Browsing Harvard Medical School by Title
Now showing items 4916-4935 of 18428
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Drug delivery, biomaterials and nanomedicine: an interview with Daniel S Kohane
(Future Science Ltd, 2016)Daniel Kohane speaks to Francesca Lake, Managing Editor: Obtaining his MD and PhD in Physiology from Boston University (MA, USA), Dan Kohane went on to complete residencies in Pediatrics at Boston Children’s Hospital (MA, ... -
Drug Induced Liver Injury: Review with a Focus on Genetic Factors, Tissue Diagnosis, and Treatment Options
(XIA & HE Publishing Ltd, 2015)Drug-induced liver injury (DILI) is a rare but potentially life threatening adverse drug reaction. DILI may mimic any morphologic characteristic of acute or chronic liver disease, and the histopathologic features of DILI ... -
Drug Rash with Eosinophilia and Systemic Symptoms: Two Emergency Department Cases
(University of California, Irvine, 2011)Drug rash with eosinophilia and systemic symptoms (DRESS) is a rare, severe adverse drug event that appears with a generalized rash, fevers, and dysfunction of 1 or more organ systems. We describe 2 patients (1 adult and ... -
Drug Resistance in Cancer: An Overview
(MDPI, 2014)Cancers have the ability to develop resistance to traditional therapies, and the increasing prevalence of these drug resistant cancers necessitates further research and treatment development. This paper outlines the current ... -
Drug Resistance Mutations for Surveillance of Transmitted HIV-1 Drug-Resistance: 2009 Update
(Public Library of Science, 2009)Programs that monitor local, national, and regional levels of transmitted HIV-1 drug resistance inform treatment guidelines and provide feedback on the success of HIV-1 treatment and prevention programs. To accurately ... -
Drug Safety in the Digital Age
(New England Journal of Medicine (NEJM/MMS), 2014) -
Drug Screening Boosted by Hyperpolarized Long-Lived States in NMR
(WILEY-VCH Verlag, 2014)Transverse and longitudinal relaxation times (T1ρ and T1) have been widely exploited in NMR to probe the binding of ligands and putative drugs to target proteins. We have shown recently that long-lived states (LLS) can be ... -
Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval
(2013)Variability in response to drug use is common and heritable, suggesting that genome-wide pharmacogenomics studies may help explain the “missing heritability” of complex traits. Here, we describe four independent analyses ... -
Drug-induced reactive oxygen species (ROS) rely on cell membrane properties to exert anticancer effects
(Nature Publishing Group, 2016)Pharmacological concentrations of small molecule natural products, such as ascorbic acid, have exhibited distinct cell killing outcomes between cancer and normal cells whereby cancer cells undergo apoptosis or necrosis ... -
Drug-Related Hyponatremic Encephalopathy: Rapid Clinical Response Averts Life-Threatening Acute Cerebral Edema
(International Scientific Literature, Inc., 2016)Patient: Female, 63 Final Diagnosis: Drug-induced hyponatremic encephalopathy Symptoms: Seizures • coma Medication: Hypertonic 3% saline infusion Clinical Procedure: — Specialty: Internal Medicine Objective: Unusual clinical ... -
Drug-Resistant Tuberculosis among HIV-Infected Patients Starting Antiretroviral Therapy in Durban, South Africa
(Public Library of Science, 2012)Objective: To estimate the prevalence of drug-resistant tuberculosis (TB) and describe the resistance patterns in patients commencing antiretroviral therapy (ART) in an HIV clinic in Durban, South Africa. Design ... -
Drug-sensitive FGFR2 mutations in endometrial carcinoma
(National Academy of Sciences, 2008)Oncogenic activation of tyrosine kinases is a common mechainism of carcinogenesis and, given the druggable nature of these enzymes, an attractive target for anticancer therapy. Here, we show that somatic mutations of the ... -
Drug-target identification in Drosophila cells: combining high-throughout RNAi and small-molecule screens
(Elsevier, 2007)RNA interference (RNAi) and small-molecule approaches are synergistic on multiple levels, from technology and high-throughput screen development to target identification and functional studies. Here, we describe the RNAi ... -
Dry Eye Disease Patients with Xerostomia Report Higher Symptom Load and Have Poorer Meibum Expressibility
(Public Library of Science, 2016)The purpose of the study was to investigate if xerostomia (dry mouth) is associated with symptoms and signs of dry eye disease (DED). At the Norwegian Dry Eye Clinic, patients with symptomatic DED with different etiologies ... -
Dry Eye Disease: an immune-mediated ocular surface disorder
(American Medical Association (AMA), 2012)Dry eye disease is a multifactorial disorder of the tears and ocular surface characterized by symptoms of dryness and irritation. Although the pathogenesis of dry eye disease is not fully understood, it is recognized that ... -
DSD and Professionalism from a Multilateral View: Supplementing the Consensus Statement on the Basis of a Qualitative Survey
(Hindawi Publishing Corporation, 2012)Treatment and support of a child with DSD calls for experience and expertise in diagnosis, surgical techniques, understanding of psychosocial issues, and recognizing and accepting the significance of individual values of ... -
DTI and MTR abnormalities in schizophrenia: Analysis of white matter integrity
(Elsevier BV, 2005)Diffusion tensor imaging (DTI) studies in schizophrenia demonstrate lower anisotropic diffusion within white matter due either to loss of coherence of white matter fiber tracts, to changes in the number and/or density of ... -
A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice
(2016)Many genetic liver diseases present in newborns with repeated, often lethal, metabolic crises. Gene therapy using non-integrating viruses such as AAV is not optimal in this setting because the non-integrating genome is ... -
Dual Adaptive Filtering by Optimal Projection Applied to Filter Muscle Artifacts on EEG and Comparative Study
(Hindawi Publishing Corporation, 2014)Muscle artifacts constitute one of the major problems in electroencephalogram (EEG) examinations, particularly for the diagnosis of epilepsy, where pathological rhythms occur within the same frequency bands as those of ... -
Dual CD4-based CAR T cells with distinct costimulatory domains mitigate HIV pathogenesis in vivo
(Springer Science and Business Media LLC, 2020-08-31)A potent and sustained antiviral T cell response will likely be a critical component of an effective HIV cure strategy. Here, we explored the utility of CD4-based Chimeric Antigen Receptor (CAR) T cells to mitigate HIV-induced ...