Browsing Harvard Medical School by Title
Now showing items 5434-5453 of 18424
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Efficacy and Safety of Vorapaxar as Approved for Clinical Use in the United States
(Blackwell Publishing Ltd, 2015)Background: Vorapaxar is a protease‐activated receptor‐1 antagonist approved by the U.S. Food and Drug Administration (FDA) for the reduction of thrombotic cardiovascular (CV) events in patients with a history of myocardial ... -
The efficacy and safety profile of albumin administration for patients with cirrhosis at high risk of hepatorenal syndrome is dose dependent
(Oxford University Press, 2015)Background: Albumin is a critical component in the standard therapeutic approach to acute renal failure (ARF) and spontaneous bacterial peritonitis (SBP) in the setting of ascites. However, data regarding the safety and ... -
Efficacy of a group-based dietary intervention for limiting gestational weight gain among obese women: a randomized trial
(2014)Objective: Observational studies suggest that minimal gestational weight gain (GWG) may optimize pregnancy outcomes for obese women. This trial tested the efficacy of a group-based weight management intervention for limiting ... -
The efficacy of a lysine-based dendritic hydrogel does not differ from those of commercially available tissue sealants and adhesives: an ex vivo study
(BioMed Central, 2015)Background: Hemostatic agents, tissue adhesives and sealants may contribute to a reduction in hemorrhage-associated morbidity and mortality. Towards this end, we have recently developed a lysine-based dendritic hydrogel ... -
Efficacy of Antibody to PNAG Against Keratitis Caused by Fungal Pathogens
(The Association for Research in Vision and Ophthalmology, 2016)Purpose Developing immunotherapies for fungal eye infections is a high priority. We analyzed fungal pathogens for expression of the surface polysaccharide, poly-N-acetyl glucosamine (PNAG), and used a mouse model of ocular ... -
Efficacy of Antidepressants in Juvenile Depression: Meta-Analysis
(Springer Nature, 2008-04-17)Background: The safety of antidepressants in children and adolescents is being questioned and the efficacy of these drugs in juvenile depression remains uncertain.AimsTo assess antidepressant efficacy in juvenile ... -
Efficacy of Atomoxetine in Adult Attention-Deficit/Hyperactivity Disorder: A Drug-placebo Response Curve Analysis
(BioMed Central, 2005)Background: The objective of this study was to evaluate the efficacy of atomoxetine, a new and highly selective inhibitor of the norepinephrine transporter, in reducing symptoms of attention-deficit/hyperactivity disorder ... -
Efficacy of cilostazol on platelet reactivity and cardiovascular outcomes in patients undergoing percutaneous coronary intervention: insights from a meta-analysis of randomised trials
(BMJ Publishing Group, 2014)Background: Cilostazol overcomes high on-treatment platelet reactivity (HTPR) and reduces adverse cardiovascular (CV) outcomes after percutaneous coronary intervention (PCI). However, the role for triple antiplatelet therapy ... -
Efficacy of Epidural Injections in the Treatment of Lumbar Central Spinal Stenosis: A Systematic Review
(Kowsar, 2015)Context: Lumbar central spinal stenosis is common and often results in chronic persistent pain and disability, which can lead to multiple interventions. After the failure of conservative treatment, either surgical or ... -
Efficacy of Esketamine Augmentation in Major Depressive Disorder: A Meta-Analysis
(Physicians Postgraduate Press, Inc, 2020-05-26)Objective: Esketamine, the s-enantiomer of ketamine, was recently approved as a rapid-acting intranasal therapy for depression and is currently under development for suicidality. The authors sought to determine the efficacy ... -
Efficacy of Infection Control Interventions in Reducing the Spread of Multidrug-Resistant Organisms in the Hospital Setting
(Public Library of Science, 2012)Multidrug-resistant organisms (MDRO) continue to spread in hospitals globally, but the population-level impact of recommended preventive strategies and the relative benefit of individual strategies targeting all MDRO in ... -
Efficacy of Metreleptin in Obese Patients With Type 2 Diabetes: Cellular and Molecular Pathways Underlying Leptin Tolerance
(American Diabetes Association, 2011)Objective: Metreleptin has been efficacious in improving metabolic control in patients with lipodystrophy, but its efficacy has not been tested in obese patients with type 2 diabetes. Research Design and Methods: We studied ... -
The Efficacy of Paroxetine and Placebo in Treating Anxiety and Depression: A Meta-Analysis of Change on the Hamilton Rating Scales
(Public Library of Science, 2014)Background: Previous meta-analyses of published and unpublished trials indicate that antidepressants provide modest benefits compared to placebo in the treatment of depression; some have argued that these benefits are not ... -
Efficacy of Sunitinib and Radiotherapy in Genetically Engineered Mouse Model of Soft-tissue Sarcoma
(Elsevier, 2009)Purpose: Sunitinib (SU) is a multitargeted receptor tyrosine kinase inhibitor of the vascular endothelial growth factor and platelet-derived growth factor receptors. The present study examined SU and radiotherapy (RT) in ... -
The efficacy of the Cook-Swartz implantable Doppler in the detection of free-flap compromise: a systematic review protocol
(BMJ, 2014)Introduction The Cook-Swartz implantable Doppler monitors venous or arterial blood flow from free flaps and can detect free-flap compromise. Previous studies have shown that the use of this Doppler can improve detection ... -
Efficacy of Topical Blockade of Interleukin-1 in Experimental Dry Eye Disease
(Elsevier BV, 2012)PURPOSE To evaluate the therapeutic efficacy of topical IL-1Ra in the treatment of Dry Eye Disease (DED). DESIGN Laboratory Investigation. METHODS DED was induced in C57BL/6 female mice through exposure to a ... -
Efficacy of WHO recommendation for continued breastfeeding and maternal cART for prevention of perinatal and postnatal HIV transmission in Zambia
(International AIDS Society, 2015)Introduction: To prevent mother-to-child transmission (MTCT) of HIV in developing countries, new World Health Organization (WHO) guidelines recommend maternal combination antiretroviral therapy (cART) during pregnancy, ... -
Efficacy, Safety, and Biomarkers of Neoadjuvant Bevacizumab, Radiation Therapy, and Fluorouracil in Rectal Cancer: A Multidisciplinary Phase II Study
(American Society of Clinical Oncology (ASCO), 2009)PURPOSE: To assess the safety and efficacy of neoadjuvant bevacizumab with standard chemoradiotherapy in locally advanced rectal cancer and explore biomarkers for response. PATIENTS AND METHODS: In a phase I/II study, 32 ... -
Efficacy, Safety, and Tolerability of Pregabalin Treatment for Painful Diabetic Peripheral Neuropathy
(American Diabetes Association, 2008)OBJECTIVE—To evaluate the efficacy, safety, and tolerability of pregabalin across the effective dosing range, to determine differences in the efficacy of three times daily (TID) versus twice daily (BID) dosage schedules, ... -
Efficiency and Cost of Primary Care by Nurses and Physician Assistants
(Massachusetts Medical Society, 1978-02-09)We conducted a prospective study in a prepaid primary-care practice (health-maintenance organization) of a system in which nurses and physician assistants used protocols, and compared the efficiency and costs of this ...