Browsing Harvard Medical School by Title
Now showing items 6698-6717 of 18428
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Functional Antagonism between CCAAT/Enhancer Binding Protein-α and Peroxisome Proliferator-activated Receptor-γ on the Leptin Promoter
(American Society for Biochemistry and Molecular Biology, 1997)The ob gene product, leptin, is a major hormonal regulator of appetite and fat cell mass, Recent work has suggested that the antidiabetic agents, the thiazolidinediones (TZ), which are also high affinity ligands of peroxisome ... -
Functional brown adipose tissue limits cardiomyocyte injury and adverse remodeling in catecholamine-induced cardiomyopathy
(Elsevier BV, 2015)Brown adipose tissue (BAT) has well recognized thermogenic properties mediated by uncoupling protein 1 (UCP1); more recently, BAT has been demonstrated to modulate cardiovascular risk factors. To investigate whether BAT ... -
Functional Characterization of HLA-G+ Regulatory T Cells in HIV-1 Infection
(Public Library of Science, 2013)Regulatory T cells represent a specialized subpopulation of T lymphocytes that may modulate spontaneous HIV-1 disease progression by suppressing immune activation or inhibiting antiviral T cell immune responses. While the ... -
Functional Characterization of JMJD2A, a Histone Deacetylase- and Retinoblastoma-binding Protein
(American Society for Biochemistry and Molecular Biology, 2005) -
Functional Characterization of Potential New Agents for Cancer Immunotherapy
(2018-05-16)PD-1/PD-L1 checkpoint blockade has demonstrated promise in a variety of malignancies. The blockade of T cell inhibitory molecules PD-1 and PD-L1 can rejuvenate T cells and improve tumor cell killing. However, the overall ... -
Functional Connectivity Density Mapping of Depressive Symptoms and Loneliness in Non-Demented Elderly Male
(Frontiers Media S.A., 2016)Background: Depression and loneliness are prevalent and highly correlated phenomena among the elderly and influence both physical and mental health. Brain functional connectivity changes associated with depressive symptoms ... -
Functional Connectivity in Multiple Cortical Networks Is Associated with Performance Across Cognitive Domains in Older Adults
(Mary Ann Liebert, Inc., 2015)Abstract Intrinsic functional connectivity MRI has become a widely used tool for measuring integrity in large-scale cortical networks. This study examined multiple cortical networks using Template-Based Rotation (TBR), a ... -
Functional Connectivity in the First Year of Life in Infants at Risk for Autism Spectrum Disorder: An EEG Study
(Public Library of Science, 2014)In the field of autism research, recent work has been devoted to studying both behavioral and neural markers that may aide in early identification of autism spectrum disorder (ASD). These studies have often tested infants ... -
Functional connectivity in the first year of life in infants at-risk for autism: a preliminary near-infrared spectroscopy study
(Frontiers Media S.A., 2013)Background: Autism spectrum disorder (ASD) has been called a “developmental disconnection syndrome,” however the majority of the research examining connectivity in ASD has been conducted exclusively with older children and ... -
Functional Connectivity Substrates for tDCS Response in Minimally Conscious State Patients
(Frontiers Media S.A., 2016)Transcranial direct current stimulation (tDCS) is a non-invasive technique recently employed in disorders of consciousness, and determining a transitory recovery of signs of consciousness in almost half of minimally conscious ... -
The Functional Consequences of Cortical Circuit Abnormalities on Gamma Oscillations in Schizophrenia: Insights from Computational Modeling
(Frontiers Research Foundation, 2009)Schizophrenia is characterized by cortical circuit abnormalities, which might be reflected in γ-frequency (30–100 Hz) oscillations in the electroencephalogram. Here we used a computational model of cortical circuitry to ... -
Functional Contributions of Carbohydrate on AIDS Virus Glycoprotein
(YJBM, 2010)Envelope glycoprotein spikes on the surface of the human immunodeficiency virus (HIV) are used by the virus to bind to cellular receptors to gain entry into target cells. As such, the envelope spikes are the targets of ... -
Functional contributions of HCN channels in the primary auditory neurons of the mouse inner ear
(The Rockefeller University Press, 2013)The hyperpolarization-activated current, Ih, is carried by members of the Hcn channel family and contributes to resting potential and firing properties in excitable cells of various systems, including the auditory system. ... -
Functional Copy-Number Alterations in Cancer
(Public Library of Science, 2008)Understanding the molecular basis of cancer requires characterization of its genetic defects. DNA microarray technologies can provide detailed raw data about chromosomal aberrations in tumor samples. Computational analysis ... -
Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62
(eLife Sciences Publications, Ltd, 2016)SQSTM1 is an adaptor protein that integrates multiple cellular signaling pathways and whose expression is tightly regulated at the transcriptional and post-translational level. Here, we describe a forward genetic screening ... -
Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells
(Nature Publishing Group, 2016)Inner ear sensory epithelia contain mechanosensitive hair cells that transmit information to the brain through innervation with bipolar neurons. Mammalian hair cells do not regenerate and are limited in number. Here we ... -
Functional Differences in Engineered Myocardium from Embryonic Stem Cell-Derived versus Neonatal Cardiomyocytes
(Elsevier, 2013)Summary Stem cell-derived cardiomyocytes represent unique tools for cell- and tissue-based regenerative therapies, drug discovery and safety, and studies of fundamental heart-failure mechanisms. However, the degree to which ... -
A Functional Difficulty and Functional Pain Instrument for Hip and Knee Osteoarthritis
(BioMed Central, 2009)Introduction: The objectives of this study were to develop a functional outcome instrument for hip and knee osteoarthritis research (OA-FUNCTION-CAT) using item response theory (IRT) and computer adaptive test (CAT) methods ... -
Functional Effects of the TMEM43 Ser358Leu Mutation in the Pathogenesis of Arrhythmogenic Right Ventricular Cardiomyopathy
(BioMed Central, 2012)Background: The Ser358Leu mutation in TMEM43, encoding an inner nuclear membrane protein, has been implicated in arrhythmogenic right ventricular cardiomyopathy (ARVC). The pathogenetic mechanisms of this mutation are ...