Browsing Harvard Medical School by Title

Now showing items 7465-7484 of 18428

    • Gray matter volume reduction in rostral middle frontal gyrus in patients with chronic schizophrenia 

      Kikinis, Zora; Fallon, J.H.; Niznikiewicz, Margaret A.; Nestor, Paul Gerard; Davidson, C.; Bobrow, L.; Pelavin, P.E.; Fischl, Bruce R.; Yendiki, Anastasia; McCarley, Robert William; Kikinis, Ron; Kubicki, Marek R.; Shenton, Martha Elizabeth (Elsevier BV, 2010)
      The dorsolateral prefrontal cortex (DLPFC) is a brain region that has figured prominently in studies of schizophrenia and working memory, yet the exact neuroanatomical localization of this brain region remains to be defined. ...

    • The Great Debate: Medicine or Surgery. What Is Best for the Patient with Type 2 Diabetes? 

      Lautz, David; Halperin, Florencia; Goebel-Fabbri, Ann Elizabeth; Goldfine, Allison Braunwald (American Diabetes Association, 2011)

    • Greater widespread functional connectivity of the caudate in older adults who practice kripalu yoga and vipassana meditation than in controls 

      Gard, Tim; Taquet, Maxime; Dixit, Rohan; Hölzel, Britta K.; Dickerson, Bradford C.; Lazar, Sara W. (Frontiers Media S.A., 2015)
      There has been a growing interest in understanding how contemplative practices affect brain functional organization. However, most studies have restricted their exploration to predefined networks. Furthermore, scientific ...

    • A Green Fluorescent Protein-Expressing Murine Tumour but Not Its Wild-Type Counterpart Is Cured by Photodynamic Therapy 

      Castano, A P; Liu, Q; Hamblin, Michael (Springer Nature, 2006-01-17)
      The ideal cancer treatment should both destroy the primary tumour and at the same time educate the immune system to recognise the tumour as foreign so that distant metastases will also be eradicated. Photodynamic therapy ...

    • Green Herring Syndrome: Bacterial Infection in Patients With Mucormycosis Cavitary Lung Disease 

      Peixoto, Driele; Hammond, Sarah P.; Issa, Nicolas C.; Madan, Rachna; Gill, Ritu R.; Milner, Danny A.; Colson, Yolonda L.; Koo, Sophia; Baden, Lindsey R.; Marty, Francisco M. (Oxford University Press, 2014)
      Mucormycosis is a life-threatening fungal disease in patients with hematological malignancies. The diagnosis of pulmonary mucormycosis is particularly challenging. We describe 3 mucormycosis cases with an uncommon presentation ...

    • Green or Yellow Laser Treatment for Diabetic Macular Edema 

      Bressler, Susan B.; Almukhtar, Talat; Aiello, Lloyd Paul; Bressler, Neil M.; Ferris, Frederick L.; Glassman, Adam R.; Greven, Craig M. (Ovid Technologies (Wolters Kluwer Health), 2013)
      Purpose: Explore differences in green compared with yellow focal/grid laser treatment on functional and anatomic endpoints in eyes with diabetic macular edema. Methods: Data from two randomized clinical trials were evaluated ...

    • A Grid-Enabled Web Service for Low-Resolution Crystal Structure Refinement 

      O’Donovan, Daniel J.; Stokes-Rees, Ian; Nam, Yunsun; Blacklow, Stephen C.; Schröder, Gunnar F.; Brunger, Axel T.; Sliz, Piotr (International Union of Crystallography, 2012)
      Deformable elastic network (DEN) restraints have proved to be a powerful tool for refining structures from low-resolution X-ray crystallographic data sets. Unfortunately, optimal refinement using DEN restraints requires ...

    • Grip Strength Cutpoints for the Identification of Clinically Relevant Weakness 

      Alley, Dawn E.; Shardell, Michelle D.; Peters, Katherine W.; McLean, Robert R.; Dam, Thuy-Tien L.; Kenny, Anne M.; Fragala, Maren S.; Harris, Tamara B.; Kiel, Douglas P.; Guralnik, Jack M.; Ferrucci, Luigi; Kritchevsky, Stephen B.; Studenski, Stephanie A.; Vassileva, Maria T.; Cawthon, Peggy M. (Oxford University Press, 2014)
      Background. Weakness is common and contributes to disability, but no consensus exists regarding a strength cutpoint to identify persons at high risk. This analysis, conducted as part of the Foundation for the National ...

    • Gross Cystic Disease Fluid Protein-15/Prolactin-Inducible Protein as a Biomarker for Keratoconus Disease 

      Priyadarsini, Shrestha; Hjortdal, Jesper; Sarker-Nag, Akhee; Sejersen, Henrik; Asara, John M.; Karamichos, Dimitrios (Public Library of Science, 2014)
      Keratoconus (KC) is a bilateral degenerative disease of the cornea characterized by corneal bulging, stromal thinning, and scarring. The etiology of the disease is unknown. In this study, we identified a new biomarker for ...

    • GrOup based physical Activity for oLder adults (GOAL) randomized controlled trial: study protocol 

      Beauchamp, Mark R.; Harden, Samantha M.; Wolf, Svenja A.; Rhodes, Ryan E.; Liu, Yan; Dunlop, William L.; Schmader, Toni; Sheel, Andrew W.; Zumbo, Bruno D.; Estabrooks, Paul A. (BioMed Central, 2015)
      Background: Physical activity has health benefits across the lifespan, yet only 13 % of Canadian older adults are sufficiently active. Results from a number of observational studies indicate that adults display positive ...

    • Group-based Trajectory Models: A New Approach to Classifying and Predicting Long-Term Medication Adherence 

      Franklin, Jessica Myers; Shrank, William; Pakes, Juliana; Sanfélix-Gimeno, Gabriel; Matlin, Olga S.; Brennan, Troyen Anthony; Choudhry, Niteesh Kumar (Ovid Technologies (Wolters Kluwer Health), 2013)
      BACKGROUND: Classifying medication adherence is important for efficiently targeting adherence improvement interventions. The purpose of this study was to evaluate the use of a novel method, group-based trajectory models, ...

    • The Growing Problem of Multidrug-Resistant Tuberculosis in North Korea 

      Seung, Kwonjune J.; Linton, Stephen W. (Public Library of Science, 2013)
      Kwonjune Seung and Stephen Linton from the non-governmental organization EugeneBell discuss the worryingly high levels of multidrug-resistant tuberculosis they have observed in North Korea's tuberculosis sanatoria. Please ...

    • The growth and gaps of genetic data sharing policies in the United States 

      Arias, Jalayne J.; Pham-Kanter, Genevieve; Campbell, Eric G. (Oxford University Press, 2015)
      The 1996 Bermuda Principles launched a new era in data sharing, reflecting a growing belief that the rapid public dissemination of research data was crucial to scientific progress in genetics. A historical review of data ...

    • Growth cone-specific functions of XMAP215 in restricting microtubule dynamics and promoting axonal outgrowth 

      Lowery, Laura Anne; Stout, Alina; Faris, Anna E; Ding, Liya; Baird, Michelle A; Davidson, Michael W; Danuser, Gaudenz; Van Vactor, David (BioMed Central, 2013)
      Background: Microtubule (MT) regulators play essential roles in multiple aspects of neural development. In vitro reconstitution assays have established that the XMAP215/Dis1/TOG family of MT regulators function as MT ...

    • Growth factors are released by mechanically wounded endothelial cells 

      McNeil, Paul L.; D'Amore, Patricia Ann; Warder, Elizabeth; Muthukrishnan, Lakshmi (Rockefeller University Press, 1989)
      Growth factors may be required at sites of mechanical injury and normal wear and tear in vivo, suggesting that the direct action of mechanical forces on cells could lead to growth factor release. Scraping of cells from the ...

    • Growth Hormone Influence on the Morphology and Size of the Mouse Meibomian Gland 

      Liu, Yang; Knop, Erich; Knop, Nadja; Sullivan, David A.; List, Edward O.; Kopchick, John J.; Kam, Wendy R.; Ding, Juan (Hindawi Publishing Corporation, 2016)
      Purpose. We hypothesize that growth hormone (GH) plays a significant role in the regulation of the meibomian gland. To test our hypothesis, we examined the influence of GH on mouse meibomian gland structure. Methods. We ...

    • Growth hormone status predicts left ventricular mass in patients after cure of acromegaly 

      Wexler, Tamara; Durst, Ronen; McCarty, David; Picard, Michael Howard; Gunnell, Lindsay; Omer, Zehra; Fazeli, Pouneh Khadejeh; Miller, Karen Klahr; Klibanski, Anne (Elsevier BV, 2010)
      Context: Growth hormone excess and growth hormone deficiency (GHD) are both associated with increased cardiovascular morbidity. A specific acromegaly-related cardiomyopathy has been described, characterized in part by ...

    • Growth in Total Height and Its Components and Cardiometabolic Health in Childhood 

      Haugaard, Line Klingen; Baker, Jennifer L.; Perng, Wei; Belfort, Mandy Brown; Rifas-Shiman, Sheryl L.; Switkowski, Karen; Oken, Emily; Gillman, Matthew W. (Public Library of Science, 2016)
      Background: Short stature or short legs is associated with cardiometabolic disease. Few studies have addressed this issue in children, incorporated repeated measures, or studied modern cohorts. Methods: We examined if ...

    • Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs 

      Hafner, Marc; Niepel, Mario; Chung, Mirra; Sorger, Peter K. (2016)
      Drug sensitivity and resistance are conventionally quantified by IC50 or Emax values, but these metrics are highly sensitive to the number of divisions taking place over the course of a response assay. The dependency of ...

    • Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake 

      Nakajima, Ken-ichiro; Cui, Zhenzhong; Li, Chia; Meister, Jaroslawna; Cui, Yinghong; Fu, Ou; Smith, Adam S.; Jain, Shalini; Lowell, Bradford B.; Krashes, Michael J.; Wess, Jürgen (Nature Publishing Group, 2016)
      Agouti-related peptide (AgRP) neurons of the hypothalamus play a key role in regulating food intake and body weight, by releasing three different orexigenic molecules: AgRP; GABA; and neuropeptide Y. AgRP neurons express ...