Now showing items 4683-4702 of 18424

    • Distinguishing direct versus indirect transcription factor–DNA interactions 

      Gordân, Raluca; Hartemink, Alexander J.; Bulyk, Martha L. (Cold Spring Harbor Laboratory Press, 2009)
      Transcriptional regulation is largely enacted by transcription factors (TFs) binding DNA. Large numbers of TF binding motifs have been revealed by ChIP-chip experiments followed by computational DNA motif discovery. However, ...
    • Distinguishing social and cultural features of cholera in urban and rural areas of Western Kenya: Implications for public health 

      Nyambedha, Erick Otieno; Sundaram, Neisha; Schaetti, Christian; Akeyo, Lilian; Chaignat, Claire-Lise; Hutubessy, Raymond; Weiss, Mitchell Gralnick (Informa UK Limited, 2013)
      Urban and rural areas have distinctive health problems, which require consideration. To examine sociocultural features of cholera and its community context, a semi-structured explanatory model interview based on vignettes ...
    • Distinguishing Untreated Osteoblastic Metastases From Enostoses Using CT Attenuation Measurements 

      Ulano, Adam; Bredella, Miriam A.; Burke, Patrick J; Chebib, Ivan Adel; Simeone, Frank J; Huang, Ambrose J.; Torriani, Martin P.; Chang, Connie Y. (American Roentgen Ray Society, 2016)
      Purpose: To determine if CT density thresholds of osteoblastic bone lesions can be used to distinguish untreated osteoblastic metastases from enostoses. Materials and Methods: The study group comprised 62 patients (37 ...
    • A distributed cell division counter reveals growth dynamics in the gut microbiota 

      Myhrvold, Cameron; Kotula, Jonathan W.; Hicks, Wade M.; Conway, Nicholas J.; Silver, Pamela A. (Nature Pub. Group, 2015)
      Microbial population growth is typically measured when cells can be directly observed, or when death is rare. However, neither of these conditions hold for the mammalian gut microbiota, and, therefore, standard approaches ...
    • Distributed Data Processing for Public Health Surveillance 

      Lazarus, Ross; Yih, Katherine Katherine; Platt, Richard (BioMed Central, 2006)
      Background: Many systems for routine public health surveillance rely on centralized collection of potentially identifiable, individual, identifiable personal health information (PHI) records. Although individual, identifiable ...
    • Distributed Health Data Networks 

      Brown, Jeffrey Stuart; Holmes, John H.; Shah, Kiran; Hall, Ken; Lazarus, Ross; Platt, Richard (Ovid Technologies (Wolters Kluwer Health), 2010)
      Background: Comparative effectiveness research, medical product safety evaluation, and quality measurement will require the ability to use electronic health data held by multiple organizations. There is no consensus about ...
    • Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population 

      Lim, Elaine T.; Würtz, Peter; Havulinna, Aki S.; Palta, Priit; Tukiainen, Taru; Rehnström, Karola; Esko, Tõnu; Mägi, Reedik; Inouye, Michael; Lappalainen, Tuuli; Chan, Yingleong; Salem, Rany M.; Lek, Monkol; Flannick, Jason; Sim, Xueling; Manning, Alisa; Ladenvall, Claes; Bumpstead, Suzannah; Hämäläinen, Eija; Aalto, Kristiina; Maksimow, Mikael; Salmi, Marko; Blankenberg, Stefan; Ardissino, Diego; Shah, Svati; Horne, Benjamin; McPherson, Ruth; Hovingh, Gerald K.; Reilly, Muredach P.; Watkins, Hugh; Goel, Anuj; Farrall, Martin; Girelli, Domenico; Reiner, Alex P.; Stitziel, Nathan O.; Kathiresan, Sekar; Gabriel, Stacey; Barrett, Jeffrey C.; Lehtimäki, Terho; Laakso, Markku; Groop, Leif; Kaprio, Jaakko; Perola, Markus; McCarthy, Mark I.; Boehnke, Michael; Altshuler, David M.; Lindgren, Cecilia M.; Hirschhorn, Joel N.; Metspalu, Andres; Freimer, Nelson B.; Zeller, Tanja; Jalkanen, Sirpa; Koskinen, Seppo; Raitakari, Olli; Durbin, Richard; MacArthur, Daniel G.; Salomaa, Veikko; Ripatti, Samuli; Daly, Mark J.; Palotie, Aarno (Public Library of Science, 2014)
      Exome sequencing studies in complex diseases are challenged by the allelic heterogeneity, large number and modest effect sizes of associated variants on disease risk and the presence of large numbers of neutral variants, ...
    • Distribution of [1,2-3H]cholesterol in mouse brain after injection in the suckling period 

      Hedley-Whyte, E. Tessa (Rockefeller University Press, 1975)
      Glutaraldehyde-carbohydrazide polymer (GACH) was used to embed olfactory tracts, trapezoid body, and sciatic nerves of 9-, 10-, and 49- day old mice 2 h, 24 h, and 6 wk (respectively) after the intraperitoneal administration ...
    • Distribution of Basement Membrane Molecules, Laminin and Collagen Type IV, in Normal and Degenerated Cartilage Tissues 

      Foldager, Casper Bindzus; Toh, Wei Seong; Gomoll, Andreas H.; Olsen, Bjørn Reino; Spector, Myron (SAGE Publications, 2014)
      Objective: The objective of the present study was to investigate the presence and distribution of 2 basement membrane (BM) molecules, laminin and collagen type IV, in healthy and degenerative cartilage tissues. Design: ...
    • Distribution of COL8A2 and COL8A1 gene variants in Caucasian primary open angle glaucoma patients with thin central corneal thickness 

      Desronvil, T.; Logan-Wyatt, D.; Abdrabou, W.; Triana, M.; Taheri, S.; Del Bono, E.; Olivier, M.; Jones, Richard Norman; Pasquale, Louis; Haines, J. L.; Fan, Baojian; Wiggs, Janey Lee (Molecular Vision, 2010)
      Purpose: One approach to identify genes that contribute to common complex ocular disorders such as primary open angle glaucoma (POAG) is to study the genetic determinates of endophenotypes that are defined by underlying ...
    • Distribution of Problems, Medications and Lab Results in Electronic Health Records: The Pareto Principle at Work 

      Bates, David; Wright, Adam (Georg Thieme Verlag KG, 2010)
      Background: Many natural phenomena demonstrate power-law distributions, where very common items predominate. Problems, medications and lab results represent some of the most important data elements in medicine, but their ...
    • Distribution, Amplitude, Incidence, Co-Occurrence, and Propagation of Human K-Complexes in Focal Transcortical Recordings1,2,3 

      Mak-McCully, Rachel A.; Rosen, Burke Q.; Rolland, Matthieu; Régis, Jean; Bartolomei, Fabrice; Rey, Marc; Chauvel, Patrick; Cash, Sydney S.; Halgren, Eric (Society for Neuroscience, 2015)
      Abstract K-complexes (KCs) are thought to play a key role in sleep homeostasis and memory consolidation; however, their generation and propagation remain unclear. The commonly held view from scalp EEG findings is that KCs ...
    • Disulfide Bonding among μ1 Trimers in Mammalian Reovirus Outer Capsid: a Late and Reversible Step in Virion Morphogenesis 

      Odegard, Amy L.; Chandran, Kartik; Liemann, Susanne; Harrison, Stephen C.; Nibert, Max L. (American Society for Microbiology, 2003)
      We examined how a particular type of intermolecular disulfide (ds) bond is formed in the capsid of a cytoplasmically replicating nonenveloped animal virus despite the normally reducing environment inside cells. The mu1 ...
    • Disulfide bridge formation between SecY and a translocating polypeptide localizes the translocation pore to the center of SecY 

      Cannon, Kurt S.; Or, Eran; Clemons, William M.; Shibata, Yoko; Rapoport, Tom A. (Rockefeller University Press, 2005)
      During their biosynthesis, many proteins pass through the membrane via a hydrophilic channel formed by the heterotrimeric Sec61/SecY complex. Whether this channel forms at the interface of multiple copies of Sec61/SecY or ...
    • Diurnal cortisol amplitude and fronto-limbic activity in response to stressful stimuli 

      Cunningham-Bussel, Amy Christine; Root, James C.; Butler, Tracy; Tuescher, Oliver; Pan, Hong; Epstein, Jane Ingrid; Weisholtz, Daniel; Pavony, Michelle; Silverman, Michael Gordon; Goldstein, Martin H.; Altemus, Margaret; Cloitre, Marylene; LeDoux, Joseph; McEwen, Bruce; Stern, Emily; Silbersweig, David A (Elsevier BV, 2009)
      The development and exacerbation of many psychiatric and neurologic conditions are associated with dysregulation of the hypothalamic pituitary adrenal (HPA) axis as measured by aberrant levels of cortisol secretion. Here ...
    • A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid utilization 

      Liu, Sihao; Brown, Jonathan D.; Stanya, Kristopher J.; Homan, Edwin; Leidl, Mathias; Inouye, Karen; Bhargava, Prerna; Gangl, Matthew R.; Dai, Lingling; Hatano, Ben; Hotamisligil, Gökhan S.; Saghatelian, Alan; Plutzky, Jorge; Lee, Chih-Hao (2014)
      Food intake increases the activity of hepatic de novo lipogenesis, which mediates the conversion of glucose to fats for storage or utilization. In mice, this program follows a circadian rhythm that peaks with nocturnal ...
    • Diurnal Variation in Retinal Thickening Measurement by Optical Coherence Tomography in Center-Involved Diabetic Macular Edema 

      Aiello, Lloyd Paul (American Medical Association, 2006)
      Objective: To evaluate diurnal variation in Optical Coherence Tomography (OCT) measured retinal thickness in patients with center-involved diabetic macular edema (DME). Methods: Serial OCT3 measurements were performed in ...
    • Diurnal Variations of Circulating Extracellular Vesicles Measured by Nano Flow Cytometry 

      Danielson, Kirsty M.; Estanislau, Jessica; Tigges, John; Toxavidis, Vasilis; Camacho, Virginia; Felton, Edward J.; Khoory, Joseph; Kreimer, Simion; Ivanov, Alexander R.; Mantel, Pierre-Yves; Jones, Jennifer; Akuthota, Praveen; Das, Saumya; Ghiran, Ionita (Public Library of Science, 2016)
      The identification of extracellular vesicles (EVs) as intercellular conveyors of biological information has recently emerged as a novel paradigm in signaling, leading to the exploitation of EVs and their contents as ...
    • Divergence of transcriptional landscape occurs early in B cell activation 

      Fowler, Trent; Garruss, Alexander S; Ghosh, Amalendu; De, Supriyo; Becker, Kevin G; Wood, William H; Weirauch, Matthew T; Smale, Stephen T; Aronow, Bruce; Sen, Ranjan; Roy, Ananda L (BioMed Central, 2015)
      Background: Signaling via B cell receptor (BCR) and Toll-like receptors (TLRs) results in activation of B cells with distinct physiological outcomes, but transcriptional regulatory mechanisms that drive activation and ...