Browsing Harvard Medical School by Title

Now showing items 671-690 of 18428

    • Alternative Calculations of Individual Patient Time in Therapeutic Range While Taking Warfarin: Results From the ROCKET AF Trial 

      Singer, Daniel E.; Hellkamp, Anne S.; Yuan, Zhong; Lokhnygina, Yuliya; Patel, Manesh R.; Piccini, Jonathan P.; Hankey, Graeme J.; Breithardt, Günter; Halperin, Jonathan L.; Becker, Richard C.; Hacke, Werner; Nessel, Christopher C.; Mahaffey, Kenneth W.; Fox, Keith A. A.; Califf, Robert M. (Blackwell Publishing Ltd, 2015)
      Background: In the ROCKET AF (Rivaroxaban–Once‐daily, oral, direct Factor Xa inhibition Compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation) trial, marked regional differences ...

    • Alternative cell death mechanisms in development and beyond 

      Yuan, Junying; Kroemer, Guido (Cold Spring Harbor Laboratory Press, 2010)
      A canonical regulatory pathway involving the members of the Bcl-2 and caspase families has been established to regulate developmental apoptosis in nematodes and flies. However, mutant mice that have major deficiencies in ...

    • Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4 

      Boboila, Cristian; Yan, Catherine; Wesemann, Duane R.; Jankovic, Mila; Wang, Jing H.; Manis, John; Nussenzweig, Andre; Nussenzweig, Michel; Alt, Frederick W. (Rockefeller University Press, 2010)
      The classical nonhomologous end-joining (C-NHEJ) DNA double-strand break (DSB) repair pathway employs the Ku70/80 complex (Ku) for DSB recognition and the XRCC4/DNA ligase 4 (Lig4) complex for ligation. During IgH class ...

    • An alternative hypothesis testing strategy for secondary phenotype data in case-control genetic association studies 

      Lutz, Sharon M.; Hokanson, John E.; Lange, Christoph (Frontiers Media S.A., 2014)
      Motivated by the challenges associated with accounting for the ascertainment when analyzing secondary phenotypes that are correlated with case-control status, Lin and Zeng have proposed a method that properly reflects the ...

    • Alternative Methods for Characterization of Extracellular Vesicles 

      Balaj, Leonora; Tigges, John; Toxavidis, Vasilis; Ivanov, Alexander R.; Skog, Johan; Momen Heravi, Fatemeh; Alian, Sara; Ericsson, Maria; Distel, Robert; Kuo, Winston Patrick (Frontiers Research Foundation, 2012)
      Extracellular vesicles (ECVs) are nano-sized vesicles released by all cells in vitro as well as in vivo. Their role has been implicated mainly in cell–cell communication, but also in disease biomarkers and more recently ...

    • Alternatives for Macronutrient Intake and Chronic Disease: A Comparison of the OmniHeart Diets With Popular Diets and With Dietary Recommendations 

      de Souza, Russell; Swain, Janis; Appel, Lawrence; Sacks, Frank (Oxford University Press (OUP), 2008-07-01)
      Background:Enhancements to current dietary advice to prevent chronic disease are of great clinical and public health importance. The OmniHeart Trial compared 3 diets designed to reduce cardiovascular disease (CVD) risk—one ...

    • Alternatives to Metronidazole 

      Komaroff, Anthony; Cohen, Alan B.; McCue, Jack D. (American Medical Association (AMA), 1976-05-10)
      To the Editor.— The recent warning in The Medical Letter1 regarding the mutagenicity and possible carcinogenicity of metronidazole (Flagyl) raises the question of whether there is an alternative treatment of equal efficacy ...

    • Alu and LINE-1 methylation and lung function in the normative ageing study 

      Lange, Nancy E; Sordillo, Joanne; Tarantini, Letizia; Bollati, Valentina; Sparrow, David; Vokonas, Pantel; Zanobetti, Antonella; Schwartz, Joel David; Baccarelli, Andrea; Litonjua, Augusto Ampil; Demeo, Dawn Lisa (BMJ Publishing Group, 2012)
      Objectives: To investigate the association between methylation of transposable elements Alu and long-interspersed nuclear elements (LINE-1) and lung function. Design: Cohort study. Setting: Outpatient Veterans Administration ...

    • Alveolar Macrophage Interaction With Air Pollution Particulates 

      Goldsmith, C A; Frevert, C; Imrich, A; Sioutas, C; Kobzik, Lester (National Institute of Environmental Health Sciences, 1997)
      We applied flow cytometric analysis to characterize the in vitro response of alveolar macrophages (AM) to air pollution particulates. Normal hamster AM were incubated with varying concentrations of residual oil fly ash ...

    • Alveolar pentraxin 3 as an early marker of microbiologically confirmed pneumonia: a threshold-finding prospective observational study 

      Mauri, Tommaso; Coppadoro, Andrea; Bombino, Michela; Bellani, Giacomo; Zambelli, Vanessa; Fornari, Carla; Berra, Lorenzo; Bittner, Edward A; Schmidt, Ulrich; Sironi, Marina; Bottazzi, Barbara; Brambilla, Paolo; Mantovani, Alberto; Pesenti, Antonio (BioMed Central, 2014)
      Introduction: Timely diagnosis of pneumonia in intubated critically ill patients is rather challenging. Pentraxin 3 (PTX3) is an acute-phase mediator produced by various cell types in the lungs. Animal studies have shown ...

    • Alzheimer's Associated β-Amyloid Protein Inhibits Influenza A Virus and Modulates Viral Interactions with Phagocytes 

      White, Mitchell R.; Kandel, Ruth; Tripathi, Shweta; Condon, David; Qi, Li; Taubenberger, Jeffrey; Hartshorn, Kevan L. (Public Library of Science, 2014)
      Accumulation of β-Amyloid (βA) is a key pathogenetic factor in Alzheimer's disease; however, the normal function of βA is unknown. Recent studies have shown that βA can inhibit growth of bacteria and fungi. In this paper ...

    • Alzheimer's Disease Amyloid-\(\beta\) Links Lens and Brain Pathology in Down Syndrome 

      Moncaster, Juliet A.; Lu, Suqian; Burton, Mark A.; Ghosh, Joy G.; Soscia, Stephanie J.; Mocofanescu, Anca; Kuszak, Jer R.; Pineda, Roberto; Moir, Robert D.; Ericsson, Maria; Folkerth, Rebecca Dunn; Robb, Richard Moore; Clark, John I.; Tanzi, Rudolph Emile; Hunter, David; Goldstein, Lee David (Public Library of Science, 2010)
      Down syndrome (DS, trisomy 21) is the most common chromosomal disorder and the leading genetic cause of intellectual disability in humans. In DS, triplication of chromosome 21 invariably includes the APP gene (21q21) ...

    • The Alzheimer's Disease-Associated Amyloid \(\beta\)-Protein Is an Antimicrobial Peptide 

      Soscia, Stephanie; Kirby, James Edward; Washicosky, Kevin J.; Tucker, Stephanie; Ingelsson, Martin; Hyman, Bradley Theodore; Burton, Mark A.; Duong, Scott; Tanzi, Rudolph Emile; Moir, Robert D.; Goldstein, Lee E. (Public Library of Science, 2010)
      Background: The amyloid \(\beta\)-protein (A\(\beta\)) is believed to be the key mediator of Alzheimer's disease (AD) pathology. A\(\beta\) is most often characterized as an incidental catabolic byproduct that lacks a ...

    • Alzheimer's Disease: Synaptic Dysfunction and Aβ 

      Shankar, Ganesh Mani; Walsh, Dominic M. (BioMed Central, 2009)
      Synapse loss is an early and invariant feature of Alzheimer's disease (AD) and there is a strong correlation between the extent of synapse loss and the severity of dementia. Accordingly, it has been proposed that synapse ...

    • Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers II: Sigma-2/PGRMC1 Receptors Mediate Abeta 42 Oligomer Binding and Synaptotoxicity 

      Izzo, Nicholas J.; Xu, Jinbin; Zeng, Chenbo; Kirk, Molly J.; Mozzoni, Kelsie; Silky, Colleen; Rehak, Courtney; Yurko, Raymond; Look, Gary; Rishton, Gilbert; Safferstein, Hank; Cruchaga, Carlos; Goate, Alison; Cahill, Michael A.; Arancio, Ottavio; Mach, Robert H.; Craven, Rolf; Head, Elizabeth; LeVine, Harry; Spires-Jones, Tara L.; Catalano, Susan M. (Public Library of Science, 2014)
      Amyloid beta (Abeta) 1–42 oligomers accumulate in brains of patients with Mild Cognitive Impairment (MCI) and disrupt synaptic plasticity processes that underlie memory formation. Synaptic binding of Abeta oligomers to ...

    • Alzheimer's-Related Cortical Atrophy Is Associated With Postoperative Delirium Severity in Persons Without Dementia 

      Racine, Annie M.; Fong, Tamara; Travison, Thomas; Jones, Richard N.; Gou, Yun; Vasunilashorn, Sarinnapha; Marcantonio, Edward; Alsop, David; Inouye, Sharon; Dickerson, Bradford (Elsevier BV, 2017-11)
      Patients with dementia due to Alzheimer’s disease (AD) have increased risk of developing delirium. This study investigated the relationship between a magnetic resonance imaging (MRI)-derived biomarker associated with ...

    • Alzheimery's disease pathology is associated with early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci 

      De Jager, PL; Srivastava, G; Lunnon, K; Burgess, J; Schalkwyk, LC; Yu, L; Eaton, ML; Keenan, BT; Ernst, J; McCabe, C; Tang, A; Raj, T; Replogle, J; Brodeur, W; Gabriel, S; Chai, HS; Younkin, C; Younkin, SG; Zou, F; Szyf, M; Epstein, CB; Schneider, JA; Bernstein, BE; Meissner, A; Ertekin-Taner, N; Chibnik, LB; Kellis, M; Mill, J; Bennett, DA (2014)
      Here, we leverage a unique collection of 708 prospectively collected autopsied brains to assess the methylation state of the brain's DNA in relation to Alzheimer's disease (AD). We find that the level of methylation at 71 ...

    • The Alzheimer’s Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide 

      Kirby, James Edward; Washicosky, Kevin J.; Tucker, Stephanie M.; Ingelsson, Martin; Hyman, Bradley Theodore; Burton, Mark A.; Goldstein, Lee E.; Duong, Scott; Tanzi, Rudolph Emile; Moir, Robert D. (Public Library of Science, 2010)
      Background: The amyloid β-protein (Aβ) is believed to be the key mediator of Alzheimer's disease (AD) pathology. Aβ is most often characterized as an incidental catabolic byproduct that lacks a normal physiological role. ...

    • Alzheimer’s loci: epigenetic associations and interaction with genetic factors 

      Chibnik, Lori B; Yu, Lei; Eaton, Matthew L; Srivastava, Gyan; Schneider, Julie A; Kellis, Manolis; Bennett, David A; De Jager, Philip L (John Wiley & Sons, Ltd, 2015)
      Objective: We explore the role of DNA methylation in Alzheimer’s disease (AD). To elucidate where DNA methylation falls along the causal pathway linking risk factors to disease, we examine causal models to assess its role ...

    • AlzPharm: integration of neurodegeneration data using RDF 

      Lam, Hugo YK; Marenco, Luis; Kinoshita, June; Shepherd, Gordon; Miller, Perry; Wu, Elizabeth; Wong, Gwendolyn T; Liu, Nian; Crasto, Chiquito; Morse, Thomas; Stephens, Susie; Cheung, Kei-Hoi; Clark, Timothy William; Gao, Yong (BioMed Central, 2007)
      Background: Neuroscientists often need to access a wide range of data sets distributed over the Internet. These data sets, however, are typically neither integrated nor interoperable, resulting in a barrier to answering ...