Browsing Harvard Medical School by Title
Now showing items 6217-6236 of 18428
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Exposure to the Chinese Famine in Early Life and the Risk of Hyperglycemia and Type 2 Diabetes in Adulthood
(American Diabetes Association, 2010)OBJECTIVE: Early developmental adaptations in response to undernutrition may play an essential role in susceptibility to type 2 diabetes, particularly for those experiencing a “mismatched rich nutritional environment” in ... -
Exposure to the Chinese Famine in Early Life and the Risk of Metabolic Syndrome in Adulthood
(American Diabetes Association, 2011)Objective: To examine whether exposure to the Chinese famine during fetal life and early childhood is associated with the risks of metabolic syndrome and whether this association is modified by later life environment. ... -
Exposure to Traffic Pollution and Increased Risk of Rheumatoid Arthritis
(National Institute of Environmental Health Sciences, 2009)Background: Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease that affects approximately 1% of the adult population, and to date, genetic factors explain < 50% of the risk. Particulate air pollution, ... -
Exposure-Response Estimates for Diesel Engine Exhaust and Lung Cancer Mortality Based on Data from Three Occupational Cohorts
(National Institute of Environmental Health Sciences, 2013)Background: Diesel engine exhaust (DEE) has recently been classified as a known human carcinogen. Objective: We derived a meta-exposure–response curve (ERC) for DEE and lung cancer mortality and estimated lifetime excess ... -
Expression Analysis of Barrett's Esophagus-Associated High-Grade Dysplasia in Laser Capture Microdissected Archival Tissue
(American Association for Cancer Research (AACR), 2008)Purpose: Identifying genes differentially expressed in nondysplastic BE (NDBE) from those expressed in high-grade dysplasia (HGD) should be of value in improving our understanding of this transition and may yield new ... -
Expression Analysis of Macrodactyly Identifies Pleiotrophin Upregulation
(Public Library of Science, 2012)Macrodactyly is a rare family of congenital disorders characterized by the diffuse enlargement of 1 or more digits. Multiple tissue types within the affected digits are involved, but skeletal patterning and gross morphological ... -
Expression and Distribution of Ectonucleotidases in Mouse Urinary Bladder
(Public Library of Science, 2011)Background: Normal urinary bladder function requires bidirectional molecular communication between urothelium, detrusor smooth muscle and sensory neurons and one of the key mediators involved in this intercellular signaling ... -
Expression and Function of Cannabinoid Receptors CB1 and CB2 and Their Cognate Cannabinoid Ligands in Murine Embryonic Stem Cells
(Public Library of Science, 2007)Background: Characterization of intrinsic and extrinsic factors regulating the self-renewal/division and differentiation of stem cells is crucial in determining embryonic stem (ES) cell fate. ES cells differentiate into ... -
Expression and Function of Nkx6.3 in Vertebrate Hindbrain
(Elsevier BV, 2008-07-30)Homeodomain transcription factors serve important functions in organogenesis and tissue differentiation, particularly with respect to the positional identity of individual cells. The Nkx6 subfamily controls tissue ... -
Expression and Role of c-myc in Chondrocytes Undergoing Endochondral Ossification
(American Society for Biochemistry and Molecular Biology, 1993)To analyze the relationship between c-myc gene expression and chondrocyte proliferation and maturation during endochondral ossification, Day 18-19 chick embryo sterna were pulse-labeled with [3H]thymidine, and serial ... -
Expression and Role of VEGF in the Adult Retinal Pigment Epithelium
(Association for Research in Vision and Ophthalmology (ARVO), 2011)Purpose.: Despite a lack of active angiogenesis, VEGF is expressed in nearly every adult tissue, and recent evidence suggests that VEGF may serve as a survival factor for both vascular and nonvascular tissues. VEGF blockade ... -
Expression and Role of VEGF-A in the Ciliary Body
(Association for Research in Vision and Ophthalmology (ARVO), 2012)Purpose.: The role of VEGF-A in the normal ciliary body is largely unexplored. The ciliary body is similar in many respects to the choroid plexus of the brain, and we demonstrated previously the importance of VEGF-A in ... -
Expression Cloning of Protein Targets for 3-Phosphorylated Phosphoinositides
(American Society for Biochemistry and Molecular Biology, 1999)The phosphatidylinositol 3-kinase (PI 3'-K) family of lipid kinases play a critical role in cell proliferation, survival, vesicle trafficking, motility, cytoskeletal rearrangements, and oncogenesis. To identify downstream ... -
Expression differences by continent of origin point to the immortalization process
(Oxford University Press, 2009)Analysis of recently available microarray expression data sets obtained from immortalized cell lines of the individuals represented in the HapMap project have led to inconclusive comparisons across cohorts with different ... -
Expression Divergence Measured by Transcriptome Sequencing of Four Yeast Species
(BioMed Central, 2011)Background: The evolution of gene expression is a challenging problem in evolutionary biology, for which accurate, well-calibrated measurements and methods are crucial. Results: We quantified gene expression with ... -
Expression Dynamics of a Cellular Metabolic Network
(Nature Publishing Group, 2005)Toward the goal of understanding system properties of biological networks, we investigate the global and local regulation of gene expression in the Saccharomyces cerevisiae metabolic network. Our results demonstrate ... -
Expression of CD68 positive macrophages in the use of different barrier materials to prevent peritoneal adhesions—an animal study
(Springer US, 2016)In preventing postoperative adhesion formation the optimal barrier material has still not been found. It is therefore imperative to assess the biocompatibility of potential barrier devices. Macrophages play a decisive role ... -
Expression of cell adhesion molecules on limbal and neovascular endothelium in corneal inflammatory neovascularization
(1999)PURPOSE: To investigate the expression of cell-adhesion molecules on corneolimbal and neovascular endothelium and the associated leukocyte infiltration in an experimental model of inflammatory corneal neovascularization ... -
Expression of Cell-Surface Marker ABCB5 Causes Characteristic Modifications of Glucose, Amino Acid and Phospholipid Metabolism in the G3361 Melanoma-Initiating Cell Line
(Public Library of Science, 2016)We present a pilot study aimed at determining the effects of expression of ATP-binding cassette member B5 (ABCB5), a previously described marker for melanoma-initiating cells, on cellular metabolism. Metabolic profiles for ... -
Expression of Class I and II Major Histocompatibility Complex (MHC) Antigens in the Developing CNS
(Hindawi Publishing Corporation, 1992)The clinical potential of neural transplantation depends upon the feasibility of allogenenic or xenogeneic transplants, particularly of fetal tissue. This, in turn, is influenced by donor cell expression of MHC antigens. ...