Browsing Harvard Medical School by Title

Now showing items 4051-4070 of 18428

    • Delay of transfer from the intensive care unit: a prospective observational study of incidence, causes, and financial impact 

      Johnson, Daniel W; Schmidt, Ulrich H; Bittner, Edward A; Christensen, Benjamin; Levi, Retsef; Pino, Richard M (BioMed Central, 2013)
      Introduction: A paucity of literature exists regarding delays in transfer out of the intensive care unit. We sought to analyze the incidence, causes, and costs of delayed transfer from a surgical intensive care unit (SICU). ...

    • Delayed Endovascular Coil Extrusion following Internal Carotid Artery Embolization 

      Dedmon, Matthew; Meier, Josh; Chambers, Kyle; Remenschneider, Aaron; Mehta, Brijesh; Lin, Derrick; Yoo, Albert J.; Curry, William; Gray, Stacey (Georg Thieme Verlag KG, 2014)
      Internal carotid artery injury is a rare and devastating complication of endoscopic sinus and skull base surgery that has an associated mortality rate of 15%. This case describes a patient who developed massive epistaxis ...

    • Delayed Infrarenal Aortic Pseudoaneurysm Treated by Endovascular Stent Graft in Pyogenic Spondylitis 

      Shin, Jae-Hyuk; Hwang, Dae-Hyun; Pang, Chae-Hyun; Wang, Shaobai; Kim, In-Sung; Ahn, Jung-Tae; Kim, Young-Woo; Chang, Ho-Guen (Korean Society of Spine Surgery, 2013)
      A 61-year-old male patient with pyogenic spondylodiscitis and epidural and psoas abscesses underwent posterior decompression, debridement, and instrumented fusion, followed by anterior debridement and reconstruction. Sudden ...

    • Delayed Posthypoxic Leukoencephalopathy: Improvement with Antioxidant Therapy 

      King, Franklin; Morris, Nicholas A.; Schmahmann, Jeremy D. (S. Karger AG, 2015)
      Introduction: Delayed posthypoxic leukoencephalopathy (DPHL) may result from a variety of hypoxic insults, including respiratory depression from an opiate overdose. The underlying pathophysiological mechanism of DPHL remains ...

    • Delayed sympathetic dependence in the spared nerve injury (SNI) model of neuropathic pain 

      Pertin, Marie; Allchorne, Andrew J; Beggah, Ahmed T; Woolf, Clifford; Decosterd, Isabelle (BioMed Central, 2007)
      Background: Clinical and experimental studies of neuropathic pain support the hypothesis that a functional coupling between postganglionic sympathetic efferent and sensory afferent fibers contributes to the pain. We ...

    • Deleterious Alleles in the Human Genome Are on Average Younger Than Neutral Alleles of the Same Frequency 

      Kiezun, Adam; Pulit, Sara L.; Francioli, Laurent C.; van Dijk, Freerk; Swertz, Morris; Boomsma, Dorret I.; van Duijn, Cornelia M.; Slagboom, P. Eline; van Ommen, G. J. B.; Wijmenga, Cisca; de Bakker, Paul I Wen; Sunyaev, Shamil R. (Public Library of Science, 2013)
      Large-scale population sequencing studies provide a complete picture of human genetic variation within the studied populations. A key challenge is to identify, among the myriad alleles, those variants that have an effect ...

    • A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome 

      Doyle, Jefferson J; Doyle, Alexander J; Wilson, Nicole K; Habashi, Jennifer P; Bedja, Djahida; Whitworth, Ryan E; Lindsay, Mark E; Schoenhoff, Florian; Myers, Loretha; Huso, Nick; Bachir, Suha; Squires, Oliver; Rusholme, Benjamin; Ehsan, Hamid; Huso, David; Thomas, Craig J; Caulfield, Mark J; Van Eyk, Jennifer E; Judge, Daniel P; Dietz, Harry C; Farrar, Carrie (eLife Sciences Publications, Ltd, 2015)
      Calcium channel blockers (CCBs) are prescribed to patients with Marfan syndrome for prophylaxis against aortic aneurysm progression, despite limited evidence for their efficacy and safety in the disorder. Unexpectedly, ...

    • Deletion and duplication of 16p11.2 are associated with opposing effects on visual evoked potential amplitude 

      LeBlanc, Jocelyn J.; Nelson, Charles A. (BioMed Central, 2016)
      Background: Duplication and deletion of the chromosomal region 16p11.2 cause a broad range of impairments, including intellectual disability, language disorders, and sensory symptoms. However, it is unclear how changes in ...

    • Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo 

      Abdel-Wahab, Omar; Gao, Jie; Adli, Mazhar; Dey, Anwesha; Trimarchi, Thomas; Chung, Young Rock; Kuscu, Cem; Hricik, Todd; Ndiaye-Lobry, Delphine; LaFave, Lindsay M.; Koche, Richard; Shih, Alan H.; Guryanova, Olga A.; Kim, Eunhee; Li, Sheng; Pandey, Suveg; Shin, Joseph Y.; Telis, Leon; Liu, Jinfeng; Bhatt, Parva K.; Monette, Sebastien; Zhao, Xinyang; Mason, Christopher E.; Park, Christopher Y.; Bernstein, Bradley E.; Aifantis, Iannis; Levine, Ross L. (The Rockefeller University Press, 2013)
      Somatic Addition of Sex Combs Like 1 (ASXL1) mutations occur in 10–30% of patients with myeloid malignancies, most commonly in myelodysplastic syndromes (MDSs), and are associated with adverse outcome. Germline ASXL1 ...

    • Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity 

      Paterson, Alison M.; Lovitch, Scott B.; Sage, Peter T.; Juneja, Vikram R.; Lee, Youjin; Trombley, Justin D.; Arancibia-Cárcamo, Carolina V.; Sobel, Raymond A.; Rudensky, Alexander Y.; Kuchroo, Vijay K.; Freeman, Gordon J.; Sharpe, Arlene H. (The Rockefeller University Press, 2015)
      Cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential negative regulator of T cell responses. Germline Ctla4 deficiency is lethal, making investigation of the function of CTLA-4 on mature T cells challenging. To elucidate ...

    • Deletion of EP4 on Bone Marrow-Derived Cells Enhances Inflammation and Angiotensin II-Induced Abdominal Aortic Aneurysm Formation 

      Tang, E. H. C.; Shvartz, E.; Shimizu, K.; Rocha, V. Z.; Zheng, Chunyu; Fukuda, D.; Shi, Guo-Ping; Sukhova, Galina K.; Libby, Peter (Ovid Technologies (Wolters Kluwer Health), 2010)
      Objective—To examine whether a lack of prostaglandin E receptor 4 (EP4) on bone marrow–derived cells would increase local inflammation and enhance the formation of abdominal aortic aneurysm (AAA) in vivo. Methods and ...

    • Deletion of Irs2 Causes Reduced Kidney Size in Mice: Role for Inhibition of GSK3β? 

      Carew, Rosemarie M; Sadagurski, Marianna; Goldschmeding, Roel; Martin, Finian; White, Morris Francis; Brazil, Derek P (BioMed Central, 2010)
      Background: Male \(Irs2^{-/-}\) mice develop fatal type 2 diabetes at 13-14 weeks. Defects in neuronal proliferation, pituitary development and photoreceptor cell survival manifest in \(Irs2^{-/-}\) mice. We identify ...

    • Deletion of the Chemokine Receptor CCR1 Prolongs Corneal Allograft Survival 

      Hamrah, Pedram; Yamagami, Satoru; Liu, Y; Zhang, Qiang; Vora, Sudhir S.; Lu, Bao; Gerard, Craig J.; Dana, Reza (Association for Research in Vision and Ophthalmology (ARVO), 2007)
      Purpose Many corneal grafts undergo immune rejection, and current therapies are associated with many side effects. The purpose of this study was to identify critical chemokine pathways involved in generating the alloimmune ...

    • Deletion of the Complement C5a Receptor Alleviates the Severity of Acute Pneumococcal Otitis Media following Influenza A Virus Infection in Mice 

      Tong, Hua Hua; Lambert, Garrett; Li, Yong Xing; Thurman, Joshua M.; Stahl, Gregory L.; Douthitt, Kelsey; Clancy, Caitlin; He, Yujuan; Bowman, Andrew S. (Public Library of Science, 2014)
      There is considerable evidence that influenza A virus (IAV) promotes adherence, colonization, and superinfection by S. pneumoniae (Spn) and contributes to the pathogenesis of otitis media (OM). The complement system is a ...

    • Deletion of the Sequence Encoding the Tail Domain of the Bone Morphogenetic Protein type 2 Receptor Reveals a Bone Morphogenetic Protein 7-Specific Gain of Function 

      Leyton, Patricio A.; Beppu, Hideyuki; Pappas, Alexandra; Martyn, Trejeeve M.; Derwall, Matthias; Baron, David M.; Galdos, Rita; Bloch, Donald B.; Bloch, Kenneth D. (Public Library of Science, 2013)
      The bone morphogenetic protein (BMP) type II receptor (BMPR2) has a long cytoplasmic tail domain whose function is incompletely elucidated. Mutations in the tail domain of BMPR2 are found in familial cases of pulmonary ...

    • Deletion of Wiskott–Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells 

      Baptista, Marisa A. P.; Keszei, Marton; Oliveira, Mariana; Sunahara, Karen K. S.; Andersson, John; Dahlberg, Carin I. M.; Worth, Austen J.; Liedén, Agne; Kuo, I-Chun; Wallin, Robert P. A.; Snapper, Scott B.; Eidsmo, Liv; Scheynius, Annika; Karlsson, Mikael C. I.; Bouma, Gerben; Burns, Siobhan O.; Forsell, Mattias N. E.; Thrasher, Adrian J.; Nylén, Susanne; Westerberg, Lisa S. (Nature Publishing Group, 2016)
      Wiskott–Aldrich syndrome (WAS) is caused by loss-of-function mutations in the WASp gene. Decreased cellular responses in WASp-deficient cells have been interpreted to mean that WASp directly regulates these responses in ...

    • A Delicate Balance: Maintaining Mutualism to Prevent Disease 

      Van Tyne, Daria; Gilmore, Michael S. (Elsevier BV, 2014)
      The intestinal microbial ecosystem is complex, and few of the principles that contribute to homeostasis in health are well understood. Pham et al. (2014) show that a network including the epithelial interleukin-22 receptor ...

    • Delirium as a Predictor of Mortality in Mechanically Ventilated Patients in the Intensive Care Unit 

      Ely, E. Wesley; Shintani, Ayumi; Truman, Brenda; Speroff, Theodore; Gordon, Sharon; Harrell, Frank; Inouye, Sharon; Bernard, Gordon; Dittus, Robert S. (American Medical Association (AMA), 2004)
      CONTEXT: In the intensive care unit (ICU), delirium is a common yet underdiagnosed form of organ dysfunction, and its contribution to patient outcomes is unclear. OBJECTIVE: To determine if delirium is an independent ...

    • Delirium Burden in Patients and Family Caregivers: Development and Testing of New Instruments 

      Racine, Anne; D’Aquila, Madeline; Schmitt, Eva M.; Gallagher, Jacqueline; Marcantonio, Edward; Jones, Richard N; Inouye, Sharon; Schulman-Green, Dena (Oxford University Press (OUP), 2018-05-08)
      BACKGROUND AND OBJECTIVES: Delirium creates distinct emotional distress in patients and family caregivers, yet there are limited tools to assess the experience. Our objective was to develop separate patient and family ...

    • Delirium in elderly people 

      Inouye, Sharon; Westendorp, Rudi GJ; Saczynski, Jane S (Elsevier BV, 2014)
      Delirium is an acute disorder of attention and cognition in elderly people (ie, those aged 65 years or older) that is common, serious, costly, under-recognised, and often fatal. A formal cognitive assessment and history ...