Browsing Harvard Medical School by Title

Now showing items 6375-6394 of 18426

    • Fast Readout of Object Identity from Macaque Inferior Temporal Cortex 

      Hung, C.; Kreiman, Gabriel; Poggio, T.; DiCarlo, J. (American Association for the Advancement of Science (AAAS), 2005)
      Understanding the brain computations leading to object recognition requires quantitative characterization of the information represented in inferior temporal (IT) cortex. We used a biologically plausible, classifier-based ...

    • A fast statistical significance test for baseline correction and comparative analysis in phase locking 

      Rana, Kunjan D.; Vaina, Lucia M.; Hämäläinen, Matti S. (Frontiers Media S.A., 2013)
      Human perception, cognition, and action are supported by a complex network of interconnected brain regions. There is an increasing interest in measuring and characterizing these networks as a function of time and frequency, ...

    • Fast, Accurate, Small-Scale 3D Scene Capture Using a Low-Cost Depth Sensor 

      Carey, Nicole; Nagpal, Radhika; Werfel, Justin (IEEE, 2017-03)
      Commercially available depth sensing devices are primarily designed for domains that are either macroscopic, or static. We develop a solution for fast microscale 3D reconstruction, using off-the-shelf components. By the ...

    • Fasting is not routinely required for determination of a lipid profile: clinical and laboratory implications including flagging at desirable concentration cut-points—a joint consensus statement from the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory Medicine 

      Nordestgaard, Børge G.; Langsted, Anne; Mora, Samia; Kolovou, Genovefa; Baum, Hannsjörg; Bruckert, Eric; Watts, Gerald F.; Sypniewska, Grazyna; Wiklund, Olov; Borén, Jan; Chapman, M. John; Cobbaert, Christa; Descamps, Olivier S.; von Eckardstein, Arnold; Kamstrup, Pia R.; Pulkki, Kari; Kronenberg, Florian; Remaley, Alan T.; Rifai, Nader; Ros, Emilio; Langlois, Michel (Oxford University Press, 2016)
      Aims To critically evaluate the clinical implications of the use of non-fasting rather than fasting lipid profiles and to provide guidance for the laboratory reporting of abnormal non-fasting or fasting lipid profiles. ...

    • FASTKD2 is associated with memory and hippocampal structure in older adults 

      Ramanan, Vijay K; Nho, Kwangsik; Shen, Li; Risacher, Shannon L.; Kim, Sungeun; McDonald, Brenna C.; Farlow, Martin R.; Foroud, Tatiana M.; Gao, Sujuan; Soininen, Hilkka; Kłoszewska, Iwona; Mecocci, Patrizia; Tsolaki, Magda; Vellas, Bruno; Lovestone, Simon; Aisen, Paul S.; Petersen, Ronald C.; Jack, Clifford R.; Shaw, Leslie M.; Trojanowski, John Q.; Weiner, Michael W.; Green, Robert C.; Toga, Arthur W.; De Jager, Philip L.; Yu, Lei; Bennett, David A.; Saykin, Andrew J. (2014)
      Memory impairment is the cardinal early feature of Alzheimer's disease (AD), a highly prevalent disorder whose causes remain only partially understood. To identify novel genetic predictors, we used an integrative genomics ...

    • Fat Mass–and Obesity-Associated (FTO) Gene Variant Is Associated With Obesity 

      Qi, Lu; Kang, Kihwa; Zhang, Cuilin; van Dam, Rob M.; Kraft, Peter; Hunter, David; Lee, Chih-Hao; Hu, Frank B. (American Diabetes Association, 2008)
      OBJECTIVE—To examine the longitudinal association of fat mass–and obesity-associated (FTO) variant with obesity, circulating adipokine levels, and FTO expression in various materials from human and mouse. RESEARCH DESIGN ...

    • Fat on sale: role of adipose-derived stem cells as anti-fibrosis agent in regenerative medicine 

      Gupta, Manoj K.; Ajay, Amrendra Kumar (BioMed Central, 2015)
      The potential use of stem cells for cell-based tissue repair and regeneration offers alternative therapeutic strategies for various diseases. Adipose-derived stem cells (ADSCs) have emerged as a promising source of stem ...

    • Fat-specific Dicer deficiency accelerates aging and mitigates several effects of dietary restriction in mice 

      Reis, Felipe C. G.; Branquinho, Jéssica L. O.; Brandão, Bruna B.; Guerra, Beatriz A.; Silva, Ismael D.; Frontini, Andrea; Thomou, Thomas; Sartini, Loris; Cinti, Saverio; Kahn, C. Ronald; Festuccia, William T.; Kowaltowski, Alicia J.; Mori, Marcelo A. (Impact Journals LLC, 2016)
      Aging increases the risk of type 2 diabetes, and this can be prevented by dietary restriction (DR). We have previously shown that DR inhibits the downregulation of miRNAs and their processing enzymes - mainly Dicer - that ...

    • FAT1 mutations cause a glomerulotubular nephropathy 

      Gee, Heon Yung; Sadowski, Carolin E.; Aggarwal, Pardeep K.; Porath, Jonathan D.; Yakulov, Toma A.; Schueler, Markus; Lovric, Svjetlana; Ashraf, Shazia; Braun, Daniela A.; Halbritter, Jan; Fang, Humphrey; Airik, Rannar; Vega-Warner, Virginia; Cho, Kyeong Jee; Chan, Timothy A.; Morris, Luc G. T.; ffrench-Constant, Charles; Allen, Nicholas; McNeill, Helen; Büscher, Rainer; Kyrieleis, Henriette; Wallot, Michael; Gaspert, Ariana; Kistler, Thomas; Milford, David V.; Saleem, Moin A.; Keng, Wee Teik; Alexander, Stephen I.; Valentini, Rudolph P.; Licht, Christoph; Teh, Jun C.; Bogdanovic, Radovan; Koziell, Ania; Bierzynska, Agnieszka; Soliman, Neveen A.; Otto, Edgar A.; Lifton, Richard P.; Holzman, Lawrence B.; Sibinga, Nicholas E. S.; Walz, Gerd; Tufro, Alda; Hildebrandt, Friedhelm (Nature Publishing Group, 2016)
      Steroid-resistant nephrotic syndrome (SRNS) causes 15% of chronic kidney disease (CKD). Here we show that recessive mutations in FAT1 cause a distinct renal disease entity in four families with a combination of SRNS, tubular ...

    • Fatal Community-acquired Pneumonia in Children Caused by Re-emergent Human Adenovirus 7d Associated with Higher Severity of Illness and Fatality Rate 

      Yu, Zhiwu; Zeng, Zhiwei; Zhang, Jing; Pan, Yuxian; Chen, Manjun; Guo, Yonghui; Yu, Nan; Chodosh, James; Fu, Ning; Che, Xiaoyan; Zhang, Qiwei (Nature Publishing Group, 2016)
      Human adenoviruses (HAdVs) are highly contagious pathogens causing acute respiratory disease (ARD), such as community-acquired pneumonia. HAdV-7d, a re-emergent genomic variant, has been recently reported in Asia and the ...

    • Fatal Hyperammonemic Brain Injury from Valproic Acid Exposure 

      Bega, Danny; Vaitkevicius, Henrikas; Boland, Torrey Ann; Murray, Michael; Chou, Sherry Hsiang-Yi (S. Karger AG, 2012)
      Background: Hyperammonemia is known to cause neuronal injury, and can result from valproic acid exposure. Prompt reduction of elevated ammonia levels may prevent permanent neurological injury. We report a case of fatal ...

    • Fatal Pediatric Cerebral Malaria Is Associated with Intravascular Monocytes and Platelets That Are Increased with HIV Coinfection 

      Hochman, Sarah E.; Madaline, Theresa F.; Wassmer, Samuel C.; Mbale, Emmie; Choi, Namjong; Seydel, Karl B.; Whitten, Richard O.; Varughese, Julie; Grau, Georges E. R.; Kamiza, Steve; Molyneux, Malcolm E.; Taylor, Terrie E.; Lee, Sunhee; Milner, Danny A.; Kim, Kami (American Society of Microbiology, 2015)
      ABSTRACT Cerebral malaria (CM) is a major contributor to malaria deaths, but its pathophysiology is not well understood. While sequestration of parasitized erythrocytes is thought to be critical, the roles of inflammation ...

    • Fatalities Among Iranian High-altitude Outdoor Enthusiasts: Causes and Mechanisms 

      Kordi, Ramin; Rostami, Mohsen; Heidari, Pedram; Ameli, Sanaz; Foroughifard, Lotfali; Kordi, Mahboobeh (Tehran University of Medical Sciences, 2012)
      Purpose: This study was performed to determine the possible causes and mechanisms of fatalities among Iranian mountaineers during climbing. Methods: By contacting several sources, deceased mountaineers were identified. ...

    • Fatty Acid Binding Protein 4 Deficiency Protects against Oxygen-Induced Retinopathy in Mice 

      Saint-Geniez, Magali; Ghelfi, Elisa; Liang, Xiaoliang; Yu, Chenwei; Spencer, Carrie; Abend, Stephanie; Hotamisligil, Gokhan; Cataltepe, Sule (Public Library of Science, 2014)
      Retinopathy of prematurity (ROP) is a leading cause of blindness in children worldwide due to increasing survival rates of premature infants. Initial suppression, followed by increased production of the retinal vascular ...

    • Fatty Acids and Cancer-Amplified ZDHHC19 Promote STAT3 Activation Through S-Palmitoylation 

      Niu, Jixiao; Sun, Yang; Chen, Baoen; Mino-Kenudson, Mari; Zheng, Baohui; Jarugumilli, Gopala; Walker, Sarah; Hata, Aaron; David, Frank; Wu, Xu (Springer Science and Business Media LLC, 2019-08-28)
      Signal transducer and activator of transcription 3 (STAT3) plays a critical role in regulating cell fate, inflammation and immunity. Cytokines and growth factors activate STAT3 through kinase-mediated tyrosine phosphorylation ...

    • FBXL20-mediated Vps34 ubiquitination as a p53 controlled checkpoint in regulating autophagy and receptor degradation 

      Xiao, Juan; Zhang, Tao; Xu, Daichao; Wang, Huibing; Cai, Yu; Jin, Taijie; Liu, Min; Jin, Mingzhi; Wu, Kejia; Yuan, Junying (Cold Spring Harbor Laboratory Press, 2015)
      Vacuolar protein-sorting 34 (Vps34), the catalytic subunit in the class III PtdIns3 (phosphatidylinositol 3) kinase complexes, mediates the production of PtdIns3P, a key intracellular lipid involved in regulating autophagy ...

    • FBXW7 and USP7 regulate CCDC6 turnover during the cell cycle and affect cancer drugs susceptibility in NSCLC 

      Morra, Francesco; Luise, Chiara; Merolla, Francesco; Poser, Ina; Visconti, Roberta; Ilardi, Gennaro; Paladino, Simona; Inuzuka, Hiroyuki; Guggino, Gianluca; Monaco, Roberto; Colecchia, David; Monaco, Guglielmo; Cerrato, Aniello; Chiariello, Mario; Denning, Krista; Claudio, Pier Paolo; Staibano, Stefania; Celetti, Angela (Impact Journals LLC, 2015)
      CCDC6 gene product is a pro-apoptotic protein substrate of ATM, whose loss or inactivation enhances tumour progression. In primary tumours, the impaired function of CCDC6 protein has been ascribed to CCDC6 rearrangements ...

    • Fc-Epsilon-RI, the High Affinity IgE-Receptor, Is Robustly Expressed in the Upper Gastrointestinal Tract and Modulated by Mucosal Inflammation 

      Bannert, Christina; Bidmon-Fliegenschnee, Bettina; Stary, Georg; Hotzy, Florian; Stift, Judith; Nurko, Samuel; Szépfalusi, Zsolt; Fiebiger, Edda; Dehlink, Eleonora (Public Library of Science, 2012)
      Background: The role of the high affinity IgE receptor, FcεRI, in IgE-mediated immune responses of the gastrointestinal (GI) mucosa is poorly understood. Currently, a detailed characterization of FcεRI expression throughout ...

    • FDG-PET Imaging Reveals Local Brain Glucose Utilization Is Altered by Class I Histone Deacetylase Inhibitors 

      Schroeder, Frederick A; Chonde, Daniel Burje; Riley, Misha M.; Moseley, Christian K.; Granda, Michael L.; Wilson, Colin M.; Wagner, Florence F.; Zhang, Yan-Ling; Gale, Jennifer; Holson, Edward B.; Haggarty, Stephen John; Hooker, Jacob M (Elsevier BV, 2013)
      The purpose of this work – the first of its kind – was to evaluate the impact of chronic selective histone deacetylase (HDAC) inhibitor treatment on brain activity using uptake of the radioligand 18F-fluorodeoxyglucose and ...

    • FDR and American Military Deployment: “My” Armed Forces and their Health 

      Hedley-Whyte, John; Milamed, Debra (The Ulster Medical Society, 2018)