Browsing Harvard Medical School by Title

Now showing items 6867-6886 of 18428

    • Gender Differences in the Motivational Processing of Babies Are Determined by Their Facial Attractiveness 

      Yamamoto, Rinah Tikvah; Ariely, Dan; Chi, Won; Langleben, Daniel D.; Elman, Igor (Public Library of Science, 2009)
      Background: This study sought to determine how esthetic appearance of babies may affect their motivational processing by the adults. Methodology and Principal Findings: Healthy men and women were administered two ...

    • Gender Disparity and Mutation Burden in Melanoma 

      Gupta, Sameer (2016-05-17)
      A female advantage in melanoma incidence and outcome has been consistently observed but remains unexplained. We hypothesized that tumors are genetically distinct between men and women and analyzed the mutation spectra in ...

    • Gender-Related Differences in the Prevalence of Cardiovascular Disease Risk Factors and their Correlates in Urban Tanzania 

      Njelekela, Marina A; Mpembeni, Rose; Mligiliche, Nuru L; Mtabaji, Jacob; Muhihi, Alfa; Spiegelman, Donna Lynn; Hertzmark, Ellen; Liu, Enju; Finkelstein, Julia Leigh; Fawzi, Wafaie W.; Willett, Walter C. (BioMed Central, 2009)
      Background: Urban areas in Africa suffer a serious problem with dual burden of infectious diseases and emerging chronic diseases such as cardiovascular diseases (CVD) and diabetes which pose a serious threat to population ...

    • Gender-specific hypertension and responsiveness to nitric oxide in sGCa1 knockout mice 

      Buys, Emmanuel; Sips, Patrick; Vermeersch, Pieter; Raher, Michael J.; Rogge, Elke; Ichinose, Fumito; Dewerchin, Mieke; Bloch, Kenneth; Janssens, Stefan; Brouckaert, Peter (Oxford University Press (OUP), 2008)
      Aim: The effects of nitric oxide (NO) in the cardiovascular system are attributed in part to cGMP synthesis by the α1β1 isoform of soluble guanylate cyclase (sGC). Because available sGC inhibitors are neither enzyme- nor ...

    • Gender-Specific Modulation of the Response to Arterial Injury by Soluble Guanylate Cyclase α1 

      Vermeersch, Pieter; Pokreisz, Peter; Marsboom, Glenn; Gillijns, Hilde; Pellens, Marijke; Dewerchin, Mieke; Brouckaert, Peter; Janssens, Stefan; Buys, Emmanuel; Sips, Patrick; Bloch, Kenneth Daniel (Bentham Open, 2009)
      Objective: Soluble guanylate cyclase (sGC), a heterodimer composed of α and β subunits, synthesizes cGMP in response to nitric oxide (NO). NO modulates vascular tone and structure but the relative contributions of ...

    • Gender-Specific Molecular and Clinical Features Underlie Malignant Pleural Mesothelioma 

      De Rienzo, Assunta; Archer, Michael A.; Yeap, Beow; Dao, Nhien; Sciaranghella, Daniele; Sideris, Antonios C.; Zheng, Yifan; Holman, Alexander G.; Wang, Yaoyu E.; Dal Cin, Paola; Fletcher, Jonathan; Rubio, Renee; Croft, Larry; Quackenbush, John; Sugarbaker, Peter E.; Munir, Kiara J.; Battilana, Jesse R.; Gustafson, Corinne; Chirieac, Lucian; Ching, Soo Meng; Wong, James; Tay, Liang Chung; Rudd, Stephen; Hercus, Robert; Sugarbaker, David J.; Richards, William; Bueno, Raphael (American Association for Cancer Research (AACR), 2016-01-15)
      Malignant pleural mesothelioma (MPM) is an aggressive cancer that occurs more frequently in men, but is associated with longer survival in women. Insight into the survival advantage of female patients may advance the ...

    • Gene 1.7 of bacteriophage T7 confers sensitivity of phage growth to dideoxythymidine 

      Tran, Ngoc Q.; Rezende, Lisa F.; Qimron, Udi; Richardson, Charles C.; Tabor, Stanley (National Academy of Sciences, 2008)
      Bacteriophage T7 DNA polymerase efficiently incorporates dideoxynucleotides into DNA, resulting in chain termination. Dideoxythymidine (ddT) present in the medium at levels not toxic to Escherichia coli inhibits phage T7. ...

    • Gene 4 DNA Primase of Bacteriophage T7 Mediates the Annealing and Extension of Ribo-oligonucleotides at Primase Recognition Sites 

      Kusakabe, Takahiro; Richardson, Charles C. (American Society for Biochemistry and Molecular Biology, 1997)
      The 63-kDa gene 4 primase of bacteriophage T7 recognizes a core trinucleotide sequence, 5'-GTC-3', on single-stranded DNA at which it catalyzes the synthesis of the ribodinucleotide pppAC. The dinucleotide is extended to ...

    • Gene 5.5 protein of bacteriophage T7 in complex with Escherichia coli nucleoid protein H-NS and transfer RNA masks transfer RNA priming in T7 DNA replication 

      Zhu, Bin; Lee, Seung-Joo; Tan, Min; Wang, En-Duo; Richardson, Charles C. (National Academy of Sciences, 2012)
      DNA primases provide oligoribonucleotides for DNA polymerase to initiate lagging strand synthesis. A deficiency in the primase of bacteriophage T7 to synthesize primers can be overcome by genetic alterations that decrease ...

    • Gene and Genome Parameters of Mammalian Liver Circadian Genes (LCGs) 

      Wu, Gang; Zhu, Jiang; He, Fuhong; Wang, Weiwei; Hu, Songnian; Yu, Jun (Public Library of Science, 2012)
      The mammalian circadian system controls various physiology processes and behavior responses by regulating thousands of circadian genes with rhythmic expressions. In this study, we redefined circadian-regulated genes based ...

    • Gene co-expression analysis identifies brain regions and cell types involved in migraine pathophysiology: a GWAS-based study using the Allen Human Brain Atlas 

      Eising, Else; Huisman, Sjoerd M. H.; Mahfouz, Ahmed; Vijfhuizen, Lisanne S.; Anttila, Verneri; Winsvold, Bendik S.; Kurth, Tobias; Ikram, M. Arfan; Freilinger, Tobias; Kaprio, Jaakko; Boomsma, Dorret I.; van Duijn, Cornelia M.; Järvelin, Marjo-Riitta R.; Zwart, John-Anker; Quaye, Lydia; Strachan, David P.; Kubisch, Christian; Dichgans, Martin; Davey Smith, George; Stefansson, Kari; Palotie, Aarno; Chasman, Daniel I.; Ferrari, Michel D.; Terwindt, Gisela M.; de Vries, Boukje; Nyholt, Dale R.; Lelieveldt, Boudewijn P. F.; van den Maagdenberg, Arn M. J. M.; Reinders, Marcel J. T. (Springer Berlin Heidelberg, 2016)
      Migraine is a common disabling neurovascular brain disorder typically characterised by attacks of severe headache and associated with autonomic and neurological symptoms. Migraine is caused by an interplay of genetic and ...

    • Gene Editing Using CRISPR 

      Komaroff, Anthony L. (American Medical Association (AMA), 2017)
      The gene-editing technique known as CRISPR (clustered regularly interspaced short palindromic repeats) is only 5 years old, yet it has galvanized biomedical research and raised important ethical questions. What is it, how ...

    • Gene expression analysis in Fmr1KO mice identifies an immunological signature in brain tissue and mGluR5-related signaling in primary neuronal cultures 

      Prilutsky, Daria; Kho, Alvin T.; Palmer, Nathan P.; Bhakar, Asha L.; Smedemark-Margulies, Niklas; Margulies, David M.; Kong, Sek Won; Bear, Mark F.; Kohane, Isaac S. (BioMed Central, 2015)
      Background: Fragile X syndrome (FXS) is a neurodevelopmental disorder whose biochemical manifestations involve dysregulation of mGluR5-dependent pathways, which are widely modeled using cultured neurons. In vitro phenotypes ...

    • Gene Expression Analysis of Embryonic Stem Cells Expressing VE-Cadherin (CD144) During Endothelial Differentiation 

      Nikolova-Krstevski, Vesna; Bhasin, Manoj; Otu, Hasan H; Libermann, Towia Aron; Oettgen, Peter (BioMed Central, 2008)
      Backgroun: Endothelial differentiation occurs during normal vascular development in the developing embryo. This process is recapitulated in the adult when endothelial progenitor cells are generated in the bone marrow and ...

    • Gene expression analysis of pig cumulus-oocyte complexes stimulated in vitro with follicle stimulating hormone or epidermal growth factor-like peptides 

      Blaha, Milan; Nemcova, Lucie; Kepkova, Katerina Vodickova; Vodicka, Petr; Prochazka, Radek (BioMed Central, 2015)
      Background: The gonadotropin-induced resumption of oocyte meiosis in preovulatory follicles is preceded by expression of epidermal growth factor (EGF)-like peptides, amphiregulin (AREG) and epiregulin (EREG), in mural ...

    • Gene Expression Analysis of Zebrafish Heart Regeneration 

      Lien, Ching-Ling; Schebesta, Michael; Makino, Shinji; Weber, Gerhard Johannes; Keating, Mark T. (Public Library of Science, 2006)
      Mammalian hearts cannot regenerate. In contrast, zebrafish hearts regenerate even when up to 20% of the ventricle is amputated. The mechanism of zebrafish heart regeneration is not understood. To systematically characterize ...

    • Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells 

      Zhou, Xiaobo; Qiu, Weiliang; Sathirapongsasuti, J. Fah; Cho, Michael Hyosang; Mancini, John D.; Lao, Taotao; Thibault, Derek M.; Litonjua, Augusto Ampil; Bakke, Per S.; Gulsvik, Amund; Lomas, David A.; Beaty, Terri H.; Hersh, Craig Palmer; Anderson, Christopher David; Geigenmuller, Ute; Raby, Benjamin Alexander; Rennard, Stephen I.; Perrella, Mark A.; Choi, Augustine M.K.; Quackenbush, John; Silverman, Edwin Kepner (Elsevier BV, 2013)
      Hedgehog Interacting Protein (HHIP) was implicated in chronic obstructive pulmonary disease (COPD) by genome-wide association studies (GWAS). However, it remains unclear how HHIP contributes to COPD pathogenesis. To identify ...

    • Gene expression changes and molecular pathways mediating activity-dependent plasticity in visual cortex 

      Tropea, Daniela; Kreiman, Gabriel; Lyckman, Alvin; Mukherjee, Sayan; Yu, Hongbo; Horng, Sam; Sur, Mriganka (Nature Publishing Group, 2006)
      Two key models for examining activity-dependent development of primary visual cortex (V1) involve either reduction of activity in both eyes via dark-rearing (DR) or imbalance of activity between the two eyes via monocular ...

    • Gene Expression Changes within Müller Glial Cells in Retinitis Pigmentosa 

      Roesch, Karin; Stadler, Michael B.; Cepko, Connie (Molecular Vision, 2012)
      Purpose: Retinitis pigmentosa (RP) is a progressive retinal degeneration in which the retina loses nearly all of its photoreceptor cells and undergoes major structural changes. Little is known regarding the role the resident ...

    • Gene expression defines natural changes in mammalian lifespan 

      Fushan, Alexey A; Turanov, Anton A; Lee, Sang-Goo; Kim, Eun Bae; Lobanov, Alexei V; Yim, Sun Hee; Buffenstein, Rochelle; Lee, Sang-Rae; Chang, Kyu-Tae; Rhee, Hwanseok; Kim, Jong-So; Yang, Kap-Seok; Gladyshev, Vadim N (BlackWell Publishing Ltd, 2015)
      Mammals differ more than 100-fold in maximum lifespan, which can be altered in either direction during evolution, but the molecular basis for natural changes in longevity is not understood. Divergent evolution of mammals ...