Browsing Harvard Medical School by Title
Now showing items 4911-4930 of 18428
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Drug Adverse Event Detection in Health Plan Data Using the Gamma Poisson Shrinker and Comparison to the Tree-based Scan Statistic
(MDPI, 2013)Background: Drug adverse event (AE) signal detection using the Gamma Poisson Shrinker (GPS) is commonly applied in spontaneous reporting. AE signal detection using large observational health plan databases can expand ... -
The Drug Data to Knowledge Pipeline: Large-Scale Claims Data Classification for Pharmacologic Insight
(American Medical Informatics Association, 2016)In biomedical informatics, assigning drug codes to categories is a common step in the analysis pipeline. Unfortunately, incomplete mappings are the norm rather than the exception with coverage values less than 85% not ... -
Drug Delivery Approaches for the Treatment of Cervical Cancer
(MDPI, 2016)Cervical cancer is a highly prevalent cancer that affects women around the world. With the availability of new technologies, researchers have increased their efforts to develop new drug delivery systems in cervical cancer ... -
A Drug Delivery System for Administration of Anti–TNF-α Antibody
(The Association for Research in Vision and Ophthalmology, 2016)Purpose To describe the fabrication, evaluation, and preliminary in vivo safety of a new drug delivery system (DDS) for topical anti–TNF-α antibody administration. Methods: A DDS was fabricated using inverse template ... -
Drug delivery systems in urology—getting “smarter”
(Elsevier BV, 2006)Urology holds the most enviable position in the medical firmament. Unique among specialties in bringing the surgeon in contact with humans throughout the spectrum of human life—from newborn to geriatric patients—urologists ... -
Drug delivery, biomaterials and nanomedicine: an interview with Daniel S Kohane
(Future Science Ltd, 2016)Daniel Kohane speaks to Francesca Lake, Managing Editor: Obtaining his MD and PhD in Physiology from Boston University (MA, USA), Dan Kohane went on to complete residencies in Pediatrics at Boston Children’s Hospital (MA, ... -
Drug Induced Liver Injury: Review with a Focus on Genetic Factors, Tissue Diagnosis, and Treatment Options
(XIA & HE Publishing Ltd, 2015)Drug-induced liver injury (DILI) is a rare but potentially life threatening adverse drug reaction. DILI may mimic any morphologic characteristic of acute or chronic liver disease, and the histopathologic features of DILI ... -
Drug Rash with Eosinophilia and Systemic Symptoms: Two Emergency Department Cases
(University of California, Irvine, 2011)Drug rash with eosinophilia and systemic symptoms (DRESS) is a rare, severe adverse drug event that appears with a generalized rash, fevers, and dysfunction of 1 or more organ systems. We describe 2 patients (1 adult and ... -
Drug Resistance in Cancer: An Overview
(MDPI, 2014)Cancers have the ability to develop resistance to traditional therapies, and the increasing prevalence of these drug resistant cancers necessitates further research and treatment development. This paper outlines the current ... -
Drug Resistance Mutations for Surveillance of Transmitted HIV-1 Drug-Resistance: 2009 Update
(Public Library of Science, 2009)Programs that monitor local, national, and regional levels of transmitted HIV-1 drug resistance inform treatment guidelines and provide feedback on the success of HIV-1 treatment and prevention programs. To accurately ... -
Drug Safety in the Digital Age
(New England Journal of Medicine (NEJM/MMS), 2014) -
Drug Screening Boosted by Hyperpolarized Long-Lived States in NMR
(WILEY-VCH Verlag, 2014)Transverse and longitudinal relaxation times (T1ρ and T1) have been widely exploited in NMR to probe the binding of ligands and putative drugs to target proteins. We have shown recently that long-lived states (LLS) can be ... -
Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval
(2013)Variability in response to drug use is common and heritable, suggesting that genome-wide pharmacogenomics studies may help explain the “missing heritability” of complex traits. Here, we describe four independent analyses ... -
Drug-induced reactive oxygen species (ROS) rely on cell membrane properties to exert anticancer effects
(Nature Publishing Group, 2016)Pharmacological concentrations of small molecule natural products, such as ascorbic acid, have exhibited distinct cell killing outcomes between cancer and normal cells whereby cancer cells undergo apoptosis or necrosis ... -
Drug-Related Hyponatremic Encephalopathy: Rapid Clinical Response Averts Life-Threatening Acute Cerebral Edema
(International Scientific Literature, Inc., 2016)Patient: Female, 63 Final Diagnosis: Drug-induced hyponatremic encephalopathy Symptoms: Seizures • coma Medication: Hypertonic 3% saline infusion Clinical Procedure: — Specialty: Internal Medicine Objective: Unusual clinical ... -
Drug-Resistant Tuberculosis among HIV-Infected Patients Starting Antiretroviral Therapy in Durban, South Africa
(Public Library of Science, 2012)Objective: To estimate the prevalence of drug-resistant tuberculosis (TB) and describe the resistance patterns in patients commencing antiretroviral therapy (ART) in an HIV clinic in Durban, South Africa. Design ... -
Drug-sensitive FGFR2 mutations in endometrial carcinoma
(National Academy of Sciences, 2008)Oncogenic activation of tyrosine kinases is a common mechainism of carcinogenesis and, given the druggable nature of these enzymes, an attractive target for anticancer therapy. Here, we show that somatic mutations of the ... -
Drug-target identification in Drosophila cells: combining high-throughout RNAi and small-molecule screens
(Elsevier, 2007)RNA interference (RNAi) and small-molecule approaches are synergistic on multiple levels, from technology and high-throughput screen development to target identification and functional studies. Here, we describe the RNAi ... -
Dry Eye Disease Patients with Xerostomia Report Higher Symptom Load and Have Poorer Meibum Expressibility
(Public Library of Science, 2016)The purpose of the study was to investigate if xerostomia (dry mouth) is associated with symptoms and signs of dry eye disease (DED). At the Norwegian Dry Eye Clinic, patients with symptomatic DED with different etiologies ... -
Dry Eye Disease: an immune-mediated ocular surface disorder
(American Medical Association (AMA), 2012)Dry eye disease is a multifactorial disorder of the tears and ocular surface characterized by symptoms of dryness and irritation. Although the pathogenesis of dry eye disease is not fully understood, it is recognized that ...