Browsing Harvard Medical School by Title
Now showing items 6270-6289 of 18428
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Extensive sequencing of seven human genomes to characterize benchmark reference materials
(Springer Nature, 2016)The Genome in a Bottle Consortium, hosted by the National Institute of Standards and Technology (NIST) is creating reference materials and data for human genome sequencing, as well as methods for genome comparison and ... -
Extensive white matter abnormalities in patients with first-episode schizophrenia: A diffusion tensor imaging (DTI) study
(Elsevier BV, 2013)Background—Previous voxelwise Diffusion Tensor Imaging (DTI) investigations of white matter in first-episode schizophrenia (FESZ) have been limited to the analysis of Fractional Anisotropy (FA) and mean diffusivity (MD), ... -
Extensively Expanded Auricular Chondrocytes Form Neocartilage In Vivo
(SAGE Publications, 2014)Objective: Our goal was to engineer cartilage in vivo using auricular chondrocytes that underwent clinically relevant expansion and using methodologies that could be easily translated into health care practice. Design: ... -
An external validation study reporting poor correlation between the claims-based index for rheumatoid arthritis severity and the disease activity score
(BioMed Central, 2015)Introduction: We conducted an external validation study to examine the correlation of a previously published claims-based index for rheumatoid arthritis severity (CIRAS) with disease activity score in 28 joints calculated ... -
External versus internal fixation for bicondylar tibial plateau fractures: systematic review and meta-analysis
(Springer International Publishing, 2015)Background: It is uncertain whether external fixation or open reduction internal fixation (ORIF) is optimal for patients with bicondylar tibial plateau fractures. Materials and methods A systematic review using Ovid MEDLINE, ... -
Extracavitary Manifestation of Primary Effusion Lymphoma as a Right Atrial Mass
(S. Karger AG, 2013)Primary effusion lymphoma (PEL) is a subset of large B cell lymphomas and has been mostly associated with human immunodeficiency virus infection. Rare cases have been reported in organ transplant recipients and chronic ... -
Extracellular DNA traps released by acute promyelocytic leukemia cells through autophagy
(Nature Publishing Group, 2016)Acute promyelocytic leukemia (APL) cells exhibit disrupted regulation of cell death and differentiation, and therefore the fate of these leukemic cells is unclear. Here, we provide the first evidence that a small percentage ... -
Extracellular HSPs: The Complicated Roles of Extracellular HSPs in Immunity
(Frontiers Media S.A., 2016)Extracellular heat-shock proteins (HSPs) interact with the immune system in a very complex manner. Many such HSPs exert powerful effects on the immune response, playing both stimulatory and regulatory roles. However, the ... -
The Extracellular Matrix Controls Gap Junction Protein Expression and Function in Postnatal Hippocampal Neural Progenitor Cells
(BioMed Central, 2009)Background: Gap junction protein and extracellular matrix signalling systems act in concert to influence developmental specification of neural stem and progenitor cells. It is not known how these two signalling systems ... -
Extracellular Matrix Molecules Facilitating Vascular Biointegration
(MDPI, 2012)All vascular implants, including stents, heart valves and graft materials exhibit suboptimal biocompatibility that significantly reduces their clinical efficacy. A range of biomolecules in the subendothelial space have ... -
Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins
(Oxford University Press, 2016)Aims Extracellular matrix remodelling has been implicated in a number of vascular conditions, including venous hypertension and varicose veins. However, to date, no systematic analysis of matrix remodelling in human veins ... -
Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver
(BioMed Central, 2014)Background: Colorectal cancer is the third most frequently diagnosed cancer and the third cause of cancer deaths in the United States. Despite the fact that tumor cell-intrinsic mechanisms controlling colorectal carcinogenesis ... -
Extracellular Microvesicle Production by Human Eosinophils Activated by “Inflammatory” Stimuli
(Frontiers Media S.A., 2016)A key function of human eosinophils is to secrete cytokines, chemokines and cationic proteins, trafficking, and releasing these mediators for roles in inflammation and other immune responses. Eosinophil activation leads ... -
Extracellular RNAs: development as biomarkers of human disease
(Co-Action Publishing, 2015)Ten ongoing studies designed to test the possibility that extracellular RNAs may serve as biomarkers in human disease are described. These studies, funded by the NIH Common Fund Extracellular RNA Communication Program, ... -
Extracellular Vesicles and Their Convergence with Viral Pathways
(Hindawi Publishing Corporation, 2012)Extracellular vesicles (microvesicles), such as exosomes and shed microvesicles, contain a variety of molecules including proteins, lipids, and nucleic acids. Microvesicles appear mostly to originate from multivesicular ... -
Extracellular vesicles, tissue factor, cancer and thrombosis – discussion themes of the ISEV 2014 Educational Day
(Co-Action Publishing, 2015)Although the association between cancer and venous thromboembolism (VTE) has long been known, the mechanisms are poorly understood. Circulating tissue factor–bearing extracellular vesicles have been proposed as a possible ... -
Extracranial injections of botulinum neurotoxin type A inhibit intracranial meningeal nociceptors’ responses to stimulation of TRPV1 and TRPA1 channels: Are we getting closer to solving this puzzle?
(SAGE Publications, 2016)Background: Administration of onabotulinumtoxinA (BoNT-A) to peripheral tissues outside the calvaria reduces the number of days chronic migraine patients experience headache. Because the headache phase of a migraine attack, ... -
Extracting Physician Group Intelligence from Electronic Health Records to Support Evidence Based Medicine
(Public Library of Science, 2013)Evidence-based medicine employs expert opinion and clinical data to inform clinical decision making. The objective of this study is to determine whether it is possible to complement these sources of evidence with information ... -
The Extraction of Depth Structure from Shading and Texture in the Macaque Brain
(Public Library of Science, 2009)We used contrast-agent enhanced functional magnetic resonance imaging (fMRI) in the alert monkey to map the cortical regions involved in the extraction of 3D shape from the monocular static cues, texture and shading. As ... -
Extracutaneous melanomas: a primer for the radiologist
(Springer Berlin Heidelberg, 2015)Objective: The purpose of this article is to provide a comprehensive review of the imaging features of extracutaneous melanomas. Conclusion: Extracutaneous melanomas are clinically and biologically distinct from their more ...