Browsing Harvard Medical School by Title
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Detection of Spontaneous Schwannomas by MRI in a Transgenic Murine Model of Neurofibromatosis Type 2
(Elsevier, 2002)Spontaneous schwannomas were detected by magnetic resonance imaging (MRI) in a transgenic murine model of neurofibromatosis type 2 (NF2) expressing a dominant mutant form of merlin under the Schwann cell-specific PO promoter. ... -
Determinants of Bone and Blood Lead Levels among Minorities Living in the Boston Area
(National Institue of Environmental Health Sciences, 2004)We measured blood and bone lead levels among minority individuals who live in some of Boston’s neighborhoods with high minority representation. Compared with samples of predominantly white subjects we had studied before, ... -
Determinants of cluster distribution in the molecular epidemiology of tuberculosis
(National Academy of Sciences, 2002)Recently developed molecular techniques have revolutionized the epidemiology of tuberculosis. Multiple studies have used these tools to examine the population structure of Mycobacterium tuberculosis isolates in different ... -
Determinants of Embryonic Hematopoietic Stem Cell Emergence and Maturation
(2015-05-13)Advances in understanding the developmental origins of hematopoietic stem cell (HSCs)—precisely the molecular mechanisms promoting their emergence and maturation—may lead to derivation of personalized HSCs, circumventing ... -
Determinants of fertility in Rwanda in the context of a fertility transition: a secondary analysis of the 2010 Demographic and Health Survey
(BioMed Central, 2014)Background: Major improvements to Rwanda’s health system, infrastructure, and social programs over the last decade have led to a rapid fertility transition unique from other African countries. The total fertility rate fell ... -
Determinants of Glycan Receptor Specificity of H2N2 Influenza A Virus Hemagglutinin
(Public Library of Science, 2010)The H2N2 subtype of influenza A virus was responsible for the Asian pandemic of 1957-58. However, unlike other subtypes that have caused pandemics such as H1N1 and H3N2, which continue to circulate among humans, H2N2 stopped ... -
Determinants of Health Service Responsiveness in Community-Based Vector Surveillance for Chagas Disease in Guatemala, El Salvador, and Honduras
(Public Library of Science, 2015)Background: Central American countries face a major challenge in the control of Triatoma dimidiata, a widespread vector of Chagas disease that cannot be eliminated. The key to maintaining the risk of transmission of ... -
Determinants of Health-Related Quality of Life in Adolescents With Repaired D-Transposition of the Great Arteries
(2018-05-15)Objective: Understanding the determinants of health-related quality of life in adolescents after infant congenital heart surgery is essential to providing life-long care to this patient population. The Boston Circulatory ... -
Determinants of Hemodynamic Stability and Patient Reported Outcomes in Hemodialysis
(2022-05-10)Patients on maintenance hemodialysis (HD) suffer from disproportionately high morbidity and mortality, with up to a 15-fold higher risk death compared to age-matched individuals without end-stage kidney disease.(1–3) This ... -
Determinants of host susceptibility to murine respiratory syncytial virus (RSV) disease identify a role for the innate immunity scavenger receptor MARCO gene in human infants
(Elsevier, 2016)Background: Respiratory syncytial virus (RSV) is the global leading cause of lower respiratory tract infection in infants. Nearly 30% of all infected infants develop severe disease including bronchiolitis, but susceptibility ... -
Determinants of Human Cyclin B1 Association with Mitotic Chromosomes
(Public Library of Science, 2013)Cyclin B1–CDK1 activity is essential for mitotic entry, but questions remain regarding how the activity of this kinase is spatially regulated. Previous studies showed that the cyclin B1 subunit localizes to several ... -
Determinants of Individual Variation in Intracellular Accumulation of Anti-HIV Nucleoside Analog Metabolites
(American Society for Microbiology, 2011)Individual variation in response to antiretroviral therapy is well-known, but it is not clear if demographic characteristics such as gender, age, and ethnicity are responsible for the variation. To optimize anti-HIV therapy ... -
Determinants of institutional birth among women in rural Nepal: a mixed-methods cross-sectional study
(BioMed Central, 2016)Background: Encouraging institutional birth is an important component of reducing maternal mortality in low-resource settings. This study aims to identify and understand the determinants of persistently low institutional ... -
Determinants of Leukocyte Margination in Rectangular Microchannels
(Public Library of Science, 2009)Microfabrication of polydimethylsiloxane (PDMS) devices has provided a new set of tools for studying fluid dynamics of blood at the scale of real microvessels. However, we are only starting to understand the power and ... -
Determinants of Racial/Ethnic Disparities in Incidence of Diabetes in Postmenopausal Women in the U.S.: The Women’s Health Initiative 1993–2009
(American Diabetes Association, 2012)OBJECTIVE To examine determinants of racial/ethnic differences in diabetes incidence among postmenopausal women participating in the Women’s Health Initiative. RESEARCH DESIGN AND METHODS Data on race/ethnicity, baseline ... -
Determinants of Smoking and Quitting in HIV-Infected Individuals
(Public Library of Science, 2016)Background: Cigarette smoking is widespread among HIV-infected patients, who confront increased risk of smoking-related co-morbidities. The effects of HIV infection and HIV-related variables on smoking and smoking cessation ... -
Determinants of specific RNA interference-mediated silencing of human β-globin alleles differing by a single nucleotide polymorphism
(National Academy of Sciences, 2006)A single nucleotide polymorphism (SNP) in the sickle beta-globin gene (ps) leads to sickle cell anemia. Sickling increases sharply with deoxy sickle Hb concentration and decreases with increasing fetal gamma-globin ... -
Determinants of the Mechanical Behavior of Human Lumbar Vertebrae After Simulated Mild Fracture
(Wiley Subscription Services, Inc., A Wiley Company, 2011)The ability of a vertebra to carry load after an initial deformation and the determinants of this postfracture load-bearing capacity are critical but poorly understood. This study aimed to determine the mechanical behavior ... -
Determination of Hemispheric Emotional Valence in Individual Subjects: A New Approach with Research and Therapeutic Implications
(BioMed Central, 2007)Background: Much has been theorized about the emotional properties of the hemispheres. Our review of the dominant hypotheses put forth by Schore, Joseph, Davidson, and Harmon-Jones on hemispheric emotional valences (HEV) ... -
Determination of Rat Vertebral Bone Compressive Fatigue Properties in Untreated Intact Rats and Zoledronic-acid-treated, Ovariectomized Rats
(Springer-Verlag, 2008)Summary: Compressive fatigue properties of whole vertebrae, which may be clinically relevant for osteoporotic vertebral fractures, were determined in untreated, intact rats and zoledronic-acid-treated, ovariectomized rats. ...