Browsing Harvard Medical School by Title
Now showing items 7455-7474 of 18428
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Grand Rounds: Asbestos-Related Pericarditis in a Boiler Operator
(National Institute of Environmental Health Sciences, 2007)Context: Occupational and environmental exposures to asbestos remain a public health problem even in developed countries. Because of the long latency in asbestos-related pathology, past asbestos exposure continues to ... -
Granulin, a novel STAT3-interacting protein, enhances STAT3 transcriptional function and correlates with poorer prognosis in breast cancer
(Impact Journals LLC, 2015)Since the neoplastic phenotype of a cell is largely driven by aberrant gene expression patterns, increasing attention has been focused on transcription factors that regulate critical mediators of tumorigenesis such as ... -
Granzyme a Activates an Endoplasmic Reticulum-associated Caspase-independent Nuclease to Induce Single-stranded DNA Nicks
(American Society for Biochemistry and Molecular Biology, 2001)The cytotoxic T lymphocyte protease granzyme A (GzmA) initiates a novel caspase-independent cell death pathway characterized by single-stranded DNA nicking. The previously identified GzmA substrate SET is in a multimeric ... -
Granzymes a and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis
(National Academy of Sciences, 2001) -
A graphical model approach for inferring large-scale networks integrating gene expression and genetic polymorphism
(BioMed Central, 2009)Background: Graphical models (e.g., Bayesian networks) have been used frequently to describe complex interaction patterns and dependent structures among genes and other phenotypes. Estimation of such networks has been a ... -
A graphical user interface for infant ERP analysis
(Springer US, 2013)Recording of event-related potentials (ERPs) is one of the best-suited technologies for examining brain function in human infants. Yet the existing software packages are not optimized for the unique requirements of analyzing ... -
Graphics Processing Unit–Accelerated Nonrigid Registration of MR Images to CT Images During CT-Guided Percutaneous Liver Tumor Ablations
(Elsevier BV, 2015)Rationale and Objectives: Accuracy and speed are essential for the intraprocedural nonrigid MR-to-CT image registration in the assessment of tumor margins during CT-guided liver tumor ablations. While both accuracy and ... -
Grateful to God or just plain grateful? A comparison of religious and general gratitude
(Informa UK Limited, 2011)Psychological science has consistently highlighted links between gratitude and religion, however mediating pathways by which religion relates to gratitude remain ambiguous. Further, it is unclear whether religious gratitude ... -
Gray matter alterations in early aging: A diffusion magnetic resonance imaging study
(Wiley-Blackwell, 2013)Many studies have observed altered neurofunctional and structural organization in the aging brain. These observations from functional neuroimaging studies show a shift in brain activity from the posterior to the anterior ... -
Gray Matter Injury Associated with Periventricular Leukomalacia in the Premature Infant
(Springer-Verlag, 2007)Neuroimaging studies indicate reduced volumes of certain gray matter regions in survivors of prematurity with periventricular leukomalacia (PVL). We hypothesized that subacute and/or chronic gray matter lesions are increased ... -
Gray matter volume reduction in rostral middle frontal gyrus in patients with chronic schizophrenia
(Elsevier BV, 2010)The dorsolateral prefrontal cortex (DLPFC) is a brain region that has figured prominently in studies of schizophrenia and working memory, yet the exact neuroanatomical localization of this brain region remains to be defined. ... -
The Great Debate: Medicine or Surgery. What Is Best for the Patient with Type 2 Diabetes?
(American Diabetes Association, 2011) -
Greater widespread functional connectivity of the caudate in older adults who practice kripalu yoga and vipassana meditation than in controls
(Frontiers Media S.A., 2015)There has been a growing interest in understanding how contemplative practices affect brain functional organization. However, most studies have restricted their exploration to predefined networks. Furthermore, scientific ... -
A Green Fluorescent Protein-Expressing Murine Tumour but Not Its Wild-Type Counterpart Is Cured by Photodynamic Therapy
(Springer Nature, 2006-01-17)The ideal cancer treatment should both destroy the primary tumour and at the same time educate the immune system to recognise the tumour as foreign so that distant metastases will also be eradicated. Photodynamic therapy ... -
Green Herring Syndrome: Bacterial Infection in Patients With Mucormycosis Cavitary Lung Disease
(Oxford University Press, 2014)Mucormycosis is a life-threatening fungal disease in patients with hematological malignancies. The diagnosis of pulmonary mucormycosis is particularly challenging. We describe 3 mucormycosis cases with an uncommon presentation ... -
Green or Yellow Laser Treatment for Diabetic Macular Edema
(Ovid Technologies (Wolters Kluwer Health), 2013)Purpose: Explore differences in green compared with yellow focal/grid laser treatment on functional and anatomic endpoints in eyes with diabetic macular edema. Methods: Data from two randomized clinical trials were evaluated ... -
A Grid-Enabled Web Service for Low-Resolution Crystal Structure Refinement
(International Union of Crystallography, 2012)Deformable elastic network (DEN) restraints have proved to be a powerful tool for refining structures from low-resolution X-ray crystallographic data sets. Unfortunately, optimal refinement using DEN restraints requires ... -
Grip Strength Cutpoints for the Identification of Clinically Relevant Weakness
(Oxford University Press, 2014)Background. Weakness is common and contributes to disability, but no consensus exists regarding a strength cutpoint to identify persons at high risk. This analysis, conducted as part of the Foundation for the National ... -
Gross Cystic Disease Fluid Protein-15/Prolactin-Inducible Protein as a Biomarker for Keratoconus Disease
(Public Library of Science, 2014)Keratoconus (KC) is a bilateral degenerative disease of the cornea characterized by corneal bulging, stromal thinning, and scarring. The etiology of the disease is unknown. In this study, we identified a new biomarker for ... -
GrOup based physical Activity for oLder adults (GOAL) randomized controlled trial: study protocol
(BioMed Central, 2015)Background: Physical activity has health benefits across the lifespan, yet only 13 % of Canadian older adults are sufficiently active. Results from a number of observational studies indicate that adults display positive ...