Browsing Harvard Medical School by Title
Now showing items 4044-4063 of 18424
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Degos disease – malignant atrophic papulosis or cutaneointestinal lethal syndrome: rarity of the disease
(Dove Medical Press, 2015)Background: Degos disease is a very rare syndrome with a rare type of multisystem vasculopathy of unknown cause that affects the skin, gastrointestinal tract, and central nervous system. Other organs such as the kidneys, ... -
Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death
(The Rockefeller University Press, 2015)Hexokinase II (HK2), a key enzyme involved in glucose metabolism, is regulated by growth factor signaling and is required for initiation and maintenance of tumors. Here we show that metabolic stress triggered by perturbation ... -
Degradation of Mnemonic Networks in Aging and Alzheimer’s Disease
(2015-05-20)Functional connectivity MRI (fcMRI) is a non-invasive method to assess the integrity of anatomically distributed neural networks underlying complex behaviors. In Alzheimer’s disease (AD), fcMRI of the default mode network ... -
Degradation of the Peroxisome Proliferator-activated Receptor γ Is Linked to Ligand-dependent Activation
(American Society for Biochemistry and Molecular Biology, 2000) -
Degree of corticospinal tract damage correlates with motor function after stroke
(BlackWell Publishing Ltd, 2014)Objectives: Direct injury to the corticospinal tract (CST) is a major factor defining motor impairment after stroke. Diffusion tensor imaging (DTI) tractography allows definition of the CST. We sought to determine whether ... -
Deinstitutionalization of the Chronically Mentally Ill
(Massachusetts Medical Society, 1981-08-06)Deinstitutionalization of the mentally ill has become the predominant public mental-health policy in most states. This policy has been supported by a curious political marriage of liberals, who decry the custodial-level ... -
Delay Discrimination and Reversal Eyeblink Classical Conditioning in Abstinent Chronic Alcoholics
(American Psychological Association (APA), 2008-03)Evidence has shown that alcoholism leads to volume reductions in brain regions critical for associative learning using the eyeblink classical conditioning paradigm (EBCC). Evidence indicates that cerebellar shrinkage causes ... -
Delay of transfer from the intensive care unit: a prospective observational study of incidence, causes, and financial impact
(BioMed Central, 2013)Introduction: A paucity of literature exists regarding delays in transfer out of the intensive care unit. We sought to analyze the incidence, causes, and costs of delayed transfer from a surgical intensive care unit (SICU). ... -
Delayed Endovascular Coil Extrusion following Internal Carotid Artery Embolization
(Georg Thieme Verlag KG, 2014)Internal carotid artery injury is a rare and devastating complication of endoscopic sinus and skull base surgery that has an associated mortality rate of 15%. This case describes a patient who developed massive epistaxis ... -
Delayed Infrarenal Aortic Pseudoaneurysm Treated by Endovascular Stent Graft in Pyogenic Spondylitis
(Korean Society of Spine Surgery, 2013)A 61-year-old male patient with pyogenic spondylodiscitis and epidural and psoas abscesses underwent posterior decompression, debridement, and instrumented fusion, followed by anterior debridement and reconstruction. Sudden ... -
Delayed Posthypoxic Leukoencephalopathy: Improvement with Antioxidant Therapy
(S. Karger AG, 2015)Introduction: Delayed posthypoxic leukoencephalopathy (DPHL) may result from a variety of hypoxic insults, including respiratory depression from an opiate overdose. The underlying pathophysiological mechanism of DPHL remains ... -
Delayed sympathetic dependence in the spared nerve injury (SNI) model of neuropathic pain
(BioMed Central, 2007)Background: Clinical and experimental studies of neuropathic pain support the hypothesis that a functional coupling between postganglionic sympathetic efferent and sensory afferent fibers contributes to the pain. We ... -
Deleterious Alleles in the Human Genome Are on Average Younger Than Neutral Alleles of the Same Frequency
(Public Library of Science, 2013)Large-scale population sequencing studies provide a complete picture of human genetic variation within the studied populations. A key challenge is to identify, among the myriad alleles, those variants that have an effect ... -
A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome
(eLife Sciences Publications, Ltd, 2015)Calcium channel blockers (CCBs) are prescribed to patients with Marfan syndrome for prophylaxis against aortic aneurysm progression, despite limited evidence for their efficacy and safety in the disorder. Unexpectedly, ... -
Deletion and duplication of 16p11.2 are associated with opposing effects on visual evoked potential amplitude
(BioMed Central, 2016)Background: Duplication and deletion of the chromosomal region 16p11.2 cause a broad range of impairments, including intellectual disability, language disorders, and sensory symptoms. However, it is unclear how changes in ... -
Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo
(The Rockefeller University Press, 2013)Somatic Addition of Sex Combs Like 1 (ASXL1) mutations occur in 10–30% of patients with myeloid malignancies, most commonly in myelodysplastic syndromes (MDSs), and are associated with adverse outcome. Germline ASXL1 ... -
Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity
(The Rockefeller University Press, 2015)Cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential negative regulator of T cell responses. Germline Ctla4 deficiency is lethal, making investigation of the function of CTLA-4 on mature T cells challenging. To elucidate ... -
Deletion of EP4 on Bone Marrow-Derived Cells Enhances Inflammation and Angiotensin II-Induced Abdominal Aortic Aneurysm Formation
(Ovid Technologies (Wolters Kluwer Health), 2010)Objective—To examine whether a lack of prostaglandin E receptor 4 (EP4) on bone marrow–derived cells would increase local inflammation and enhance the formation of abdominal aortic aneurysm (AAA) in vivo. Methods and ... -
Deletion of Irs2 Causes Reduced Kidney Size in Mice: Role for Inhibition of GSK3β?
(BioMed Central, 2010)Background: Male \(Irs2^{-/-}\) mice develop fatal type 2 diabetes at 13-14 weeks. Defects in neuronal proliferation, pituitary development and photoreceptor cell survival manifest in \(Irs2^{-/-}\) mice. We identify ... -
Deletion of the Chemokine Receptor CCR1 Prolongs Corneal Allograft Survival
(Association for Research in Vision and Ophthalmology (ARVO), 2007)Purpose Many corneal grafts undergo immune rejection, and current therapies are associated with many side effects. The purpose of this study was to identify critical chemokine pathways involved in generating the alloimmune ...