Browsing Harvard Medical School by Title

Now showing items 7026-7045 of 18428

    • Genetic Odyssey to Generate Marked Clones in Drosophila Mosaics 

      Griffin, Ruth; Binari, Richard; Perrimon, Norbert (National Academy of Sciences, 2014-04-01)
      Chimaeras, fanciful beasts that drew their force from being composed of parts of disparate animals, have stimulated our collective imagination for centuries. In modern terms, chimaeras are composite animals consisting of ...

    • Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci 

      Andreassen, O A; Harbo, H F; Wang, Y; Thompson, W K; Schork, A J; Mattingsdal, M; Zuber, V; Bettella, F; Ripke, S; Kelsoe, J R; Kendler, K S; O'Donovan, M C; Sklar, P; McEvoy, L K; Desikan, R S; Lie, B A; Djurovic, S; Dale, A M (Nature Publishing Group, 2015)
      Converging evidence implicates immune abnormalities in schizophrenia (SCZ), and recent genome-wide association studies (GWAS) have identified immune-related single-nucleotide polymorphisms (SNPs) associated with SCZ. Using ...

    • Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking 

      Costenbader, Karen Harte; Chang, Shun-Chiao; De Vivo, Immaculata; Plenge, Robert M.; Karlson, Elizabeth Wood (BioMed Central, 2008)
      Introduction: PTPN22, PADI-4, and CTLA-4 have been associated with risk for rheumatoid arthritis (RA). We investigated whether polymorphisms in these genes were associated with RA in Caucasian women included in two large ...

    • Genetic polymorphisms of angiotensin-2 type 1 receptor and angiotensinogen and risk of renal dysfunction and coronary heart disease in type 2 diabetes mellitus 

      Lin, Julie; Hu, Frank B.; Qi, Lu; Curhan, Gary Craig (BioMed Central, 2009)
      Background: Increased activation of the renin-angiotensin system (RAS) may be important in promoting coronary heart disease (CHD) and renal dysfunction, but limited data are available on associations between angiotensin ...

    • Genetic Polymorphisms of Interleukin-1 Alpha and the Vitamin D Receptor in Mexican Mestizo Patients with Intervertebral Disc Degeneration 

      Cervin Serrano, Salvador; González Villareal, Dalia; Aguilar-Medina, Maribel; Romero-Navarro, Jose Guillermo; Romero Quintana, Jose Geovanni; Arámbula Meraz, Eliakym; Osuna Ramírez, Ignacio; Picos-Cárdenas, Veronica; Granados, Julio; Estrada-García, Iris; Sánchez-Schmitz, Guzman; Ramos-Payán, Rosalío (Hindawi Publishing Corporation, 2014)
      Intervertebral disc degeneration (IDD) is the most common diagnosis in patients with back pain, a leading cause of musculoskeletal disability worldwide. Several conditions, such as occupational activities, gender, age, and ...

    • Genetic Polymorphisms of the Glycine N-Methyltransferase and Prostate Cancer Risk in the Health Professionals Follow-Up Study 

      Chen, Marcelo; Huang, Yi-Ling; Huang, Yu-Chuen; Shui, Irene M.; Giovannucci, Edward; Chen, Yen-Ching; Chen, Yi-Ming Arthur (Public Library of Science, 2014)
      Purpose Glycine N-methyltransferase (GNMT) affects genetic stability by regulating the ratio of S-adenosylmethionine to S-adenosylhomocysteine, by binding to folate, and by interacting with environmental carcinogens. In ...

    • Genetic Predictors of Weight Loss and Weight Regain After Intensive Lifestyle Modification, Metformin Treatment, or Standard Care in the Diabetes Prevention Program 

      Delahanty, Linda Michele; Pan, Qing; Jablonski, Kathleen A.; Watson, Karol E.; McCaffery, Jeanne M.; Shuldiner, Alan; Kahn, Steven E.; Knowler, William C.; Florez, Jose Carlos; Franks, Paul W. (American Diabetes Association, 2012)
      OBJECTIVE: We tested genetic associations with weight loss and weight regain in the Diabetes Prevention Program, a randomized controlled trial of weight loss–inducing interventions (lifestyle and metformin) versus placebo. ...

    • Genetic Predisposition to Dyslipidemia and Type 2 Diabetes Risk in Two Prospective Cohorts 

      Qi, Qibin; Liang, Liming; Doria, Alessandro; Hu, Frank B.; Qi, Lu (American Diabetes Association, 2012)
      Dyslipidemia has been associated with type 2 diabetes, but it remains unclear whether dyslipidemia plays a causal role in type 2 diabetes. We aimed to examine the association between the genetic predisposition to dyslipdemia ...

    • Genetic Predisposition to High Blood Pressure Associates With Cardiovascular Complications Among Patients With Type 2 Diabetes: Two Independent Studies 

      Qi, Qibin; Forman, John P.; Jensen, Majken K.; Flint, Alan; Curhan, Gary C.; Rimm, Eric B.; Hu, Frank B.; Qi, Lu (American Diabetes Association, 2012)
      Hypertension and type 2 diabetes (T2D) commonly coexist, and both conditions are major risk factors for cardiovascular disease (CVD). We aimed to examine the association between genetic predisposition to high blood pressure ...

    • Genetic Predisposition to Higher Body Mass Index or Type 2 Diabetes and Leukocyte Telomere Length in the Nurses' Health Study 

      Du, Mengmeng; Prescott, Jennifer; Cornelis, Marilyn; Hankinson, Susan Elizabeth; Giovannucci, Edward L.; Kraft, Phillip L.; De Vivo, Immaculata (Public Library of Science, 2013)
      Background: Although cross-sectional studies have linked higher body mass index (BMI) and type 2 diabetes (T2D) to shortened telomeres, whether these metabolic conditions play a causal role in telomere biology is unknown. ...

    • Genetic Predisposition to Long-Term Nondiabetic Deteriorations in Glucose Homeostasis: Ten-Year Follow-Up of the GLACIER Study 

      Renström, Frida; Shungin, Dmitry; Johansson, Ingegerd; Florez, Jose Carlos; Hallmans, Göran; Hu, Frank B.; Franks, Paul W. (American Diabetes Association, 2011)
      Objective: To assess whether recently discovered genetic loci associated with hyperglycemia also predict long-term changes in glycemic traits. Research Design and Methods: Sixteen fasting glucose-raising loci were genotyped ...

    • Genetic Predisposition to Mosaic Y Chromosome Loss in Blood 

      Genovese, Giulio; Wright, Daniel J.; Terao, Chikashi; Davidsson, Olafur B.; Day, Felix R.; Sulem, Patrick; Jiang, Yunxuan; Danielsson, Marcus; Davies, Hanna; Dennis, Joe; Dunlop, Malcolm G.; Easton, Douglas F.; Fisher, Victoria A.; Zink, Florian; Houlston, Richard S.; Ingelsson, Martin; Kar, Siddhartha; Kerrison, Nicola D.; Kinnersley, Ben; Kristjansson, Ragnar P.; Law, Philip J.; Li, Rong; Loveday, Chey; Mattisson, Jonas; Murakami, Yoshinori; Murray, Anna; Olszewski, Pawel; Rychlicka-Buniowska, Edyta; Scott, Robert A.; Thorsteinsdottir, Unnur; Tomlinson, Ian; Moghadam, Behrooz Torabi; Turnbull, Clare; Wareham, Nicholas J.; Gudbjartsson, Daniel F.; Kamatani, Yoichiro; Hoffmann, Eva R.; Jackson, Steve P.; Stefansson, Kari; Auton, Adam; Ong, Ken K.; Machiela, Mitchell J.; Loh, Po-Ru; Dumanski, Jan P.; Chanock, Stephen J.; Forsberg, Lars A.; Perry, John R. B.; Thompson, Deborah; Halvardson, Jonatan; Ulirsch, Jacob; McCarroll, Steven; Wright, Daniel (Springer Science and Business Media LLC, 2019-11)
      Mosaic loss of chromosome Y (LOY) in circulating white blood cells is the most common form of clonal mosaicism yet our knowledge of the causes and consequences of this is limited. Here, using a computational approach, we ...

    • The genetic prehistory of southern Africa 

      Pickrell, Joseph; Patterson, Nick; Barbieri, Chiara; Berthold, Falko; Gerlach, Linda; Güldemann, Tom; Kure, Blesswell; Mpoloka, Sununguko Wata; Nakagawa, Hirosi; Naumann, Christfried; Lipson, Mark; Loh, Po-Ru; Lachance, Joseph; Mountain, Joanna; Bustamante, Carlos D.; Berger, Bonnie; Tishkoff, Sarah A.; Henn, Brenna M.; Stoneking, Mark; Reich, David; Pakendorf, Brigitte (Nature Pub. Group, 2012)
      Southern and eastern African populations that speak non-Bantu languages with click consonants are known to harbour some of the most ancient genetic lineages in humans, but their relationships are poorly understood. Here, ...

    • Genetic Regulation of Caenorhabditis elegans Lysosome Related Organelle Function 

      Soukas, Alexander A.; Carr, Christopher E.; Ruvkun, Gary (Public Library of Science, 2013)
      Lysosomes are membrane-bound organelles that contain acid hydrolases that degrade cellular proteins, lipids, nucleic acids, and oligosaccharides, and are important for cellular maintenance and protection against age-related ...

    • Genetic regulation of expression of leukotriene A4 hydrolase 

      Szul, Tomasz; Castaldi, Peter; Cho, Michael H.; Blalock, J. Edwin; Gaggar, Amit (European Respiratory Society, 2016)
      In chronic inflammatory lung disorders such as chronic obstructive pulmonary disease (COPD), the concurrent organ-specific and systemic inflammatory responses lead to airway remodelling and vascular dysfunction. Although ...

    • Genetic reporter analysis reveals an expandable reservoir of OCT4+ cells in adult skin 

      Limbourg, Anne; Schnabel, Sabine; Lozanovski, Vladimir J; Napp, L Christian; Ha, Teng-Cheong; Maetzig, Tobias; Bauersachs, Johann; Naim, Hassan Y; Schambach, Axel; Limbourg, Florian P (BioMed Central, 2014)
      The transcription factor Oct4 (Pou5f1) is a critical regulator of pluripotency in embryonic and induced pluripotent stem cells. Therefore, Oct4 expression might identify somatic stem cell populations with inherent multipotent ...

    • Genetic Reporter System for Positioning of Proteins at the Bacterial Pole 

      Fixen, Kathryn R.; Janakiraman, Anuradha; Garrity, Sean; Slade, Daniel J.; Gray, Andrew N.; Karahan, Nilay; Hochschild, Ann; Goldberg, Marcia Beurman (American Society of Microbiology, 2012)
      Spatial organization within bacteria is fundamental to many cellular processes, although the basic mechanisms underlying localization of proteins to specific sites within bacteria are poorly understood. The study of protein ...

    • Genetic Requirements for Sensitivity of Bacteriophage T7 to Dideoxythymidine 

      Tran, Ngoc; Tabor, Stanley; Richardson, Charles (American Society for Microbiology, 2014)
      We previously reported that the presence of dideoxythymidine (ddT) in the growth medium selectively inhibits the ability of bacteriophage T7 to infect Escherichia coli by inhibiting phage DNA synthese (N. Q. Tran, L. F. ...

    • Genetic Rescue of Chondrodysplasia and the Perinatal Lethal Effect of Cartilage Link Protein Deficiency 

      Czipri, Mátyás; Otto, Jeffrey; Cs-Szabó, Gabriella; Kamath, Rajesh; Vermes, Csaba; Firneisz, Gabor; Kolman, Kevin; Watanabe, Hideto; Roughley, Peter; Yamada, Yoshihiko; Olsen, Bjorn; Glant, Tibor (American Society for Biochemistry & Molecular Biology (ASBMB), 2003-05-05)
      The targeted disruption of cartilage link protein gene (Crtl1) in homozygous mice resulted in a severe chon- drodysplasia and perinatal lethality. This raised the question of whether the abnormalities seen in Crtl1 null ...

    • Genetic research in autism spectrum disorders 

      Robinson, Elise B.; Neale, Benjamin M.; Hyman, Steven E. (Lippincott Williams and Wilkins, 2015)
      Purpose of review The recent explosion of genetic findings in autism spectrum disorder (ASD) research has improved knowledge of the disorder's underlying biology and etiologic architecture. This review introduces concepts ...