Browsing Harvard Medical School by Title
Now showing items 5-24 of 18424
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136 HIV-1 Nef regulates activity of endoplasmic reticulum chaperone calnexin
(JAIDS Journal of Acquired Immune Deficiency Syndromes, 2014)HIV-1 Nef promotes viral replication by downmodulating a number of cell surface transmembrane proteins, such as CD4, MHC-I and MHC-II, which are targeted by Nef to various degradation pathways. Nef is also responsible for ... -
14-3-3 proteins regulate Tctp–Rheb interaction for organ growth in Drosophila
(Nature Publishing Group, 2016)14-3-3 family proteins regulate multiple signalling pathways. Understanding biological functions of 14-3-3 proteins has been limited by the functional redundancy of conserved isotypes. Here we provide evidence that 14-3-3 ... -
14-3-3 Proteins: Active Cofactors in Cellular Regulation by Serine/Threonine Phosphorylation
(American Society for Biochemistry and Molecular Biology, 2002) -
The 15kDa Selenoprotein and Thioredoxin Reductase 1 Promote Colon Cancer by Different Pathways
(Public Library of Science, 2015)Selenoproteins mediate much of the cancer-preventive properties of the essential nutrient selenium, but some of these proteins have been shown to also have cancer-promoting effects. We examined the contributions of the ... -
The 16p11.2 locus modulates brain structures common to autism, schizophrenia and obesity
(Nature Publishing Group, 2015)Anatomical structures and mechanisms linking genes to neuropsychiatric disorders are not deciphered. Reciprocal copy number variants at the 16p11.2 BP4-BP5 locus offer a unique opportunity to study the intermediate phenotypes ... -
18-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in the Management of Aggressive Non-Hodgkin's B-Cell Lymphoma
(International Scholarly Research Network, 2012)18-Fluorodeoxyglucose (FDG-PET/CT) is an established imaging modality that has been proven to be of benefit in the management of aggressive B-cell non-Hodgkin's lymphoma, such as diffuse large B-cell lymphoma and advanced ... -
18-HEPE, an n-3 fatty acid metabolite released by macrophages, prevents pressure overload–induced maladaptive cardiac remodeling
(The Rockefeller University Press, 2014)N-3 polyunsaturated fatty acids (PUFAs) have potential cardiovascular benefit, although the mechanisms underlying this effect remain poorly understood. Fat-1 transgenic mice expressing Caenorhabditis elegans n-3 fatty acid ... -
[18F]-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography of LAPC4-CR Castration-Resistant Prostate Cancer Xenograft Model in Soft Tissue Compartments1
(Neoplasia Press, 2015)Preclinical xenograft models have contributed to advancing our understanding of the molecular basis of prostate cancer and to the development of targeted therapy. However, traditional preclinical in vivo techniques using ... -
18q Loss of Heterozygosity in Microsatellite Stable Colorectal Cancer is Correlated with CpG Island Methylator Phenotype-negative (CIMP-0) and Inversely with CIMP-low and CIMP-high
(BioMed Central, 2007)Background: The CpG island methylator phenotype (CIMP) with widespread promoter methylation is a distinct epigenetic phenotype in colorectal cancer, associated with microsatellite instability-high (MSI-high) and BRAF ... -
A 19-year-old at 37 weeks gestation with an acute acetylsalicylic acid overdose
(Oxford University Press, 2011)Acute salicylate overdose in pregnancy is potentially fatal for both the mother and fetus and presents a unique challenge in intensive care management. While suggested thresholds exist for hemodialysis in adults with toxic ... -
2-Year BMI Changes of Children Referred for Multidisciplinary Weight Management
(Hindawi Publishing Corporation, 2014)Objective. To examine body mass index (BMI) changes among pediatric multidisciplinary weight management participants and nonparticipants. Design. In this retrospective database analysis, we used multivariable mixed effect ... -
20-HETE Mediates Ozone-Induced, Neutrophil-Independent Airway Hyper-Responsiveness in Mice
(Public Library of Science, 2010)Background Ozone, a pollutant known to induce airway hyper-responsiveness (AHR), increases morbidity and mortality in patients with obstructive airway diseases and asthma. We postulate oxidized lipids mediate in vivo ... -
2001: A Mouse Genome Odyssey
(BioMed Central, 2002)A report on the 15th International Mouse Genome Conference, Edinburgh, UK, 21-24 October 2001. -
The 2007 WHO Classification of Tumours of the Central Nervous System
(Springer-Verlag, 2007)The fourth edition of the World Health Organization (WHO) classification of tumours of the central nervous system, published in 2007, lists several new entities, including angiocentric glioma, papillary glioneuronal tumour, ... -
2016 WSES guidelines on acute calculous cholecystitis
(BioMed Central, 2016)Acute calculus cholecystitis is a very common disease with several area of uncertainty. The World Society of Emergency Surgery developed extensive guidelines in order to cover grey areas. The diagnostic criteria, the ... -
24-Hour Rhythms of DNA Methylation and Their Relation with Rhythms of RNA Expression in the Human Dorsolateral Prefrontal Cortex
(Public Library of Science, 2014)Circadian rhythms modulate the biology of many human tissues, including brain tissues, and are driven by a near 24-hour transcriptional feedback loop. These rhythms are paralleled by 24-hour rhythms of large portions of ... -
24H FOLLOW-UP CT| METFORMIN PRETREATMENT: TWO REFLECTIONS FROM CLINICAL STROKE PRACTICE
(2023-05-11)Acute ischemic stroke is a serious medical emergency caused by the blockage of blood flow to the brain. With an estimated 15 million new cases each year, it is a leading cause of morbidity and mortality worldwide. The ... -
A 25-Year-Old Man with Exudative Retinal Detachments and Infiltrates without Hematological or Neurological Findings Found to Have Relapsed Precursor T-Cell Acute Lymphoblastic Leukemia
(S. Karger AG, 2015)Background: Precursor T-cell acute lymphoblastic leukemia (pre-T-ALL) may cause ocular pathologies such as cotton-wool spots, retinal hemorrhage, and less commonly, retinal detachment or leukemic infiltration of the retina ... -
2K09 and Thereafter : The Coming Era of Integrative Bioinformatics, Systems Biology and Intelligent Computing for Functional Genomics and Personalized Medicine Research
(BioMed Central, 2010)Significant interest exists in establishing synergistic research in bioinformatics, systems biology and intelligent computing. Supported by the United States National Science Foundation (NSF), International Society of ... -
3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) and mutagenic activity in Massachusetts drinking water.
(2002)There is limited information on the prevalence of the potent mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in U.S. water supplies. We measured MX concentrations and mutagenic activity in tap water samples ...