Browsing Harvard Medical School by Title
Now showing items 3892-3911 of 18428
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Cytokines and Growth Factors Positively and Negatively Regulate Interstitial Collagen Gene Expression in Human Vascular Smooth Muscle Cells
(American Heart Association, 1991)Human atheromas accumulate extracellular matrix proteins such as collagen types I and III. We tested whether cytokines or growth factors produced by cells found in human atherosclerotic plaques alter collagen gene expression ... -
Cytokines in Systemic Lupus Erythematosus
(Hindawi Publishing Corporation, 2010) -
Cytokines in Systemic Lupus Erythematosus 2011
(Hindawi Publishing Corporation, 2012) -
Cytological profiling: providing more haystacks for chemists' needles
(BioMed Central, 2005)Conventional high-throughput ‘chemical genetic’ screening seeks to identify small-molecule inhibitors of a specific protein or pathway. A recent study describes how unbiased screening of cellular morphology, followed by ... -
Cytomegalovirus Infection Causes an Increase of Arterial Blood Pressure
(Public Library of Science, 2009)Cytomegalovirus (CMV) infection is a common infection in adults (seropositive 60–99% globally), and is associated with cardiovascular diseases, in line with risk factors such as hypertension and atherosclerosis. Several ... -
Cytomegalovirus Reinfections Stimulate CD8 T-Memory Inflation
(Public Library of Science, 2016)Cytomegalovirus (CMV) has been shown to induce large populations of CD8 T-effector memory cells that unlike central memory persist in large quantities following infection, a phenomenon commonly termed “memory inflation”. ... -
Cytomegalovirus-Specific T Cells Persist at Very High Levels during Long-Term Antiretroviral Treatment of HIV Disease
(Public Library of Science, 2010)Background: In healthy, HIV seronegative, CMV seropositive adults, a large proportion of T cells are CMV-specific. High-level CMV-specific T cell responses are associated with accelerated immunologic aging (‘‘immunosenesence’’) ... -
Cytoplasmic CUG RNA Foci Are Insufficient to Elicit Key DM1 Features
(Public Library of Science, 2008)The genetic basis of myotonic dystrophy type I (DM1) is the expansion of a CTG tract located in the 3′ untranslated region of DMPK. Expression of mutant RNAs encoding expanded CUG repeats plays a central role in the ... -
The Cytoplasmic Tail of FPC Antagonizes the Full-Length Protein in the Regulation of mTOR Pathway
(Public Library of Science, 2014)FPC (fibrocystin or polyductin) is a single transmembrane receptor-like protein, responsible for the human autosomal recessive polycystic kidney disease (ARPKD). It was recently proposed that FPC undergoes a Notch-like ... -
Cytosine and adenine base editing of the brain, liver, retina, heart and skeletal muscle of mice via adeno-associated viruses
(Springer Science and Business Media LLC, 2020-01-14)Base editors are widely used engineered proteins that introduce targeted point mutations into DNA without creating double-stranded DNA breaks. The application of base editors to study and treat genetic diseases is dependent ... -
A Cytosine Methytransferase Modulates the Cell Envelope Stress Response in the Cholera Pathogen
(Public Library of Science, 2015)DNA methylation is a key epigenetic regulator in all domains of life, yet the effects of most bacterial DNA methyltransferases on cellular processes are largely undefined. Here, we used diverse techniques, including bisulfite ... -
Cytosine specific DNA sequencing with hydrogen peroxide
(Oxford University Press (OUP), 1995) -
Cytoskeletal Mechanics of Proplatelet Maturation and Platelet Release
(Rockefeller University Press, 2010)Megakaryocytes generate platelets by remodeling their cytoplasm into long proplatelet extensions, which serve as assembly lines for platelet production. Although the mechanics of proplatelet elongation have been studied, ... -
Cytoskeletal proteins in cortical development and disease: actin associated proteins in periventricular heterotopia
(Frontiers Media S.A., 2015)The actin cytoskeleton regulates many important cellular processes in the brain, including cell division and proliferation, migration, and cytokinesis and differentiation. These developmental processes can be regulated ... -
Cytosolic 5′-Nucleotidase 1A Autoimmunity in Sporadic Inclusion Body Myositis
(Wiley, 2013-03)Objective We previously identified a circulating autoantibody against a 43 kDa muscle autoantigen in sporadic inclusion body myositis (IBM) and demonstrated the feasibility of an IBM diagnostic blood test. Here, we sought ... -
Cytosolic Phospholipase A2 Protein as a Novel Therapeutic Target for Spinal Cord Injury
(BlackWell Publishing Ltd, 2014)Objective: The objective of this study was to investigate whether cytosolic phospholipase A2 (cPLA2), an important isoform of PLA2 that mediates the release of arachidonic acid, plays a role in the pathogenesis of spinal ... -
Cytotoxicity of Botulinum Neurotoxins Reveals a Direct Role of Syntaxin 1 and SNAP-25 in Neuron Survival
(2014)Botulinum neurotoxins (BoNT/A-G) are well-known to act by blocking synaptic vesicle exocytosis. Whether BoNTs disrupt additional neuronal functions has not been addressed. Here we report that cleavage of syntaxin 1 (Syx ... -
Cytotoxicity of Hydrogen Peroxide Produced by Enterococcus faecium
(American Society for Microbiology, 2004)Although the opportunistic bacterial pathogen Enterococcus faecium is a leading source of nosocomial infections, it appears to lack many of the overt virulence factors produced by other bacterial pathogens, and the underlying ... -
d-Cycloserine enhances durability of social skills training in autism spectrum disorder
(BioMed Central, 2017)Background: d-Cycloserine (DCS) enhances extinction learning across species, but it has proven challenging to identify consistent benefit of DCS when added to therapeutic interventions. We conducted a placebo-controlled ... -
d-Dimer elevation and adverse outcomes
(Springer US, 2014)d-Dimer is a biomarker of fibrin formation and degradation. While a d-dimer within normal limits is used to rule out the diagnosis of deep venous thrombosis and pulmonary embolism among patients with a low clinical probability ...