Browsing Harvard Medical School by Title

Now showing items 5914-5933 of 18428

    • Ethanol Affects the Development of Sensory Hair Cells in Larval Zebrafish (Danio rerio) 

      Uribe, Phillip M.; Asuncion, James D.; Matsui, Jonathan I. (Public Library of Science, 2013)
      Children born to mothers with substantial alcohol consumption during pregnancy can present a number of morphological, cognitive, and sensory abnormalities, including hearing deficits, collectively known as fetal alcohol ...

    • Ethical and Practical Guidelines for Reporting Genetic Research Results to Study Participants 

      Fabsitz, Richard R.; McGuire, Amy; Sharp, Richard R.; Puggal, Mona; Beskow, Laura M.; Biesecker, Leslie G.; Bookman, Ebony; Burke, Wylie; Clayton, Ellen Wright; Eckfeldt, John H.; Fernandez, Conrad V.; Fisher, Rebecca; Fullerton, Stephanie M.; Gachupin, Francine; James, Cynthia; Jarvik, Gail P.; Kittles, Rick; Leib, Jennifer R.; O'Donnell, Christopher; O'Rourke, P. Pearl; Rodriguez, Laura Lyman; Schully, Sheri D.; Shuldiner, Alan R.; Sze, Rebecca K.F.; Thakuria, Joseph V.; Wolf, Susan M.; Burke, Gregory L.; Burchard, Esteban Gonzalez; Church, George; Gabriel, Stacey (Ovid Technologies (Wolters Kluwer Health), 2010-12)
      In January 2009 the National Heart, Lung, and Blood Institute (NHLBI) convened a 28-member multidisciplinary Working Group to update the recommendations of a 2004 NHLBI Working Group focused on Guidelines to the Return of ...

    • Ethical deliberations about involuntary treatment: interviews with Swedish psychiatrists 

      Sjöstrand, Manne; Sandman, Lars; Karlsson, Petter; Helgesson, Gert; Eriksson, Stefan; Juth, Niklas (BioMed Central, 2015)
      Background: Involuntary treatment is a key issue in healthcare ethics. In this study, ethical issues relating to involuntary psychiatric treatment are investigated through interviews with Swedish psychiatrists. Methods: ...

    • Ethics in Community-Based Research with Vulnerable Children: Perspectives from Rwanda 

      Betancourt, Theresa; Smith Fawzi, Mary C.; Stevenson, Anne; Kanyanganzi, Fredrick; Kirk, Catherine; Ng, Lauren; Mushashi, Christina; Bizimana, Justin I.; Beardslee, William; Raviola, Giuseppe; Smith, Stephanie; Kayiteshonga, Yvonne; Binagwaho, Agnes (Public Library of Science, 2016)
      A “risk of harm” protocol to identify youth in need of immediate emergency assistance in a study on mental health and HIV in Rwanda among 680 youth ages 10–17 is described. Cases are presented that describe the experience ...

    • Ethics of DNA Research on Human Remains: Five Globally Applicable Guidelines 

      Alpaslan-Roodenberg, Songül; Anthony, David; Babiker, Hiba; Bánffy, Eszter; Booth, Thomas; Capone, Patricia; Deshpande-Mukherjee, Arati; Eisenmann, Stefanie; Fehren-Schmitz, Lars; Frachetti, Michael; Fujita, Ricardo; Frieman, Catherine J.; Fu, Qiaomei; Gibbon, Victoria; Haak, Wolfgang; Hajdinjak, Mateja; Hofmann, Kerstin; Holguin, Brian; Inomata, Takeshi; Kanzawa-Kiriyama, Hideaki; Keegan, William; Kelso, Janet; Krause, Johannes; Kumaresan, Ganesan; Kusimba, Chapurukha; Kusimba, Sibel; Lalueza-Fox, Carles; Llamas, Bastien; MacEachern, Scott; Mallick, Swapan; Matsumura, Hirofumi; Morales-Arce, Ana Y.; Motuzaite Matuzeviciute, Giedre; Mushrif-Tripathy, Veena; Nakatsuka, Nathan; Nores, Rodrigo; Ogola, Christine; Okumura, Mercedes; Patterson, Nick; Pinhasi, Ron; Prasad, Samayamantri P. R.; Prendergast, Mary E.; Punzo, Jose Luis; Reich, David; Sawafuji, Rikai; Sawchuk, Elizabeth; Schiffels, Stephan; Sedig, Jakob; Shnaider, Svetlana; Sirak, Kendra; Skoglund, Pontus; Slon, Viviane; Snow, Meradeth; Soressi, Marie; Spriggs, Matthew; Stockhammer, Philipp; Szécsényi-Nagy, Anna; Thangaraj, Kumarasamy; Tiesler, Vera; Tobler, Ray; Wang, Chuan-Chao; Warinner, Christina; Yasawardene, Surangi; Zahir, Muhammad (Nature, 2021-10-20)
      We are a group of archaeologists, anthropologists, curators, and geneticists representing 24 countries and diverse global communities, most of whom met in November 2020 in a virtual workshop dedicated to ethics in ancient ...

    • The Ethics of Electronically Monitoring Adherence to Antiretroviral Therapy: Theoretical Considerations and Empiric Findings 

      Campbell, Jeffrey I. (2016-05-17)
      Research Problem: Many electronic adherence monitors (EAMs) exist to track medication adherence, but despite attention in the popular press and expanding use of these devices, the ethics of using EAMs are largely unexplored. ...

    • The Ethics of Organ Donation: First, Do No Harm? 

      Segal, J. Bradley (2018-05-15)
      The dead donor rule (DDR) stipulates that donors must be dead before life-sustaining organs are removed. Its normative basis is to protect organ donors from suffering unacceptable harm. The central ethical consideration ...

    • The ethics of talking about ‘HIV cure’ 

      Rennie, Stuart; Siedner, Mark; Tucker, Joseph D; Moodley, Keymanthri (BioMed Central, 2015)
      Background: In 2008, researchers reported that Timothy Brown (the ‘Berlin Patient’), a man with HIV infection and leukemia, received a stem-cell transplant that removed HIV from his body as far as can be detected. In 2013, ...

    • Ethnic Differences in Body Composition and Obesity Related Risk Factors: Study in Chinese and White Males Living in China 

      Fan, Jinhui; Zhang, Gong; Wu, Jiang; Ji, Yong; Li, Songlin; Li, Yunping; Wang, Doug; Lee, Simin Gharib; Wang, Lei (Public Library of Science, 2011)
      The purpose of this cross-sectional observational study was to identify ethnic differences in body composition and obesity-related risk factors between Chinese and white males living in China. 115 Chinese and 114 white ...

    • Ethnic Differences in Physiological Responses to Fear Conditioned Stimuli 

      Martínez, Karen G.; Franco-Chaves, José A.; Milad, Mohammed R.; Quirk, Gregory J. (Public Library of Science, 2014)
      The idea that emotional expression varies with ethnicity is based largely on questionnaires and behavioral observations rather than physiological measures. We therefore compared the skin conductance responses (SCR) of ...

    • Ethnic variations in asthma hospital admission, readmission and death: a retrospective, national cohort study of 4.62 million people in Scotland 

      Sheikh, Aziz; Steiner, Markus F. C.; Cezard, Genevieve; Bansal, Narinder; Fischbacher, Colin; Simpson, Colin R.; Douglas, Anne; Bhopal, Raj (BioMed Central, 2016)
      Background: Our previous meta-analysis found that South Asians and Blacks in the UK were at a substantially increased risk of hospital admission from asthma. These estimates were, however, derived from pooling data from a ...

    • Ethnic-specific associations of rare and low-frequency DNA sequence variants with asthma 

      Igartua, Catherine; Myers, Rachel A.; Mathias, Rasika A.; Pino-Yanes, Maria; Eng, Celeste; Graves, Penelope E.; Levin, Albert M.; Del-Rio-Navarro, Blanca E.; Jackson, Daniel J.; Livne, Oren E.; Rafaels, Nicholas; Edlund, Christopher K.; Yang, James J.; Huntsman, Scott; Salam, Muhammad T.; Romieu, Isabelle; Mourad, Raphael; Gern, James E.; Lemanske, Robert F.; Wyss, Annah; Hoppin, Jane A.; Barnes, Kathleen C.; Burchard, Esteban G.; Gauderman, W. James; Martinez, Fernando D.; Raby, Benjamin A.; Weiss, Scott T.; Williams, L. Keoki; London, Stephanie J.; Gilliland, Frank D.; Nicolae, Dan L.; Ober, Carole (Nature Pub. Group, 2015)
      Common variants at many loci have been robustly associated with asthma but explain little of the overall genetic risk. Here we investigate the role of rare (<1%) and low-frequency (1–5%) variants using the Illumina HumanExome ...

    • Etiology and Pathogenesis of Epithelial Ovarian Cancer 

      Mok, Samuel C.; Kwong, Joseph; Welch, William R.; Samimi, Goli; Ozbun, Laurent; Bonome, Tomas; Birrer, Michael J.; Berkowitz, Ross S.; Wong, Kwong-Kwok (IOS Press, 2007)
      Ovarian cancer is complex disease composed of different histological grades and types. However, the underlying molecular mechanisms involved in the development of different phenotypes remain largely unknown. Epidemiological ...

    • Etiology and risk factors associated with a pruritic papular eruption in people living with HIV in India 

      Farsani, Terry T; Kore, Sachin; Nadol, Patrick; Ramam, Mandalaparthy; Thierman, Sara J; Leslie, Kieron; Chandrasekar, Chockalingam; Sikhamani, Rajasekaran; Manoharan, Gurusamy; Kubba, Asha; Maurer, Toby A (International AIDS Society, 2013)
      Introduction: Papulopruritic eruption (PPE) occurs in people living with HIV in India. Understanding the risk factors associated with this disease may help decrease the prevalence of PPE. Methods: This study was a case-control ...

    • Etomidate and Ketamine: Residual Motor and Adrenal Dysfunction that Persist beyond Recovery from Loss of Righting Reflex in Rats 

      Diaz-Gil, Daniel; Mueller, Noomi; Moreno-Duarte, Ingrid; Lin, Hsin; Ayata, Cenk; Cusin, Cristina; Cotten, Joseph F.; Eikermann, Matthias (MDPI, 2014)
      We tested the hypothesis that etomidate and ketamine produce residual effects that modify functional mobility (measured by the balance beam test) and adrenal function (adrenocorticotropic hormone (ACTH) stimulation) ...

    • Eukaryotic Systems Broaden the Scope of Synthetic Biology 

      Haynes, Karmella A.; Silver, Pamela A. (The Rockefeller University Press, 2009)
      Synthetic biology aims to engineer novel cellular functions by assembling well-characterized molecular parts (i.e., nucleic acids and proteins) into biological “devices” that exhibit predictable behavior. Recently, efforts ...

    • Evaluating hormonal mechanisms of vitamin D receptor agonist therapy in diabetic kidney disease: the VALIDATE-D study 

      Brown, Jenifer M; Secinaro, Kristina; Williams, Jonathan S; Vaidya, Anand (BioMed Central, 2013)
      Background: Insufficient vitamin D status and increased renin-angiotensin system (RAS) activity have been associated with renal-vascular disease and nephropathy in diabetes. Accumulating evidence indicates that vitamin D ...

    • Evaluating more naturalistic outcome measures: A 1-year smartphone study in multiple sclerosis 

      Bove, Riley; White, Charles C.; Giovannoni, Gavin; Glanz, Bonnie; Golubchikov, Victor; Hujol, Johnny; Jennings, Charles; Langdon, Dawn; Lee, Michelle; Legedza, Anna; Paskavitz, James; Prasad, Sashank; Richert, John; Robbins, Allison; Roberts, Susan; Weiner, Howard; Ramachandran, Ravi; Botfield, Martyn; De Jager, Philip L. (Lippincott Williams & Wilkins, 2015)
      Objective: In this cohort of individuals with and without multiple sclerosis (MS), we illustrate some of the novel approaches that smartphones provide to monitor patients with chronic neurologic disorders in their natural ...

    • Evaluating Multiplexed Quantitative Phosphopeptide Analysis on a Hybrid Quadrupole Mass Filter/Linear Ion Trap/Orbitrap Mass Spectrometer 

      Erickson, Brian K.; Jedrychowski, Mark P.; McAlister, Graeme C.; Everley, Robert A.; Kunz, Ryan; Gygi, Steven P. (American Chemical Society, 2014)
      As a driver for many biological processes, phosphorylation remains an area of intense research interest. Advances in multiplexed quantitation utilizing isobaric tags (e.g., TMT and iTRAQ) have the potential to create a new ...

    • Evaluating Quality of Care for Patients with Type 2 Diabetes Using Electronic Health Record Information in Mexico 

      Pérez-Cuevas, Ricardo; Doubova, Svetlana V; Suarez-Ortega, Magdalena; Law, Michael; Pande, Aakanksha H; Escobedo, Jorge; Espinosa-Larrañaga, Francisco; Ross-Degnan, Dennis; Wagner, Anita Katharina (BioMed Central, 2012)
      Background: Several low and middle-income countries are implementing electronic health records (EHR). In the near future, EHRs could become an efficient tool to evaluate healthcare performance if appropriate indicators are ...