Now showing items 5474-5493 of 18424

    • Efficient Universal Computing Architectures for Decoding Neural Activity 

      Rapoport, Benjamin Isaac; Turicchia, Lorenzo; Wattanapanitch, Woradorn; Davidson, Thomas J.; Sarpeshkar, Rahul (Public Library of Science, 2012)
      The ability to decode neural activity into meaningful control signals for prosthetic devices is critical to the development of clinically useful brain– machine interfaces (BMIs). Such systems require input from tens to ...
    • An efficient, scalable, and adaptable framework for solving generic systems of level-set PDEs 

      Mosaliganti, Kishore R.; Gelas, Arnaud; Megason, Sean G. (Frontiers Media S.A., 2013)
      In the last decade, level-set methods have been actively developed for applications in image registration, segmentation, tracking, and reconstruction. However, the development of a wide variety of level-set PDEs and their ...
    • EGb761, a Ginkgo Biloba Extract, is Effective against Atherosclerosis In Vitro, and in a Rat Model of Type 2 Diabetes 

      Kang, Seon Mee; Cho, Bong Jun; Shin, Hayley; Jang, Hak Chul; Park, Kyong Soo; Lim, Soo; Yoon, Ji Won; Choi, Sung Hee; Kim, Min; Park, Ho Seon; Cho, Hyun Ju; Kim, Young-Bum; Kim, Hyo Soo (Public Library of Science, 2011)
      Background: EGb761, a standardized Ginkgo biloba extract, has antioxidant and antiplatelet aggregation and thus might protect against atherosclerosis. However, molecular and functional properties of EGb761 and its major ...
    • EGF-Like-Domain-7 Is Required for VEGF-Induced Akt/ERK Activation and Vascular Tube Formation in an Ex Vivo Angiogenesis Assay 

      Takeuchi, Kimio; Yanai, Ryoji; Kumase, Fumiaki; Morizane, Yuki; Suzuki, Jun; Kayama, Maki; Brodowska, Katarzyna; Nakazawa, Mitsuru; Miller, Joan W.; Connor, Kip M.; Vavvas, Demetrios G. (Public Library of Science, 2014)
      EGFL7 is a secreted angiogenic factor, which in contrast to the well-known secreted angiogenic molecules VEGF and FGF-2, is almost exclusively expressed by endothelial cells and may act in an autocrine fashion. Prior studies ...
    • EGF-R is Expressed and AP-1 and NF-κ:B Are Activated in Stromal Myofibroblasts Surrounding Colon Adenocarcinomas Paralleling Expression of COX-2 and VEGF 

      Konstantinopoulos, Panagiotis A.; Vandoros, Gerasimos P.; Karamouzis, Michalis V.; Gkermpesi, Maria; Sotiropoulou-Bonikou, Georgia; Papavassiliou, Athanasios G. (IOS Press, 2007)
      Background:: COX-2 and VEGF are important triggers of colon cancer growth, metastasis and angiogenesis. Cox-2 promoter contains transcriptional regulatory elements for AP-1 and NF-κ:B transcription factors whilst vegf is ...
    • EGFR and MET receptor tyrosine kinase-altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers 

      Garofalo, Michela; Romano, Giulia; Di Leva, Gianpiero; Nuovo, Gerard; Jeon, Young-Jun; Ngankeu, Apollinaire; Sun, Jin; Lovat, Francesca; Alder, Hansjuerg; Condorelli, Gerolama; Engelman, Jeffrey Adam; Ono, Mayumi; Rho, Jin Kyung; Cascione, Luciano; Volinia, Stefano; Nephew, Kenneth P.; Croce, Carlo M. (2012)
      The involvement of the MET oncogene in de novo and acquired resistance of non-small cell lung cancers (NSCLC) to tyrosine kinase inhibitors (TKIs) has been reported, but the precise mechanism by which MET overexpression ...
    • EGFR mutation detection in circulating cell-free DNA of lung adenocarcinoma patients: analysis of LUX-Lung 3 and 6 

      Wu, Yi-Long; Sequist, Lecia V; Hu, Cheng-Ping; Feng, Jifeng; Lu, Shun; Huang, Yunchao; Li, Wei; Hou, Mei; Schuler, Martin; Mok, Tony; Yamamoto, Nobuyuki; O'Byrne, Kenneth; Hirsh, Vera; Gibson, Neil; Massey, Dan; Kim, Miyoung; Yang, James Chih-Hsin (Nature Publishing Group, 2017)
      Background: In the Phase III LUX-Lung 3/6 (LL3/LL6) trials in epidermal growth factor receptor (EGFR) mutation-positive lung adenocarcinoma patients, we evaluated feasibility of EGFR mutation detection using circulating ...
    • EGFR T790M Mutation as a Possible Target for Immunotherapy; Identification of HLA-A*0201-Restricted T Cell Epitopes Derived from the EGFR T790M Mutation 

      Yamada, Teppei; Azuma, Koichi; Muta, Emi; Kim, Jintaek; Sugawara, Shunichi; Zhang, Guang Lan; Matsueda, Satoko; Kasama-Kawaguchi, Yuri; Yamashita, Yuichi; Yamashita, Takuto; Nishio, Kazuto; Itoh, Kyogo; Hoshino, Tomoaki; Sasada, Tetsuro (Public Library of Science, 2013)
      Treatment with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), such as gefitinib and erlotinib, has achieved high clinical response rates in patients with non–small cell lung cancers (NSCLCs). ...
    • An EGFR Targeted PET Imaging Probe for the Detection of Colonic Adenocarcinomas in the Setting of Colitis 

      Turker, N. Selcan; Heidari, Pedram; Kucherlapati, Raju; Kucherlapati, Melanie; Mahmood, Umar (Ivyspring International Publisher, 2014)
      Colorectal cancer is a serious complication associated with inflammatory bowel disease, often indistinguishable by screening with conventional FDG PET probes. We have developed an alternative EGFR-targeted PET imaging probe ...
    • EGFR-mediated tumor immunoescape: The imbalance between phosphorylated STAT1 and phosphorylated STAT3 

      Concha-Benavente, Fernando; Srivastava, Raghvendra M; Ferrone, Soldano; Ferris, Robert L (Landes Bioscience, 2013)
      The epidermal growth factor receptor (EGFR) supports the escape of malignant cells from immunosurveillance by inhibiting the activation of signal transducer and activator of transcription 1 (STAT1) while promoting that of ...
    • EGFRMutation Is a Better Predictor of Response to Tyrosine Kinase Inhibitors in Non–Small Cell Lung Carcinoma Than FISH, CISH, and Immunohistochemistry 

      Sholl, Lynette Marie; Xiao, Yun; Joshi, Victoria; Yeap, Beow Yong; Cioffredi, Leigh-Anne; Jackman, David M; Lee, Charles; Janne, Pasi Antero; Lindeman, Neal I. (Oxford University Press (OUP), 2010)
      About 10% of patients with non–small cell lung carcinoma (NSCLC) respond to epidermal growth factor receptor (EGFR)-targeted tyrosine kinase inhibitors (TKIs). More than 75% of “responders” have activating mutations in ...
    • EGFRvIII/integrin β3 interaction in hypoxic and vitronectinenriching microenvironment promote GBM progression and metastasis 

      Liu, Zhaoyu; Han, Lei; Dong, Yucui; Tan, Yanli; Li, Yongsheng; Zhao, Manli; Xie, Hui; Ju, Huanyu; Wang, He; Zhao, Yu; Zheng, Qifan; Wang, Qixue; Su, Jun; Fang, Chuan; Fu, Songbin; Jiang, Tao; Liu, Jiaren; Li, Xia; Kang, Chunsheng; Ren, Huan (Impact Journals LLC, 2016)
      Glioblastoma (GBM) is one of the most lethal brain tumors with a short survival time. EGFR amplification and mutation is the most significant genetic signature in GBM. About half of the GBMs with EGFR amplification express ...
    • Egg Consumption and Risk of Type 2 Diabetes in Men and Women 

      Djoussé, Luc; Gaziano, John Michael; Buring, Julie Elizabeth; Lee, I-Min (American Diabetes Association, 2009)
      OBJECTIVE—Whereas limited and inconsistent findings have been reported on the relation between dietary cholesterol or egg consumption and fasting glucose, no previous study has examined the association between egg consumption ...
    • EGL-9 Controls C. elegans Host Defense Specificity through Prolyl Hydroxylation-Dependent and -Independent HIF-1 Pathways 

      Luhachack, Lyly G.; Visvikis, Orane; Wollenberg, Amanda C.; Lacy-Hulbert, Adam; Stuart, Lynda; Irazoqui, Javier Elbio (Public Library of Science, 2012)
      Understanding host defense against microbes is key to developing new and more effective therapies for infection and inflammatory disease. However, how animals integrate multiple environmental signals and discriminate between ...
    • Egocentric Social Network Structure, Health, and Pro-Social Behaviors in a National Panel Study of Americans 

      O’Malley, A. James; Arbesman, Samuel; Steiger, Darby Miller; Fowler, James H.; Christakis, Nicholas Alexander (Public Library of Science, 2012)
      Using a population-based, panel survey, we study how egocentric social networks change over time, and the relationship between egocentric network properties and health and pro-social behaviors. We find that the number of ...
    • Egr-1 Regulates Autophagy in Cigarette Smoke-induced Chronic Obstructive Pulmonary Disease 

      Chen, Zhi-Hua; Kim, Hong Pyo; Sciurba, Frank C.; Feghali-Bostwick, Carol; Stolz, Donna B.; Dhir, Rajiv; Landreneau, Rodney J.; Schuchert, Mathew J.; Yousem, Samuel A.; Pilewski, Joseph M.; Lee, Janet S.; Zhang, Yingze; Lee, Seon-Jin; Nakahira, Kiichi; Ryter, Stefan W.; Choi, Augustine M.K. (Public Library of Science, 2008)
      Background: Chronic obstructive pulmonary disease (COPD) is a progressive lung disease characterized by abnormal cellular responses to cigarette smoke, resulting in tissue destruction and airflow limitation. Autophagy is ...
    • Ehlers Danlos Syndrome: An Unusual Presentation You Need to Know about 

      Karaa, Amel; Stoler, Joan M. (Hindawi Publishing Corporation, 2013)
      The Ehlers Danlos syndromes (EDS) comprise a group of connective tissue disorders characterized by tissue fragility of the skin, ligaments, blood vessels and internal organs. Variable degrees of clinical severity and organ ...
    • eIF1A augments Ago2-mediated Dicer-independent miRNA biogenesis and RNA interference 

      Yi, Tingfang; Arthanari, Haribabu; Akabayov, Barak; Song, Huaidong; Papadopoulos, Evangelos; Qi, Hank H.; Jedrychowski, Mark; Güttler, Thomas; Guo, Cuicui; Luna, Rafael E.; Gygi, Steven P.; Huang, Stephen A.; Wagner, Gerhard (2015)
      MicroRNA (miRNA) biogenesis and miRNA-guided RNA interference (RNAi) are essential for gene expression in eukaryotes. Here we report that translation initiation factor eIF1A directly interacts with Ago2 and promotes Ago2 ...
    • Eight Common Genetic Variants Associated with Serum DHEAS Levels Suggest a Key Role in Ageing Mechanisms 

      Zhai, Guangju; Teumer, Alexander; Stolk, Lisette; Vandenput, Liesbeth; Coviello, Andrea D.; Koster, Annemarie; Bell, Jordana T.; Bhasin, Shalender; Eriksson, Joel; Eriksson, Anna; Ernst, Florian; Ferrucci, Luigi; Frayling, Timothy M.; Grundberg, Elin; Haring, Robin; Kroemer, Heyo K.; Liu, Yongmei; Lunetta, Kathryn L.; Maggio, Marcello; Lorentzon, Mattias; Mangino, Massimo; Melzer, David; Miljkovic, Iva; Nica, Alexandra; Penninx, Brenda W. J. H.; Vasan, Ramachandran S.; Rivadeneira, Fernando; Small, Kerrin S.; Soranzo, Nicole; Xi, Li; Zhuang, Wei Vivian; Harris, Tamara B.; Murabito, Joanne M.; Ohlsson, Claes; Murray, Anna; de Jong, Frank H.; Spector, Tim D.; Wallaschofski, Henri; Perry, John; Wilson, Scott G.; Glass, Daniel; Hofman, Albert; Kiel, Douglas P.; Hedman, Asa K.; Uitterlinden, Andre G.; Volzke, Henry (Public Library of Science, 2011)
      Dehydroepiandrosterone sulphate (DHEAS) is the most abundant circulating steroid secreted by adrenal glands, yet its function is unknown. Its serum concentration declines significantly with increasing age, which has led ...
    • ElaD, a Deubiquitinating Protease Expressed by E. Coli 

      Catic, Andre; Misaghi, Shahram; Korbel, Gregory A.; Ploegh, Hidde L. (Public Library of Science, 2007)
      Background: Ubiquitin and ubiquitin-like proteins (Ubl) are designed to modify polypeptides in eukaryotes. Covalent binding of ubiquitin or Ubls to substrate proteins can be reversed by specific hydrolases. One particular ...