Browsing Harvard Medical School by Title

Now showing items 7386-7405 of 18428

    • Global health education in U.S. Medical schools 

      Khan, Omar A; Guerrant, Richard; Sanders, James; Carpenter, Charles; Spottswood, Margaret Elise Pullin; Jones, David Shumway; O’Callahan, Cliff; Brewer, Timothy F; Markuns, Jeffrey F; Gillam, Stephen; O’Neill, Joseph; Nathanson, Neal; Wright, Stephen (BioMed Central, 2013)
      Interest in global health (GH) among medical students worldwide is measurably increasing. There is a concomitant emphasis on emphasizing globally-relevant health professions education. Through a structured literature review, ...

    • Global Health: Role of HPV Testing in Resource Poor Environment 

      Goodman, Annekathryn; Joseph, Naima; Bradford, Leslie; Dey, Bimalangshu (OMICS Publishing Group, 2015)
      Eighty-five percent of cervical cancer deaths occur in the developing world. While cervical cancer is only the tenth most common cancer in women in developed countries, it is the leading cause of cancer related deaths in ...

    • Global Identification of Modular Cullin-RING Ligase Substrates 

      Emanuele, Michael J.; Xu, Qikai; Thoma, Claudio R.; Izhar, Lior; Leng, Yumei; Guo, Ailan; Chen, Yi-Ning; Rush, John; Hsu, Paul Wei-Che; Yen, Hsueh-Chi Sherry; Elledge, Stephen; Elia, Andrew (Elsevier BV, 2011-10)
      Cullin-RING ligases (CRLs) represent the largest E3 ubiquitin ligase family in eukaryotes, and the identification of their substrates is critical to understanding regulation of the proteome. Using genetic and pharmacologic ...

    • Global mapping of infectious disease 

      Hay, Simon I.; Battle, Katherine E.; Pigott, David M.; Smith, David L.; Moyes, Catherine L.; Bhatt, Samir; Brownstein, John S.; Collier, Nigel; Myers, Monica F.; George, Dylan B.; Gething, Peter W. (The Royal Society, 2013)
      The primary aim of this review was to evaluate the state of knowledge of the geographical distribution of all infectious diseases of clinical significance to humans. A systematic review was conducted to enumerate cartographic ...

    • Global Medical Shape Analysis Using the Laplace-Beltrami Spectrum 

      Niethammer, Marc; Reuter, Martin; Wolter, Franz-Erich; Bouix, Sylvain; Peinecke, Niklas; Koo, Min-Seong; Shenton, Martha Elizabeth (Springer, 2007)
      This paper proposes to use the Laplace-Beltrami spectrum (LBS) as a global shape descriptor for medical shape analysis, allowing for shape comparisons using minimal shape preprocessing: no registration, mapping, or remeshing ...

    • Global Metabolomic Profiling Reveals an Association of Metal Fume Exposure and Plasma Unsaturated Fatty Acids 

      Wei, Yongyue; Wang, Zhaoxi; Chang, Chiung-yu; Fan, Tianteng; Su, Li; Chen, Feng; Christiani, David C. (Public Library of Science, 2013)
      Background: Welding-associated air pollutants negatively affect the health of exposed workers; however, their molecular mechanisms in causing disease remain largely unclear. Few studies have systematically investigated the ...

    • Global Patterns of QALY and DALY Use in Surgical Cost-Utility Analyses: A Systematic Review 

      Rios-Diaz, Arturo J.; Lam, Jimmy; Ramos, Margarita S.; Moscoso, Andrea V.; Vaughn, Patrick; Zogg, Cheryl K.; Caterson, Edward J. (Public Library of Science, 2016)
      Background: Surgical interventions are being increasingly recognized as cost-effective global priorities, the utility of which are frequently measured using either quality-adjusted (QALY) or disability-adjusted (DALY) life ...

    • A Global Protein–Lipid Interactome Map 

      Brehme, Marc J; Vidal, Marc (Nature Publishing Group, 2010)

    • Global Research Priorities to Better Understand the Burden of Iatrogenic Harm in Primary Care: An International Delphi Exercise 

      Cresswell, Kathrin M.; Panesar, Sukhmeet S.; Salvilla, Sarah A.; Carson-Stevens, Andrew; Larizgoitia, Itziar; Donaldson, Liam J.; Bates, David; Sheikh, Aziz (Public Library of Science, 2013)
      Using a modified Delphi exercise, Aziz Sheikh and colleagues identify research priorities for patient safety research in primary care contexts. Please see later in the article for the Editors' Summary

    • Global RNA Half-Life Analysis in Escherichia coli Reveals Positional Patterns of Transcript Degradation 

      Selinger, Douglas; Saxena, Rini Mukherjee; Cheung, Kevin J.; Church, George; Rosenow, Carsten (Cold Spring Harbor Laboratory, 2003-01-14)
      Subgenic-resolution oligonucleotide microarrays were used to study global RNA degradation in wild-type Escherichia coli MG1655. RNA chemical half-lives were measured for 1036 open reading frames (ORFs) and for 329 known ...

    • Global surgery in a postconflict setting - 5-year results of implementation in the Russian North Caucasus 

      Lunze, Fatima I.; Lunze, Karsten; Tsorieva, Zemfira M.; Esenov, Constantin T.; Reutov, Alexandr; Eichhorn, Thomas; Offergeld, Christian (Co-Action Publishing, 2015)
      Background: Collaborations for global surgery face many challenges to achieve fair and safe patient care and to build sustainable capacity. The 2004 terrorist attack on a school in Beslan in North Ossetia in the Russian ...

    • Global, national, and local approaches to mental health: examples from India 

      Weiss, Mitchell Gralnick; Isaac, Mohan; Parkar, Shubhangi R.; Chowdhury, Arabinda N.; Raguram, R. (Wiley-Blackwell, 2001)
      Neuropsychiatric disorders and suicide amount to 12.7% of the global burden of disease and related conditions (GBD) according to World Health Organization (WHO) estimates for 1999, and recognition of the enormous component ...

    • Global, regional and national sodium intakes in 1990 and 2010: a systematic analysis of 24 h urinary sodium excretion and dietary surveys worldwide 

      Powles, John; Fahimi, Saman; Micha, Renata; Khatibzadeh, Shahab; Shi, Peilin; Ezzati, Majid; Engell, Rebecca E; Lim, Stephen S; Danaei, Goodarz; Mozaffarian, Dariush (BMJ Publishing Group, 2013)
      Objectives: To estimate global, regional (21 regions) and national (187 countries) sodium intakes in adults in 1990 and 2010. Design: Bayesian hierarchical modelling using all identifiable primary sources. Data sources and ...

    • Global, regional, and national consumption levels of dietary fats and oils in 1990 and 2010: a systematic analysis including 266 country-specific nutrition surveys 

      Micha, Renata; Khatibzadeh, Shahab; Shi, Peilin; Fahimi, Saman; Lim, Stephen; Andrews, Kathryn G; Engell, Rebecca E; Powles, John; Ezzati, Majid; Mozaffarian, Dariush (BMJ Publishing Group Ltd., 2014)
      Objectives: To quantify global consumption of key dietary fats and oils by country, age, and sex in 1990 and 2010. Design: Data were identified, obtained, and assessed among adults in 16 age- and sex-specific groups from ...

    • Globalization of Diabetes: The Role of Diet, Lifestyle, and Genes 

      Hu, Frank B. (American Diabetes Association, 2011)
      Type 2 diabetes is a global public health crisis that threatens the economies of all nations, particularly developing countries. Fueled by rapid urbanization, nutrition transition, and increasingly sedentary lifestyles, ...

    • Globally Distributed Object Identification for Biological Knowledge Bases 

      Clark, Timothy William; Martin, Sean; Liefeld, Ted (Henry Stewart Publications, 2004)
      The World-Wide Web provides a globally distributed communication framework that is essential for almost all scientific collaboration, including bioinformatics. However, several limits and inadequacies have become apparent, ...

    • Globus Pallidus Externus Neurons Expressing parvalbumin Interconnect the Subthalamic Nucleus and Striatal Interneurons 

      Saunders, Arpiar; Huang, Kee Wui; Sabatini, Bernardo Luis (Public Library of Science, 2016)
      The globus pallidus externus (GP) is a nucleus of the basal ganglia (BG), containing GABAergic projection neurons that arborize widely throughout the BG, thalamus and cortex. Ongoing work seeks to map axonal projection ...

    • GLP-1R–Targeting Magnetic Nanoparticles for Pancreatic Islet Imaging 

      Wang, Ping; Yoo, Byunghee; Yang, Jingsheng; Zhang, Xueli; Ross, Alana; Pantazopoulos, Pamela; Dai, Guangping; Moore, Anna (American Diabetes Association, 2014)
      Noninvasive assessment of pancreatic β-cell mass would tremendously aid in managing type 1 diabetes (T1D). Toward this goal, we synthesized an exendin-4 conjugated magnetic iron oxide–based nanoparticle probe targeting ...

    • GLT-1 Transport Stoichiometry Is Constant at Low and High Glutamate Concentrations when Chloride Is Substituted by Gluconate 

      Kabakov, Anatoli Y.; Rosenberg, Paul A. (Public Library of Science, 2015)
      Glutamate is the major excitatory neurotransmitter, but prolonged exposure even at micromolar concentrations causes neuronal death. Extracellular glutamate is maintained at nanomolar level by glutamate transporters, which, ...

    • GLTSCR2/PICT1 links mitochondrial stress and Myc signaling 

      Yoon, John C.; Ling, Alvin Y.; Isik, Meltem; Lee, Dong-Young Donna; Steinbaugh, Michael J.; Sack, Laura M.; Boduch, Abigail N.; Blackwell, T. Keith; Sinclair, David A.; Elledge, Stephen J. (National Academy of Sciences, 2014)
      Mitochondrial defects underlie a multitude of human diseases. Genetic manipulation of mitochondrial regulatory pathways represents a potential therapeutic approach. We have carried out a high-throughput overexpression ...