Browsing Harvard Medical School by Title

Now showing items 4089-4108 of 18428

    • Dendritic Cell Cancer Vaccines: From the Bench to the Bedside 

      Katz, Tamar; Avivi, Irit; Benyamini, Noam; Rosenblatt, Jacalyn; Avigan, David (Rambam Health Care Campus, 2014)
      The recognition that the development of cancer is associated with acquired immunodeficiency, mostly against cancer cells themselves, and understanding pathways inducing this immunosuppression, has led to a tremendous ...

    • Dendritic cell-bound IgE functions to restrain allergic inflammation at mucosal sites 

      Platzer, Barbara; Baker, Kristi; Vera, Miguel Pinilla; Singer, Kathleen; Panduro, Marisella; Lexmond, Willem S.; Turner, Devin; Vargas, Sara O.; Kinet, Jean-Pierre; Maurer, Dieter; Baron, Rebecca M.; Blumberg, Richard S.; Fiebiger, Edda (2014)
      Antigen-mediated crosslinking of Immunoglobulin E (IgE) bound to mast cells/basophils via FcεRI, the high affinity IgE Fc-receptor, is a well-known trigger of allergy. In humans, but not mice, dendritic cells (DCs) also ...

    • Dendritic Cells are Preferentially Targeted among Hematolymphocytes by Modified Vaccinia Virus Ankara and Play a Key Role in the Induction of Virus-Specific T Cell Responses In Vivo 

      Liu, Luzheng; Chavan, Rahul; Feinberg, Mark B. (BioMed Central, 2008)
      Background: Modified Vaccinia Ankara (MVA) is a highly attenuated strain of vaccinia virus (VV) that has lost approximately 15% of the VV genome, along with the ability to replicate in most mammalian cells. It has demonstrated ...

    • Denervation protects limbs from inflammatory arthritis via an impact on the microvasculature 

      Stangenberg, Lars; Burzyn, Dalia; Binstadt, Bryce; Weissleder, Ralph; Mahmood, Umar; Benoist, Christophe; Mathis, Diane (National Academy of Sciences, 2014)
      Two-way communication between the mammalian nervous and immune systems is increasingly recognized and appreciated. An intriguing example of such crosstalk comes from clinical observations dating from the 1930s: Patients ...

    • Dengue on islands: a Bayesian approach to understanding the global ecology of dengue viruses 

      Feldstein, Leora R.; Brownstein, John S.; Brady, Oliver J.; Hay, Simon I.; Johansson, Michael A. (Oxford University Press, 2015)
      Background: Transmission of dengue viruses (DENV), the most common arboviral pathogens globally, is influenced by many climatic and socioeconomic factors. However, the relative contributions of these factors on a global ...

    • Denoising Two-Photon Calcium Imaging Data 

      Schummers, James; Sur, Mriganka; Perc, Matjaz; Malik, Wasim; Brown, Emery Neal (Public Library of Science, 2011)
      Two-photon calcium imaging is now an important tool for in vivo imaging of biological systems. By enabling neuronal population imaging with subcellular resolution, this modality offers an approach for gaining a fundamental ...

    • Dense, shape‐optimized posterior 32‐channel coil for submillimeter functional imaging of visual cortex at 3T 

      Farivar, Reza; Grigorov, Filip; van der Kouwe, Andre J.; Wald, Lawrence L.; Keil, Boris (John Wiley and Sons Inc., 2015)
      Purpose Functional neuroimaging of small cortical patches such as columns is essential for testing computational models of vision, but imaging from cortical columns at conventional 3T fields is exceedingly difficult. By ...

    • Densely Interconnected Transcriptional Circuits Control Cell States in Human Hematopoiesis 

      Novershtern, Noa; Subramanian, Aravind; Lawton, Lee N.; Mak, Raymond Heungwing; Haining, William Nicholas; McConkey, Marie E.; Habib, Naomi; Yosef, Nir; Chang, Cindy Hsin-Yu; Shay, Tal; Frampton, Garrett M.; Drake, Adam C.B.; Leskov, Ilya; Nilsson, Bjorn; Preffer, Frederic Ira; Dombkowski, David; Evans, John W.; Liefeld, Ted; Smutko, John S.; Chen, Jianzhu; Friedman, Nir; Young, Richard A.; Golub, Todd Robert; Regev, Aviv; Ebert, Benjamin L. (Elsevier BV, 2011)
      While many individual transcription factors are known to regulate hematopoietic differentiation, major aspects of the global architecture of hematopoiesis remain unknown. Here, we profiled gene expression in 38 distinct ...

    • Dent in the Forehead: A Rare Manifestation of Metastatic Cancer 

      Whitman, Mary Catherine; Kazim, Michael (American Medical Association (AMA), 2012)

    • Dental amalgam restorations and children’s neuropsychological function: The New England Children’s Amalgam Trial 

      Bellinger, David C.; Daniel, David; Trachtenberg, Felicia; Tavares, Mary Angela; McKinlay, Sonja (National Institute of Environmental Health Sciences, 2006)
      Background: A concern persists that children’s exposure to mercury vapor from dental amalgams produces neurotoxicity. Objective: Our goal was to compare the neuropsychological function of children, without prior exposure ...

    • Dental clinical research: an illustration of the value of standardized diagnostic terms 

      Kalenderian, Elsbeth; Tokede, Bunmi; Ramoni, Rachel; Khan, Maria; Kimmes, Nicole; White, Joel; Vaderhobli, Ram; Yansane, Alfa; Feilzer, Albert; Walji, Muhammad (John Wiley and Sons Inc., 2015)
      Abstract Objective: Secondary data are a significant resource for in‐depth epidemiologic and public health research. It also allows for effective quality control and clinical outcomes measurement. To illustrate the value ...

    • Dental status and incident falls among older Japanese: a prospective cohort study 

      Yamamoto, Tatsuo; Kondo, Katsunori; Misawa, Jimpei; Hirai, Hiroshi; Nakade, Miyo; Aida, Jun; Kondo, Naoki; Kawachi, Ichiro; Hirata, Yukio (BMJ Group, 2012)
      Objective: To examine if self-reported number of teeth, denture use and chewing ability are associated with incident falls. Design: Longitudinal cohort study (the Aichi Gerontological Evaluation Study). Setting: 5 Japanese ...

    • Dental utilization disparities in a Jewish context: reasons and potential solutions 

      Lazarus, Z; Pirutinsky, S; Korbman, M; Rosmarin, David Hillel (2015)
      Demographic discrepancies in dental healthcare utilization and access to care have historically been studied and attributed to such factors as socioeconomic status, race, and ethnicity. Such potential discrepancies and ...

    • Dentate gyrus abnormalities in sudden unexplained death in infants: morphological marker of underlying brain vulnerability 

      Kinney, Hannah C.; Cryan, Jane B.; Haynes, Robin L.; Paterson, David S.; Haas, Elisabeth A.; Mena, Othon J.; Minter, Megan; Journey, Kelley W.; Trachtenberg, Felicia L.; Goldstein, Richard D.; Armstrong, Dawna D. (Springer Berlin Heidelberg, 2014)
      Sudden unexplained death in infants, including the sudden infant death syndrome, is likely due to heterogeneous causes that involve different intrinsic vulnerabilities and/or environmental factors. Neuropathologic research ...

    • Denture Group Visits: A Model To Improve Access to Care and Reduce Treatment Period for Dentures 

      Chandrupatla, Siddardha Gowtam; Thompson, Lisa; Kuna, Sirisha; Swann, Brian (California Dental Association, 2018-11-01)
      Objective- To evaluate the efficiency of denture group visits program by delivering dentures in shorter number of days when compared to individual appointments. Methods- Group denture visits model was developed and ...

    • Dependence of antibody-mediated presentation of antigen on FcRn 

      Qiao, Shuo-Wang; Kobayashi, Kanna; Johansen, Finn-Eirik; Sollid, Ludvig M.; Andersen, Jan Terje; Milford, Edgar; Roopenian, Derry C.; Lencer, Wayne I.; Blumberg, Richard S. (National Academy of Sciences, 2008)
      The neonatal Fc receptor for IgG (FcRn) is a distant member of the MHC class I protein family. It binds IgG and albumin in a pH-dependent manner and protects these from catabolism by diverting them from a degradative fate ...

    • Dependence of Corneal Stem/Progenitor Cells on Ocular Surface Innervation 

      Ueno, Hiroki; Ferrari, Giulio; Hattori, Takaaki; Saban, Daniel R.; Katikireddy, Kishore R.; Chauhan, Sunil Kumar; Dana, Reza (Association for Research in Vision and Ophthalmology (ARVO), 2012)
      Purpose. Neurotrophic keratopathy (NK) is a corneal degeneration associated with corneal nerve dysfunction. It can cause corneal epithelial defects, stromal thinning, and perforation. However, it is not clear if and to ...

    • Dephosphorylation of DBC1 by Protein Phosphatase 4 Is Important for p53-Mediated Cellular Functions 

      Lee, Jihye; Adelmant, Guillaume; Marto, Jarrod A.; Lee, Dong-Hyun (Korean Society for Molecular and Cellular Biology, 2015)
      Deleted in breast cancer-1 (DBC1) contributes to the regulation of cell survival and apoptosis. Recent studies demonstrated that DBC is phosphorylated at Thr454 by ATM/ATR kinases in response to DNA damage, which is a ...

    • Depleting Gene Activities in Early Drosophila Embryos with the 'Maternal-Gal4–shRNA' System 

      Staller, Max V.; Yan, Dong; Randklev, Sakara; Bragdon, Meghan D.; Wunderlich, Zeba B.; Tao, Rong; Perkins, Lizabeth A.; DePace, Angela H.; Perrimon, Norbert (Genetics Society of America, 2013)
      In a developing Drosophila melanogaster embryo, mRNAs have a maternal origin, a zygotic origin, or both. During the maternal-zygotic transition, maternal products are degraded and gene expression comes under the control ...

    • Depletion of CD11c+ cells in the CD11c.DTR model drives expansion of unique CD64+ Ly6C+ monocytes that are poised to release TNF-α 

      Sivakumaran, Shivajanani; Henderson, Stephen; Ward, Sophie; Santos E Sousa, Pedro; Manzo, Teresa; Zhang, Lei; Conlan, Thomas; Means, Terry K; D'Aveni, Maud; Hermine, Olivier; Rubio, Marie-Thérèse; Chakraverty, Ronjon; Bennett, Clare L (John Wiley & Sons, Ltd, 2015)
      Dendritic cells (DCs) play a vital role in innate and adaptive immunities. Inducible depletion of CD11c+ DCs engineered to express a high-affinity diphtheria toxin receptor has been a powerful tool to dissect DC function ...