Browsing Harvard Medical School by Title
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Affinity Inequality among Serum Antibodies That Originate in Lymphoid Germinal Centers
(Public Library of Science, 2015)Upon natural infection with pathogens or vaccination, antibodies are produced by a process called affinity maturation. As affinity maturation ensues, average affinity values between an antibody and ligand increase with ... -
Affinity maturation in an HIV broadly neutralizing B-cell lineage through reorientation of variable domains
(National Academy of Sciences, 2014)Rapidly evolving pathogens, such as human immunodeficiency and influenza viruses, escape immune defenses provided by most vaccine-induced antibodies. Proposed strategies to elicit broadly neutralizing antibodies require a ... -
An affinity-based scoring scheme for predicting DNA-binding activities of modularly assembled zinc-finger proteins
(Oxford University Press, 2009)Zinc-finger proteins (ZFPs) have long been recognized for their potential to manipulate genetic information because they can be engineered to bind novel DNA targets. Individual zinc-finger domains (ZFDs) bind specific DNA ... -
An affinity-structure database of helix-turn-helix: DNA complexes with a universal coordinate system
(BioMed Central, 2015)Background: Molecular interactions between proteins and DNA molecules underlie many cellular processes, including transcriptional regulation, chromosome replication, and nucleosome positioning. Computational analyses of ... -
Affordability of health care under publicly subsidized insurance after Massachusetts health care reform: a qualitative study of safety net patients
(BioMed Central, 2015)Introduction: The Affordable Care Act (ACA) and the 2006 Massachusetts (MA) health reform law, on which the ACA was based, aimed to improve the affordability of care largely by expanding publicly sponsored insurances. Both ... -
African Ancestry and Its Correlation to Type 2 Diabetes in African Americans: A Genetic Admixture Analysis in Three U.S. Population Cohorts
(Public Library of Science, 2012)The risk of type 2 diabetes is approximately 2-fold higher in African Americans than in European Americans even after adjusting for known environmental risk factors, including socioeconomic status (SES), suggesting that ... -
After abduction: exploring access to reintegration programs and mental health status among young female abductees in Northern Uganda
(BioMed Central, 2014)Background: Reintegration programs are commonly offered to former combatants and abductees to acquire civilian status and support services to reintegrate into post-conflict society. Among a group of young female abductees ... -
After Adoption: Sustaining the Innovation A Case Study of Disseminating the Hospital Elder Life Program
(Wiley-Blackwell, 2005)OBJECTIVES: To examine key factors that influence sustainability in the diffusion of the Hospital Elder Life Program (HELP) as an example of an evidence-based, multifaceted, innovative program to improve care for hospitalized ... -
Age and Gender Moderate the Impact of Early Palliative Care in Metastatic Non-Small Cell Lung Cancer
(AlphaMed Press, 2016)Background. Studies demonstrate that early palliative care (EPC) improves advanced cancer patients’ quality of life (QOL) and mood. However, it remains unclear whether the role of palliative care differs based upon patients’ ... -
Age and Sex Dependent Variations in Knee Anatomy During Skeletal Maturation in Children and Adolescents
(2016-05-18)Knee joint is the most common site of injury in children and adolescents and accounts for up to 60% of all sports-related injuries in this population. Ruptures of the anterior cruciate ligament (ACL) are among the most ... -
Age at Developmental Cortical Injury Differentially Alters Corpus Callosum Volume in the Rat
(BioMed Central, 2007)Background: Freezing lesions to developing rat cortex induced between postnatal day (P) one and three (P1 – 3) lead to malformations similar to human microgyria, and further correspond to reductions in brain weight and ... -
Age cutoff for Epstein-Barr virus-positive diffuse large B-cell lymphoma–is it necessary?
(Impact Journals LLC, 2015)Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly (EBV+ DLBCL-e) is a molecularly distinct variant of DLBCL, characterized by a monoclonal B-cell proliferation that occurs in patients >50 years of ... -
Age Differences in the Required Coefficient of Friction During Level Walking Do Not Exist When Experimentally-Controlling Speed and Step Length
(Human Kinetics, 2014)The effects of gait speed and step length on the required coefficient of friction (COF) confounds the investigation of age-related differences in required COF. The goals of this study were to investigate whether age ... -
Age Is the Only Predictor of Poor Bowel Preparation in the Hospitalized Patient
(Hindawi Publishing Corporation, 2016)We examine the impact of key variables on the likelihood of inpatient poor bowel preparation for colonoscopy. Records of inpatients that underwent colonoscopy at our institution between January 2010 and December 2011 were ... -
Age, Tumor Characteristics, and Treatment Regimen as Event Predictors in Ewing: A Children's Oncology Group Report
(Hindawi Publishing Corporation, 2015)Purpose. To associate baseline patient characteristics and relapse across consecutive COG studies. Methods:. We analyzed risk factors for LESFT patients in three randomized COG trials. We evaluated age at enrollment, primary ... -
Age- and Gender-Associated Differences in Electrical Impedance Values of Skeletal Muscle
(IOP Publishing, 2013)Electrical impedance measurements of skeletal muscle may be sensitive to age-associated declines in muscle health. In an effort to evaluate this concept further, we performed electrical impedance myography (EIM) using a ... -
Age- and Gender-Related Differences in Ischemia/Reperfusion Injury and Cardioprotection: Effects of Diazoxide
(Elsevier BV, 2006)Background Recent studies have demonstrated that aging is associated with reduced tolerance to ischemia and that the aged (not senescent) female heart has greater susceptibility to ischemia as compared with the aged ... -
Age- and Gender-Related Differences in Mitochondrial Oxygen Consumption and Calcium With Cardioplegia and Diazoxide
(Elsevier BV, 2007)Background We have recently shown that the cardioprotection afforded by cardioplegia is affected by age and gender and is less effective in the aged female rabbit heart compared with the aged male rabbit heart. We ... -
Age- and Pregnancy-Associated DNA Methylation Changes in Mammary Epithelial Cells
(Elsevier, 2015)Summary Postnatal mammary gland development and differentiation occur during puberty and pregnancy. To explore the role of DNA methylation in these processes, we determined the genome-wide DNA methylation and gene expression ... -
Age-adjusted nonparametric detection of differential DNA methylation with case–control designs
(BioMed Central, 2013)Background: DNA methylation profiles differ among disease types and, therefore, can be used in disease diagnosis. In addition, large-scale whole genome DNA methylation data offer tremendous potential in understanding the ...