Browsing Harvard Medical School by Title
Now showing items 6496-6515 of 18428
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The Fitness Landscape of HIV-1 Gag: Advanced Modeling Approaches and Validation of Model Predictions by In Vitro Testing
(Public Library of Science, 2014)Viral immune evasion by sequence variation is a major hindrance to HIV-1 vaccine design. To address this challenge, our group has developed a computational model, rooted in physics, that aims to predict the fitness landscape ... -
Five components of the ethylene-response pathway identified in a screen for weak ethylene-insensitive mutants in Arabidopsis
(National Academy of Sciences, 2003)Five ethylene-insensitive loci (wei1-wei5) were identified by using a low-dose screen for "weak" ethylene-insensitive mutants. wei1, wei2, and wei3 seedlings showed hormone insensitivity only in roots, whereas wei4 and ... -
Five Features Of Value-Based Insurance Design Plans Were Associated With Higher Rates Of Medication Adherence
(Health Affairs (Project Hope), 2014)Value-based insurance design (VBID) plans selectively lower cost sharing to increase medication adherence. Existing plans have been structured in a variety of ways, and these variations could influence the effectiveness ... -
Five of Five VHHs Neutralizing Poliovirus Bind the Receptor-Binding Site
(American Society for Microbiology, 2016)Nanobodies, or VHHs, that recognize poliovirus type 1 have previously been selected and characterized as candidates for antiviral agents or reagents for standardization of vaccine quality control. In this study, we present ... -
The five-factor model in schizotypal personality disorder
(Elsevier BV, 2005)Studies of the five-factor model of personality in schizotypal personality disorder (SPD) have produced inconsistent results, particularly with respect to openness. In the present study, the NEO-FFI was used to measure ... -
Fixing DNA breaks during class switch recombination
(Rockefeller University Press, 2008)Immunoglobulin (Ig) class switch recombination (CSR) involves the breakage and subsequent repair of two DNA sequences, known as switch (S) regions, which flank IgH constant region exons. The resolution of CSR-associated ... -
FLAG Assay as a Novel Method for Real-Time Signal Generation During PCR: Application to Detection and Genotyping of KRAS Codon 12 Mutations
(Oxford University Press, 2007)Real-time signal generation methods for detection and characterization of low-abundance mutations in genomic DNA are powerful tools for cancer diagnosis and prognosis. Mutations in codon 12 of the oncogene KRAS, for example, ... -
Flagellar Motility Is Critical for Listeria monocytogenes Biofilm Formation
(American Society for Microbiology, 2007)The food-borne pathogen Listeria monocytogenes attaches to environmental surfaces and forms biofilms that can be a source of food contamination, yet little is known about the molecular mechanisms of its biofilm development. ... -
Flagellin-Deficient Legionella Mutants Evade Caspase-1- and Naip5-Mediated Macrophage Immunity
(Public Library of Science, 2006)Macrophages from C57BL/6J (B6) mice restrict growth of the intracellular bacterial pathogen Legionella pneumophila. Restriction of bacterial growth requires caspase-1 and the leucine-rich repeat-containing protein Naip5 ... -
Flap Endonuclease Activity of Gene 6 Exonuclease of Bacteriophage T7
(American Society for Biochemistry and Molecular Biology, 2014)Background: Flap endonucleases remove 5-single-stranded DNA termini. Results: T7 gene 6 exonuclease is a flap endonuclease that cleaves 5-single-stranded termini one nucleotide into the duplex. Conclusion: The flap ... -
Flap endonuclease of bacteriophage T7: Possible roles in RNA primer removal, recombination and host DNA breakdown
(Landes Bioscience, 2014)Gene 6 protein of bacteriophage T7 has 5′-3′-exonuclease activity specific for duplex DNA. We have found that gene 6 protein also has flap endonuclease activity. The flap endonuclease activity is considerably weaker than ... -
Flare frequency, healthcare resource utilisation and costs among patients with gout in a managed care setting: a retrospective medical claims-based analysis
(BMJ Publishing Group, 2015)Objectives: For most gout patients, excruciatingly painful gout attacks are the major clinical burden of the disease. The goal of this study was to assess the association of frequent gout flares with healthcare burden, and ... -
Flash Memory: Photochemical Imprinting of Neuronal Action Potentials onto a Microbial Rhodopsin
(American Chemical Society, 2014)We developed a technique, “flash memory”, to record a photochemical imprint of the activity state—firing or not firing—of a neuron at a user-selected moment in time. The key element is an engineered microbial rhodopsin ... -
Flavanols, Mild Cognitive Impairment, and Alzheimer’s Dementia
(2008-04-15)Alzheimer’s disease (AD) is a dementing neurological disorder that results in progressive memory loss and cognitive decline thought to be associated with buildup of amyloid plaques and neurofibrillary tangles in the brain. ... -
Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis
(Nature Pub. Group, 2015)Despite the well-documented association between insulin resistance and cardiovascular disease, the key targets of insulin relevant to the development of cardiovascular disease are not known. Here, using non-biased profiling ... -
Flavonoid Ampelopsin Inhibits the Growth and Metastasis of Prostate Cancer In Vitro and in Mice
(Public Library of Science, 2012)The objective of this study was to evaluate the chemopreventive effect of a novel flavonoid, ampelopsin (AMP) on the growth and metastasis of prostate cancer cells. AMP showed the more potent activity in inhibiting the ... -
Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome
(American Diabetes Association, 2013)Metabolic syndrome is a growing health problem worldwide. It is therefore imperative to develop new strategies to treat this pathology. In the past years, the manipulation of NAD+ metabolism has emerged as a plausible ... -
Flavonoid intake and ovarian cancer risk in a population-based case-control study
(Wiley-Blackwell, 2009)Several recent studies have evaluated the association between dietary flavonoid intake and ovarian cancer risk, and all reported significant or suggestive inverse associations with certain flavonoids or flavonoid subclasses; ... -
Flavoring Chemicals in E-Cigarettes: Diacetyl, 2,3-Pentanedione, and Acetoin in a Sample of 51 Products, Including Fruit-, Candy-, and Cocktail-Flavored E-Cigarettes
(National Institute of Environmental Health Sciences, 2015)Background: There are > 7,000 e-cigarette flavors currently marketed. Flavoring chemicals gained notoriety in the early 2000s when inhalation exposure of the flavoring chemical diacetyl was found to be associated with a ... -
Flexible Promoter Architecture Requirements for Coactivator Recruitment
(BioMed Central, 2006)Background: The spatial organization of transcription factor binding sites in regulatory DNA, and the composition of intersite sequences, influences the assembly of the multiprotein complexes that regulate RNA polymerase ...