Now showing items 4745-4764 of 18424

    • DNA methyltransferase 1 functions through C/ebpa to maintain hematopoietic stem and progenitor cells in zebrafish 

      Liu, Xiaohui; Jia, Xiaoe; Yuan, Hao; Ma, Ke; Chen, Yi; Jin, Yi; Deng, Min; Pan, Weijun; Chen, Saijuan; Chen, Zhu; de The, Hugues; Zon, Leonard I; Zhou, Yi; Zhou, Jun; Zhu, Jun (BioMed Central, 2015)
      Background: DNA methyltransferase 1 (Dnmt1) regulates expression of many critical genes through maintaining parental DNA methylation patterns on daughter DNA strands during mitosis. It is essential for embryonic development ...
    • DNA mismatch repair gene MSH6 implicated in determining age at natural menopause 

      Perry, John R.B.; Hsu, Yi-Hsiang; Chasman, Daniel I.; Johnson, Andrew D.; Elks, Cathy; Albrecht, Eva; Andrulis, Irene L.; Beesley, Jonathan; Berenson, Gerald S.; Bergmann, Sven; Bojesen, Stig E.; Bolla, Manjeet K.; Brown, Judith; Buring, Julie E.; Campbell, Harry; Chang-Claude, Jenny; Chenevix-Trench, Georgia; Corre, Tanguy; Couch, Fergus J.; Cox, Angela; Czene, Kamila; D'adamo, Adamo Pio; Davies, Gail; Deary, Ian J.; Dennis, Joe; Easton, Douglas F.; Engelhardt, Ellen G.; Eriksson, Johan G.; Esko, Tõnu; Fasching, Peter A.; Figueroa, Jonine D.; Flyger, Henrik; Fraser, Abigail; Garcia-Closas, Montse; Gasparini, Paolo; Gieger, Christian; Giles, Graham; Guenel, Pascal; Hägg, Sara; Hall, Per; Hayward, Caroline; Hopper, John; Ingelsson, Erik; Kardia, Sharon L.R.; Kasiman, Katherine; Knight, Julia A.; Lahti, Jari; Lawlor, Debbie A.; Magnusson, Patrik K.E.; Margolin, Sara; Marsh, Julie A.; Metspalu, Andres; Olson, Janet E.; Pennell, Craig E.; Polasek, Ozren; Rahman, Iffat; Ridker, Paul M.; Robino, Antonietta; Rudan, Igor; Rudolph, Anja; Salumets, Andres; Schmidt, Marjanka K.; Schoemaker, Minouk J.; Smith, Erin N.; Smith, Jennifer A.; Southey, Melissa; Stöckl, Doris; Swerdlow, Anthony J.; Thompson, Deborah J.; Truong, Therese; Ulivi, Sheila; Waldenberger, Melanie; Wang, Qin; Wild, Sarah; Wilson, James F; Wright, Alan F.; Zgaga, Lina; Ong, Ken K.; Murabito, Joanne M.; Karasik, David; Murray, Anna (Oxford University Press, 2013)
      The length of female reproductive lifespan is associated with multiple adverse outcomes, including breast cancer, cardiovascular disease and infertility. The biological processes that govern the timing of the beginning and ...
    • DNA Nanoswitches: A quantitative platform for gel-based biomolecular interaction analysis 

      Koussa, Mounir A; Halvorsen, Ken; Ward, Andrew; Wong, Wesley P (2014)
      We introduce a nanoscale experimental platform that enables kinetic and equilibrium measurements of a wide range of molecular interactions by expanding the functionality of gel electrophoresis. Programmable, self-assembled ...
    • DNA repair in species with extreme lifespan differences 

      MacRae, Sheila L.; Croken, Matthew McKnight; Calder, R.B.; Aliper, Alexander; Milholland, Brandon; White, Ryan R.; Zhavoronkov, Alexander; Gladyshev, Vadim N.; Seluanov, Andrei; Gorbunova, Vera; Zhang, Zhengdong D.; Vijg, Jan (Impact Journals LLC, 2015)
      Differences in DNA repair capacity have been hypothesized to underlie the great range of maximum lifespans among mammals. However, measurements of individual DNA repair activities in cells and animals have not substantiated ...
    • DNA Self-Assembly of Targeted Near-Infrared-Responsive Gold Nanoparticles for Cancer Thermo-Chemotherapy 

      Xiao, Zeyu; Ji, Changwei; Shi, Jinjun; Pridgen, Eric M; Frieder, Jillian; Farokhzad, Omid Cameron (WILEY-VCH Verlag, 2012)
      Targeted Cancer Therapy: Inspired by the ability of DNA hybridization, a targeted near-infrared (NIR) light-responsive delivery system has been developed through simple DNA self-assembly (PEG=polyethylene glycol). This ...
    • DNA Sequence Variants in PPARGC1A, a Gene Encoding a Coactivator of the ω-3 LCPUFA Sensing PPAR-RXR Transcription Complex, Are Associated with NV AMD and AMD-Associated Loci in Genes of Complement and VEGF Signaling Pathways 

      SanGiovanni, John Paul; Chen, Jing; Sapieha, Przemyslaw; Aderman, Christopher; Stahl, Andreas; Clemons, Traci E.; Chew, Emily Y.; Smith, Lois Elaine Hodgson (Public Library of Science (PLoS), 2013)
      BACKGROUND: Increased intake of ω-3 long-chain polyunsaturated fatty acids (LCPUFAs) and use of peroxisome proliferator activator receptor (PPAR)-activating drugs are associated with attenuation of pathologic retinal ...
    • DNA Sequence Variants in the LOXL1 Gene are Associated with Pseudoexfoliation Glaucoma in a U.S. Clinic-Based Population with Broad Ethnic Diversity 

      del Bono, Elizabeth; Haines, Jonathan L; Fan, Baojian; Pasquale, Louis; Grosskreutz, Cynthia Lee; Rhee, Douglas J.; Chen, Teresa Chia-Ching; DeAngelis, Margaret M.; Kim, Ivana Kyung; Miller, Joan Whitten; Li, Tiansen; Wiggs, Janey Lee (BioMed Central, 2008)
      Background: Pseudoexfoliation syndrome is a major risk factor for glaucoma in many populations throughout the world. Using a U.S. clinic-based case control sample with broad ethnic diversity, we show that three common SNPs ...
    • A DNA target-enrichment approach to detect mutations, copy number changes and immunoglobulin translocations in multiple myeloma 

      Bolli, N; Li, Y; Sathiaseelan, V; Raine, K; Jones, D; Ganly, P; Cocito, F; Bignell, G; Chapman, M A; Sperling, A S; Anderson, K C; Avet-Loiseau, H; Minvielle, S; Campbell, P J; Munshi, N C (Nature Publishing Group, 2016)
      Genomic lesions are not investigated during routine diagnostic workup for multiple myeloma (MM). Cytogenetic studies are performed to assess prognosis but with limited impact on therapeutic decisions. Recently, several ...
    • A DNA-based molecular probe for optically reporting cellular traction forces 

      Blakely, Brandon L.; Dumelin, Christoph E.; Trappmann, Britta; McGregor, Lynn M.; Choi, Colin K.; Anthony, Peter C.; Duesterberg, Van K.; Baker, Brendon M.; Block, Steven M.; Liu, David R.; Chen, Christopher S. (2014)
      We developed molecular tension probes (TPs) that report traction forces of adherent cells with high spatial resolution, can be linked to virtually any surface, and obviate monitoring deformations of elastic substrates. TPs ...
    • DNA-Binding and -Bending Activities of SAP30L and SAP30 Are Mediated by a Zinc-Dependent Module and Monophosphoinositides 

      Viiri, Keijo M.; Jänis, Janne; Siggers, Trevor; Heinonen, Taisto K.; Valjakka, Jarkko; Bulyk, Martha L.; Mäki, Markku; Lohi, Olli (American Society for Microbiology, 2009)
      Deacetylation of histones is carried out by a corepressor complex in which Sin3A is an essential scaffold protein. Two proteins in this complex, the Sin3A-associated proteins SAP30L and SAP30, have previously been suggested ...
    • DNA-loop extruding SMC complexes can traverse one another in vivo 

      Wang, Xindan; Brandão, Hugo; Ren, Zhongqing; Karaboja, Xheni; Mirny, Leonid (Research Square Platform LLC, 2021-01-06)
      Chromosome organization by structural maintenance of chromosomes (SMC) complexes is vital to living organisms. SMC complexes were recently found to be motors that extrude DNA loops. However, it remains unclear what happens ...
    • DNA-Protein Interactions in High Definition 

      Mendenhall, Eric M; Bernstein, Bradley E. (BioMed Central, 2012)
      An elegant, genome-wide approach to define the precise DNA sequences bound by transcription factors has been developed by Rhee and Pugh.
    • DNAvisualization.org: A Serverless Web Tool for DNA Sequence Visualization 

      Lee, Benjamin; Timony, Michael; Ruiz, Pablo (Oxford University Press, 2019-07-02)
      Raw DNA sequences contain an immense amount of meaningful biological information. However, these sequences are hard for humans to intuitively interpret. To solve this problem, a number of methods have been proposed to ...
    • DNMT1-interacting RNAs block gene specific DNA methylation 

      Di Ruscio, Annalisa; Ebralidze, Alexander K.; Benoukraf, Touati; Amabile, Giovanni; Goff, Loyal A.; Terragni, Joylon; Figueroa, Maria Eugenia; De Figureido Pontes, Lorena Lobo; Alberich-Jorda, Meritxell; Zhang, Pu; Wu, Mengchu; D’Alò, Francesco; Melnick, Ari; Leone, Giuseppe; Ebralidze, Konstantin K.; Pradhan, Sriharsa; Rinn, John L.; Tenen, Daniel G. (2013)
      Summary DNA methylation was described almost a century ago. However, the rules governing its establishment and maintenance remain elusive. Here, we present data demonstrating that active transcription regulates levels of ...
    • Do Ask, Do Tell: High Levels of Acceptability by Patients of Routine Collection of Sexual Orientation and Gender Identity Data in Four Diverse American Community Health Centers 

      Cahill, Sean; Singal, Robbie; Grasso, Chris; King, Dana; Mayer, Kenneth; Baker, Kellan; Makadon, Harvey (Public Library of Science, 2014)
      Background: The Institute of Medicine and The Joint Commission have recommended asking sexual orientation and gender identity (SOGI) questions in clinical settings and including such data in Electronic Health Records (EHRs). ...
    • Do Atypical Antipsychotics Have Antisuicidal Effects? A Hypothesis-Generating Overview 

      Pompili, Maurizio; Baldessarini, Ross J.; Forte, Alberto; Erbuto, Denise; Serafini, Gianluca; Fiorillo, Andrea; Amore, Mario; Girardi, Paolo (MDPI, 2016)
      Modern antipsychotic drugs are employed increasingly in the treatment of mood disorders as well as psychoses, stimulating interest in their possible contributions to altering suicidal risk. Clozapine remains the only ...
    • Do biologic markers predict cardiovascular end points in diabetic end-stage renal disease? A prospective longitudinal study 

      Bayliss, George P.; Weinrauch, Larry A.; Gleason, Ray E.; Lee, Annette T.; D'Elia, John A. (Oxford University Press, 2013)
      Background: Diabetic patients on hemodialysis are at high risk of death from cardiovascular disease, and research has suggested that various biologic markers of inflammation, oxidative stress and hemostasis may give added ...
    • Do Cyclosporine A, an IL-1 Receptor Antagonist, Uridine Triphosphate, Rebamipide, and/or Bimatoprost Regulate Human Meibomian Gland Epithelial Cells? 

      Kam, Wendy R.; Liu, Yang; Ding, Juan; Sullivan, David A. (The Association for Research in Vision and Ophthalmology, 2016)
      Purpose Researchers have hypothesized that treatment with cyclosporine A (CyA), interleukin-1 receptor antagonists (IL-1RA; e.g., anakinra), P2Y2 receptor agonists (e.g., uridine triphosphate; UTP), and rebamipide may ...
    • Do design variations in the artificial disc influence cervical spine biomechanics? A finite element investigation 

      Faizan, Ahmad; Goel, Vijay K.; Garfin, Steven R.; Bono, Christopher M; Serhan, Hassan; Biyani, Ashok; Elgafy, Hossein; Krishna, Manoj; Friesem, Tai (Springer-Verlag, 2009)
      Various ball and socket-type designs of cervical artificial discs are in use or under investigation. Many artificial disc designs claim to restore the normal kinematics of the cervical spine. What differentiates one type ...
    • Do Diabetic Patients with Acute Coronary Syndromes Have a Higher Threshold for Ischemic Pain? 

      Nicolau, José Carlos; Barbosa, Carlos José Dornas Gonçalves; Franci, André; Baracioli, Luciano Moreira; Franken, Marcelo; Lima, Felipe Gallego; Giraldez, Roberto Rocha; Kalil Filho, Roberto; Ramires, José Antônio Franchini; Giugliano, Robert P. (Sociedade Brasileira de Cardiologia, 2014)
      Background: Data from over 4 decades have reported a higher incidence of silent infarction among patients with diabetes mellitus (DM), but recent publications have shown conflicting results regarding the correlation between ...