Browsing Harvard Medical School by Title
Now showing items 3748-3767 of 18428
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Cross-Cultural Adaptation, Validation, and Reliability Testing of the Modified Oswestry Disability Questionnaire in Persian Population with Low Back Pain
(Korean Society of Spine Surgery, 2016)Study Design Prospective study. Purpose We aimed to validate the Persian version of the modified Oswestry disability questionnaire (MODQ) in patients with low back pain. Overview of Literature Modified Oswestry low back ... -
Cross-cultural measurement equivalence of the 5-level EQ-5D (EQ-5D-5L) in patients with type 2 diabetes mellitus in Singapore
(BioMed Central, 2015)Background: This study aimed to assess the measurement equivalence of the 5-level EQ-5D (EQ-5D-5L) among the English, Chinese, and Malay versions. Methods: A convenience sample of patients with type 2 diabetes mellitus ... -
Cross-Linking of Rotavirus Outer Capsid Protein VP7 by Antibodies or Disulfides Inhibits Viral Entry
(American Society for Microbiology, 2011)Antibodies that neutralize rotavirus infection target outer coat proteins VP4 and VP7 and inhibit viral entry. The structure of a VP7-Fab complex (S. T. Aoki, et al., Science 324: 1444-1447, 2009) led us to reclassify ... -
A cross-national comparison of 17 countries' insulin glargine drug labels
(Wiley-Blackwell, 2014)Purpose: Type 2 diabetes mellitus has reached epidemic proportions worldwide. Many patients with type 2 diabetes mellitus will require insulin, and the evidence-based use of insulin is described in the prescription drug ... -
Cross-national comparison of socioeconomic inequalities in obesity in the United States and Canada
(BioMed Central, 2015)Introduction: Prior cross-national studies of socioeconomic inequalities in obesity have only compared summary indices of inequality but not specific, policy-relevant dimensions of inequality: (a) shape of the socioeconomic ... -
Cross-National Variation in Glycemic Control and Diabetes-Related Distress Among East Asian Patients Using Insulin: Results from the MOSAIc Study
(Springer Healthcare, 2016)Introduction: Guidelines recommend insulin progression for patients with type 2 diabetes (T2D) with inadequate glycemic control. The Multinational Observational Study Assessing Insulin use (MOSAIc [ClinicalTrials.gov ... -
Cross-Pollination of Research Findings, Although Uncommon, May Accelerate Discovery of Human Disease Genes
(BioMed Central, 2012)Background: Technological leaps in genome sequencing have resulted in a surge in discovery of human disease genes. These discoveries have led to increased clarity on the molecular pathology of disease and have also ... -
Cross-Sectional Analysis of Late HAART Initiation in Latin America and the Caribbean: Late Testers and Late Presenters
(Public Library of Science, 2011)Background: Starting HAART in a very advanced stage of disease is assumed to be the most prevalent form of initiation in HIV-infected subjects in developing countries. Data from Latin America and the Caribbean is still ... -
A Cross-Sectional and Longitudinal Magnetic Resonance Imaging Study of Cingulate Gyrus Gray Matter Volume Abnormalities in First-Episode Schizophrenia and First-Episode Affective Psychosis
(American Medical Association (AMA), 2008)Context: Previous magnetic resonance imaging (MRI) findings have demonstrated psychopathological symptom–related smaller gray matter volumes in various cingulate gyrus subregions in schizophrenia and bipolar disorder. ... -
Cross-sectional imaging of aortic infections
(Springer Nature, 2016)Aortic infections are uncommon clinical entities, but are associated with a high morbidity and mortality. In this review, we focus on the cross-sectional imaging appearances of aortic infections, including aortic valve ... -
A cross-sectional mixed methods study protocol to generate learning from patient safety incidents reported from general practice
(BMJ Publishing Group, 2015)Introduction: Incident reports contain descriptions of errors and harms that occurred during clinical care delivery. Few observational studies have characterised incidents from general practice, and none of these have been ... -
A cross-sectional study of osteocalcin and body fat measures among obese adolescents
(2016)Osteocalcin (OCN), a marker of osteoblast activity, has been implicated in the regulation of energy metabolism by the skeleton and thus may affect body fat measures. We examined the relationships of OCN to body fat measures ... -
A cross-sectional study of the identification of prevalent asthma and chronic obstructive pulmonary disease among initiators of long-acting β-agonists in health insurance claims data
(BioMed Central, 2014)Background: Claims data are potentially useful for identifying long-acting β-agonist (LABA) use by patients with asthma, a practice that is associated with increased mortality. We evaluated the accuracy of claims data for ... -
A cross-sectional study on tobacco use and dependence among women: Does menthol matter?
(BioMed Central, 2012)Background: The question of whether mentholation of cigarettes enhances tobacco dependence has generated conflicting findings. Potential mediating factors in a putative relationship between menthol use and tobacco dependence ... -
A Cross-Sectional Survey of the Association between Bilateral Topical Prostaglandin Analogue Use and Ocular Adnexal Features
(Public Library of Science, 2013)We studied the relation between prostaglandin analogue use and ocular adnexal features. We used a prospective, cross-sectional study involving 157 current, 15 past, and 171 never users of prostaglandin analogues. Patients ... -
Cross-Species Array Comparative Genomic Hybridization Identifies Novel Oncogenic Events in Zebrafish and Human Embryonal Rhabdomyosarcoma
(Public Library of Science, 2013)Human cancer genomes are highly complex, making it challenging to identify specific drivers of cancer growth, progression, and tumor maintenance. To bypass this obstacle, we have applied array comparative genomic hybridization ... -
Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action
(Wiley Open Access, 2010)We present a cross-species chemogenomic screening platform using libraries of haploid deletion mutants from two yeast species, Saccharomyces cerevisiae and Schizosaccharomyces pombe. We screened a set of compounds of known ... -
Cross-Species RNAi Rescue Platform in Drosophila melanogaster
(Genetics Society of America, 2009)RNAi-mediated gene knockdown in Drosophila melanogaster is a powerful method to analyze loss-of-function phenotypes both in cell culture and in vivo. However, it has also become clear that false positives caused by off-target ... -
A Cross-Species Study of PI3K Protein-Protein Interactions Reveals the Direct Interaction of P85 and SHP2
(Nature Publishing Group, 2016)Using a series of immunoprecipitation (IP) – tandem mass spectrometry (LC-MS/MS) experiments and reciprocal BLAST, we conducted a fly-human cross-species comparison of the phosphoinositide-3-kinase (PI3K) interactome in a ... -
Cross-tissue methylomic profiling strongly implicates a role for cortex-specific deregulation of ANK1 in Alzheimer’s disease neuropathology
(2014)Alzheimer’s disease (AD) is a chronic neurodegenerative disorder characterized by progressive neuropathology and cognitive decline. We describe a cross-tissue analysis of methylomic variation in AD using samples from three ...