Browsing Harvard Medical School by Title
Now showing items 7445-7464 of 18428
-
GPU-Accelerated Framework for Intracoronary Optical Coherence Tomography Imaging at the Push of a Button
(Public Library of Science, 2015)Frequency domain optical coherence tomography (FD-OCT) has become one of the important clinical tools for intracoronary imaging to diagnose and monitor coronary artery disease, which has been one of the leading causes of ... -
Gq/11-Mediated Signaling and Hypertrophy in Mice with Cardiac-Specific Transgenic Expression of Regulator of G-Protein Signaling 2
(Public Library of Science, 2012)Cardiac hypertrophy is a well-established risk factor for cardiovascular morbidity and mortality. Activation of \(G_{q/11}\)-mediated signaling is required for pressure overload-induced cardiomyocyte (CM) hypertrophy to ... -
Graded Nodal/Activin Signaling Titrates Conversion of Quantitative Phospho-Smad2 Levels into Qualitative Embryonic Stem Cell Fate Decisions
(Public Library of Science, 2011)Nodal and Activin are morphogens of the TGFbeta superfamily of signaling molecules that direct differential cell fate decisions in a dose- and distance-dependent manner. During early embryonic development the Nodal/Activin ... -
Gradual Increases in Scheduled and Actual Early Follow-Up After Heart Failure Hospitalization
(Ovid Technologies (Wolters Kluwer Health), 2016) -
Graft Site Microenvironment Determines Dendritic Cell Trafficking Through the CCR7-CCL19/21 Axis
(The Association for Research in Vision and Ophthalmology, 2016)Purpose The graft site microenvironment has a profound effect on alloimmunity and graft survival. We aimed to study the kinetics and phenotype of trafficking antigen-presenting cells (APC) to the draining lymph nodes (DLNs) ... -
Graft versus Host Disease in the Bone Marrow, Liver and Thymus Humanized Mouse Model
(Public Library of Science, 2012)Mice bearing a “humanized” immune system are valuable tools to experimentally manipulate human cells in vivo and facilitate disease models not normally possible in laboratory animals. Here we describe a form of GVHD that ... -
Grafted c-kit+/SSEA1− eye-wall progenitor cells delay retinal degeneration in mice by regulating neural plasticity and forming new graft-to-host synapses
(BioMed Central, 2016)Background: Despite diverse pathogenesis, the common pathological change observed in age-related macular degeneration and in most hereditary retinal degeneration (RD) diseases is photoreceptor loss. Photoreceptor replacement ... -
Gram-Negative Bacterial Infection in Thigh Abscess Can Migrate to Distant Burn Depending on Burn Depth
(Hindawi Publishing Corporation, 2012)Sepsis remains the major cause of death in patients with major burn injuries. In the present investigation we evaluated the interaction between burn injuries of varying severity and preexisting distant infection. We used ... -
Grammar-Based Distance in Progressive Multiple Sequence Alignment
(BioMed Central, 2008)Background: We propose a multiple sequence alignment (MSA) algorithm and compare the alignment-quality and execution-time of the proposed algorithm with that of existing algorithms. The proposed progressive alignment ... -
Grand challenges in global mental health
(Springer Nature, 2011) -
Grand Rounds: Asbestos-Related Pericarditis in a Boiler Operator
(National Institute of Environmental Health Sciences, 2007)Context: Occupational and environmental exposures to asbestos remain a public health problem even in developed countries. Because of the long latency in asbestos-related pathology, past asbestos exposure continues to ... -
Granulin, a novel STAT3-interacting protein, enhances STAT3 transcriptional function and correlates with poorer prognosis in breast cancer
(Impact Journals LLC, 2015)Since the neoplastic phenotype of a cell is largely driven by aberrant gene expression patterns, increasing attention has been focused on transcription factors that regulate critical mediators of tumorigenesis such as ... -
Granzyme a Activates an Endoplasmic Reticulum-associated Caspase-independent Nuclease to Induce Single-stranded DNA Nicks
(American Society for Biochemistry and Molecular Biology, 2001)The cytotoxic T lymphocyte protease granzyme A (GzmA) initiates a novel caspase-independent cell death pathway characterized by single-stranded DNA nicking. The previously identified GzmA substrate SET is in a multimeric ... -
Granzymes a and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis
(National Academy of Sciences, 2001) -
A graphical model approach for inferring large-scale networks integrating gene expression and genetic polymorphism
(BioMed Central, 2009)Background: Graphical models (e.g., Bayesian networks) have been used frequently to describe complex interaction patterns and dependent structures among genes and other phenotypes. Estimation of such networks has been a ... -
A graphical user interface for infant ERP analysis
(Springer US, 2013)Recording of event-related potentials (ERPs) is one of the best-suited technologies for examining brain function in human infants. Yet the existing software packages are not optimized for the unique requirements of analyzing ... -
Graphics Processing Unit–Accelerated Nonrigid Registration of MR Images to CT Images During CT-Guided Percutaneous Liver Tumor Ablations
(Elsevier BV, 2015)Rationale and Objectives: Accuracy and speed are essential for the intraprocedural nonrigid MR-to-CT image registration in the assessment of tumor margins during CT-guided liver tumor ablations. While both accuracy and ... -
Grateful to God or just plain grateful? A comparison of religious and general gratitude
(Informa UK Limited, 2011)Psychological science has consistently highlighted links between gratitude and religion, however mediating pathways by which religion relates to gratitude remain ambiguous. Further, it is unclear whether religious gratitude ... -
Gray matter alterations in early aging: A diffusion magnetic resonance imaging study
(Wiley-Blackwell, 2013)Many studies have observed altered neurofunctional and structural organization in the aging brain. These observations from functional neuroimaging studies show a shift in brain activity from the posterior to the anterior ... -
Gray Matter Injury Associated with Periventricular Leukomalacia in the Premature Infant
(Springer-Verlag, 2007)Neuroimaging studies indicate reduced volumes of certain gray matter regions in survivors of prematurity with periventricular leukomalacia (PVL). We hypothesized that subacute and/or chronic gray matter lesions are increased ...