Browsing Harvard Medical School by Title
Now showing items 6160-6179 of 18428
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Expanding the Role of Radiology in the Detection of Physical Elder Abuse
(2018-05-15)Pediatric radiologists play a key role in the detection of child abuse, through the identification of characteristic fracture and injury patterns. Emergency radiologists have the potential to play an equally important role ... -
Expanding Whole Exome Resequencing into Non-Human Primates
(BioMed Central, 2011)Background: Complete exome resequencing has the power to greatly expand our understanding of non-human primate genomes. This includes both a better appreciation of the variation that exists in non-human primate model ... -
Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells
(eLife Sciences Publications, Ltd, 2013)Pancreatic islet β-cell insufficiency underlies pathogenesis of diabetes mellitus; thus, functional β-cell replacement from renewable sources is the focus of intensive worldwide effort. However, in vitro production of ... -
Expansion of GA Dinucleotide Repeats Increases the Density of CLAMP Binding Sites on the X-Chromosome to Promote Drosophila Dosage Compensation
(Public Library of Science, 2016)Dosage compensation is an essential process that equalizes transcript levels of X-linked genes between sexes by forming a domain of coordinated gene expression. Throughout the evolution of Diptera, many different X-chromosomes ... -
Expansion of host cellular niche can drive adaptation of a zoonotic malaria parasite to humans
(Nature Research (part of Springer Nature), 2013)The macaque malaria parasite Plasmodium knowlesi has recently emerged as an important zoonosis in Southeast Asia. Infections are typically mild but can cause severe disease, achieving parasite densities similar to fatal ... -
Expansion Thoracoplasty Affects Lung Growth and Morphology in a Rabbit Model: A Pilot Study
(Springer-Verlag, 2011)Background: Thoracic insufficiency syndrome represents a novel form of postnatal restrictive respiratory disease occurring in children with early-onset scoliosis and chest wall anomalies. Expansion thoracoplasty improves ... -
Expectation versus Reality: The Impact of Utility on Emotional Outcomes after Returning Individualized Genetic Research Results in Pediatric Rare Disease Research, a Qualitative Interview Study
(Public Library of Science, 2016)Purpose Much information on parental perspectives on the return of individual research results (IRR) in pediatric genomic research is based on hypothetical rather than actual IRR. Our aim was to understand how the expected ... -
Expedited mapping of the ligandable proteome using fully functionalized enantiomeric probe pairs
(Springer Science and Business Media LLC, 2019-10-28)A fundamental challenge in chemical biology and medicine is to understand and expand the fraction of the human proteome that can be targeted by small molecules. We recently described a strategy that integrates fragment-based ... -
Experience and Lessons From Health Impact Assessment for Human Rights Impact Assessment
(Springer Science and Business Media LLC, 2015-09-16)As globalisation has opened remote parts of the world to foreign investment, global leaders at the United Nations and beyond have called on multinational companies to foresee and mitigate negative impacts on the communities ... -
Experience of Pleasure and Emotional Expression in Individuals with Schizotypal Personality Features
(Public Library of Science, 2012)Difficulties in feeling pleasure and expressing emotions are one of the key features of schizophrenia spectrum conditions, and are significant contributors to constricted interpersonal interactions. The current study ... -
Experience Playing a Musical Instrument and Overnight Sleep Enhance Performance on a Sequential Typing Task
(Public Library of Science, 2016)The smooth, coordinated fine motor movements required to play a musical instrument are not only highly valued in our society; they also predict academic success in areas that generalize beyond the motor domain, including ... -
Experience with targeted next generation sequencing for the care of lung cancer: Insights into promises and limitations of genomic oncology in day-to-day practice
(Elsevier BV, 2015)Introduction Tumor genotyping using single gene assays (SGAs) is standard practice in advanced non-small-cell lung cancer (NSCLC). We evaluated how the introduction of next generation sequencing (NGS) into day-to-day ... -
Experiences and Attitudes of Genome Investigators Regarding Return of Individual Genetic Test Results
(2014)Purpose Whether and how to return individual genetic results to study participants is among the most contentious policy issues in contemporary genomic research. Methods: We surveyed corresponding authors of genome-wide ... -
Experiences applying for and understanding health insurance under Massachusetts health care reform
(BioMed Central, 2016)Background: The Affordable Care Act was modeled on the Massachusetts Health Reform of 2006, which reduced the number of uninsured largely through a Medicaid expansion and the provision of publicly subsidized insurance ... -
Experiences of health care transition voiced by young adults with type 1 diabetes: a qualitative study
(Dove Medical Press, 2014)Objective: This qualitative study aimed to explore the experience of transition from pediatric to adult diabetes care reported by posttransition emerging adults with type 1 diabetes (T1D), with a focus on preparation for ... -
Experimental Comparison of Parametric Versus Nonparametric Analyses of Data From the Cold Pressor Test
(Elsevier BV, 2015)Parametric statistical methods are common in human pain research. They require normally distributed data, but this assumption is rarely tested. The current study analyzes the appropriateness of parametric testing for ... -
Experimental discovery of sRNAs in Vibrio cholerae by direct cloning, 5S/tRNA depletion and parallel sequencing
(Oxford University Press, 2009)Direct cloning and parallel sequencing, an extremely powerful method for microRNA (miRNA) discovery, has not yet been applied to bacterial transcriptomes. Here we present sRNA-Seq, an unbiased method that allows for ... -
Experimental Glaucoma Induced by Ocular Injection of Magnetic Microspheres
(MyJove Corporation, 2015)Progress in understanding the pathophysiology, and providing novel treatments for glaucoma is dependent on good animal models of the disease. We present here a protocol for elevating intraocular pressure (IOP) in the rat, ... -
Experimental Models for Analysis of Oligodendrocyte Pathophysiology in Stroke
(BioMed Central, 2009)White matter damage is a clinically important part of stroke. However, compared to the mechanisms of neuronal injury in gray matter, white matter pathophysiology remains relatively understudied and poorly understood. This ... -
Expired Nitric Oxide after Bronchoprovocation and Repeated Spirometry in Patients with Asthma
(American Thoracic Society, 1998-03)Compared with normal individuals, subjects with asthma have elevated levels of expired nitric oxide (NO). These levels are hypothesized to reflect the degree of airway inflammation. Expired NO levels rise during the late ...