Browsing Harvard Medical School by Title

Now showing items 4339-4358 of 18428

    • Diagnosis and Treatment Trends in Mucopolysaccharidosis I: Findings from the MPS I Registry 

      D’Aco, Kristin; Underhill, Lisa; Rangachari, Lakshmi; Arn, Pamela; Cox, Gerald Frank; Giugliani, Roberto; Okuyama, Torayuki; Wijburg, Frits; Kaplan, Paige (Springer-Verlag, 2012)
      Our objective was to assess how the diagnosis and treatment of mucopolysaccharidosis I (MPS I) have changed over time. We used data from 891 patients in the MPS I Registry, an international observational database, to analyze ...

    • Diagnosis of Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia: Proposed Modification of the Task Force Criteria 

      Marcus, F. I.; McKenna, William; Sherrill, D.; Basso, C.; Bauce, B.; Bluemke, D. A.; Calkins, H.; Corrado, D.; Cox, M. G. P. J.; Daubert, J. P.; Fontaine, G.; Gear, K.; Hauer, R.; Nava, A.; Picard, Michael Howard; Protonotarios, N.; Saffitz, Jeffrey E; Sanborn, Danita M. Yoerger; Steinberg, J. S.; Tandri, H.; Thiene, G.; Towbin, J. A.; Tsatsopoulou, A.; Wichter, T.; Zareba, W. (Ovid Technologies (Wolters Kluwer Health), 2010)
      Background: In 1994, an International Task Force proposed criteria for the clinical diagnosis of ARVC/D which facilitated recognition and interpretation of the frequently non-specific clinical features of ARVC/D. This ...

    • The Diagnosis of Colorectal Cancer in Patients with Symptoms: Finding a Needle in a Haystack 

      Fletcher, Robert H. (BioMed Central, 2009)
      Patients often see primary care physicians with symptoms that might signal colorectal cancer but are also common in adults without cancer. Physicians and patients must then make a difficult decision about whether and how ...

    • Diagnosis of Influenza from Lower Respiratory Tract Sampling after Negative Upper Respiratory Tract Sampling 

      Bogoch, Isaac; Andrews, Jason Randolph; Zachary, Kimon C.; Hohmann, Elizabeth Louise (Landes Bioscience, 2013)
      In this retrospective cohort study, we demonstrate that PCR-confirmed diagnoses of influenza were made solely by lower respiratory sampling in 6.9% of cases, as traditional upper respiratory tract tests were negative, ...

    • Diagnosis of Non-Celiac Gluten Sensitivity (NCGS): The Salerno Experts’ Criteria 

      Catassi, Carlo; Elli, Luca; Bonaz, Bruno; Bouma, Gerd; Carroccio, Antonio; Castillejo, Gemma; Cellier, Christophe; Cristofori, Fernanda; de Magistris, Laura; Dolinsek, Jernej; Dieterich, Walburga; Francavilla, Ruggiero; Hadjivassiliou, Marios; Holtmeier, Wolfgang; Körner, Ute; Leffler, Dan A.; Lundin, Knut E. A.; Mazzarella, Giuseppe; Mulder, Chris J.; Pellegrini, Nicoletta; Rostami, Kamran; Sanders, David; Skodje, Gry Irene; Schuppan, Detlef; Ullrich, Reiner; Volta, Umberto; Williams, Marianne; Zevallos, Victor F.; Zopf, Yurdagül; Fasano, Alessio (MDPI, 2015)
      Non-Celiac Gluten Sensitivity (NCGS) is a syndrome characterized by intestinal and extra-intestinal symptoms related to the ingestion of gluten-containing food, in subjects that are not affected by either celiac disease ...

    • Diagnostic Accuracy of a Point-of-Care Urine Test for Tuberculosis Screening Among Newly-Diagnosed HIV-Infected Adults: A Prospective, Clinic-Based Study 

      Drain, Paul K.; Losina, Elena; Coleman, Sharon M.; Giddy, Janet; Ross, Douglas; Katz, Jeffrey; Walensky, Rochelle; Freedberg, Kenneth; Bassett, Ingrid (Springer Science and Business Media LLC, 2014-02-26)
      Background A rapid diagnostic test for active tuberculosis (TB) at the clinical point-of-care could expedite case detection and accelerate TB treatment initiation. We assessed the diagnostic accuracy of a rapid urine ...

    • Diagnostic accuracy of administrative data algorithms in the diagnosis of osteoarthritis: a systematic review 

      Shrestha, Swastina; Dave, Amish Jayant; Losina, Elena; Katz, Jeffrey Neil (Springer Science and Business Media LLC, 2016-07-07)
      Background: Administrative health care data are frequently used to study disease burden and treatment outcomes in many conditions including osteoarthritis (OA). OA is a chronic condition with significant disease burden ...

    • Diagnostic Accuracy of Sixty Four Multi-Slice CT Angiography in Assessment of Arterial Cut-Off and Run-Off in Comparison with Surgical Findings 

      Noaparast, M.; Rabani, A.; Karimian, F.; Bodaghabadi, M.; Aran, Shima; Mirsharifi, R.; Jafarian, A.; Vaezi, F.; Ghanaati, H. (Kowsar, 2011)
      Background/Objective: The accurate anatomic mapping and determination of the severity of arterial disease, an important health problem of the elderly, is of great significance. We aimed to determine the diagnostic value ...

    • Diagnostic delay in progressive multifocal leukoencephalopathy 

      Miskin, Dhanashri P.; Ngo, Long H.; Koralnik, Igor J. (John Wiley and Sons Inc., 2016)
      Abstract We investigated delay in diagnosing progressive multifocal leukoencephalopathy (PML). The median time from initial symptom to diagnosis was 74 days (range 1–1643) in 111 PML patients seen at our institution from ...

    • Diagnostic Immunohistochemistry in Cutaneous Neoplasia: An Update 

      Compton, Leigh A.; Murphy, George F.; Lian, Christine G. (S. Karger AG, 2015)
      Immunohistochemistry (IHC) is an important adjunct in the diagnosis of neoplastic skin diseases. In addition to the many established IHC markers currently in use, new markers continue to emerge, although their general ...

    • Diagnostic Implications of an Elevated Troponin in the Emergency Department 

      Yiadom, Maame Yaa; Jarolim, Petr; Jenkins, Cathy; Melanson, Stacy E. F.; Conrad, Michael; Kosowsky, Joshua M. (Hindawi Publishing Corporation, 2015)
      Objective:. To determine the proportion of initial troponin (cTn) elevations associated with Type I MI versus other cardiovascular and noncardiovascular diagnoses in an emergency department (ED) and whether or not a ...

    • Diagnostic reproducibility of tumour budding in colorectal cancer: a multicentre, multinational study using virtual microscopy 

      Puppa, Giacomo; Senore, Carlo; Sheahan, Kieran; Vieth, Michael; Lugli, Alessandro; Zlobec, Inti; Pecori, Sara; Wang, Lai Mun; Langner, Cord; Mitomi, Hiroyuki; Nakamura, Takatoshi; Watanabe, Masahiko; Ueno, Hideki; Chasle, Jacques; Conley, Stephen A; Herlin, Paulette; Lauwers, Gregory Y.; Risio, Mauro (Wiley-Blackwell, 2012)
      Aims:  Despite the established prognostic relevance of tumour budding in colorectal cancer, the reproducibility of the methods reported for its assessment has not yet been determined, limiting its use and reporting in ...

    • Diagnostic technologies for circulating tumour cells and exosomes 

      Shao, Huilin; Chung, Jaehoon; Issadore, David (Portland Press Ltd., 2016)
      Circulating tumour cells (CTCs) and exosomes are promising circulating biomarkers. They exist in easily accessible blood and carry large diversity of molecular information. As such, they can be easily and repeatedly obtained ...

    • Diagnostic Utility of Ocular Symptoms and Vision for Cytomegalovirus Retinitis 

      Liu, Yingna; Chen, Alexander; Kamphaengkham, Siripim; Leenasirimakul, Prattana; Jirawison, Choeng; Ausayakhun, Somsanguan; Margolis, Todd P.; Keenan, Jeremy D. (Public Library of Science (PLoS), 2016)
      Purpose: CMV retinitis remains a leading cause of blindness in countries with a high burden of AIDS. Although dilated fundus examinations are recommended for those with CD4 counts below 100 cells/µL, in practice only those ...

    • Diagnostic Validity of the Generalized Anxiety Disorder - 7 (GAD-7) among Pregnant Women 

      Zhong, Qiu-Yue; Gelaye, Bizu; Zaslavsky, Alan M.; Fann, Jesse R.; Rondon, Marta B.; Sánchez, Sixto E.; Williams, Michelle A. (Public Library of Science, 2015)
      Objective: Generalized anxiety disorder (GAD) during pregnancy is associated with several adverse maternal and perinatal outcomes. A reliable and valid screening tool for GAD should lead to earlier detection and treatment. ...

    • The diagnostic value of circulating microRNAs for middle-aged (40–60-year-old) coronary artery disease patients 

      Md Sayed, Ali Sheikh; Xia, Ke; Li, Fei; Deng, Xu; Salma, Umme; Li, Tingbo; Deng, Hai; Yang, Dafeng; Haoyang, Zhou; Yang, TianLun; Peng, Jun (Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, 2015)
      OBJECTIVE: Circulating microRNAs have been recognized as promising biomarkers for various diseases. The present study aimed to explore the potential roles of circulating miR-149, miR-424 and miR-765 as non-invasive biomarkers ...

    • Diagnostic Value of Multidetector CT and Its Multiplanar Reformation, Volume Rendering and Virtual Bronchoscopy Postprocessing Techniques for Primary Trachea and Main Bronchus Tumors 

      Luo, Mingyue; Duan, Chaijie; Qiu, Jianping; Li, Wenru; Zhu, Dongyun; Cai, Wenli (Public Library of Science, 2015)
      Purpose To evaluate the diagnostic value of multidetector CT (MDCT) and its multiplanar reformation (MPR), volume rendering (VR) and virtual bronchoscopy (VB) postprocessing techniques for primary trachea and main bronchus ...

    • Diagnostic yield of endobronchial ultrasound-guided transbronchial needle aspiration for mediastinal staging in lung cancer* 

      Fernández-Bussy, Sebastián; Labarca, Gonzalo; Canals, Sofia; Caviedes, Iván; Folch, Erik; Majid, Adnan (Sociedade Brasileira de Pneumologia e Tisiologia, 2015)
      OBJECTIVE: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive diagnostic test with a high diagnostic yield for suspicious central pulmonary lesions and for mediastinal lymph ...

    • DIAPH3 Governs the Cellular Transition to the Amoeboid Tumour Phenotype 

      Hager, Martin H; Morley, Samantha; Bielenberg, Diane R; Gao, Sizhen; Morello, Matteo; Holcomb, Ilona N; Liu, Wennuan; Mouneimne, Ghassan; Demichelis, Francesca; Kim, Jayoung; Solomon, Keith R; Adam, Rosalyn M; Isaacs, William B; Higgs, Henry N; Vessella, Robert L; Di Vizio, Dolores; Freeman, Michael R (WILEY-VCH Verlag, 2012)
      Therapies for most malignancies are generally ineffective once metastasis occurs. While tumour cells migrate through tissues using diverse strategies, the signalling networks controlling such behaviours in human tumours ...

    • Diarrhea as a cause of mortality in a mouse model of infectious colitis 

      Borenshtein, Diana; Fry, Rebecca C; Groff, Elizabeth B; Nambiar, Prashant R; Carey, Vincent James; Fox, James G; Schauer, David B (BioMed Central, 2008)
      Background: Comparative characterization of genome-wide transcriptional changes during infection can help elucidate the mechanisms underlying host susceptibility. In this study, transcriptional profiling of the mouse ...