Browsing Harvard Medical School by Title

Now showing items 6836-6855 of 18428

    • Gastric Extremely Well-Diferentiated Intestinal-Type Adenocarcinoma: A Challenging Lesion to Achieve Complete Endoscopic Resection 

      Kang, K.; Kim, K.-M.; Kim, J.; Rhee, P.-L.; Lee, J.; Min, B.-H.; Rhee, J.; Kushima, R.; Lauwers, Gregory Y. (Thieme Publishing Group, 2012)
      Extremely well-differentiated tubular adenocarcinomas (EWDAs) of the stomach are characterized by surface maturation and their mimicking of intestinal metaplasia. Endoscopically, intramucosal EWDAs are frequently ill defined ...

    • Gastric Hyperplastic Polyps: A Heterogeneous Clinicopathologic Group Including a Distinct Subset Best Categorized as Mucosal Prolapse Polyp 

      Gonzalez-Obeso, Elvira; Fujita, Hiroshi; Deshpande, Vikram; Ogawa, Fumihiro; Lisovsky, Mikhail; Genevay, Muriel; Grzyb, Krzysztof; Brugge, William Robert; Lennerz, Jochen K.; Shimizu, Michio; Srivastava, Amitabh; Lauwers, Gregory Y. (Ovid Technologies (Wolters Kluwer Health), 2011)
      BACKGROUND: Gastric hyperplastic polyps are the second most common subtype of gastric polyps. There has been an ongoing debate about their precise diagnostic criteria and etiological associations. MATERIALS AND METHODS: A ...

    • Gastric intestinal metaplasia with basal gland atypia: a morphological and biologic evaluation in a large Chinese cohort 

      Li, Yuan; Chang, Xiaoyan; Zhou, Weixun; Xiao, Yun; Nakatsuka, Laura N.; Chen, Jie; Lauwers, Gregory Y. (Elsevier BV, 2013)
      Gastric intestinal metaplasia can display cytoarchitectural atypia that falls short of qualifying for dysplasia but can be classified as indefinite for dysplasia. Yet few studies have evaluated the prevalence, the morphologic, ...

    • Gastric Pit Dysplasia in Adjacent Gastric Mucosa in 414 Gastric Cancers 

      Shin, Nari; Jo, Hong-Jae; Kim, Woo-Kyung; Park, Won-Young; Lee, Jeong-Hee; Shin, Dong Hun; Choi, Kyung Un; Kim, Jee-Yeon; Lee, Chang-Hun; Sol, Mee Young; Jeon, Tae Yong; Kim, Dae Hyun; Huh, Gi-Young; Kim, Gwang Ha; Lauwers, Gregory Y.; Park, Do Youn (Ovid Technologies (Wolters Kluwer Health), 2011)
      Despite wide acceptance of the chronic gastritis-intestinal metaplasia-dysplasia-carcinoma sequence, especially for intestinal-type gastric adenocarcinoma, the precise nature of the subtle precursor lesions of gastric ...

    • Gastritis Cystica Profunda Versus Invasive Adenocarcinoma 

      Odze, Robert D.; Greenson, Joel; Lauwers, Gregory Y.; Goldblum, John (Ovid Technologies (Wolters Kluwer Health), 2012)

    • Gastrointestinal Adenocarcinomas of the Esophagus, Stomach, and Colon Exhibit Distinct Patterns of Genome Instability and Oncogenesis 

      Dulak, A. M.; Schumacher, S. E.; van Lieshout, J.; Imamura, Y.; Fox, Cameron; Shim, B.; Ramos, A. H.; Saksena, G.; Baca, Sylvan Charles; Baselga, J.; Tabernero, J.; Barretina, J.; Enzinger, Peter C.; Corso, G.; Roviello, F.; Lin, Lin; Bandla, S.; Luketich, J. D.; Pennathur, A.; Meyerson, Matthew Langer; Ogino, Shuji; Shivdasani, Ramesh Arjun; Beer, Dennis J; Godfrey, T. E.; Beroukhim, Rameen; Bass, Adam Joel (American Association for Cancer Research (AACR), 2012)
      A more detailed understanding of the somatic genetic events that drive gastrointestinal adenocarcinomas is necessary to improve diagnosis and therapy. Using data from high-density genomic profiling arrays, we conducted an ...

    • Gastrointestinal Stromal Tumor: A Rare Abdominal Tumor 

      Shaheen, Shagufta; Guddati, Achuta K (S. Karger AG, 2013)
      Gastrointestinal stromal tumors (GISTs) are rare abdominal tumors which arise from the interstitial cells of Cajal in the gastrointestinal tract. Gastric GISTs are the most commonly seen GIST tumors and may grow to a very ...

    • GATA transcription factors directly regulate the Parkinson's disease-linked gene α-synuclein 

      Scherzer, Clemens R.; Grass, Jeffrey A.; Liao, Zhixiang; Pepivani, Imelda; Zheng, Bin; Eklund, Aron C.; Ney, Paul A.; Ng, Juliana; McGoldrick, Meghan; Mollenhauer, Brit; Bresnick, Emery H.; Schlossmacher, Michael G. (National Academy of Sciences, 2008)

    • A GATA-1-regulated microRNA locus essential for erythropoiesis 

      Dore, L. C.; Amigo, J. D.; Dos Santos, Carolina; Zhang, Z.; Gai, Xiaowu; Tobias, J. W.; Yu, D.; Klein, A. M.; Dorman, C.; Wu, W.; Hardison, R. C.; Paw, Barry Htin; Weiss, M. J. (Proceedings of the National Academy of Sciences, 2008)
      MicroRNAs (miRNAs) control tissue development, but their mechanism of regulation is not well understood. We used a gene complementation strategy combined with microarray screening to identify miRNAs involved in the formation ...

    • GATA1s induces hyperproliferation of eosinophil precursors in Down syndrome transient leukemia 

      Maroz, Aliaksandra; Stachorski, Lena; Emmrich, Stephan; Reinhardt, Katarina; Xu, Jian; Shao, Zhen; Käbler, Sebastian; Dertmann, Tobias; Hitzler, Johann; Roberts, Irene; Vyas, Paresh; Juban, Gaetan; Hennig, Christian; Hansen, Gesine; Li, Zhe; Orkin, Stuart; Reinhardt, Dirk; Klusmann, Jan-Henning (2014)
      Transient leukemia (TL) is evident in 5–10% of all neonates with Down syndrome (DS) and associated with N-terminal truncating GATA1-mutations (GATA1s). Here we report that TL cell clones generate abundant eosinophils in a ...

    • A Gata3–Mafb transcriptional network directs post-synaptic differentiation in synapses specialized for hearing 

      Yu, Wei-Ming; Appler, Jessica M; Kim, Ye-Hyun; Nishitani, Allison M; Holt, Jeffrey R; Goodrich, Lisa V (eLife Sciences Publications, Ltd, 2013)
      Information flow through neural circuits is determined by the nature of the synapses linking the subtypes of neurons. How neurons acquire features distinct to each synapse remains unknown. We show that the transcription ...

    • GATA5 mutation homozygosity linked to a double outlet right ventricle phenotype in a Lebanese patient 

      Kassab, Kameel; Hariri, Hadla; Gharibeh, Lara; Fahed, Akl C.; Zein, Manal; El‐Rassy, Inaam; Nemer, Mona; El‐Rassi, Issam; Bitar, Fadi; Nemer, Georges (John Wiley and Sons Inc., 2015)
      Abstract Background: GATA transcription factors are evolutionary conserved zinc finger proteins with multiple roles in cell differentiation/proliferation and organogenesis. GATA5 is only transiently expressed in the embryonic ...

    • GATA6 Is a Crucial Regulator of Shh in the Limb Bud 

      Kozhemyakina, Elena; Ionescu, Andreia; Lassar, Andrew B. (Public Library of Science, 2014)
      In the limb bud, patterning along the anterior-posterior (A-P) axis is controlled by Sonic Hedgehog (Shh), a signaling molecule secreted by the “Zone of Polarizing Activity”, an organizer tissue located in the posterior ...

    • Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry 

      Kluk, Michael J.; Ashworth, Todd; Wang, Hongfang; Knoechel, Birgit; Mason, Emily F.; Morgan, Elizabeth A.; Dorfman, David; Pinkus, Geraldine; Weigert, Oliver; Hornick, Jason L.; Chirieac, Lucian R.; Hirsch, Michelle; Oh, David J.; South, Andrew P.; Leigh, Irene M.; Pourreyron, Celine; Cassidy, Andrew J.; DeAngelo, Daniel J.; Weinstock, David M.; Krop, Ian E.; Dillon, Deborah; Brock, Jane E.; Lazar, Alexander J. F.; Peto, Myron; Cho, Raymond J.; Stoeck, Alexander; Haines, Brian B.; Sathayanrayanan, Sriram; Rodig, Scott; Aster, Jon C. (Public Library of Science, 2013)
      Fixed, paraffin-embedded (FPE) tissues are a potentially rich resource for studying the role of NOTCH1 in cancer and other pathologies, but tests that reliably detect activated NOTCH1 (NICD1) in FPE samples have been ...

    • GBM Volumetry using the 3D Slicer Medical Image Computing Platform 

      Egger, Jan; Kapur, Tina; Fedorov, Andriy; Pieper, Steve; Miller, James V.; Veeraraghavan, Harini; Freisleben, Bernd; Golby, Alexandra Jacqueline; Nimsky, Christopher; Kikinis, Ron (Nature Publishing Group, 2013)
      Volumetric change in glioblastoma multiforme (GBM) over time is a critical factor in treatment decisions. Typically, the tumor volume is computed on a slice-by-slice basis using MRI scans obtained at regular intervals. ...

    • GC-rich sequence elements recruit PRC2 in mammalian ES cells 

      Mendenhall, Eric M; Koche, Richard Patrick; Truong, Thanh; Zhou, Vicky Weijie; Issac, Biju; Chi, Andrew S.; Ku, Manching; Bernstein, Bradley E. (Public Library of Science, 2010)
      Polycomb proteins are epigenetic regulators that localize to developmental loci in the early embryo where they mediate lineage-specific gene repression. In Drosophila, these repressors are recruited to sequence elements ...

    • Gd(DOTAlaP): Exploring the Boundaries of Fast Water Exchange in Gadolinium-Based Magnetic Resonance Imaging Contrast Agents 

      Boros, Eszter; Karimi, Shima; Kenton, Nathaniel; Helm, Lothar; Caravan, Peter (American Chemical Society, 2014)
      Here, we describe the synthesis of the single amino acid chelator DOTAlaP and four of its derivatives. The corresponding gadolinium(III) complexes were investigated for their kinetic inertness, relaxometric properties at ...

    • Ge-1 is a central component of the mammalian cytoplasmic mRNA processing body 

      Yu, Jiang Hong; Yang, Wei-hong; Gulick, Tod; Bloch, Kenneth D.; Bloch, Donald B. (Cold Spring Harbor Laboratory Press, 2005)
      The mRNA processing body (P-body) is a cellular structure that regulates gene expression by degrading cytoplasmic mRNA. The objective of this study was to identify and characterize novel components of the mammalian P-body. ...

    • GEF-H1 controls microtubule-dependent sensing of nucleic acids for antiviral host defenses 

      Chiang, Hao-Sen; Zhao, Yun; Song, Joo-Hye; Liu, Song; Wang, Ninghai; Terhorst, Cox; Sharpe, Arlene H.; Basavappa, Megha; Jeffrey, Kate L.; Reinecker, Hans-Christian (2014)
      Detailed understanding of the signaling intermediates that confer the sensing of intracellular viral nucleic acids for induction of type I interferons is critical for strategies to curtail viral mechanisms that impede ...

    • GEF-H1 Mediated Control of NOD1 Dependent NF-κB Activation by Shigella Effectors 

      Fukazawa, Atsuko; Alonso, Carmen; Kurachi, Kiyotaka; Gupta, Sonal; Philpott, Dana J.; Lesser, Cammie; McCormick, Beth A.; Reinecker, Hans-Christian (Public Library of Science, 2008)
      Shigella flexneri has evolved the ability to modify host cell function with intracellular active effectors to overcome the intestinal barrier. The detection of these microbial effectors and the initiation of innate immune ...