Browsing Harvard Medical School by Title
Now showing items 7472-7491 of 18427
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Grip Strength Cutpoints for the Identification of Clinically Relevant Weakness
(Oxford University Press, 2014)Background. Weakness is common and contributes to disability, but no consensus exists regarding a strength cutpoint to identify persons at high risk. This analysis, conducted as part of the Foundation for the National ... -
Gross Cystic Disease Fluid Protein-15/Prolactin-Inducible Protein as a Biomarker for Keratoconus Disease
(Public Library of Science, 2014)Keratoconus (KC) is a bilateral degenerative disease of the cornea characterized by corneal bulging, stromal thinning, and scarring. The etiology of the disease is unknown. In this study, we identified a new biomarker for ... -
GrOup based physical Activity for oLder adults (GOAL) randomized controlled trial: study protocol
(BioMed Central, 2015)Background: Physical activity has health benefits across the lifespan, yet only 13 % of Canadian older adults are sufficiently active. Results from a number of observational studies indicate that adults display positive ... -
Group-based Trajectory Models: A New Approach to Classifying and Predicting Long-Term Medication Adherence
(Ovid Technologies (Wolters Kluwer Health), 2013)BACKGROUND: Classifying medication adherence is important for efficiently targeting adherence improvement interventions. The purpose of this study was to evaluate the use of a novel method, group-based trajectory models, ... -
The Growing Problem of Multidrug-Resistant Tuberculosis in North Korea
(Public Library of Science, 2013)Kwonjune Seung and Stephen Linton from the non-governmental organization EugeneBell discuss the worryingly high levels of multidrug-resistant tuberculosis they have observed in North Korea's tuberculosis sanatoria. Please ... -
The growth and gaps of genetic data sharing policies in the United States
(Oxford University Press, 2015)The 1996 Bermuda Principles launched a new era in data sharing, reflecting a growing belief that the rapid public dissemination of research data was crucial to scientific progress in genetics. A historical review of data ... -
Growth cone-specific functions of XMAP215 in restricting microtubule dynamics and promoting axonal outgrowth
(BioMed Central, 2013)Background: Microtubule (MT) regulators play essential roles in multiple aspects of neural development. In vitro reconstitution assays have established that the XMAP215/Dis1/TOG family of MT regulators function as MT ... -
Growth factors are released by mechanically wounded endothelial cells
(Rockefeller University Press, 1989)Growth factors may be required at sites of mechanical injury and normal wear and tear in vivo, suggesting that the direct action of mechanical forces on cells could lead to growth factor release. Scraping of cells from the ... -
Growth Hormone Influence on the Morphology and Size of the Mouse Meibomian Gland
(Hindawi Publishing Corporation, 2016)Purpose. We hypothesize that growth hormone (GH) plays a significant role in the regulation of the meibomian gland. To test our hypothesis, we examined the influence of GH on mouse meibomian gland structure. Methods. We ... -
Growth hormone status predicts left ventricular mass in patients after cure of acromegaly
(Elsevier BV, 2010)Context: Growth hormone excess and growth hormone deficiency (GHD) are both associated with increased cardiovascular morbidity. A specific acromegaly-related cardiomyopathy has been described, characterized in part by ... -
Growth in Total Height and Its Components and Cardiometabolic Health in Childhood
(Public Library of Science, 2016)Background: Short stature or short legs is associated with cardiometabolic disease. Few studies have addressed this issue in children, incorporated repeated measures, or studied modern cohorts. Methods: We examined if ... -
Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs
(2016)Drug sensitivity and resistance are conventionally quantified by IC50 or Emax values, but these metrics are highly sensitive to the number of divisions taking place over the course of a response assay. The dependency of ... -
Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake
(Nature Publishing Group, 2016)Agouti-related peptide (AgRP) neurons of the hypothalamus play a key role in regulating food intake and body weight, by releasing three different orexigenic molecules: AgRP; GABA; and neuropeptide Y. AgRP neurons express ... -
GSDMD pore structure reveals mechanism of preferential IL-1 release
Inflammasomes are innate immune organelles that activate inflammatory caspases, which proteolytically process gasdermin D (GSDMD). In addition, caspase-1, one of the inflammatory caspases, cleaves inactive interleukin ... -
Guanidine Hydrochloride Inhibits Mammalian Orthoreovirus Growth by Reversibly Blocking the Synthesis of Double-Stranded RNA
(American Society for Microbiology, 2007)Millimolar concentrations of guanidine hydrochloride (GuHCl) are known to inhibit the replication of many plant and animal viruses having positive-sense RNA genomes. For example, GuHCl reversibly interacts with the ... -
A Guanidine-rich Regulatory Oligodeoxynucleotide Improves Type-2 Diabetes in Obese Mice by Blocking T-cell Differentiation
(WILEY-VCH Verlag, 2012)T lymphocytes exhibit pro-inflammatory or anti-inflammatory activities in obesity and diabetes, depending on their subtypes. Guanidine-rich immunosuppressive oligodeoxynucleotides (ODNs) effectively control Th1/Th2-cell ... -
Guanine Nucleotide Exchange Factor Vav1 Regulates Perivascular Homing and Bone Marrow Retention of Hematopoietic Stem and Progenitor Cells
(Proceedings of the National Academy of Sciences, 2011)Engraftment and maintenance of hematopoietic stem and progenitor cells (HSPC) depend on their ability to respond to extracellular signals from the bone marrow microenvironment, but the critical intracellular pathways ... -
Guarding Embryo Development of Zebrafish by Shell Engineering: A Strategy to Shield Life from Ozone Depletion
(Public Library of Science, 2010)Background: The reduced concentration of stratospheric ozone results in an increased flux of biologically damaging mid-ultraviolet radiation (UVB, 280 to 320 nm) reaching earth surfaces. Environmentally relevant levels of ... -
Guest Editor's Concluding Remarks―Advances in Usage of ANN, Discussion of an Unsolved Problem, and Some Differences between Papers Written by Engineers and by Physicians
(Molecular Diversity Preservation International (MDPI), 2009) -
Guest Editorial: From Neuroscience to Neuro-rehabilitation: Transferring Basic Neuroscientific Principles from Laboratory to Bedside
(BioMed Central, 2013)Several new approaches for treatment of Central Nervous System (CNS) disorders are currently under investigation, including the use of rehabilitation training strategies, which are often combined with electrical and/or ...