Low Back Pain
(Korean Society of Spine Surgery, 2016)Study Design Prospective study. Purpose We aimed to validate the Persian version of the modified Oswestry disability questionnaire (MODQ) in patients with low back pain. Overview of Literature Modified Oswestry low back ... -
Cross-cultural measurement equivalence of the 5-level EQ-5D (EQ-5D-5L) in patients with type 2 diabetes mellitus in Singapore
(BioMed Central, 2015)Background: This study aimed to assess the measurement equivalence of the 5-level EQ-5D (EQ-5D-5L) among the English, Chinese, and Malay versions. Methods: A convenience sample of patients with type 2 diabetes mellitus ... -
Cross-Linking of Rotavirus Outer Capsid Protein VP7 by Antibodies or Disulfides Inhibits Viral Entry
(American Society for Microbiology, 2011)Antibodies that neutralize rotavirus infection target outer coat proteins VP4 and VP7 and inhibit viral entry. The structure of a VP7-Fab complex (S. T. Aoki, et al., Science 324: 1444-1447, 2009) led us to reclassify ... -
A cross-national comparison of 17 countries' insulin glargine drug labels
(Wiley-Blackwell, 2014)Purpose: Type 2 diabetes mellitus has reached epidemic proportions worldwide. Many patients with type 2 diabetes mellitus will require insulin, and the evidence-based use of insulin is described in the prescription drug ... -
Cross-national comparison of socioeconomic inequalities in obesity in the United States and Canada
(BioMed Central, 2015)Introduction: Prior cross-national studies of socioeconomic inequalities in obesity have only compared summary indices of inequality but not specific, policy-relevant dimensions of inequality: (a) shape of the socioeconomic ... -
Cross-National Variation in Glycemic Control and Diabetes-Related Distress Among East Asian Patients Using Insulin: Results from the MOSAIc Study
(Springer Healthcare, 2016)Introduction: Guidelines recommend insulin progression for patients with type 2 diabetes (T2D) with inadequate glycemic control. The Multinational Observational Study Assessing Insulin use (MOSAIc [ClinicalTrials.gov ... -
Cross-Pollination of Research Findings, Although Uncommon, May Accelerate Discovery of Human Disease Genes
(BioMed Central, 2012)Background: Technological leaps in genome sequencing have resulted in a surge in discovery of human disease genes. These discoveries have led to increased clarity on the molecular pathology of disease and have also ... -
Cross-Sectional Analysis of Late HAART Initiation in Latin America and the Caribbean: Late Testers and Late Presenters
(Public Library of Science, 2011)Background: Starting HAART in a very advanced stage of disease is assumed to be the most prevalent form of initiation in HIV-infected subjects in developing countries. Data from Latin America and the Caribbean is still ...