Browsing Harvard Medical School by Title
Now showing items 3808-3827 of 18428
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Crystalline silica-induced leukotrieneB4-dependent inflammation promotes lung tumor growth
(2015)Chronic exposure to crystalline silica (CS) causes silicosis, an irreversible lung inflammatory disease that may eventually lead to lung cancer. In this study, we demonstrate that in K-rasLA1 mice, CS exposure markedly ... -
Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia
(The Rockefeller University Press, 2014)Despite extensive insights into the underlying genetics and biology of acute myeloid leukemia (AML), overall survival remains poor and new therapies are needed. We found that casein kinase 1 α (Csnk1a1), a serine-threonine ... -
CT Coronary Angiography: 256-Slice and 320-Detector Row Scanners
(Springer Nature, 2010)Multidetector computed tomography (MDCT) has rapidly evolved from 4-detector row systems in 1998 to 256-slice and 320-detector row CT systems. With smaller detector element size and faster gantry rotation speed, spatial ... -
CT-based radiomic signature predicts distant metastasis in lung adenocarcinoma
(Elsevier BV, 2015)Background and Purpose: Radiomics provides opportunities to quantify the tumor phenotype non-invasively by applying a large number of quantitative imaging features. This study evaluates computed-tomography (CT) radiomic ... -
CTCF Orchestrates Long-Range Cohesin-Driven V(D)J Recombinational Scanning
(Springer Nature Publishing Group, 2020-07-27)RAG endonuclease initiates V(D)J recombination in progenitor (pro)-B cells1. Upon binding a recombination center (RC)-based JH, RAG scans upstream chromatin via loop extrusion, potentially mediated by cohesin, to locate ... -
CTF meeting 2012: Translation of the basic understanding of the biology and genetics of NF1, NF2, and schwannomatosis toward the development of effective therapies
(Wiley-Blackwell, 2014)The neurofibromatoses (NF) are autosomal dominant genetic disorders that encompass the rare diseases NF1, NF2, and schwannomatosis. The NFs affect more people worldwide than Duchenne muscular dystrophy and Huntington's ... -
CTL Responses of High Functional Avidity and Broad Variant Cross-Reactivity Are Associated with HIV Control
(Public Library of Science, 2012)Cytotoxic T lymphocyte (CTL) responses targeting specific HIV proteins, in particular Gag, have been associated with relative control of viral replication \(in\) \(vivo\). However, Gag-specific CTL can also be detected in ... -
CTLA-4 and PD-1 Pathways: Similarities, Differences, and Implications of Their Inhibition
(Lippincott Williams & Wilkins, 2016)The cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4) and programmed death 1 (PD-1) immune checkpoints are negative regulators of T-cell immune function. Inhibition of these targets, resulting in increased activation ... -
Cultural competency of health-care providers in a Swiss University Hospital: self-assessed cross-cultural skillfulness in a cross-sectional study
(BioMed Central, 2014)Background: As the diversity of the European population evolves, measuring providers’ skillfulness in cross-cultural care and understanding what contextual factors may influence this is increasingly necessary. Given limited ... -
Cultural context and impact of alcohol use in the Sundarban Delta, West Bengal, India
(Elsevier BV, 2006)Hazardous alcohol consumption is a worldwide problem with many locally distinctive features across cultures, but studies to guide policy in developing countries are notably lacking. This community study aimed to clarify ... -
Cultural dimensions of psychiatric diagnosis. A comparison of DSM-III-R and illness explanatory models in south India
(Royal College of Psychiatrists, 1995)BACKGROUND Cross-cultural research to examine the cultural validity of diagnostic categories and underlying concepts requires methods that integrate epidemiological and anthropological frameworks. METHOD The Explanatory ... -
Cultural elements underlying the community health representative – client relationship on Navajo Nation
(BioMed Central, 2017)Background: Navajo Nation Community Health Representatives (CHR) are trained community health workers (CHWs) who provide crucial services for patients and families. The success of the CHRs’ interventions depends on the ... -
Cultural epidemiology of neurasthenia spectrum disorders in four general hospital outpatient clinics of urban Pune, India
(SAGE Publications, 2011-07)Disorders emphasizing symptoms of fatigue and/or weakness, collectively termed Neurasthenia Spectrum Disorders (NSDs), typically emphasize a biological basis in the West and social origins in East Asia. In India, explanatory ... -
Cultural Epidemiology of Pandemic Influenza in Urban and Rural Pune, India: A Cross-Sectional, Mixed-Methods Study
(BMJ, 2014-12)Objective To identify and compare sociocultural features of pandemic influenza with reference to illness-related experience, meaning and behaviour in urban and rural areas of India. Design Cross-sectional, mixed-methods, ... -
Cultural epidemiology: An introduction and overview
(Informa UK Limited, 2001)Although the value of interdisciplinary collaboration between epidemiology and anthropology is both widely acknowledged and hotly contested, effective international health policy and multicultural health programmes require ... -
Cultural Models of Diarrheal Illness: Conceptual Framework and Review
(Elsevier BV, 1988)Health planning for diarrheal diseases must be responsive to both epidemiological patterns and local perceptions of health, illness and need. A conceptual framework that relates patterns of distress, explanatory models, ... -
Culture of Drosophila primary cells dissociated from gastrula embryos and their use in RNAi screening
(Nature Research, 2009)We provide a detailed protocol for the mass culturing of primary cells dissociated from Drosophila embryos. The advantage of this protocol over others is that we have optimized it for a robust large-scale performance that ... -
Culture, gaze and the neural processing of fear expressions
(Oxford University Press, 2010)The direction of others' eye gaze has important influences on how we perceive their emotional expressions. Here, we examined differences in neural activation to direct-versus averted-gaze fear faces as a function of culture ... -
Cumulative Community-Level Lead Exposure and Pulse Pressure: The Normative Aging Study
(National Institute of Environmental Health Sciences, 2007)Background: Pulse pressure increases with age in industrialized societies as a manifestation of arterial stiffening. Lead accumulates in the vasculature and is associated with vascular oxidative stress, which can promote ... -
Cumulative Exposure to Lead in Relation to Cognitive Function in Older Women
(National Institute of Environmental Health Sciences, 2008)Background: Recent data indicate that chronic low-level exposure to lead is associated with accelerated declines in cognition in older age, but this has not been examined in women. Objective: We examined biomarkers of lead ...