Browsing Harvard Medical School by Title
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Expression and Distribution of Ectonucleotidases in Mouse Urinary Bladder
(Public Library of Science, 2011)Background: Normal urinary bladder function requires bidirectional molecular communication between urothelium, detrusor smooth muscle and sensory neurons and one of the key mediators involved in this intercellular signaling ... -
Expression and Function of Cannabinoid Receptors CB1 and CB2 and Their Cognate Cannabinoid Ligands in Murine Embryonic Stem Cells
(Public Library of Science, 2007)Background: Characterization of intrinsic and extrinsic factors regulating the self-renewal/division and differentiation of stem cells is crucial in determining embryonic stem (ES) cell fate. ES cells differentiate into ... -
Expression and Function of Nkx6.3 in Vertebrate Hindbrain
(Elsevier BV, 2008-07-30)Homeodomain transcription factors serve important functions in organogenesis and tissue differentiation, particularly with respect to the positional identity of individual cells. The Nkx6 subfamily controls tissue ... -
Expression and Role of c-myc in Chondrocytes Undergoing Endochondral Ossification
(American Society for Biochemistry and Molecular Biology, 1993)To analyze the relationship between c-myc gene expression and chondrocyte proliferation and maturation during endochondral ossification, Day 18-19 chick embryo sterna were pulse-labeled with [3H]thymidine, and serial ... -
Expression and Role of VEGF in the Adult Retinal Pigment Epithelium
(Association for Research in Vision and Ophthalmology (ARVO), 2011)Purpose.: Despite a lack of active angiogenesis, VEGF is expressed in nearly every adult tissue, and recent evidence suggests that VEGF may serve as a survival factor for both vascular and nonvascular tissues. VEGF blockade ... -
Expression and Role of VEGF-A in the Ciliary Body
(Association for Research in Vision and Ophthalmology (ARVO), 2012)Purpose.: The role of VEGF-A in the normal ciliary body is largely unexplored. The ciliary body is similar in many respects to the choroid plexus of the brain, and we demonstrated previously the importance of VEGF-A in ... -
Expression Cloning of Protein Targets for 3-Phosphorylated Phosphoinositides
(American Society for Biochemistry and Molecular Biology, 1999)The phosphatidylinositol 3-kinase (PI 3'-K) family of lipid kinases play a critical role in cell proliferation, survival, vesicle trafficking, motility, cytoskeletal rearrangements, and oncogenesis. To identify downstream ... -
Expression differences by continent of origin point to the immortalization process
(Oxford University Press, 2009)Analysis of recently available microarray expression data sets obtained from immortalized cell lines of the individuals represented in the HapMap project have led to inconclusive comparisons across cohorts with different ... -
Expression Divergence Measured by Transcriptome Sequencing of Four Yeast Species
(BioMed Central, 2011)Background: The evolution of gene expression is a challenging problem in evolutionary biology, for which accurate, well-calibrated measurements and methods are crucial. Results: We quantified gene expression with ... -
Expression Dynamics of a Cellular Metabolic Network
(Nature Publishing Group, 2005)Toward the goal of understanding system properties of biological networks, we investigate the global and local regulation of gene expression in the Saccharomyces cerevisiae metabolic network. Our results demonstrate ... -
Expression of CD68 positive macrophages in the use of different barrier materials to prevent peritoneal adhesions—an animal study
(Springer US, 2016)In preventing postoperative adhesion formation the optimal barrier material has still not been found. It is therefore imperative to assess the biocompatibility of potential barrier devices. Macrophages play a decisive role ... -
Expression of cell adhesion molecules on limbal and neovascular endothelium in corneal inflammatory neovascularization
(1999)PURPOSE: To investigate the expression of cell-adhesion molecules on corneolimbal and neovascular endothelium and the associated leukocyte infiltration in an experimental model of inflammatory corneal neovascularization ... -
Expression of Cell-Surface Marker ABCB5 Causes Characteristic Modifications of Glucose, Amino Acid and Phospholipid Metabolism in the G3361 Melanoma-Initiating Cell Line
(Public Library of Science, 2016)We present a pilot study aimed at determining the effects of expression of ATP-binding cassette member B5 (ABCB5), a previously described marker for melanoma-initiating cells, on cellular metabolism. Metabolic profiles for ... -
Expression of Class I and II Major Histocompatibility Complex (MHC) Antigens in the Developing CNS
(Hindawi Publishing Corporation, 1992)The clinical potential of neural transplantation depends upon the feasibility of allogenenic or xenogeneic transplants, particularly of fetal tissue. This, in turn, is influenced by donor cell expression of MHC antigens. ... -
Expression of estrogen receptor, progesterone receptor, and Ki67 in normal breast tissue in relation to subsequent risk of breast cancer
(2016)Although expression of estrogen receptor (ER), progesterone receptor (PR), and cell proliferation marker Ki67 serve as predictive and prognostic factors in breast cancers, little is known about their roles in normal breast ... -
Expression of Extremely Low Levels of Thymidine Kinase from an Acyclovir-Resistant Herpes Simplex Virus Mutant Supports Reactivation from Latently Infected Mouse Trigeminal Ganglia
(American Society for Microbiology, 2007)A single-cytosine-deletion in the herpes simplex virus gene encoding thymidine kinase (TK) was previously found in an acyclovir-resistant clinical isolate. A laboratory strain engineered to carry this mutation did not ... -
Expression of fibroblast growth factor by F9 teratocarcinoma cells as a function of differentiation
(Rockefeller University Press, 2018-04-25)Growth factors may be required at sites of mechanical injury and normal wear and tear in vivo, suggesting that the direct action of mechanical forces on cells could lead to growth factor release. Scraping of cells from the ... -
Expression of Herpes Simplex Virus 1 MicroRNAs in Cell Culture Models of Quiescent and Latent Infection
(American Society for Microbiology, 2014)To facilitate studies of herpes simplex virus 1 latency, cell culture models of quiescent or latent infection have been developed. Using deep sequencing, we analyzed the expression of viral microRNAs (miRNAs) in two models ... -
Expression of hypoxia-inducible factor-1α in synovial fluid and articular cartilage is associated with disease severity in knee osteoarthritis
(D.A. Spandidos, 2016)The aim of the present study was to examine hypoxia-inducible factor 1α (HIF-1α) levels in the synovial fluid and articular cartilage of patients with primary knee osteoarthritis (OA) and to investigate their association ... -
Expression of monocyte chemotactic protein and interleukin-8 by cytokine-activated human vascular smooth muscle cells
(Ovid Technologies (Wolters Kluwer Health), 1991)The present study was designed to investigate the capacity of human vascular smooth muscle cells (SMCs) to produce a cytokine chemotactic for monocytes (monocyte chemotactic protein [MCP]) and by way of comparison, a related ...