Browsing Harvard Medical School by Title
Now showing items 4179-4198 of 18428
-
Detection and manipulation of live antigen-expressing cells using conditionally stable nanobodies
(eLife Sciences Publications, Ltd, 2016)The ability to detect and/or manipulate specific cell populations based upon the presence of intracellular protein epitopes would enable many types of studies and applications. Protein binders such as nanobodies (Nbs) can ... -
Detection and Quantification of Microparticles from Different Cellular Lineages Using Flow Cytometry. Evaluation of the Impact of Secreted Phospholipase A2 on Microparticle Assessment
(Public Library of Science, 2015)Microparticles, also called microvesicles, are submicron extracellular vesicles produced by plasma membrane budding and shedding recognized as key actors in numerous physio(patho)logical processes. Since they can be released ... -
Detection of Cold Pain, Cold Allodynia and Cold Hyperalgesia in Freely Behaving Rats
(BioMed Central, 2005)Background: Pain is elicited by cold, and a major feature of many neuropathic pain states is that normally innocuous cool stimuli begin to produce pain (cold allodynia). To expand our understanding of cold induced pain ... -
Detection of curved robots using 3D ultrasound
(IEEE, 2011)Three-dimensional ultrasound can be an effective imaging modality for image-guided interventions since it enables visualization of both the instruments and the tissue. For robotic applications, its realtime frame rates ... -
Detection of Delirium in the Intensive Care Unit: Comparison of Confusion Assessment Method for the Intensive Care Unit with Confusion Assessment Method Ratings
(Wiley-Blackwell, 2005)Objectives: To compare the Confusion Assessment Method (CAM) and CAM for the Intensive Care Unit (CAM-ICU) methods for detecting delirium in alert, nonintubated older ICU patients. Design: Comparison study. Setting: ... -
Detection of Early Prostate Cancer using a Hepsin Targeted Imaging Agent
(American Association for Cancer Research, 2008)Early detection and diagnosis of prostate cancer is key to designing effective treatment strategies. Microarrays have resulted in the discovery of hepsin (HPN) as a biomarker for detection of prostate cancer. In this study, ... -
Detection of ERBB2 Amplification in Uterine Serous Carcinoma by Next-Generation Sequencing: An Approach Highly Concordant With Standard Assays
(Springer Science and Business Media LLC, 2020-10-19)Uterine serous carcinoma is an aggressive subtype of endometrial cancer that accounts for fewer than 10% of endometrial carcinomas but is responsible for about half of deaths. A subset of cases has HER2 overexpression ... -
Detection of Invasive Colon Cancer Using a Novel, Targeted, Library-Derived Fluorescent Peptide
(American Association for Cancer Research, 2004) -
Detection of JC Virus-Specific Immune Responses in a Novel Humanized Mouse Model
(Public Library of Science, 2013)Progressive Multifocal Leukoencephalopathy (PML) is an often fatal disease caused by the reactivation of the JC virus (JCV). Better understanding of viral-host interactions has been hampered by the lack of an animal model. ... -
Detection of Lipid-Linked Peptidoglycan Precursors by Exploiting an Unexpected Transpeptidase Reaction
(American Chemical Society, 2014)Penicillin-binding proteins (PBPs) are involved in the synthesis and remodeling of bacterial peptidoglycan (PG). Staphylococcus aureus expresses four PBPs. Genetic studies in S. aureus have implicated PBP4 in the formation ... -
Detection of Macrophages in Aortic Aneurysms by Nanoparticle Positron Emission Tomography-Computed Tomography
(American Heart Association, 2011)Objective-Current management of aortic aneurysms (AAs) relies primarily on size criteria to determine whether invasive repair is indicated to preempt rupture. We hypothesized that emerging molecular imaging tools could be ... -
Detection of Murine Post-Pneumonectomy Lung Regeneration by 18FDG PET Imaging
(Springer, 2012)Background: An intriguing biologic process in most adult mammals is post-pneumonectomy lung regeneration, that is, the removal of one lung (pneumonectomy) results in the rapid compensatory growth of the remaining lung. The ... -
Detection of Mutations in the Dystrophin Gene via Automated DHPLC Screening and Direct Sequencing
(BioMed Central, 2001)Background: Currently molecular diagnostic laboratories focus only on the identification of large deletion and duplication mutations (spanning one exon or more) for Duchenne Muscular Dystrophy (DMD) yielding 65% of causative ... -
Detection of recurrent cytogenetic aberrations in multiple myeloma: A comparison between MLPA and iFISH
(Impact Journals LLC, 2015)Multiple myeloma (MM) is a genetically heterogeneous disease with diverse clinical characteristics and outcomes. Recently, multiplex ligation-dependent probe amplification (MLPA) has emerged as an effective and robust ... -
Detection of respiratory syncytial virus and rhinovirus in healthy infants
(BioMed Central, 2015)Background: Despite the research importance of rhinovirus detection in asymptomatic healthy infants, the literature remains sparse. Objective: To investigate the prevalence of respiratory syncytial virus (RSV) and rhinovirus ... -
Detection of Spontaneous Schwannomas by MRI in a Transgenic Murine Model of Neurofibromatosis Type 2
(Elsevier, 2002)Spontaneous schwannomas were detected by magnetic resonance imaging (MRI) in a transgenic murine model of neurofibromatosis type 2 (NF2) expressing a dominant mutant form of merlin under the Schwann cell-specific PO promoter. ... -
Determinants of Bone and Blood Lead Levels among Minorities Living in the Boston Area
(National Institue of Environmental Health Sciences, 2004)We measured blood and bone lead levels among minority individuals who live in some of Boston’s neighborhoods with high minority representation. Compared with samples of predominantly white subjects we had studied before, ... -
Determinants of cluster distribution in the molecular epidemiology of tuberculosis
(National Academy of Sciences, 2002)Recently developed molecular techniques have revolutionized the epidemiology of tuberculosis. Multiple studies have used these tools to examine the population structure of Mycobacterium tuberculosis isolates in different ... -
Determinants of Embryonic Hematopoietic Stem Cell Emergence and Maturation
(2015-05-13)Advances in understanding the developmental origins of hematopoietic stem cell (HSCs)—precisely the molecular mechanisms promoting their emergence and maturation—may lead to derivation of personalized HSCs, circumventing ... -
Determinants of fertility in Rwanda in the context of a fertility transition: a secondary analysis of the 2010 Demographic and Health Survey
(BioMed Central, 2014)Background: Major improvements to Rwanda’s health system, infrastructure, and social programs over the last decade have led to a rapid fertility transition unique from other African countries. The total fertility rate fell ...