Browsing Harvard Medical School by Title
Now showing items 5154-5173 of 18426
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Effect of Dietary Composition of Weight Loss Diets on High Sensitivity C-Reactive Protein: The Randomized POUNDS LOST Trial
(2012)Overweight and obesity are associated with increased high sensitivity C-reactive protein (hsCRP) levels. The purpose of this study was to determine if weight loss diets differing in fat, protein, or carbohydrate composition ... -
The Effect of Dimethyl Fumarate on Cerebral Gray Matter Atrophy in Multiple Sclerosis
(Springer Healthcare, 2016)Introduction: The objective of this pilot study was to compare cerebral gray matter (GM) atrophy over 1 year in patients starting dimethyl fumarate (DMF) for multiple sclerosis (MS) to that of patients on no disease-modifying ... -
The Effect of Dose and Timing of Dose on the Association between Airborne Particles and Survival
(2008)BACKGROUND: Understanding the shape of the concentration–response curve for particles is important for public health, and lack of such understanding was recently cited by U.S. Environmental Protection Agency (EPA) as a ... -
Effect of Environmental Tobacco Smoke on Levels of Urinary Hormone Markers
(National Institute of Environmental Health Sciences, 2005)Our recent study showed a dose–response relationship between environmental tobacco smoke (ETS) and the risk of early pregnancy loss. Smoking is known to affect female reproductive hormones. We explored whether ETS affects ... -
The Effect of Fingolimod on Conversion of Acute Gadolinium-Enhancing Lesions to Chronic T1 Hypointensities in Multiple Sclerosis
(Wiley-Blackwell, 2015)BACKGROUND: Brain lesions converting to chronic T1 hypointensities (“chronic black holes” [CBH]), indicate severe tissue destruction (axonal loss and irreversible demyelination) in multiple sclerosis (MS). Two mechanisms ... -
Effect of follower load on motion and stiffness of the human thoracic spine with intact rib cage
(Elsevier BV, 2016)Researchers have reported on the importance of the rib cage in maintaining mechanical stability in the thoracic spine and on the validity of a compressive follower preload. However, dynamic mechanical testing using both ... -
Effect of FXIII on Monocyte and Fibroblast Function
(Karger Publishers Open Access, 2007)Factor XIII is a plasma transglutaminase that participates in the final stage of the coagulation cascade. Thrombin-activated FXIII (FXIIIa) catalyzes the formation of covalent crosslinks between gamma-glutamyl and epsilon-lysyl ... -
Effect of Gait Speed on Gait Rhythmicity in Parkinson's Disease: Variability of Stride Time and Swing Time Respond Differently
(BioMed Central, 2005)Background: The ability to maintain a steady gait rhythm is impaired in patients with Parkinson's disease (PD). This aspect of locomotor dyscontrol, which likely reflects impaired automaticity in PD, can be quantified by ... -
Effect of gastrointestinal resection on sunitinib exposure in patients with GIST
(BioMed Central, 2014)Background: GIST patients often undergo GI-surgery. Previous studies have shown that imatinib and nilotinib exposures were decreased in GIST patients with prior major gastrectomy. We investigated whether major gastrectomy ... -
Effect of Glycemic Treatment and Microvascular Complications on Menopause in Women With Type 1 Diabetes in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Cohort
(American Diabetes Association, 2014)OBJECTIVE We examined the impact of intensive versus conventional diabetes treatment upon menopause among women with type 1 diabetes in the Diabetes Control and Complications Trial (DCCT), a randomized controlled trial of ... -
The Effect of Hepatitis C Virologic Clearance on Cardiovascular Disease Biomarkers in Human Immunodeficiency Virus/Hepatitis C Virus Coinfection
(Oxford University Press, 2014)Background: Successful hepatitis C virus (HCV) treatment may reduce cardiovascular disease (CVD) risk and improve levels of CVD biomarkers produced outside the liver (nonhepatic biomarkers). Methods: Stored serum or plasma ... -
Effect of Homocysteine-Lowering Treatment With Folic Acid and B Vitamins on Risk of Type 2 Diabetes in Women
(American Diabetes Association, 2009)OBJECTIVE: Homocysteinemia may play an etiologic role in the pathogenesis of type 2 diabetes by promoting oxidative stress, systemic inflammation, and endothelial dysfunction. We investigated whether homocysteine-lowering ... -
The effect of hospital care on early survival after penetrating trauma
(Springer International Publishing, 2014)Background: The effectiveness of emergency medical interventions can be best evaluated using time-to-event statistical methods with time-varying covariates (TVC), but this approach is complicated by uncertainty about the ... -
The Effect of Hospital Volume on Mortality in Patients Admitted with Severe Sepsis
(Public Library of Science, 2014)Importance The association between hospital volume and inpatient mortality for severe sepsis is unclear. Objective: To assess the effect of severe sepsis case volume and inpatient mortality. Design Setting and Participants ... -
The Effect of Human Genetic Variation on CRISPR Targeting Specificity
(2018-05-15)The clustered regularly interspaced short palindromic repeats (CRISPR) nuclease system offers the ability for unprecedented functional genetic experiments and the promise for therapy of a variety of genetic disorders. The ... -
The Effect of Hydrostatic Pressure on Three-Dimensional Chondroinduction of Human Adipose–Derived Stem Cells
(Mary Ann Liebert Inc, 2009)Background: The optimal production of three-dimensional cartilage in vitro requires both inductive factors and specified culture conditions (e.g., hydrostatic pressure [HP], gas concentration, and nutrient supply) to promote ... -
The Effect of Hypercarbia and Hyperoxia on the Total Blood Flow to the Retina as Assessed by Magnetic Resonance Imaging
(Association for Research in Vision and Ophthalmology (ARVO), 2011-08-29)Purpose: The feasibility of measuring total blood flow to the retina with Arterial Spin Labeling Magnetic Resonance Imaging (ASL-MRI) has been described previously. In the present study, the hypothesis was that the reactivity ... -
Effect of Illicit Direct to Consumer Advertising on Use of Etanercept, Mometasone, and Tegaserod in Canada: Controlled Longitudinal Study
(BMJ Publishing Group Ltd., 2008)Objective: To assess the impact of direct to consumer advertising of prescription drugs in the United States on Canadian prescribing rates for three heavily marketed drugs—etanercept, mometasone, and tegaserod. Design: ... -
Effect of incentives on insecticide-treated bed net use in sub-Saharan Africa: a cluster randomized trial in Madagascar
(BioMed Central, 2010)Background: Insecticide-treated bed nets (ITNs) have been shown to reduce morbidity and mortality due to malaria in sub-Saharan Africa. Strategies using incentives to increase ITN use could be more efficient than traditional ... -
Effect of Inhibition of Angiotensin-Converting Enzyme and/or Neutral Endopeptidase on Neuropathy in High-Fat-Fed C57Bl/6J Mice
(Hindawi Publishing Corporation, 2012)We have demonstrated that treating diet-induced obese (DIO) mice with the vasopeptidase inhibitor ilepatril improved neural function. Vasopeptidase inhibitors block angiotensin-converting enzyme (ACE) and neutral endopeptidase ...